CN104583203B - Schweinfurthin类似物 - Google Patents

Schweinfurthin类似物 Download PDF

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Publication number
CN104583203B
CN104583203B CN201380027722.XA CN201380027722A CN104583203B CN 104583203 B CN104583203 B CN 104583203B CN 201380027722 A CN201380027722 A CN 201380027722A CN 104583203 B CN104583203 B CN 104583203B
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CN
China
Prior art keywords
compound
mmol
alkyl
etoac
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380027722.XA
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English (en)
Chinese (zh)
Other versions
CN104583203A (zh
Inventor
J.科德特
J.D.奈博尔斯
D.F.维默
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University of Iowa Research Foundation UIRF
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University of Iowa Research Foundation UIRF
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Publication of CN104583203A publication Critical patent/CN104583203A/zh
Application granted granted Critical
Publication of CN104583203B publication Critical patent/CN104583203B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201380027722.XA 2012-03-26 2013-03-25 Schweinfurthin类似物 Expired - Fee Related CN104583203B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261615725P 2012-03-26 2012-03-26
US61/615725 2012-03-26
PCT/US2013/033722 WO2013148584A1 (en) 2012-03-26 2013-03-25 Schweinfurthin analogues

Publications (2)

Publication Number Publication Date
CN104583203A CN104583203A (zh) 2015-04-29
CN104583203B true CN104583203B (zh) 2017-06-13

Family

ID=49261149

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380027722.XA Expired - Fee Related CN104583203B (zh) 2012-03-26 2013-03-25 Schweinfurthin类似物

Country Status (8)

Country Link
US (1) US9428493B2 (enExample)
EP (1) EP2831063B1 (enExample)
JP (1) JP2015512404A (enExample)
CN (1) CN104583203B (enExample)
AU (1) AU2013240007B2 (enExample)
CA (1) CA2868508A1 (enExample)
ES (1) ES2655027T3 (enExample)
WO (1) WO2013148584A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12427133B2 (en) * 2018-02-12 2025-09-30 The Penn State Research Foundation Combination therapies comprising schweinfurthin compounds for treating cancer
CN108658949B (zh) * 2018-06-29 2021-05-25 云南大学 一种用作抗肿瘤药物的化合物及其生产方法
FR3124946B1 (fr) * 2021-07-06 2024-11-08 Centre Nat Rech Scient Nouveaux composés dérivés des schweinfurthines G, E, F

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005092878A2 (en) * 2004-03-29 2005-10-06 University Of Iowa Research Foundation Schweinfurthin analogues
WO2009158516A1 (en) * 2008-06-27 2009-12-30 University Of Iowa Research Foundation Schweinfurthin analogues

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US8686016B2 (en) * 2009-04-30 2014-04-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Schweinfurthins and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005092878A2 (en) * 2004-03-29 2005-10-06 University Of Iowa Research Foundation Schweinfurthin analogues
WO2009158516A1 (en) * 2008-06-27 2009-12-30 University Of Iowa Research Foundation Schweinfurthin analogues

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Indole containing analogs of the natural schweinfurthins;John G. Kodet et al.;《The 236th ACS National Meeting, Poster》;20080820;MEDI 421 *
Studies on heteroaromatic schweinfurthin analogues;John Gordon Kodet et al.;《University of Iowa, Ph.D. Thesis》;20101130;摘要，第32,48,51,53,55-57,187-195页 *

Also Published As

Publication number Publication date
EP2831063A4 (en) 2015-07-29
EP2831063A1 (en) 2015-02-04
ES2655027T3 (es) 2018-02-16
US9428493B2 (en) 2016-08-30
AU2013240007B2 (en) 2017-06-29
AU2013240007A1 (en) 2014-10-16
HK1206745A1 (en) 2016-01-15
JP2015512404A (ja) 2015-04-27
US20150045404A1 (en) 2015-02-12
EP2831063B1 (en) 2017-10-04
CA2868508A1 (en) 2013-10-03
WO2013148584A1 (en) 2013-10-03
CN104583203A (zh) 2015-04-29

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Granted publication date: 20170613

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