JP2015511245A - ピリドピリミジノン系キナーゼ阻害薬 - Google Patents

ピリドピリミジノン系キナーゼ阻害薬 Download PDF

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Publication number
JP2015511245A
JP2015511245A JP2014558849A JP2014558849A JP2015511245A JP 2015511245 A JP2015511245 A JP 2015511245A JP 2014558849 A JP2014558849 A JP 2014558849A JP 2014558849 A JP2014558849 A JP 2014558849A JP 2015511245 A JP2015511245 A JP 2015511245A
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JP
Japan
Prior art keywords
alkyl
amino
phenyl
pyrido
pyrimidin
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Pending
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JP2014558849A
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English (en)
Japanese (ja)
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JP2015511245A5 (enExample
Inventor
ウッズ，キース
マストラッチオ，アンソニー
ライ，チュンチウ
ガンディー，ビラージクマール・ビー
ペニング，トーマス
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AbbVie Inc
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AbbVie Inc
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Publication of JP2015511245A publication Critical patent/JP2015511245A/ja
Publication of JP2015511245A5 publication Critical patent/JP2015511245A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014558849A 2012-02-23 2013-02-22 ピリドピリミジノン系キナーゼ阻害薬 Pending JP2015511245A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261602163P 2012-02-23 2012-02-23
US61/602,163 2012-02-23
PCT/US2013/027265 WO2013126656A1 (en) 2012-02-23 2013-02-22 Pyridopyrimidinone inhibitors of kinases

Publications (2)

Publication Number Publication Date
JP2015511245A true JP2015511245A (ja) 2015-04-16
JP2015511245A5 JP2015511245A5 (enExample) 2016-06-30

Family

ID=47757712

Family Applications (1)

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JP2014558849A Pending JP2015511245A (ja) 2012-02-23 2013-02-22 ピリドピリミジノン系キナーゼ阻害薬

Country Status (8)

Country Link
US (1) US9718821B2 (enExample)
EP (1) EP2817308B1 (enExample)
JP (1) JP2015511245A (enExample)
CN (1) CN104271576A (enExample)
CA (1) CA2864142A1 (enExample)
ES (1) ES2606640T3 (enExample)
MX (1) MX2014010176A (enExample)
WO (1) WO2013126656A1 (enExample)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
KR20190128673A (ko) * 2017-03-10 2019-11-18 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2022502438A (ja) * 2018-09-27 2022-01-11 貝達薬業股▲ふん▼有限公司Betta Pharmaceuticals Co., Ltd Ｆｇｆｒ４阻害剤及びその使用
JP2022523073A (ja) * 2019-01-29 2022-04-21 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用
JP2024522304A (ja) * 2021-06-04 2024-06-13 アプレラ セラピューティクス、インク． Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体

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GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
GB201322602D0 (en) * 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds
MX382781B (es) * 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
EP3189051A1 (en) * 2014-09-02 2017-07-12 Pierre Fabre Médicament Isoquinolinone derivatives useful in the treatment of cancer
GB201612095D0 (en) * 2016-07-12 2016-08-24 Almac Discovery Ltd Pharmaceutical compounds
PT3497103T (pt) * 2016-08-15 2021-06-17 Pfizer Inibidores de piridopirimidinona cdk2/4/6
JP6717457B2 (ja) 2017-01-23 2020-07-01 シージャーズォアン サガシティ ニュー ドラッグ デベロップメント カンパニー リミテッド Ｗｅｅ１阻害剤としての１，２−ジヒドロ−３Ｈ−ピラゾロ［３，４−ｄ］ピリミジン−３−オン誘導体
CN110678169A (zh) 2017-03-31 2020-01-10 西雅图遗传学公司 Chk1-抑制剂与weel-抑制剂的组合
WO2019014513A1 (en) * 2017-07-13 2019-01-17 Syros Pharmaceuticals, Inc. INHIBITORS OF KINASES TAM
CN109422754A (zh) * 2017-08-24 2019-03-05 上海迪诺医药科技有限公司 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用
AU2018347307A1 (en) 2017-10-09 2020-04-23 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
EP3694861A4 (en) 2017-10-09 2021-05-19 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND USES THEREOF
SG11202003974XA (en) 2017-11-01 2020-05-28 Shijiazhuang Sagacity New Drug Development Co Ltd Macrocyclic compound serving as weel inhibitor and applications thereof
GB201800378D0 (en) * 2018-01-10 2018-02-21 Almac Discovery Ltd Pharmaceutical compounds
US12180184B2 (en) 2018-10-26 2024-12-31 Wuxi Biocity Biopharmaceutics Co., Ltd. Pyrimidopyrazolone derivative as Wee1 inhibitor and use thereof
KR102697799B1 (ko) 2019-03-22 2024-08-23 쇼우야오 홀딩스 (베이징) 코., 엘티디. Wee1 억제제 및 이의 제조 및 용도
JP2022526831A (ja) 2019-04-09 2022-05-26 ニューベイション・バイオ・インコーポレイテッド ヘテロ環式化合物およびその使用
SI3964510T1 (sl) 2019-04-30 2024-10-30 Wuxi Biocity Biopharmaceutics Co., Ltd. Kristalna oblika WEE1 inhibitorske spojine in njena uporaba
WO2021022163A2 (en) 2019-07-31 2021-02-04 Foghorn Therapeutics Inc. Compounds and uses thereof
US12528825B2 (en) 2020-01-29 2026-01-20 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2021190623A1 (zh) * 2020-03-27 2021-09-30 贝达药业股份有限公司 Fgfr4抑制剂的盐型、晶型及其用途
CA3180664A1 (en) 2020-06-17 2021-12-23 Yuli Xie Pyrazolo[3,4-d]pyrimidine-3-one derivative as wee-1 inhibitor
US12551584B1 (en) 2020-12-07 2026-02-17 Actinium Pharmaceuticals, Inc. Lewis Y radioimmunotherapy for the treatment of cancer
KR20240004539A (ko) 2021-04-30 2024-01-11 위겐 바이오메더슨 테크널러지 (상하이) 컴퍼니 리미티드 Wee-1 억제제로서의 축합 고리 화합물, 그를 위한 제조 방법 및 그의 용도
CN116462687B (zh) 2022-01-18 2025-01-07 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
CA3253688A1 (en) 2022-03-07 2023-09-14 Debiopharm International S.A. TREATMENT METHODS FOR SMALL CELL LUNG CANCER
CN117402162A (zh) 2022-07-13 2024-01-16 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
WO2025056747A1 (en) 2023-09-14 2025-03-20 Debiopharm International S.A. Combination of a wee1 inhibitor and a pkmyt1 inhibitor
TW202541810A (zh) 2023-12-22 2025-11-01 瑞士商德彪製藥國際公司 治療實體腫瘤之方法
WO2025186213A1 (en) 2024-03-04 2025-09-12 Debiopharm International S.A. Combination of a wee1 inhibitor and a topoisomerase 1 inhibitor

