JP2015516405A5 - - Google Patents
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- Publication number
- JP2015516405A5 JP2015516405A5 JP2015510812A JP2015510812A JP2015516405A5 JP 2015516405 A5 JP2015516405 A5 JP 2015516405A5 JP 2015510812 A JP2015510812 A JP 2015510812A JP 2015510812 A JP2015510812 A JP 2015510812A JP 2015516405 A5 JP2015516405 A5 JP 2015516405A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- alkyl
- substituted
- alkanoyl
- hal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 24
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims description 22
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 19
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 12
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 claims description 12
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 20
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 10
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 9
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 229910052717 sulfur Inorganic materials 0.000 description 7
- 0 CC(CC(*)*C(*=C(*)*)=C(**)C(*)=C)C[*@@](*)C(N=*)=*C Chemical compound CC(CC(*)*C(*=C(*)*)=C(**)C(*)=C)C[*@@](*)C(N=*)=*C 0.000 description 5
- 125000005842 heteroatom Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167126 | 2012-05-08 | ||
| EP12167126.7 | 2012-05-08 | ||
| PCT/EP2013/059584 WO2013167653A1 (en) | 2012-05-08 | 2013-05-08 | 18f-labelled folate/antifolate analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516405A JP2015516405A (ja) | 2015-06-11 |
| JP2015516405A5 true JP2015516405A5 (https=) | 2016-06-30 |
| JP6198814B2 JP6198814B2 (ja) | 2017-09-20 |
Family
ID=48407549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510812A Active JP6198814B2 (ja) | 2012-05-08 | 2013-05-08 | １８ｆ標識された葉酸／葉酸代謝拮抗物質同族体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10357576B2 (https=) |
| EP (1) | EP2864329B1 (https=) |
| JP (1) | JP6198814B2 (https=) |
| KR (1) | KR102116000B1 (https=) |
| CN (1) | CN104379585B (https=) |
| AU (1) | AU2013258027B2 (https=) |
| CA (1) | CA2870124C (https=) |
| DK (1) | DK2864329T3 (https=) |
| EA (1) | EA201401225A1 (https=) |
| ES (1) | ES2703627T3 (https=) |
| IL (1) | IL235476B (https=) |
| PL (1) | PL2864329T3 (https=) |
| PT (1) | PT2864329T (https=) |
| SG (1) | SG11201406481TA (https=) |
| TR (1) | TR201819802T4 (https=) |
| WO (1) | WO2013167653A1 (https=) |
| ZA (1) | ZA201407266B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101646577B1 (ko) * | 2014-08-14 | 2016-08-09 | 원광대학교산학협력단 | 엽산수용체 표적용 화합물 또는 이의 약학적으로 허용가능한 염과, 이를 유효성분으로 포함하는 암 예방, 진단 또는 치료용 조성물 |
| JP7204662B2 (ja) * | 2017-03-20 | 2023-01-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 異性体的に純粋な１８ｆ－標識されたテトラヒドロ葉酸 |
| EP3671511B1 (en) | 2018-12-19 | 2022-07-06 | Rohde & Schwarz GmbH & Co. KG | Communication system and method |
| DE102019110904B4 (de) * | 2019-04-26 | 2022-01-20 | Helmholtz-Zentrum Dresden - Rossendorf E. V. | N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-acetamid-Derivate und deren Verwendung |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| SMT202500271T1 (it) | 2020-07-02 | 2025-09-12 | Incyte Corp | Composti di urea triciclici come inibitori di v617f di jak2 |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
| AR125273A1 (es) | 2021-02-25 | 2023-07-05 | Incyte Corp | Lactamas espirocíclicas como inhibidores de jak2 v617f |
| CN119173514A (zh) | 2022-03-17 | 2024-12-20 | 因赛特公司 | 作为jak2 v617f抑制剂的三环脲化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2007128036A (ru) | 2004-12-23 | 2009-01-27 | Пердью Рисерч Фаундейшн (Us) | Способ получения изображения позитронно-эмиссионной томографией |
| JP4503039B2 (ja) | 2006-04-27 | 2010-07-14 | 三洋電機株式会社 | 回路装置 |
| US8586595B2 (en) | 2007-02-07 | 2013-11-19 | Purdue Research Foundation | Positron emission tomography imaging method |
| DK2150514T3 (en) | 2007-04-11 | 2019-02-18 | Merck & Cie | 18F-LABELED FOLATES |
| WO2008125615A1 (en) | 2007-04-11 | 2008-10-23 | Merck Eprova Ag | 18 f-labelled folates |
| CA2670363C (en) | 2007-04-11 | 2015-07-21 | Merck Eprova Ag | 18f-labelled folates |
| US20100143249A1 (en) | 2007-04-11 | 2010-06-10 | Merck Eprova Ag | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
| SG195545A1 (en) | 2008-10-10 | 2013-12-30 | Merck & Cie | 18f-labelled folates as pet radiotracers |
-
2013
- 2013-05-08 AU AU2013258027A patent/AU2013258027B2/en active Active
- 2013-05-08 CA CA2870124A patent/CA2870124C/en active Active
- 2013-05-08 DK DK13721738.6T patent/DK2864329T3/en active
- 2013-05-08 KR KR1020147033749A patent/KR102116000B1/ko active Active
- 2013-05-08 JP JP2015510812A patent/JP6198814B2/ja active Active
- 2013-05-08 WO PCT/EP2013/059584 patent/WO2013167653A1/en not_active Ceased
- 2013-05-08 PT PT13721738T patent/PT2864329T/pt unknown
- 2013-05-08 TR TR2018/19802T patent/TR201819802T4/tr unknown
- 2013-05-08 ES ES13721738T patent/ES2703627T3/es active Active
- 2013-05-08 PL PL13721738T patent/PL2864329T3/pl unknown
- 2013-05-08 CN CN201380024067.2A patent/CN104379585B/zh active Active
- 2013-05-08 EP EP13721738.6A patent/EP2864329B1/en active Active
- 2013-05-08 EA EA201401225A patent/EA201401225A1/ru unknown
- 2013-05-08 US US14/399,688 patent/US10357576B2/en active Active
- 2013-05-08 SG SG11201406481TA patent/SG11201406481TA/en unknown
-
2014
- 2014-10-07 ZA ZA2014/07266A patent/ZA201407266B/en unknown
- 2014-11-03 IL IL235476A patent/IL235476B/en active IP Right Grant
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