JP2015511245A - ピリドピリミジノン系キナーゼ阻害薬 - Google Patents

ピリドピリミジノン系キナーゼ阻害薬 Download PDF

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Publication number
JP2015511245A
JP2015511245A JP2014558849A JP2014558849A JP2015511245A JP 2015511245 A JP2015511245 A JP 2015511245A JP 2014558849 A JP2014558849 A JP 2014558849A JP 2014558849 A JP2014558849 A JP 2014558849A JP 2015511245 A JP2015511245 A JP 2015511245A
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Prior art keywords
alkyl
amino
phenyl
pyrido
pyrimidin
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Japanese (ja)
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JP2015511245A5 (enExample
Inventor
ウッズ，キース
マストラッチオ，アンソニー
ライ，チュンチウ
ガンディー，ビラージクマール・ビー
ペニング，トーマス
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アッヴィ・インコーポレイテッド
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Publication of JP2015511245A publication Critical patent/JP2015511245A/ja
Publication of JP2015511245A5 publication Critical patent/JP2015511245A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014558849A 2012-02-23 2013-02-22 ピリドピリミジノン系キナーゼ阻害薬 Pending JP2015511245A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261602163P 2012-02-23 2012-02-23
US61/602,163 2012-02-23
PCT/US2013/027265 WO2013126656A1 (en) 2012-02-23 2013-02-22 Pyridopyrimidinone inhibitors of kinases

Publications (2)

Publication Number Publication Date
JP2015511245A true JP2015511245A (ja) 2015-04-16
JP2015511245A5 JP2015511245A5 (enExample) 2016-06-30

Family

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Family Applications (1)

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JP2014558849A Pending JP2015511245A (ja) 2012-02-23 2013-02-22 ピリドピリミジノン系キナーゼ阻害薬

Country Status (8)

Country Link
US (1) US9718821B2 (enExample)
EP (1) EP2817308B1 (enExample)
JP (1) JP2015511245A (enExample)
CN (1) CN104271576A (enExample)
CA (1) CA2864142A1 (enExample)
ES (1) ES2606640T3 (enExample)
MX (1) MX2014010176A (enExample)
WO (1) WO2013126656A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190128673A (ko) * 2017-03-10 2019-11-18 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2022502438A (ja) * 2018-09-27 2022-01-11 貝達薬業股▲ふん▼有限公司Betta Pharmaceuticals Co., Ltd Ｆｇｆｒ４阻害剤及びその使用
JP2022523073A (ja) * 2019-01-29 2022-04-21 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用

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GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
GB201322602D0 (en) 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds
KR102373700B1 (ko) * 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논
JP2017525734A (ja) * 2014-09-02 2017-09-07 ピエール、ファーブル、メディカマン 癌の治療において有用なイソキノリノン誘導体
GB201612095D0 (en) * 2016-07-12 2016-08-24 Almac Discovery Ltd Pharmaceutical compounds
CN114394966B (zh) * 2016-08-15 2024-10-11 辉瑞公司 吡啶并嘧啶酮cdk2/4/6抑制剂
CN110198943B (zh) 2017-01-23 2021-04-16 石家庄智康弘仁新药开发有限公司 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物
SG11201908788YA (en) 2017-03-31 2019-10-30 Seattle Genetics Inc Combinations of chk1- and wee1 - inhibitors
US20200291018A1 (en) * 2017-07-13 2020-09-17 Syros Pharmaceuticals, Inc. Tam kinase inhibitors
CN109422754A (zh) * 2017-08-24 2019-03-05 上海迪诺医药科技有限公司 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用
AU2018347307A1 (en) 2017-10-09 2020-04-23 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
WO2019074979A1 (en) 2017-10-09 2019-04-18 Girafpharma, Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF
WO2019085933A1 (zh) 2017-11-01 2019-05-09 南京明德新药研发股份有限公司 作为Wee1抑制剂的大环类化合物及其应用
GB201800378D0 (en) * 2018-01-10 2018-02-21 Almac Discovery Ltd Pharmaceutical compounds
US12180184B2 (en) 2018-10-26 2024-12-31 Wuxi Biocity Biopharmaceutics Co., Ltd. Pyrimidopyrazolone derivative as Wee1 inhibitor and use thereof
KR102697799B1 (ko) 2019-03-22 2024-08-23 쇼우야오 홀딩스 (베이징) 코., 엘티디. Wee1 억제제 및 이의 제조 및 용도
CN113939296A (zh) 2019-04-09 2022-01-14 诺维逊生物股份有限公司 杂环化合物及其用途
HRP20241008T1 (hr) 2019-04-30 2024-11-08 Wuxi Biocity Biopharmaceutics Co., Ltd. Kristalni oblik spoja inhibitora wee1 i njegova uporaba
TW202144354A (zh) * 2020-03-27 2021-12-01 大陸商貝達藥業股份有限公司 Fgfr4抑制劑的鹽型、晶型及其用途
CN115698006B (zh) 2020-06-17 2024-03-29 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的吡唑并[3，4-d]嘧啶-3-酮衍生物
JP2024515318A (ja) 2021-04-30 2024-04-08 ウィゲン・バイオメディシン・テクノロジー・（シャンハイ）・カンパニー・リミテッド Ｗｅｅ－１阻害剤としての縮合環状化合物、その調製方法およびその使用
KR20240044409A (ko) * 2021-06-04 2024-04-04 아프레아 테라퓨틱스, 인크. Wee1 키나아제 저해제로서 유용한 피리도피리미딘 유도체
CN116462687B (zh) 2022-01-18 2025-01-07 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
KR20240158972A (ko) 2022-03-07 2024-11-05 데비오팜 인터네셔날 에스 에이 소세포 폐암의 치료 방법
CN117402162A (zh) 2022-07-13 2024-01-16 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
WO2025056747A1 (en) 2023-09-14 2025-03-20 Debiopharm International S.A. Combination of a wee1 inhibitor and a pkmyt1 inhibitor
WO2025133381A2 (en) 2023-12-22 2025-06-26 Debiopharm International S.A. Methods of treating solid tumors
WO2025186213A1 (en) 2024-03-04 2025-09-12 Debiopharm International S.A. Combination of a wee1 inhibitor and a topoisomerase 1 inhibitor

