JP2015509366A5 - - Google Patents

Download PDF

Info

Publication number
JP2015509366A5
JP2015509366A5 JP2014558252A JP2014558252A JP2015509366A5 JP 2015509366 A5 JP2015509366 A5 JP 2015509366A5 JP 2014558252 A JP2014558252 A JP 2014558252A JP 2014558252 A JP2014558252 A JP 2014558252A JP 2015509366 A5 JP2015509366 A5 JP 2015509366A5
Authority
JP
Japan
Prior art keywords
mir
mirna
group
differentiation
star
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014558252A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015509366A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2013/051429 external-priority patent/WO2013124816A2/en
Publication of JP2015509366A publication Critical patent/JP2015509366A/ja
Publication of JP2015509366A5 publication Critical patent/JP2015509366A5/ja
Pending legal-status Critical Current

Links

JP2014558252A 2012-02-22 2013-02-21 神経幹細胞および運動ニューロンの生成 Pending JP2015509366A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261601596P 2012-02-22 2012-02-22
US61/601,596 2012-02-22
PCT/IB2013/051429 WO2013124816A2 (en) 2012-02-22 2013-02-21 Generation of neural stem cells and motor neurons

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017232724A Division JP6526164B2 (ja) 2012-02-22 2017-12-04 神経幹細胞および運動ニューロンの生成

Publications (2)

Publication Number Publication Date
JP2015509366A JP2015509366A (ja) 2015-03-30
JP2015509366A5 true JP2015509366A5 (https=) 2016-04-14

Family

ID=48014135

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014558252A Pending JP2015509366A (ja) 2012-02-22 2013-02-21 神経幹細胞および運動ニューロンの生成
JP2017232724A Expired - Fee Related JP6526164B2 (ja) 2012-02-22 2017-12-04 神経幹細胞および運動ニューロンの生成

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017232724A Expired - Fee Related JP6526164B2 (ja) 2012-02-22 2017-12-04 神経幹細胞および運動ニューロンの生成

Country Status (4)