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JP2003528101A (ja) * 2000-03-06 2003-09-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ５−アルキルピリド［２，３−ｄ］ピリミジンチロシンキナーゼ阻害剤
JP2007536370A (ja) * 2004-05-04 2007-12-13 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 療法薬としてのピロリル置換ピリド［２，３−ｄ］ピリミジン−７−オンおよびその誘導体
JP2009525292A (ja) * 2006-01-31 2009-07-09 エフ．ホフマン−ラ ロシュ アーゲー ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用
WO2010019637A1 (en) * 2008-08-12 2010-02-18 Smithkline Beecham Corporation Chemical compounds
WO2010063352A1 (en) * 2008-12-01 2010-06-10 Merck Patent Gmbh 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer
JP2010132689A (ja) * 2006-04-27 2010-06-17 Banyu Pharmaceut Co Ltd ジヒドロピラゾロピリミジノン誘導体
WO2010067888A1 (en) * 2008-12-12 2010-06-17 Banyu Pharmaceutical Co.,Ltd. Dihydropyrimidopyrimidine derivatives
WO2014023385A1 (en) * 2012-08-07 2014-02-13 Merck Patent Gmbh Pyridopyrimidine derivatives as protein kinase inhibitors

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190128673A (ko) * 2017-03-10 2019-11-18 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2020510040A (ja) * 2017-03-10 2020-04-02 アルマック・ディスカバリー・リミテッドＡｌｍａｃ Ｄｉｓｃｏｖｅｒｙ Ｌｉｍｉｔｅｄ Ｗｅｅ−１キナーゼ阻害剤として有用なピリミドピリミジノン
JP7244430B2 (ja) 2017-03-10 2023-03-22 アルマック・ディスカバリー・リミテッド Ｗｅｅ－１キナーゼ阻害剤として有用なピリミドピリミジノン
KR102605546B1 (ko) 2017-03-10 2023-11-22 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2022502438A (ja) * 2018-09-27 2022-01-11 貝達薬業股▲ふん▼有限公司Betta Pharmaceuticals Co., Ltd Ｆｇｆｒ４阻害剤及びその使用
JP7446287B2 (ja) 2018-09-27 2024-03-08 貝達薬業股▲ふん▼有限公司 Ｆｇｆｒ４阻害剤及びその使用
JP2022523073A (ja) * 2019-01-29 2022-04-21 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用
JP2024522304A (ja) * 2021-06-04 2024-06-13 アプレラ セラピューティクス、インク． Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体

Also Published As

Publication number Publication date
ES2606640T3 (es) 2017-03-24
MX2014010176A (es) 2014-11-10
CA2864142A1 (en) 2013-08-29
EP2817308A1 (en) 2014-12-31
EP2817308B1 (en) 2016-09-07
US20130225589A1 (en) 2013-08-29
WO2013126656A1 (en) 2013-08-29
CN104271576A (zh) 2015-01-07
US9718821B2 (en) 2017-08-01

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