IN2014DN09045A - - Google Patents

Info

Publication number
IN2014DN09045A
IN2014DN09045A IN9045DEN2014A IN2014DN09045A IN 2014DN09045 A IN2014DN09045 A IN 2014DN09045A IN 9045DEN2014 A IN9045DEN2014 A IN 9045DEN2014A IN 2014DN09045 A IN2014DN09045 A IN 2014DN09045A
Authority
IN
India
Prior art keywords
nifedipine
diuretic
optionally
released
pharmaceutical dosage
Prior art date
Application number
Inventor
Adrian Funke
GüNTER MEYER
Martina Smikalla
Andreas Meeners
Markus Wirges
Daniela Brock
Sarah Just
Peter Kleinebudde
Klaus Knop
Jochen Axel Zeitler
Rolf Anton Boeggering
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48289160&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN09045(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of IN2014DN09045A publication Critical patent/IN2014DN09045A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to manufacturing processes for the preparation of a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil and optionally at least one diuretic characterized in that nifedipine is released in the body in a controlled (modified) manner and the candesartan cilexetil is released rapidly (immediate release (IR)) and optionally the diuretic is released rapidly (immediate release (IR)) and the pharmaceutical dosage forms obtainable by these processes.
IN9045DEN2014 2012-05-07 2013-05-02 IN2014DN09045A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12167035 2012-05-07
EP13151946 2013-01-18
PCT/EP2013/059110 WO2013167453A1 (en) 2012-05-07 2013-05-02 Process for manufacturing a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil

Publications (1)

Publication Number Publication Date
IN2014DN09045A true IN2014DN09045A (en) 2015-05-22

Family

ID=48289160

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9045DEN2014 IN2014DN09045A (en) 2012-05-07 2013-05-02

Country Status (27)

