CN116333994A - 非编码rna介导的神经性疾病治疗 - Google Patents

非编码rna介导的神经性疾病治疗 Download PDF

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CN116333994A
CN116333994A CN202111488197.4A CN202111488197A CN116333994A CN 116333994 A CN116333994 A CN 116333994A CN 202111488197 A CN202111488197 A CN 202111488197A CN 116333994 A CN116333994 A CN 116333994A
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lncrna
mirna
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周海波
胡新德
苏锦霖
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Shanghai Jingqi Biotechnology Co ltd
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Abstract

非编码RNA介导的神经性疾病治疗。本公开内容涉及生物医药领域。更具体地，本公开内容涉及使某些非编码RNA(例如某些miRNA和/或lncRNA)的表达或活性增强或降低的试剂用于预防和/或治疗与神经元功能缺失或死亡相关的疾病的用途。本公开内容通过增强或降低某些miRNA和lncRNA在非神经元细胞中的表达或活性，可有效地诱导非神经元细胞向神经元细胞的转分化。

Description

非编码RNA介导的神经性疾病治疗
技术领域
本公开内容涉及生物医药领域。更具体地，本公开内容涉及使某些非编码RNA(例如某些miRNA和lncRNA)的表达或活性增强或降低的试剂用于治疗与神经元功能缺失或死亡相关的疾病的用途。
背景技术
细胞的转分化(cell transdifferentiation)是指一种类型的分化细胞通过基因选择性表达或基因的重编程使其在结构和功能上转变成另一种分化细胞的过程。
MicroRNA(miRNA)是一类存在于动物或植物细胞内的高度保守的非编码功能性RNA分子，其长度大约为17-27个核苷酸。miRNA通过与靶标mRNA序列的3’UTR区域结合，导致翻译抑制或者RNA降解，从而抑制靶标基因的功能。当miRNA与靶标RNA完全互补时导致mRNA的降解，而当与靶标RNA不完全互补时阻止基因翻译。在哺乳动物细胞中，miRNA主要以阻止mRNA翻译而不是影响其稳定性。长链非编码RNA(LncRNA)是一类长度超过200个碱基的RNA分子，并不参与蛋白编码，但能以RNA的形式参与调控基因的表达。以前LncRNA被当做是基因转录的“噪音”，是RNA转录的副产物，没有生物学功能。但近些年的研究表明，LncRNA广泛参与多种生物学过程，比如基因的转录调控、基因组印迹、染色质沉默、染色质修饰、基因表达激活或抑制等多种生物学过程。在基因组中大约有4-8％的序列用于转录LncRNA，但LncRNA的功能研究确比较少，而且受限于技术方法，LncRNA的研究相对滞后。LncRNA从表观遗传学、基因转录调控、转录后调控等多个层次参与基因的表达调控，而且有一些LncRNA还参与miRNA的调控，从而间接调控基因表达。
帕金森病(PD)是一种与神经元功能缺失或死亡相关的疾病，其特征是中脑黑质多巴胺神经元的丧失。目前对帕金森病的主要治疗手段是以左旋多巴制剂为代表的药物。同时手术治疗也能在一定程度上改善症状。需要指出的是所有这些手段只能部分的缓解病情，还达不到阻止病情发展的效果。