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JP2003528101A (ja) * 2000-03-06 2003-09-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ５−アルキルピリド［２，３−ｄ］ピリミジンチロシンキナーゼ阻害剤
JP2007536370A (ja) * 2004-05-04 2007-12-13 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 療法薬としてのピロリル置換ピリド［２，３−ｄ］ピリミジン−７−オンおよびその誘導体
JP2009525292A (ja) * 2006-01-31 2009-07-09 エフ．ホフマン−ラ ロシュ アーゲー ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用
WO2010019637A1 (en) * 2008-08-12 2010-02-18 Smithkline Beecham Corporation Chemical compounds
WO2010063352A1 (en) * 2008-12-01 2010-06-10 Merck Patent Gmbh 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer
JP2010132689A (ja) * 2006-04-27 2010-06-17 Banyu Pharmaceut Co Ltd ジヒドロピラゾロピリミジノン誘導体
WO2010067888A1 (en) * 2008-12-12 2010-06-17 Banyu Pharmaceutical Co.,Ltd. Dihydropyrimidopyrimidine derivatives
WO2014023385A1 (en) * 2012-08-07 2014-02-13 Merck Patent Gmbh Pyridopyrimidine derivatives as protein kinase inhibitors

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190128673A (ko) * 2017-03-10 2019-11-18 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2020510040A (ja) * 2017-03-10 2020-04-02 アルマック・ディスカバリー・リミテッドＡｌｍａｃ Ｄｉｓｃｏｖｅｒｙ Ｌｉｍｉｔｅｄ Ｗｅｅ−１キナーゼ阻害剤として有用なピリミドピリミジノン
JP7244430B2 (ja) 2017-03-10 2023-03-22 アルマック・ディスカバリー・リミテッド Ｗｅｅ－１キナーゼ阻害剤として有用なピリミドピリミジノン
KR102605546B1 (ko) 2017-03-10 2023-11-22 알막 디스커버리 리미티드 Wee-1 키나아제 억제제로서 유용한 피리미도피리미디논
JP2022502438A (ja) * 2018-09-27 2022-01-11 貝達薬業股▲ふん▼有限公司Betta Pharmaceuticals Co., Ltd Ｆｇｆｒ４阻害剤及びその使用
JP7446287B2 (ja) 2018-09-27 2024-03-08 貝達薬業股▲ふん▼有限公司 Ｆｇｆｒ４阻害剤及びその使用
JP2022523073A (ja) * 2019-01-29 2022-04-21 フォグホーン セラピューティクス インコーポレイテッド 化合物及びその使用

Also Published As

Publication number Publication date
EP2817308A1 (en) 2014-12-31
MX2014010176A (es) 2014-11-10
US20130225589A1 (en) 2013-08-29
ES2606640T3 (es) 2017-03-24
US9718821B2 (en) 2017-08-01
CN104271576A (zh) 2015-01-07
CA2864142A1 (en) 2013-08-29
EP2817308B1 (en) 2016-09-07
WO2013126656A1 (en) 2013-08-29

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