Country Link
US (1) US9539176B2 (en)
EP (1) EP2846777B1 (en)
JP (1) JP6231553B2 (en)
KR (1) KR20150007297A (en)
CN (1) CN104507459A (en)
AR (1) AR090940A1 (en)
AU (1) AU2013258273A1 (en)
BR (1) BR112014027618A2 (en)
CA (1) CA2872542A1 (en)
CL (1) CL2014002988A1 (en)
CO (1) CO7190241A2 (en)
CR (1) CR20140511A (en)
DO (1) DOP2014000251A (en)
EA (1) EA201492026A1 (en)
EC (1) ECSP14025965A (en)
ES (1) ES2612532T3 (en)
GT (1) GT201400245A (en)
HK (1) HK1204292A1 (en)
IL (1) IL235040A0 (en)
IN (1) IN2014DN09045A (en)
MX (1) MX2014013320A (en)
PE (1) PE20142284A1 (en)
PH (1) PH12014502469A1 (en)
SG (1) SG11201406363VA (en)
TW (1) TW201410266A (en)
UY (1) UY34786A (en)
WO (1) WO2013167453A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9244004B2 (en) * 2013-08-08 2016-01-26 Stichting Sron—Netherlands Institute For Space Research Method and system for inspection of composite assemblies using terahertz radiation
US10071482B2 (en) 2015-08-19 2018-09-11 Ford Global Technologies, Llc Robotic vehicle painting instrument including a terahertz radiation device
US10365229B2 (en) * 2015-12-31 2019-07-30 Kaiser Optical Systems, Inc. Real-time characterization of pharmaceutical tablet coatings using Raman spectroscopy
DE102016222667A1 (en) * 2016-11-17 2018-05-17 Robert Bosch Gmbh Method for operating a plant for the production of pharmaceutical products
US10323932B1 (en) 2017-12-28 2019-06-18 Ford Motor Company System for inspecting vehicle bodies
JP7263047B2 (en) 2019-02-25 2023-04-24 沢井製薬株式会社 film coated tablets
CN110411978B (en) * 2019-07-26 2020-05-22 中国农业大学 Material uniformity detection equipment and detection method
JP7312676B2 (en) 2019-11-13 2023-07-21 ナブテスコ株式会社 Brake abnormality determination device, brake state storage device, abnormality determination method, abnormality determination program, and brake control device
CN115192538B (en) * 2022-08-02 2023-09-15 沈阳信康药物研究有限公司 Compression-coated nifedipine sustained-release tablet and preparation method thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (en) 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4- (2'-nitrophenyl) -2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4426019A (en) 1981-10-15 1984-01-17 The Coca-Cola Company Membrane seal and knife combination for a post-mix beverage dispensing system
US4576604A (en) 1983-03-04 1986-03-18 Alza Corporation Osmotic system with instant drug availability
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US5082668A (en) 1983-05-11 1992-01-21 Alza Corporation Controlled-release system with constant pushing source
NZ206600A (en) 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
US4783337A (en) 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
US4948592A (en) 1986-05-09 1990-08-14 Alza Corporation Pulsed drug delivery
DE3720757A1 (en) 1987-06-24 1989-01-05 Bayer Ag DHP COAT TABLET
US4931285A (en) 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
DE59000232D1 (en) 1989-02-11 1992-09-10 Bayer Ag MEDICINAL PRODUCTS WITH CONTROLLED DELIVERY OF ACTIVE SUBSTANCES.
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
KR100222252B1 (en) 1990-12-14 1999-10-01 스튜어트 알. 수터 Angiotensin ii receptor blocking compositions
US5656650A (en) 1990-12-14 1997-08-12 Smithkline Beecham Corp. Angiotensin II receptor blocking compositions
US5160744A (en) 1991-06-27 1992-11-03 Alza Corporation Verapmil therapy
US5178867A (en) 1991-08-19 1993-01-12 Alza Corporation Dosage form for delivering drug in short-time period
US5543154A (en) 1991-12-27 1996-08-06 Merck & Co., Inc. Controlled release nifedipine delivery device
CA2125251C (en) 1993-06-07 2005-04-26 Yoshiyuki Inada A pharmaceutical composition for angiotensin ii-mediated diseases
DE19747261A1 (en) 1997-10-25 1999-04-29 Bayer Ag Single-chamber osmotic pharmaceutical release system
WO2000059481A1 (en) 1999-04-06 2000-10-12 Pharmaquest Ltd. PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF d-threo-METHYLPHENIDATE AND A SECOND CNS STIMULANT
US20040115134A1 (en) 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
CA2456034A1 (en) 2001-08-03 2003-02-20 Takeda Chemical Industries, Ltd. Sustained-release medicines
US7413751B2 (en) 2001-10-25 2008-08-19 Depomed, Inc. Methods of treatment using a gastric retained losartan dosage
US20030161882A1 (en) 2002-02-01 2003-08-28 Waterman Kenneth C. Osmotic delivery system
WO2003080057A1 (en) 2002-03-27 2003-10-02 Bayer Aktiengesellschaft Downsized core tablet containing nifedipine
EG24716A (en) 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
US8029822B2 (en) 2003-05-22 2011-10-04 Osmotica Kereskedelmi és Seolgáltató KFT Rupturing controlled release device having a preformed passageway
CA2536111A1 (en) 2003-07-24 2005-02-03 Wockhardt Limited Oral compositions for treatment of diseases
WO2005070398A2 (en) 2004-01-23 2005-08-04 Ranbaxy Laboratories Limited Pharmaceutical compositions of candesartan cilexetil stabilized with co-solvents
WO2005079751A2 (en) 2004-01-23 2005-09-01 Ranbaxy Laboratories Limited Oral pharmaceutical compositions of candesartan cilexetil
WO2005084648A1 (en) 2004-02-27 2005-09-15 Ranbaxy Laboratories Limited Pharmaceutical compositions comprising candesartan cilexetil
TW200534879A (en) 2004-03-25 2005-11-01 Bristol Myers Squibb Co Coated tablet formulation and method
TWI415635B (en) 2004-05-28 2013-11-21 必治妥施貴寶公司 Coated tablet formulation and method
DE102004062475A1 (en) 2004-12-24 2006-07-06 Bayer Healthcare Ag Solid, orally administrable, modified release pharmaceutical dosage forms
KR100978592B1 (en) 2005-05-10 2010-08-27 테바 파마슈티컬 인더스트리즈 리미티드 Stable micronized candesartan cilexetil and methods for preparing thereof
DE102005031577A1 (en) * 2005-07-06 2007-01-11 Bayer Healthcare Ag Pharmaceutical dosage forms containing a combination of nifedipine and / or nisoldipine and an angiotensin II antagonist
WO2008003560A1 (en) 2006-07-03 2008-01-10 Novo Nordisk A/S Coupling for injection devices
KR100888131B1 (en) 2006-10-10 2009-03-11 한올제약주식회사 Combination preparation for Cardiovascular disease therapy by Chronotherapy theory.
WO2008045006A1 (en) 2006-10-11 2008-04-17 Fako Ilaclari A. S. Formulations of candesartan
EP2099431B1 (en) 2006-11-28 2013-06-05 Laboratorios Liconsa, S.A. Stabilized solid pharmaceutical composition of candesartan cilexetil
WO2009054550A1 (en) 2007-10-25 2009-04-30 Bayer Yakuhin, Ltd. Nifedipine-containing press coated tablet and method of preparing the same
DE102008059206A1 (en) * 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical dosage form containing nifedipine or nisoldipine and an angiotensin II antagonist and / or a diuretic
WO2012031124A2 (en) 2010-09-03 2012-03-08 Bristol-Myers Squibb Company Drug formulations using water soluble antioxidants

