JP2015514057A - 疾患を治療するための新規の方法及び組成物 - Google Patents
疾患を治療するための新規の方法及び組成物 Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- B01D—SEPARATION
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
Description
本出願は、米国特許法119(e)条により2012年3月14日出願米国仮出願第61/610480号の利益を主張するものであり、その開示は参照することにより本明細書に組込まれる。
体重約95gの雄シリアンゴールデンハムスター(「ハムスター」)を無作為に、2つの溶媒対照群(各群ハムスター8匹)と、4つの試験品群(各群ハムスター6匹)とに割り当てた。研究0日目に、それぞれのハムスターに左頬側頬袋に向けて40Gy(グレイ)の急性放射線線量を与えた。試験品を、−1日(放射線線量の前日)から20日に1日3回局所投与した。−1日から25日まで、ハムスターの状態を毎日評価し、体重を1日1回測定した。粘膜炎を7、10、13、16、19、22及び25日に評定した。粘膜炎の経過への試験品の影響力を測定するために、粘膜炎の持続時間及び重症度を、治療群と未治療対照群とで比較した。
Claims (26)
- サンブクス・ニグラ、エキナセア・プルプレア及びセンテラ・アジアティカの含水アルコール薬草エキスと水とを組み合わせて、水性混合物を形成すること;
前記水性混合物とアルコールとを組み合わせて、約50%より高いアルコール濃度を有するアルコール混合物を形成すること;
不溶性材料及びアルコールをアルコール混合物から分離して、水性治療組成物を生成すること:
を含む、水性治療組成物を調製する方法。 - 前記アルコール混合物が、約70%アルコールを含む、請求項1に記載の方法。
- 前記水性治療組成物を更に乾燥させて、乾燥治療組成物を形成する、請求項1に記載の方法。
- 前記アルコールはエタノールである、請求項1に記載の方法。
- 不溶性材料を前記アルコール混合物から遠心分離、濾過又は沈降を用いて分離する、請求項1に記載の方法。
- アルコールを前記アルコール混合物から真空を用いて分離する、請求項1に記載の方法。
- 前記水性治療組成物を噴霧乾燥又はフリーズドライにより乾燥させる、請求項3に記載の方法。
- 前記乾燥治療組成物と、少なくとも1つの薬学的に許容可能な賦形剤とを、組み合わせることを更に含む、請求項3に記載の方法。
- 前記賦形剤は、プロピレングリコール、ポリエチレングリコール、グリセリン及び精油からなる群から選択される、請求項8に記載の方法。
- サンブクス・ニグラ、エキナセア・プルプレア及びセンテラ・アジアティカの含水アルコール薬草エキスが、約70%アルコールを含む溶剤中に前記植物物質を混合することにより調製される、請求項1に記載の方法。
- 前記植物物質を約8時間混合する、請求項10に記載の方法。
- 植物物質対溶剤の比は約1:8である、請求項11に記載の方法。
- 植物物質及び溶剤の前記混合物から溶剤を除去して、含水アルコール薬草エキスを形成することを更に含む、請求項10に記載の方法。
- 0.055%以上のナリンゲニン濃度を有するエキスである、サンブクス・ニグラ、エキナセア・プルプレア及びセンテラ・アジアティカのそれぞれの含水アルコール薬草エキスを含む、薬草エキス。
- プロピレングリコール中の20%溶液中で溶解性を有する、請求項14に記載の薬草エキス。
- サンブクス・ニグラ:エキナセア・プルプレア:センテラ・アジアティカの比が約7:1:2である、請求項14に記載の薬草エキス。
- 請求項14に記載の薬草エキスを含む、医薬組成物。
- 薬学的に許容可能な担体を更に含む、請求項17に記載の医薬組成物。
- 前記担体がプロピレングリコールを含む、請求項18に記載の医薬組成物。
- 口内洗浄液、パッチ、軟膏、ペースト、ローション、クリーム、トローチ、キャンディ、チューインガム、溶液、ゲル、フォームまたはスプレーの形態の、請求項17に記載の医薬組成物。
- 薬学的に許容可能な量の請求項17記載の医薬組成物を投与することを含む、疾患を治療する方法。
- 前記疾患は、粘膜又は皮膚の疾患である、請求項21に記載の方法。
- 前記疾患は、炎症性疾患である、請求項21に記載の方法。
- 前記疾患は、組織修復により改善される、請求項21に記載の方法。
- 前記疾患は、口腔粘膜炎、炎症性腸疾患、放射線誘発直腸炎、萎縮性膣炎、歯周病、歯肉炎、アフタ性潰瘍、機械的外傷、熱的外傷、扁平苔癬、水疱性類天疱瘡、尋常性天疱瘡、疱疹状皮膚炎、口角びらん症及び再発性ヘルペスからなる群から選択される、請求項21に記載の方法。
- 薬草エキスの投与量は、1日当たり1mg〜1.5gの間である、請求項21に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261610480P | 2012-03-14 | 2012-03-14 | |
US61/610,480 | 2012-03-14 | ||
PCT/IB2013/051970 WO2013136270A1 (en) | 2012-03-14 | 2013-03-13 | Novel methods and compositions for treatment of disease |
Publications (2)
Publication Number | Publication Date |
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JP2015514057A true JP2015514057A (ja) | 2015-05-18 |
JP6410355B2 JP6410355B2 (ja) | 2018-10-24 |
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JP2014561570A Active JP6410355B2 (ja) | 2012-03-14 | 2013-03-13 | 疾患を治療するための新規の方法及び組成物 |
Country Status (12)
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US (2) | US20150064291A1 (ja) |
EP (1) | EP2825185A1 (ja) |
JP (1) | JP6410355B2 (ja) |
KR (1) | KR102168118B1 (ja) |
CN (1) | CN104394875B (ja) |
AU (1) | AU2013233943B2 (ja) |
BR (1) | BR112014022694B1 (ja) |
CA (1) | CA2867260C (ja) |
IL (1) | IL234606B (ja) |
IN (1) | IN2014DN08440A (ja) |
RU (1) | RU2683774C2 (ja) |
WO (1) | WO2013136270A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019196550A (ja) * | 2018-05-07 | 2019-11-14 | 国立大学法人信州大学 | ナノ繊維及びその製造方法 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2015056160A1 (en) * | 2013-10-14 | 2015-04-23 | Izun Pharmaceuticals Ltd. | Methods for treatment of m-tor inhibitor-associated stomatitis |
