JP2015515999A5 - - Google Patents
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- Publication number
- JP2015515999A5 JP2015515999A5 JP2015510742A JP2015510742A JP2015515999A5 JP 2015515999 A5 JP2015515999 A5 JP 2015515999A5 JP 2015510742 A JP2015510742 A JP 2015510742A JP 2015510742 A JP2015510742 A JP 2015510742A JP 2015515999 A5 JP2015515999 A5 JP 2015515999A5
- Authority
- JP
- Japan
- Prior art keywords
- candesartan cilexetil
- nifedipine
- micronized
- water
- osmotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 description 5
- 229960004349 candesartan cilexetil Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000000576 coating method Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 3
- 229960001597 nifedipine Drugs 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- UEJMFQHOVKQHHB-UHFFFAOYSA-N 1-cyclohexyloxycarbonyloxyethyl 2-oxo-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-1h-benzimidazole-4-carboxylate Chemical compound C=1C=CC=2NC(=O)N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C=3NN=NN=3)C=2C=1C(=O)OC(C)OC(=O)OC1CCCCC1 UEJMFQHOVKQHHB-UHFFFAOYSA-N 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12167035.0 | 2012-05-07 | ||
| EP12167035 | 2012-05-07 | ||
| EP13151946 | 2013-01-18 | ||
| EP13151946.4 | 2013-01-18 | ||
| PCT/EP2013/059110 WO2013167453A1 (en) | 2012-05-07 | 2013-05-02 | Process for manufacturing a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015515999A JP2015515999A (ja) | 2015-06-04 |
| JP2015515999A5 true JP2015515999A5 (enExample) | 2016-06-23 |
| JP6231553B2 JP6231553B2 (ja) | 2017-11-15 |
Family
ID=48289160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510742A Expired - Fee Related JP6231553B2 (ja) | 2012-05-07 | 2013-05-02 | ニフェジピンおよびカンデサルタン・シレキセチルを含む医薬投与形を製造する方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9539176B2 (enExample) |
| EP (1) | EP2846777B1 (enExample) |
| JP (1) | JP6231553B2 (enExample) |
| KR (1) | KR20150007297A (enExample) |
| CN (1) | CN104507459A (enExample) |
| AR (1) | AR090940A1 (enExample) |
| AU (1) | AU2013258273A1 (enExample) |
| BR (1) | BR112014027618A2 (enExample) |
| CA (1) | CA2872542A1 (enExample) |
| CL (1) | CL2014002988A1 (enExample) |
| CO (1) | CO7190241A2 (enExample) |
| CR (1) | CR20140511A (enExample) |
| DO (1) | DOP2014000251A (enExample) |
| EA (1) | EA201492026A1 (enExample) |
| EC (1) | ECSP14025965A (enExample) |
| ES (1) | ES2612532T3 (enExample) |
| GT (1) | GT201400245A (enExample) |
| HK (1) | HK1204292A1 (enExample) |
| IL (1) | IL235040A0 (enExample) |
| IN (1) | IN2014DN09045A (enExample) |
| MX (1) | MX2014013320A (enExample) |
| PE (1) | PE20142284A1 (enExample) |
| PH (1) | PH12014502469A1 (enExample) |
| SG (1) | SG11201406363VA (enExample) |
| TW (1) | TW201410266A (enExample) |
| UY (1) | UY34786A (enExample) |
| WO (1) | WO2013167453A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9244004B2 (en) * | 2013-08-08 | 2016-01-26 | Stichting Sron—Netherlands Institute For Space Research | Method and system for inspection of composite assemblies using terahertz radiation |
| US10071482B2 (en) | 2015-08-19 | 2018-09-11 | Ford Global Technologies, Llc | Robotic vehicle painting instrument including a terahertz radiation device |
| US10365229B2 (en) * | 2015-12-31 | 2019-07-30 | Kaiser Optical Systems, Inc. | Real-time characterization of pharmaceutical tablet coatings using Raman spectroscopy |