Also Published As

Publication number Publication date
HK1204292A1 (en) 2015-11-13
PH12014502469A1 (en) 2014-12-22
JP6231553B2 (en) 2017-11-15
CO7190241A2 (en) 2015-02-19
MX2014013320A (en) 2015-08-10
CN104507459A (en) 2015-04-08
AR090940A1 (en) 2014-12-17
TW201410266A (en) 2014-03-16
PE20142284A1 (en) 2014-12-17
KR20150007297A (en) 2015-01-20
BR112014027618A2 (en) 2017-06-27
US20130309302A1 (en) 2013-11-21
EP2846777B1 (en) 2016-10-26
IL235040A0 (en) 2014-12-31
DOP2014000251A (en) 2014-12-31
CA2872542A1 (en) 2013-11-14
EA201492026A1 (en) 2015-09-30
CL2014002988A1 (en) 2015-03-13
ES2612532T3 (en) 2017-05-17
WO2013167453A1 (en) 2013-11-14
US9539176B2 (en) 2017-01-10
ECSP14025965A (en) 2015-12-31
EP2846777A1 (en) 2015-03-18
JP2015515999A (en) 2015-06-04
CR20140511A (en) 2014-12-02
SG11201406363VA (en) 2014-11-27
UY34786A (en) 2013-11-29
AU2013258273A1 (en) 2014-11-13
GT201400245A (en) 2015-08-25

Similar Documents

Publication Publication Date Title
IN2014DN09045A (en)
NZ593045A (en) Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin-ii antagonist and/or a diuretic
PH12015501096A1 (en) Composition for immediate and extended release
HK1218884A1 (en) Solid pharmaceutical dosage form for release of at least one active pharmaceutical ingredient in the oral cavity
MX340188B (en) Manufacturing of active-free granules and tablets comprising the same.
MX344846B (en) Combination of active loaded granules with additional actives.
TN2015000135A1 (en) Modified release formulations for oprozomib
WO2014125504A3 (en) Pharmaceutical compositions of febuxostat
IL239670A0 (en) Monolithic dosage form for modified release of a combination of active ingredients
MX2014006201A (en) Imatinib solid dosage forms reconstituted just before use.
SI3083582T1 (en) A new process for the preparation of candesartan cilexetil
MY182801A (en) Compound for activating ampk and uses thereof
MX2013010415A (en) Treatment of vaginal atrophy as novel indication for myrrh.
HK1198128A1 (en) Use of arctigenin in the preparation of medicament for the treatment of gastrointestinal ulcer diseases
EP2902024A4 (en) Synergic composition of nitazoxanide and mebendazole, methods for the preparation thereof, and use of said composition for the treatment of human parasitosis
CU20140126A7 (en) MANUFACTURING PROCEDURE FOR A PHARMACEUTICAL DOSAGE FORM INCLUDING NIFEDIPINE AND CANDESARTÁN CILEXETILO
UA80535U (en) Pharmaceutical composition for treating sexual dysfunction
GB201300437D0 (en) Injectable Active Ingredient Release Compositions and Methods for Their Production and Use
MX2016004445A (en) Stable triflusal powder formulation for oral administration and method of preparation thereof.
IN2013MU02588A (en)