穆勒胶质细胞是视网膜组织中的主要神经胶质细胞。视网膜神经节细胞(retinalganglion cell，RGC)是位于视网膜最内层的神经细胞，它的树突主要与双极细胞联系，它的轴突延伸至视神经乳头处，形成视神经。视网膜神经节细胞(RGC)退化是造成永久性失明的主要缘由。RGC是视网膜惟一的输出神经元，因此RGC退化可导致造成永久性失明的视网膜疾病。重建RGC可有助于恢复视力，是恢复视觉功能的潜在治疗。
本领域仍然迫切需要开发能够有效治疗与神经元功能缺失或死亡相关的疾病的新靶点和新疗法。
发明内容
在一个实施方案中，本公开内容提供了由非神经元细胞产生神经元细胞的方法，其包括通过使选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA，或其任意组合的表达或活性增强来使所述非神经元细胞转分化为或重编程为神经元细胞。
在一个优选的实施方案中，通过例如过表达、基因激活剂、表观遗传修饰、miRNA模拟物、直接递送RNA、小分子化合物、和/或RNA稳定剂来增强所述miRNA或lncRNA的表达或活性。
在另一个实施方案中，本公开内容提供了由非神经元细胞产生神经元细胞的方法，其包括通过使选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA，或其任意组合的表达或活性降低来使所述非神经元细胞转分化为或重编程为神经元细胞。
在一个优选的实施方案中，通过例如基因编辑技术介导的DNA编辑和RNA编辑、RNA表达抑制剂、反义寡核苷酸(ASO)、小RNA干扰、miRNA技术、小分子化合物、基因抑制技术(dCas-Krab等)、和/或表观遗传调控来降低所述miRNA或lncRNA的表达或活性。
在一个优选的实施方案中，RNA编辑包括CRISPR介导的RNA降解和翻译抑制、RNA单碱基编辑、RNA上碱基的插入或缺失、RNA剪切的改变、RNA表观修饰。
在一个优选的实施方案中，所述选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA、或选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA为来自不同物种的同源miRNA或同源lncRNA。
在一个优选的实施方案中，所述非神经元细胞包括例如胶质细胞、成纤维细胞、干细胞、神经前体细胞、神经干细胞，其中胶质细胞选自星形胶质细胞、小胶质细胞、少突胶质细胞、室管膜细胞、施万细胞、NG2细胞、卫星细胞、视网膜穆勒胶质细胞、耳蜗螺旋神经节胶质细胞或其组合，优选星形胶质细胞、视网膜穆勒胶质细胞和耳蜗螺旋神经节胶质细胞。
在一个优选的实施方案中，所述胶质细胞来源于脑、脊髓、眼或耳，其中脑部胶质细胞来源于纹状体、黑质、中脑腹侧被盖区、脊髓、下丘脑、背侧中脑或大脑皮层，优选纹状体和黑质。
在一个优选的实施方案中，所述神经元细胞优选多巴胺神经元、GABA神经元、5-HT神经元、谷氨酸能神经元、ChAT神经元、NE神经元、运动神经元、脊髓神经元、脊髓运动神经元、脊髓感觉神经元、感光细胞(视杆细胞和视锥细胞)、双极细胞、水平细胞、无长突细胞、视网膜神经节细胞(RGC)、耳蜗神经细胞(耳蜗螺旋神经节细胞(SGN)和前庭神经元)、锥体神经元、中间神经元、中型多棘神经元(MSN)、浦肯野细胞、颗粒细胞、嗅感觉神经元、球周细胞或其组合，更优选多巴胺神经元、视网膜神经节细胞(RGC)、感光细胞和耳蜗螺旋神经节细胞(SGN)。
在一个优选的实施方案中，所述非神经元细胞和/或神经元细胞来自例如人、非人灵长类动物、大鼠和小鼠，优选人。
在一个优选的实施方案中，所述方法为体内方法或体外方法。
在另一个实施方案中，本公开内容提供了使选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA，或其任意组合的表达或活性增强的试剂在制备用于预防和/或治疗与神经元功能缺失或死亡相关疾病的药物的用途，其中所述试剂增强所述miRNA或所述lncRNA的表达或活性。