| DE102016222667A1 (de) * | 2016-11-17 | 2018-05-17 | Robert Bosch Gmbh | Verfahren zum Betrieb einer Anlage zum Herstellen von pharmazeutischen Produkten |
| US10323932B1 (en) | 2017-12-28 | 2019-06-18 | Ford Motor Company | System for inspecting vehicle bodies |
| JP7263047B2 (ja) * | 2019-02-25 | 2023-04-24 | 沢井製薬株式会社 | フィルムコーティング錠剤 |
| CN110411978B (zh) * | 2019-07-26 | 2020-05-22 | 中国农业大学 | 一种物料均匀性检测设备及检测方法 |
| CN115192538B (zh) * | 2022-08-02 | 2023-09-15 | 沈阳信康药物研究有限公司 | 一种压制包衣型硝苯地平缓释片及其制备方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670827C3 (de) | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| US4426019A (en) | 1981-10-15 | 1984-01-17 | The Coca-Cola Company | Membrane seal and knife combination for a post-mix beverage dispensing system |
| US4576604A (en) | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
| US5082668A (en) | 1983-05-11 | 1992-01-21 | Alza Corporation | Controlled-release system with constant pushing source |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| NZ206600A (en) | 1983-05-11 | 1987-01-23 | Alza Corp | Osmotic drug delivery device |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4948592A (en) | 1986-05-09 | 1990-08-14 | Alza Corporation | Pulsed drug delivery |
| DE3720757A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
| US4931285A (en) | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
| EP0386440B1 (de) | 1989-02-11 | 1992-08-05 | Bayer Ag | Arzneimittel mit kontrollierter Wirkstoffabgabe |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| JP3398379B2 (ja) | 1990-12-14 | 2003-04-21 | スミスクライン・ビーチャム・コーポレイション | アンジオテンシンｉｉ受容体遮断組成物 |
| US5656650A (en) | 1990-12-14 | 1997-08-12 | Smithkline Beecham Corp. | Angiotensin II receptor blocking compositions |
| US5160744A (en) | 1991-06-27 | 1992-11-03 | Alza Corporation | Verapmil therapy |
| US5178867A (en) | 1991-08-19 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug in short-time period |
| US5543154A (en) | 1991-12-27 | 1996-08-06 | Merck & Co., Inc. | Controlled release nifedipine delivery device |
| CA2125251C (en) | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
| DE19747261A1 (de) | 1997-10-25 | 1999-04-29 | Bayer Ag | Osmotisches Arzneimittelfreisetzungssystem |
| EP1165054A4 (en) | 1999-04-06 | 2005-02-09 | Pharmaquest Ltd | PHARMACEUTICAL DOSAGE FORM FOR INTERMITTENT DELIVERY OF METHYLPHENIDATE |
| US20040115134A1 (en) | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
| CA2456034A1 (en) | 2001-08-03 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Sustained-release medicines |
| JP2005508358A (ja) | 2001-10-25 | 2005-03-31 | デポメド・インコーポレイテッド | 胃滞留型ロサルタン投与量を用いる治療方法 |
| US20030161882A1 (en) | 2002-02-01 | 2003-08-28 | Waterman Kenneth C. | Osmotic delivery system |
| WO2003080057A1 (fr) | 2002-03-27 | 2003-10-02 | Bayer Aktiengesellschaft | Comprime-noyau de taille reduite contenant de la nifedipine |
| EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| US8029822B2 (en) | 2003-05-22 | 2011-10-04 | Osmotica Kereskedelmi és Seolgáltató KFT | Rupturing controlled release device having a preformed passageway |
| AU2003249492A1 (en) | 2003-07-24 | 2005-02-14 | Eswaran Krishnan Iyer | Oral compositions for treatment of diseases |
| EP1711168A2 (en) | 2004-01-23 | 2006-10-18 | Ranbaxy Laboratories Limited | Oral pharmaceutical compositions of candesartan cilexetil |
| WO2005070398A2 (en) | 2004-01-23 | 2005-08-04 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of candesartan cilexetil stabilized with co-solvents |
