JP2015511245A - ピリドピリミジノン系キナーゼ阻害薬 - Google Patents

ピリドピリミジノン系キナーゼ阻害薬 Download PDF

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Publication number
JP2015511245A
JP2015511245A JP2014558849A JP2014558849A JP2015511245A JP 2015511245 A JP2015511245 A JP 2015511245A JP 2014558849 A JP2014558849 A JP 2014558849A JP 2014558849 A JP2014558849 A JP 2014558849A JP 2015511245 A JP2015511245 A JP 2015511245A
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Prior art keywords
alkyl
amino
phenyl
pyrido
pyrimidin
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JP2015511245A5 (enExample
Inventor
ウッズ，キース
マストラッチオ，アンソニー
ライ，チュンチウ
ガンディー，ビラージクマール・ビー
ペニング，トーマス
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アッヴィ・インコーポレイテッド
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Publication of JP2015511245A5 publication Critical patent/JP2015511245A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014558849A 2012-02-23 2013-02-22 ピリドピリミジノン系キナーゼ阻害薬 Pending JP2015511245A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261602163P 2012-02-23 2012-02-23
US61/602,163 2012-02-23
PCT/US2013/027265 WO2013126656A1 (en) 2012-02-23 2013-02-22 Pyridopyrimidinone inhibitors of kinases

Publications (2)

Publication Number Publication Date
JP2015511245A true JP2015511245A (ja) 2015-04-16
JP2015511245A5 JP2015511245A5 (enExample) 2016-06-30

Family

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JP2014558849A Pending JP2015511245A (ja) 2012-02-23 2013-02-22 ピリドピリミジノン系キナーゼ阻害薬

Country Status (8)

Country Link
US (1) US9718821B2 (enExample)
EP (1) EP2817308B1 (enExample)
JP (1) JP2015511245A (enExample)
CN (1) CN104271576A (enExample)
CA (1) CA2864142A1 (enExample)
ES (1) ES2606640T3 (enExample)
MX (1) MX2014010176A (enExample)
WO (1) WO2013126656A1 (enExample)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
KR20190128673A (ko) * 2017-03-10 2019-11-18 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2022502438A (ja) * 2018-09-27 2022-01-11 貝達薬業股▲ふん▼有限公司Betta Pharmaceuticals Co., Ltd Ｆｇｆｒ４阻害剤及びその使用
JP2022523073A (ja) * 2019-01-29 2022-04-21 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用
JP2024522304A (ja) * 2021-06-04 2024-06-13 アプレラ セラピューティクス、インク． Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体

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GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
GB201322602D0 (en) 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds
CN106459042B (zh) * 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
CN106795154B (zh) * 2014-09-02 2019-07-05 皮埃尔法布雷医药公司 用于治疗癌症的异喹啉酮衍生物
GB201612095D0 (en) * 2016-07-12 2016-08-24 Almac Discovery Ltd Pharmaceutical compounds
JP6563623B1 (ja) * 2016-08-15 2019-08-21 ファイザー・インク ピリドピリミジノンｃｄｋ２／４／６阻害剤
US10954253B2 (en) 2017-01-23 2021-03-23 Shijiazhuang Sagacity New Drug Development Co., Ltd. 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
AU2018243667A1 (en) 2017-03-31 2019-10-17 Seagen Inc. Combinations of Chk1- and Wee1 - inhibitors
US20200291018A1 (en) * 2017-07-13 2020-09-17 Syros Pharmaceuticals, Inc. Tam kinase inhibitors
WO2019037678A1 (zh) * 2017-08-24 2019-02-28 上海迪诺医药科技有限公司 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用
EP3694509A4 (en) 2017-10-09 2021-07-14 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND THEIR USES
EP3694861A4 (en) 2017-10-09 2021-05-19 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND USES THEREOF
AU2018361010B2 (en) 2017-11-01 2023-01-12 Wuxi Biocity Biopharmaceutics Co., Ltd. Macrocyclic compound serving as Wee1 inhibitor and applications thereof
GB201800378D0 (en) * 2018-01-10 2018-02-21 Almac Discovery Ltd Pharmaceutical compounds
EP3875460A4 (en) 2018-10-26 2022-07-20 Wuxi Biocity Biopharmaceutics Co., Ltd. PYRIMIDINDOPYRAZOLONE DERIVATIVE AS WEE1 INHIBITOR AND USE THEREOF
JP2022528047A (ja) 2019-03-22 2022-06-08 ショウヤオ ホールディングス（ベイジン） カンパニー， リミテッド Ｗｅｅ１阻害剤、その製造および用途
JP2022526831A (ja) 2019-04-09 2022-05-26 ニューベイション・バイオ・インコーポレイテッド ヘテロ環式化合物およびその使用
HUE068061T2 (hu) 2019-04-30 2024-12-28 Wuxi Biocity Biopharmaceutics Co Ltd WEE1 inhibitor vegyület kristályos formája és felhasználása
WO2021155100A1 (en) 2020-01-29 2021-08-05 Foghorn Therapeutics Inc. Compounds and uses thereof
TW202144354A (zh) * 2020-03-27 2021-12-01 大陸商貝達藥業股份有限公司 Fgfr4抑制劑的鹽型、晶型及其用途
CA3180664A1 (en) 2020-06-17 2021-12-23 Yuli Xie Pyrazolo[3,4-d]pyrimidine-3-one derivative as wee-1 inhibitor
US12551584B1 (en) 2020-12-07 2026-02-17 Actinium Pharmaceuticals, Inc. Lewis Y radioimmunotherapy for the treatment of cancer
EP4332104A4 (en) 2021-04-30 2025-04-16 Wigen Biomedicine Technology (Shanghai) Co., Ltd. Fused ring compound as a WEE-1 inhibitor, as well as production process and use thereof
CN116462687B (zh) 2022-01-18 2025-01-07 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
MX2024010900A (es) 2022-03-07 2024-09-17 Debiopharm Int Sa Metodos para tratar el cancer de pulmon de celulas peque?as.
CN117402162A (zh) 2022-07-13 2024-01-16 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
AR133820A1 (es) 2023-09-14 2025-11-05 Debiopharm Int Sa Combinación de un inhibidor de wee1 y un inhibidor de pkmyt1
WO2025133381A2 (en) 2023-12-22 2025-06-26 Debiopharm International S.A. Methods of treating solid tumors
WO2025186213A1 (en) 2024-03-04 2025-09-12 Debiopharm International S.A. Combination of a wee1 inhibitor and a topoisomerase 1 inhibitor