在另一个实施方案中，本公开内容提供了使选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA，或其任意组合的表达或活性降低的试剂在制备用于预防和/或治疗与神经元功能缺失或死亡相关疾病的药物的用途，其中所述试剂降低所述miRNA或所述lncRNA的表达或活性。
在一个优选的实施方案中，所述药物配制成用于在体内施用于神经系统、视觉系统和听觉系统，例如纹状体、黑质、中脑腹侧被盖区、脊髓、下丘脑、背侧中脑、大脑皮层、海马、小脑、视网膜下、玻璃体腔、内耳耳蜗和前庭，优选纹状体、黑质、视网膜下、玻璃体腔和内耳耳蜗。
在一个优选的实施方案中，所述与神经元功能缺失或死亡相关的疾病选自：帕金森病、阿尔茨海默病、脑卒中(中风)、精神分裂症、亨廷顿舞蹈症、抑郁症、运动神经元病、脑缺血、脑损伤、肌萎缩性侧索硬化(ALS)、脊髓性肌萎缩症、Pick病、睡眠失调、癫痫、共济失调、PloyQ疾病、成瘾、RGC细胞功能缺失或死亡导致的失明或视力损伤、感光细胞功能缺失或死亡导致的失明或视力损伤、青光眼、年龄相关的RGC病变、视神经损伤、视网膜缺血或出血、Leber遗传性视神经病变、损伤或退行性病变导致的感光细胞变性或死亡、黄斑变性、视网膜色素变性、糖尿病有关的失明、夜盲症、色盲、遗传性失明、先天性黑蒙症、耳蜗螺旋神经节细胞死亡导致的耳聋或听觉减退、或其组合，优选帕金森病和RGC或感光细胞功能缺失或死亡导致的视觉系统疾病。
在一个优选的实施方案中，所述使所述miRNA或lncRNA或其组合的表达或活性增强包括：
(a)外源表达所述miRNA或lncRNA或其组合，例如通过包含启动子的表达载体来实现；
(b)向细胞内递送DNA或RNA形式的所述miRNA或lncRNA或其组合；
(c)激活所述miRNA或lncRNA或其组合的内源表达，如基因表达激活剂和表观调控元件等；或者
(d)向细胞递送所述miRNA或lncRNA或其组合的类似物或激动剂；
其中优选外源表达所述miRNA或lncRNA或其组合，例如通过包含启动子的表达载体来实现。
在一个优选的实施方案中，通过以下使所述miRNA或lncRNA或其组合的表达或活性降低：抗体、小分子化合物、microRNA、siRNA、shRNA、反义寡核苷酸、结合蛋白或蛋白结构域、多肽、核酸适配体、基因编辑器、表观调控元件、转录抑制元件或其组合。
在另一个实施方案中，本公开内容提供了药物组合物或药盒或试剂盒，其包含使选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA，或其任意组合的表达或活性增强的试剂；或者使选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA，或其任意组合的表达或活性降低的试剂。
在一个优选的实施方案中，使所述miRNA或lncRNA或其组合的表达或活性增强的试剂选自：表达载体，DNA或RNA形式的所述miRNA或lncRNA或其组合，所述miRNA或lncRNA或其组合的内源性激活剂，所述miRNA或lncRNA或其组合的类似物或激动剂。
在一个优选的实施方案中，所述表达载体是基因治疗载体，优选病毒基因治疗载体，更优选选自以下的病毒载体：腺相关病毒(AAV)载体、重组腺相关病毒载体(rAAV)、自互补AAV(scAAV)、腺病毒载体、慢病毒载体、逆转录病毒载体、疱疹病毒、SV40载体、痘病毒载体、及其组合，其中优选AAV和rAAV。
在一个优选的实施方案中，使所述miRNA或lncRNA或其组合的表达或活性降低的试剂选自：抗体、小分子化合物、microRNA、siRNA、shRNA、反义寡核苷酸、结合蛋白或蛋白结构域、多肽、核酸适配体、基因编辑器、表观调控元件、转录抑制元件，或其组合。
在一个优选的实施方案中，所述药物组合物或药盒或试剂盒还包含用于递送所述试剂的载体或运载体。
在一个优选的实施方案中，所述载体或运载体为病毒载体、脂质体、纳米颗粒、外泌体、类病毒颗粒，优选AAV。