Country Link
US (3) US9803175B2 (https=)
EP (2) EP3401394A1 (https=)
JP (2) JP2015509366A (https=)
WO (1) WO2013124816A2 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2354246A1 (en) 2010-02-05 2011-08-10 febit holding GmbH miRNA in the diagnosis of ovarian cancer
US10385314B2 (en) 2010-08-16 2019-08-20 Exostem Biotec Ltd. Methods of generating oligodendrocytes and cell populations comprising same
SG187845A1 (en) 2010-08-16 2013-03-28 Brainstem Biotech Ltd Methods of generating oligodendrocytes and cell populations comprising same
EP2844744A2 (en) 2012-02-22 2015-03-11 Brainstem Biotec Ltd. MicroRNAS FOR THE GENERATION OF ASTROCYTES
EP3401394A1 (en) 2012-02-22 2018-11-14 Exostem Biotec Ltd Generation of neural stem cells
SG11201406336YA (en) * 2012-04-03 2014-11-27 Reneuron Ltd Stem cell microparticles
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
US20170002349A1 (en) * 2013-10-09 2017-01-05 Sun Yat-Sen University Small rna, preparation method therefor and application thereof in pharmaceuticals for specifically up-regulating gene transcriptional activity
EP3760741A1 (en) 2013-12-19 2021-01-06 Hummingbird Diagnostics GmbH Mirnas as non-invasive biomarkers for parkinson's disease
US10487324B2 (en) 2015-02-25 2019-11-26 Washington University Methods to detect motor neuron disease comprising micro-RNAs
WO2016157175A1 (en) * 2015-03-27 2016-10-06 Yeda Research And Development Co. Ltd. Methods of treating motor neuron diseases
JP2018510005A (ja) 2015-03-31 2018-04-12 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 幹細胞の送達媒体およびその使用
US11041006B2 (en) 2015-12-28 2021-06-22 Riken Compositions for use in recovering or ameliorating deterioration of physiological functions due to aging
JP7048977B2 (ja) * 2016-03-16 2022-04-06 サイナータ セラピューティクス リミテッド コロニー形成培地及びその使用
IT201600093825A1 (it) * 2016-09-19 2018-03-19 Fondazione St Italiano Tecnologia Composizione farmaceutica di miRNA e suoi usi terapeutici.
MX2019005127A (es) * 2016-11-03 2019-09-26 Exostem Biotec Ltd Poblaciones y productos de células madre mesenquimales y sus usos.
IT201700012604A1 (it) * 2017-02-06 2018-08-06 Consiglio Naz Delle Ricerche Cnr Nuovi regolatori dell’angiogenesi
KR102113647B1 (ko) 2017-03-30 2020-05-22 울산대학교 산학협력단 신경줄기세포 사멸 억제 효과를 가지는 miR-494-3p 억제제를 유효성분으로 포함하는 퇴행성 신경질환 예방 또는 치료용 조성물
KR102113646B1 (ko) 2017-03-30 2020-05-22 울산대학교 산학협력단 신경줄기세포 사멸 억제 효과를 가지는 miR-383-5p 억제제를 유효성분으로 포함하는 퇴행성 신경질환 예방 또는 치료용 조성물
KR101964748B1 (ko) 2017-06-01 2019-04-03 울산대학교 산학협력단 신경줄기세포 사멸 억제 효과를 가지는 miR-141-5p 억제제를 유효성분으로 포함하는 퇴행성 신경질환 예방 또는 치료용 조성물
CN107982537A (zh) * 2017-11-17 2018-05-04 厦门大学 针对microRNA-155的治疗性药物及其应用
KR20190105334A (ko) 2018-03-05 2019-09-17 울산대학교 산학협력단 신경줄기세포 사멸 억제 효과를 가지는 miR-125a-5p 억제제를 유효성분으로 포함하는 퇴행성 신경질환 치료용 조성물
EP3587575A1 (en) * 2018-06-26 2020-01-01 Institut National de la Santé et de la Recherche Medicale Mirna mir-218 and use thereof for stimulating mesenchymal stem cells
WO2020037254A1 (en) * 2018-08-17 2020-02-20 City Of Hope Compounds of chemically modified oligonucleotides and methods of use thereof
CN109609554B (zh) * 2018-11-29 2022-03-15 南方医科大学 一种mir338基因沉默的脐带间充质干细胞及其制备方法和应用
WO2021034164A1 (ko) * 2019-08-22 2021-02-25 서울대학교 산학협력단 유사교세포로 분화 유도된 후기 단계의 인간 중간엽 줄기세포를 유효성분으로 함유하는 알츠하이머 치료용 약학적 조성물
ES2973364T3 (es) * 2019-09-16 2024-06-19 Genieus Genomics Pty Ltd Biomarcadores para enfermedades neurodegenerativas
US20220364091A1 (en) * 2019-10-09 2022-11-17 The Regents Of The University Of California Compositions and methods for reprogramming age-restricted non-neuronal cells
WO2021105407A1 (en) * 2019-11-29 2021-06-03 Novadip Biosciences miRNA-BASED PHARMACEUTICAL COMPOSITIONS AND USES THEREOF FOR THE PREVENTION AND THE TREATMENT OF TISSUE DISORDERS
CN111850047B (zh) * 2020-07-28 2022-08-12 枣庄学院 一种miR-16与miR-30c联合表达载体及其构建方法与应用
RU2742449C1 (ru) * 2020-09-30 2021-02-05 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии" Министерства здравоохранения Российской Федерации Способ ортотопической трансплантации фрагмента глиобластомы головного мозга человека в область cortex parietalis головного мозга иммунодефицитных мышей
CN116615449A (zh) * 2020-10-09 2023-08-18 加利福尼亚大学校董会 用于治疗移植排斥反应的免疫工程生物材料
KR102791586B1 (ko) 2021-11-23 2025-04-08 재단법인 아산사회복지재단 miR-92b-5p 억제제를 유효성분으로 포함하는 퇴행성 뇌신경질환 예방 또는 치료용 조성물
CN116333994A (zh) * 2021-12-07 2023-06-27 上海鲸奇生物科技有限公司 非编码rna介导的神经性疾病治疗
WO2023238948A1 (ja) * 2022-06-09 2023-12-14 国立大学法人九州大学 ｍｉＲＮＡを含む新規脳神経新生促進剤
WO2025255571A1 (en) * 2024-06-07 2025-12-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ask neurogenic and neurotrophic reprogramming of the skin