| WO2005084648A1 (en) | 2004-02-27 | 2005-09-15 | Ranbaxy Laboratories Limited | Pharmaceutical compositions comprising candesartan cilexetil |
| TW200534879A (en) | 2004-03-25 | 2005-11-01 | Bristol Myers Squibb Co | Coated tablet formulation and method |
| TWI415635B (zh) | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
| DE102004062475A1 (de) | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| KR100978592B1 (ko) | 2005-05-10 | 2010-08-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 안정한 미세 분말 칸데사탄 실렉세틸 및 이것의 제조 방법 |
| DE102005031577A1 (de) | 2005-07-06 | 2007-01-11 | Bayer Healthcare Ag | Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten |
| EP2040780B1 (en) | 2006-07-03 | 2016-01-06 | Novo Nordisk A/S | Coupling for injection devices |
| KR100888131B1 (ko) | 2006-10-10 | 2009-03-11 | 한올제약주식회사 | 시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제 |
| WO2008045006A1 (en) | 2006-10-11 | 2008-04-17 | Fako Ilaclari A. S. | Formulations of candesartan |
| WO2008065097A2 (en) | 2006-11-28 | 2008-06-05 | Laboratorios Liconsa, S.A. | Stabilized solid pharmaceutical composition of candesartan cilexetil |
| US20100316711A1 (en) | 2007-10-25 | 2010-12-16 | Bayer Yakuhin ,Ltd. | Nifedipine containing opress coated tablet and method of preparing same |
| DE102008059206A1 (de) * | 2008-11-27 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum |
| WO2012031124A2 (en) | 2010-09-03 | 2012-03-08 | Bristol-Myers Squibb Company | Drug formulations using water soluble antioxidants |
-
2013
- 2013-05-02 MX MX2014013320A patent/MX2014013320A/es unknown
- 2013-05-02 BR BR112014027618A patent/BR112014027618A2/pt not_active IP Right Cessation
- 2013-05-02 SG SG11201406363VA patent/SG11201406363VA/en unknown
- 2013-05-02 WO PCT/EP2013/059110 patent/WO2013167453A1/en not_active Ceased
- 2013-05-02 KR KR1020147030966A patent/KR20150007297A/ko not_active Withdrawn
- 2013-05-02 IN IN9045DEN2014 patent/IN2014DN09045A/en unknown
- 2013-05-02 CA CA2872542A patent/CA2872542A1/en not_active Abandoned
- 2013-05-02 ES ES13720375.8T patent/ES2612532T3/es active Active
- 2013-05-02 CN CN201380024042.2A patent/CN104507459A/zh active Pending
- 2013-05-02 AU AU2013258273A patent/AU2013258273A1/en not_active Abandoned
- 2013-05-02 EP EP13720375.8A patent/EP2846777B1/en not_active Not-in-force
- 2013-05-02 HK HK15104963.8A patent/HK1204292A1/xx unknown
- 2013-05-02 JP JP2015510742A patent/JP6231553B2/ja not_active Expired - Fee Related
- 2013-05-02 EA EA201492026A patent/EA201492026A1/ru unknown
- 2013-05-02 PE PE2014001923A patent/PE20142284A1/es not_active Application Discontinuation
- 2013-05-03 AR ARP130101527A patent/AR090940A1/es unknown
- 2013-05-06 TW TW102116014A patent/TW201410266A/zh unknown
- 2013-05-06 UY UY0001034786A patent/UY34786A/es not_active Application Discontinuation
- 2013-05-07 US US13/889,100 patent/US9539176B2/en not_active Expired - Fee Related
-
2014
- 2014-10-07 IL IL235040A patent/IL235040A0/en unknown
- 2014-11-04 CL CL2014002988A patent/CL2014002988A1/es unknown
- 2014-11-05 PH PH12014502469A patent/PH12014502469A1/en unknown
- 2014-11-06 DO DO2014000251A patent/DOP2014000251A/es unknown
- 2014-11-06 GT GT201400245A patent/GT201400245A/es unknown
- 2014-11-06 EC ECIEPI201425965A patent/ECSP14025965A/es unknown
- 2014-11-06 CO CO14245829A patent/CO7190241A2/es unknown
- 2014-11-07 CR CR20140511A patent/CR20140511A/es unknown
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