JP2015512404A5 - - Google Patents
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- Publication number
- JP2015512404A5 JP2015512404A5 JP2015503434A JP2015503434A JP2015512404A5 JP 2015512404 A5 JP2015512404 A5 JP 2015512404A5 JP 2015503434 A JP2015503434 A JP 2015503434A JP 2015503434 A JP2015503434 A JP 2015503434A JP 2015512404 A5 JP2015512404 A5 JP 2015512404A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- formula
- pharmaceutically acceptable
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 18
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 11
- 125000006732 (C1-C15) alkyl group Chemical group 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 125000003342 alkenyl group Chemical group 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000005862 (C1-C6)alkanoyl group Chemical group 0.000 claims description 2
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 201000007455 central nervous system cancer Diseases 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 238000013160 medical therapy Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 4
- 230000000116 mitigating effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
- MBNQXEUOFQURGF-XGEHFMGCSA-N CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc(O)c(c(C/C=C(\C)/CCC=C(C)C)c[nH]3)c3c2)cc1OC Chemical compound CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc(O)c(c(C/C=C(\C)/CCC=C(C)C)c[nH]3)c3c2)cc1OC MBNQXEUOFQURGF-XGEHFMGCSA-N 0.000 description 1
- UWEGZBFSAFASSB-DVGHAREFSA-N CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc(OC)c(c(C/C=C(\C)/CCC=C(C)C)c[nH]3)c3c2)cc1OC Chemical compound CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc(OC)c(c(C/C=C(\C)/CCC=C(C)C)c[nH]3)c3c2)cc1OC UWEGZBFSAFASSB-DVGHAREFSA-N 0.000 description 1
- JAOCYEFTUGAJIP-MTIGNSPTSA-N CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc([nH]cc3)c3c(O)c2)cc1O Chemical compound CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc([nH]cc3)c3c(O)c2)cc1O JAOCYEFTUGAJIP-MTIGNSPTSA-N 0.000 description 1
- LFTRKWQUHYVXDY-LJOVTLDOSA-N CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc([nH]cc3)c3c(O)c2)cc1OC Chemical compound CC(C)(CCC1)C(C2)[C@]1(C)Oc1c2cc(/C=C/c2cc([nH]cc3)c3c(O)c2)cc1OC LFTRKWQUHYVXDY-LJOVTLDOSA-N 0.000 description 1
- DWHJORUYJNJIJG-QCVFCVKRSA-N CC(C)(CCC1)[C@H](CC2)[C@]1(C)Oc1c2cc(/C=C/c2cc([nH]cc3)c3c(OC)c2)cc1C=O Chemical compound CC(C)(CCC1)[C@H](CC2)[C@]1(C)Oc1c2cc(/C=C/c2cc([nH]cc3)c3c(OC)c2)cc1C=O DWHJORUYJNJIJG-QCVFCVKRSA-N 0.000 description 1
- 0 C[C@@]1([C@](C2)C(*)(*)CCC1)Oc1c2cc(C=C[C@@](C2)C=C3NC=C(CC=C(C)C)C3=C2O)cc1O Chemical compound C[C@@]1([C@](C2)C(*)(*)CCC1)Oc1c2cc(C=C[C@@](C2)C=C3NC=C(CC=C(C)C)C3=C2O)cc1O 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615725P | 2012-03-26 | 2012-03-26 | |
| US61/615,725 | 2012-03-26 | ||
| PCT/US2013/033722 WO2013148584A1 (en) | 2012-03-26 | 2013-03-25 | Schweinfurthin analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015512404A JP2015512404A (ja) | 2015-04-27 |
| JP2015512404A5 true JP2015512404A5 (enExample) | 2016-05-12 |
Family
ID=49261149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503434A Ceased JP2015512404A (ja) | 2012-03-26 | 2013-03-25 | シュワインフルチン類似体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9428493B2 (enExample) |
| EP (1) | EP2831063B1 (enExample) |
| JP (1) | JP2015512404A (enExample) |
| CN (1) | CN104583203B (enExample) |
| AU (1) | AU2013240007B2 (enExample) |
| CA (1) | CA2868508A1 (enExample) |
| ES (1) | ES2655027T3 (enExample) |
| WO (1) | WO2013148584A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12427133B2 (en) * | 2018-02-12 | 2025-09-30 | The Penn State Research Foundation | Combination therapies comprising schweinfurthin compounds for treating cancer |
| CN108658949B (zh) * | 2018-06-29 | 2021-05-25 | 云南大学 | 一种用作抗肿瘤药物的化合物及其生产方法 |
| FR3124946B1 (fr) * | 2021-07-06 | 2024-11-08 | Centre Nat Rech Scient | Nouveaux composés dérivés des schweinfurthines G, E, F |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| AU2005227328A1 (en) | 2004-03-29 | 2005-10-06 | John A. Beutler | Schweinfurthin analogues |
| WO2009158516A1 (en) | 2008-06-27 | 2009-12-30 | University Of Iowa Research Foundation | Schweinfurthin analogues |
| US8686016B2 (en) * | 2009-04-30 | 2014-04-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Schweinfurthins and uses thereof |
-
2013
- 2013-03-25 EP EP13769473.3A patent/EP2831063B1/en not_active Not-in-force
- 2013-03-25 US US14/388,202 patent/US9428493B2/en not_active Expired - Fee Related
- 2013-03-25 CA CA2868508A patent/CA2868508A1/en not_active Abandoned
- 2013-03-25 AU AU2013240007A patent/AU2013240007B2/en not_active Ceased
- 2013-03-25 JP JP2015503434A patent/JP2015512404A/ja not_active Ceased
- 2013-03-25 WO PCT/US2013/033722 patent/WO2013148584A1/en not_active Ceased
- 2013-03-25 ES ES13769473.3T patent/ES2655027T3/es active Active
- 2013-03-25 CN CN201380027722.XA patent/CN104583203B/zh not_active Expired - Fee Related