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JP2003528101A (ja) * 2000-03-06 2003-09-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ５−アルキルピリド［２，３−ｄ］ピリミジンチロシンキナーゼ阻害剤
JP2007536370A (ja) * 2004-05-04 2007-12-13 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 療法薬としてのピロリル置換ピリド［２，３−ｄ］ピリミジン−７−オンおよびその誘導体
JP2009525292A (ja) * 2006-01-31 2009-07-09 エフ．ホフマン−ラ ロシュ アーゲー ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用
WO2010019637A1 (en) * 2008-08-12 2010-02-18 Smithkline Beecham Corporation Chemical compounds
WO2010063352A1 (en) * 2008-12-01 2010-06-10 Merck Patent Gmbh 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer
JP2010132689A (ja) * 2006-04-27 2010-06-17 Banyu Pharmaceut Co Ltd ジヒドロピラゾロピリミジノン誘導体
WO2010067888A1 (en) * 2008-12-12 2010-06-17 Banyu Pharmaceutical Co.,Ltd. Dihydropyrimidopyrimidine derivatives
WO2014023385A1 (en) * 2012-08-07 2014-02-13 Merck Patent Gmbh Pyridopyrimidine derivatives as protein kinase inhibitors

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GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190128673A (ko) * 2017-03-10 2019-11-18 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2020510040A (ja) * 2017-03-10 2020-04-02 アルマック・ディスカバリー・リミテッドＡｌｍａｃ Ｄｉｓｃｏｖｅｒｙ Ｌｉｍｉｔｅｄ Ｗｅｅ−１キナーゼ阻害剤として有用なピリミドピリミジノン
JP7244430B2 (ja) 2017-03-10 2023-03-22 アルマック・ディスカバリー・リミテッド Ｗｅｅ－１キナーゼ阻害剤として有用なピリミドピリミジノン
KR102605546B1 (ko) 2017-03-10 2023-11-22 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2022502438A (ja) * 2018-09-27 2022-01-11 貝達薬業股▲ふん▼有限公司Betta Pharmaceuticals Co., Ltd Ｆｇｆｒ４阻害剤及びその使用
JP7446287B2 (ja) 2018-09-27 2024-03-08 貝達薬業股▲ふん▼有限公司 Ｆｇｆｒ４阻害剤及びその使用
JP2022523073A (ja) * 2019-01-29 2022-04-21 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用
JP2024522304A (ja) * 2021-06-04 2024-06-13 アプレラ セラピューティクス、インク． Ｗｅｅ１キナーゼ阻害剤として有用なピリドピリミジン誘導体

Also Published As

Publication number Publication date
CA2864142A1 (en) 2013-08-29
CN104271576A (zh) 2015-01-07
ES2606640T3 (es) 2017-03-24
MX2014010176A (es) 2014-11-10
WO2013126656A1 (en) 2013-08-29
US20130225589A1 (en) 2013-08-29
EP2817308A1 (en) 2014-12-31
EP2817308B1 (en) 2016-09-07
US9718821B2 (en) 2017-08-01

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