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5023243A (en) 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
US4476301A (en) 1982-04-29 1984-10-09 Centre National De La Recherche Scientifique Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US5550111A (en) 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5405938A (en) 1989-12-20 1995-04-11 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5276019A (en) 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US5264423A (en) 1987-03-25 1993-11-23 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US4924624A (en) 1987-10-22 1990-05-15 Temple University-Of The Commonwealth System Of Higher Education 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
US5188897A (en) 1987-10-22 1993-02-23 Temple University Of The Commonwealth System Of Higher Education Encapsulated 2',5'-phosphorothioate oligoadenylates
WO1989009221A1 (en) 1988-03-25 1989-10-05 University Of Virginia Alumni Patents Foundation Oligonucleotide n-alkylphosphoramidates
US5278302A (en) 1988-05-26 1994-01-11 University Patents, Inc. Polynucleotide phosphorodithioates
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
CA2006008C (en) 1988-12-20 2000-02-15 Donald J. Kessler Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5399676A (en) 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US5264564A (en) 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
US5264562A (en) 1989-10-24 1993-11-23 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages
US5177198A (en) 1989-11-30 1993-01-05 University Of N.C. At Chapel Hill Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
US5587361A (en) 1991-10-15 1996-12-24 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
US5321131A (en) 1990-03-08 1994-06-14 Hybridon, Inc. Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
US5470967A (en) 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
US5677437A (en) 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5610289A (en) 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5608046A (en) 1990-07-27 1997-03-04 Isis Pharmaceuticals, Inc. Conjugated 4'-desmethyl nucleoside analog compounds
US5623070A (en) 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5489677A (en) 1990-07-27 1996-02-06 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
US5618704A (en) 1990-07-27 1997-04-08 Isis Pharmacueticals, Inc. Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
US5541307A (en) 1990-07-27 1996-07-30 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs and solid phase synthesis thereof
ES2083593T3 (es) 1990-08-03 1996-04-16 Sterling Winthrop Inc Compuestos y metodos para inhibir la expresion de genes.
US5177196A (en) 1990-08-16 1993-01-05 Microprobe Corporation Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
US5214134A (en) 1990-09-12 1993-05-25 Sterling Winthrop Inc. Process of linking nucleosides with a siloxane bridge
US5561225A (en) 1990-09-19 1996-10-01 Southern Research Institute Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
CA2092002A1 (en) 1990-09-20 1992-03-21 Mark Matteucci Modified internucleoside linkages
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US20020123476A1 (en) 1991-03-19 2002-09-05 Emanuele R. Martin Therapeutic delivery compositions and methods of use thereof
US6933286B2 (en) 1991-03-19 2005-08-23 R. Martin Emanuele Therapeutic delivery compositions and methods of use thereof
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5571799A (en) 1991-08-12 1996-11-05 Basco, Ltd. (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
US5434257A (en) 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5721138A (en) 1992-12-15 1998-02-24 Sandford University Apolipoprotein(A) promoter and regulatory sequence constructs and methods of use
US5476925A (en) 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
GB9304618D0 (en) 1993-03-06 1993-04-21 Ciba Geigy Ag Chemical compounds
CA2159629A1 (en) 1993-03-31 1994-10-13 Sanofi Oligonucleotides with amide linkages replacing phosphodiester linkages
US5625050A (en) 1994-03-31 1997-04-29 Amgen Inc. Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
US5807718A (en) 1994-12-02 1998-09-15 The Scripps Research Institute Enzymatic DNA molecules
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
WO1999056759A1 (en) 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
CA2328457A1 (en) 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
US6303374B1 (en) 2000-01-18 2001-10-16 Isis Pharmaceuticals Inc. Antisense modulation of caspase 3 expression
GB0001309D0 (en) 2000-01-20 2000-03-08 Nestle Sa Valve arrangement
DK1479767T3 (da) 2002-02-06 2013-11-25 Sanbio Inc Fremgangsmåde til differentiering/inducering af stromaceller fra knoglemarv til nerveceller ved overføring af Notch-gen
US20050058641A1 (en) 2002-05-22 2005-03-17 Siemionow Maria Z. Tolerance induction and maintenance in hematopoietic stem cell allografts
DK1620544T3 (en) 2003-04-17 2019-01-14 Alnylam Pharmaceuticals Inc MODIFIED iRNA AGENTS
EP1506997A1 (en) 2003-08-14 2005-02-16 NeuroProgen GmbH Leipzig Method of generating neural stem cells
US20050182005A1 (en) 2004-02-13 2005-08-18 Tuschl Thomas H. Anti-microRNA oligonucleotide molecules
CA2565070A1 (en) 2004-04-28 2005-11-24 Fibrogen, Inc. Anti-ctgf agents for the treatment of pancreatic cancer
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
CA2857881A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
EP1705245B1 (en) 2005-03-23 2009-05-20 Stiftung CAESAR Neural stem cells
EP1893747B1 (en) 2005-06-16 2014-09-03 Ramot at Tel Aviv University Ltd. Isolated cells and populations comprising same for the treatment of cns diseases
KR101022401B1 (ko) 2005-09-29 2011-03-15 아주대학교산학협력단 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물
WO2007066338A1 (en) 2005-12-08 2007-06-14 Ramot At Tel Aviv University Ltd. Isolated oligodendrocyte-like cells and populations comprising same for the treatment of cns diseases
US8809052B2 (en) 2006-08-28 2014-08-19 Yeda Research And Development Co. Ltd. Methods of generating mature oligodendrocytes
US20080176328A1 (en) 2007-01-19 2008-07-24 Seoul National University Industry Foundation Method of inducing differentiation of mesenchymal stem cells into neurons
US8580757B2 (en) * 2007-08-09 2013-11-12 Thermo Fisher Scientific Biosciences Inc. Methods of modulating mesenchymal stem cell differentiation
US8071562B2 (en) * 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
EP2268797A1 (en) 2008-03-31 2011-01-05 Hadasit Medical Research Services & Development Limited Motor neurons developed from stem cells
EP2620493B1 (en) 2008-05-28 2019-03-27 Ramot at Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
CN102439136A (zh) 2009-03-26 2012-05-02 加州大学校董 产生用于疾病修饰的抑制性rna的间充质干细胞
US8852940B2 (en) * 2009-04-01 2014-10-07 The Regents Of The University Of California Embryonic stem cell specific microRNAs promote induced pluripotency
CN102666855A (zh) 2009-06-10 2012-09-12 脑干生物技术有限公司 用于多能性基质细胞的神经元分化的方法、系统和组合物
EP2475784A1 (en) 2009-09-08 2012-07-18 Ramot at Tel-Aviv University Ltd. Methods of diagnosing amyotrophic lateral sclerosis (als)
WO2011159075A2 (ko) 2010-06-14 2011-12-22 차의과학대학교 산학협력단 2차원 배양을 이용한 성체줄기세포의 신경전구세포로의 분화방법 및 신경전구세포를 이용한 신경손상 질환 치료용 약학 조성물
KR101183620B1 (ko) 2010-06-18 2012-09-18 서울대학교산학협력단 지방조직 유래의 간엽줄기세포를 포함하는 파킨슨병 진단용 조성물 및 파킨슨병 진단용 바이오마커
CA2804791C (en) * 2010-07-08 2019-07-30 Duke University Direct reprogramming of cells to cardiac myocyte fate
SG187845A1 (en) 2010-08-16 2013-03-28 Brainstem Biotech Ltd Methods of generating oligodendrocytes and cell populations comprising same
US20150024966A1 (en) 2012-02-22 2015-01-22 Brainstem Biotec Ltd. Mesenchymal stem cells for in vitro modeling and cell-based therapy of human diseases and banks thereof
EP3401394A1 (en) 2012-02-22 2018-11-14 Exostem Biotec Ltd Generation of neural stem cells
EP2844744A2 (en) 2012-02-22 2015-03-11 Brainstem Biotec Ltd. MicroRNAS FOR THE GENERATION OF ASTROCYTES