KR101649450B1 (ko) * | 2015-08-19 | 2016-08-18 | 이상철 | 피부 상처 치료조성물 |
WO2017053915A1 (en) * | 2015-09-24 | 2017-03-30 | Caris Science, Inc. | Method, apparatus, and computer program product for analyzing biological data |
KR101751486B1 (ko) * | 2016-03-02 | 2017-06-28 | 광주과학기술원 | BKCa 채널 활성화용 조성물 |
IL262744B (en) * | 2018-11-04 | 2020-03-31 | Izun Pharmaceuticals Corp | Hydrogel compositions comprising plant extracts |
RU2716501C1 (ru) * | 2019-03-11 | 2020-03-12 | Тамара Владимировна Пономаренко | Композиция для профилактики и лечения воспалительных заболеваний полости рта |
US20230390350A1 (en) * | 2020-10-28 | 2023-12-07 | Izun Pharmaceuticals Corp. | Treatment of oral mucositis |
KR102613837B1 (ko) * | 2021-11-25 | 2023-12-15 | 주식회사 젠트리바이오 | 천연물질 추출물의 혼합물을 주성분으로 하는 항산화 및 항염증 효능을 갖는 조성물 및 그 제조방법 |
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JP2001048798A (ja) * | 1999-08-06 | 2001-02-20 | Sakamoto Yakuhin Kogyo Co Ltd | 抗菌剤 |
JP2004530698A (ja) * | 2001-05-23 | 2004-10-07 | ハーバル シンセシス コーポレイション | 粘膜損傷の治療用薬草組成物 |
JP2005179252A (ja) * | 2003-12-19 | 2005-07-07 | Taiyo Kagaku Co Ltd | 血栓形成抑制剤 |
WO2009078022A2 (en) * | 2007-12-17 | 2009-06-25 | Izun Pharmaceuticals Corporation | Synergistic combinations of growth factors with herbal compositions for the enhancement of tissue repair |
JP2011529055A (ja) * | 2008-07-22 | 2011-12-01 | イズン ファーマシューティカルズ, インコーポレイテッド | 局所的抗炎症配合剤 |
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- 2013-03-13 RU RU2014136776A patent/RU2683774C2/ru active
- 2013-03-13 US US14/385,158 patent/US20150064291A1/en not_active Abandoned
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- 2013-03-13 BR BR112014022694-6A patent/BR112014022694B1/pt active IP Right Grant
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Patent Citations (5)
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JP2001048798A (ja) * | 1999-08-06 | 2001-02-20 | Sakamoto Yakuhin Kogyo Co Ltd | 抗菌剤 |
JP2004530698A (ja) * | 2001-05-23 | 2004-10-07 | ハーバル シンセシス コーポレイション | 粘膜損傷の治療用薬草組成物 |
JP2005179252A (ja) * | 2003-12-19 | 2005-07-07 | Taiyo Kagaku Co Ltd | 血栓形成抑制剤 |
WO2009078022A2 (en) * | 2007-12-17 | 2009-06-25 | Izun Pharmaceuticals Corporation | Synergistic combinations of growth factors with herbal compositions for the enhancement of tissue repair |
JP2011529055A (ja) * | 2008-07-22 | 2011-12-01 | イズン ファーマシューティカルズ, インコーポレイテッド | 局所的抗炎症配合剤 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019196550A (ja) * | 2018-05-07 | 2019-11-14 | 国立大学法人信州大学 | ナノ繊維及びその製造方法 |
JP7121944B2 (ja) | 2018-05-07 | 2022-08-19 | 国立大学法人信州大学 | ナノ繊維及びその製造方法 |
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Publication number | Publication date |
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BR112014022694B1 (pt) | 2021-03-09 |
RU2014136776A (ru) | 2016-05-10 |
KR102168118B1 (ko) | 2020-10-21 |
AU2013233943B2 (en) | 2017-10-19 |
JP6410355B2 (ja) | 2018-10-24 |
RU2683774C2 (ru) | 2019-04-02 |
US20210128661A1 (en) | 2021-05-06 |
BR112014022694A2 (pt) | 2018-02-27 |
IL234606B (en) | 2021-04-29 |
US20150064291A1 (en) | 2015-03-05 |
EP2825185A1 (en) | 2015-01-21 |
CA2867260C (en) | 2021-10-05 |
IN2014DN08440A (ja) | 2015-05-08 |
KR20140138894A (ko) | 2014-12-04 |
CN104394875B (zh) | 2018-12-04 |
IL234606A0 (en) | 2014-11-30 |
CA2867260A1 (en) | 2013-09-19 |
WO2013136270A1 (en) | 2013-09-19 |
AU2013233943A1 (en) | 2014-09-25 |
CN104394875A (zh) | 2015-03-04 |
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