Similar Documents

Publication Publication Date Title
JP2015509366A5 (https=)
US9821009B2 (en) Method for modulating microRNA content in living beings and the use thereof
CN102218144B (zh) 一种调节生物体内微小核糖核酸含量的方法及其用途
CN108463561B (zh) 用于诊断、预后和治疗监测基于神经性、神经退行性和炎症的疾病的包含基于微rna的小神经胶质细胞微泡的方法
Guo et al. The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells
Im et al. MicroRNAs in neuronal function and dysfunction
JP2015504307A5 (https=)
ES2536422T3 (es) Métodos y composiciones basados en microARN para el diagnóstico y tratamiento de cáncer pancreático
US10308932B2 (en) Method for expressing, secreting and transferring functional microRNAs/siRNAs and application thereof
Nohata et al. MicroRNAs function as tumor suppressors or oncogenes: aberrant expression of microRNAs in head and neck squamous cell carcinoma
JP2008519606A5 (https=)
RU2018130673A (ru) Онколитические вирусные векторы и их применение
JP2019508063A5 (https=)
US20090099034A1 (en) Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers
US20150337332A1 (en) Methods and Compositions to Modulate RNA Processing
EP2775300A3 (en) miRNA Biomarkers of Lung Disease
JP2010538653A5 (https=)
CN101386848A (zh) 细胞微粒子所载微小核糖核酸及其制备研究方法和应用
JP2012231801A5 (https=)
JP2013502931A5 (https=)
Zhang et al. MicroRNAs as big regulators of neural stem/progenitor cell proliferation, differentiation and migration: a potential treatment for stroke
WO2018025242A3 (en) Methods for diagnosing and treating esophageal cancer
KR102180550B1 (ko) FAF1 단백질의 발현을 억제하는 miRNA를 유효성분으로 함유하는 신경 퇴행성 질환 예방 또는 치료용 약학적 조성물
Sole et al. Aberrant expression of MicroRNAs in B-cell lymphomas
Jiang et al. Induction of MiR‐17‐3p and MiR‐160a by TNFα and LPS