在一个优选的实施方案中，所述组合物局部施用至以下至少一种：1)视网膜中的胶质细胞；ii)纹状体中的胶质细胞；iii)黑质中的胶质细胞；iv)内耳中的胶质细胞；v)脊髓中的胶质细胞；vi)前额皮质中的胶质细胞；vii)运动皮质中的胶质细胞；viii)下丘脑中的胶质细胞；以及ix)腹侧被盖区(VTA)中的胶质细胞。
在一个优选的实施方案中，所述药物组合物或药盒或试剂盒配制成用于细胞转染、细胞感染、细胞内吞、注射、颅内给药、眼内给药、内耳注射、吸入、肠胃外施用、静脉内施用、肌内施用、皮内施用、表面施用或经口施用。
在一个优选的实施方案中，非神经元细胞的转分化效率为至少1％，或至少10％、20％、30％、40％或50％。
应理解，在本公开内容范围内中，本公开内容的上述各技术特征和在下文(如实施例)中具体描述的各技术特征之间都可以互相组合，从而构成新的或优选的技术方案。限于篇幅，在此不再一一累述。
附图说明
图1.敲低Pnky介导的胶质细胞向神经元转分化。(A)AAV载体设计示意图，Vector1为GFAP驱动mCherry表达的载体示意图，GFAP是一种胶质细胞中特异性表达的启动子，mCherry是一种红色荧光蛋白，应用于标记胶质细胞。Vector 2是GFAP-CasRx表达载体示意图，由星形胶质细胞特异性启动子GFAP驱动CasRx的表达。Vector3是U6-gRNA-GFAP-CasRx表达载体示意图，gRNA由U6启动子启动表达，CasRx由GFAP启动子启动。(B)在293T细胞中利用CasRx敲低Pnky的表达，CasRx-gRNA(Pnky)高效敲低Pnky的mRNA。(C)AAV注射和转分化示意图，在小鼠脑中注射不同的AAV，研究胶质细胞向神经元转分化：对照组注射GFAP-mCherry与GFAP-CasRx的混合病毒，实验组注射GFAP-mCherry与GFAP-CasRx-gRNA(Pnky)的混合AAV，GFAP-mCherry标记星形胶质细胞。
图2.miRNA或LncRNA介导的胶质细胞向神经元转分化。(A)GFAP-mCherry和GFAP-miRNA/lncRNA表达载体设计示意图。由胶质细胞特异性启动子GFAP驱动mCherry，miRNA或LncRNA表达。(B)Tuna,Let-7b,miR-137的AAV表达载体示意图，其中Tuna为LncRNA，Let-7b和miRNA-137为miRNA,都由GFAP启动子启动表达。(C)AAV注射和miRNA/LncRNA将胶质细胞转分化为神经元示意图。(D)在C57小鼠纹状体中注射对照组AAV结果代表图，在注射AAV后1个月取材分析，红色荧光信号为GFAP-mCherry所标记的细胞，白色信号为神经元特异性标志物NeuN，白色信号与红色信号不重合。(E-G)在小鼠纹状体中分别注射GFAP-Tuna，GFAP-Let-7b或miR-137后1个月取材分析结果代表图，红色荧光信号(mCherry)为GFAP-mCherry标记的神经元，白色信号为神经元特异性标志物NeuN，黄色箭头指示的为mCherry与NeuN共标的细胞，标尺为50微米。
具体实施方式
miRNA和LncRNA在神经系统中广泛表达并具有重要的功能，在神经系统的发育和多中神经疾病的发生发展中都扮演着重要的角色。神经系统发育过程中miRNA广泛表达于多种神经细胞，而且不同的神经细胞中表达的miRNA种类不同。这表明，不同的miRNA可能参与调解不同的神经细胞发育。之前的研究表明，在神经系统发育过程中miRNA-124具有促进神经前体细胞向神经元分化的作用，而且miRNA-124可以通过调控Ptbp1等基因的表达，抑制神经前体细胞向胶质细胞的分化。而且，在体外培养的穆勒胶质细胞(Müller glia，MG)中，过表达miRNA-9和miRNA-124可以将穆勒胶质细胞转分化为视网膜神经元，并且过表达miRNA-9和miRNA-124可以促进AscL1介导的穆勒胶质细胞向视网膜神经元转分化。LncRNA是一类在神经系统中非常丰富的非编码功能性RNA，大约有一半的LncRNA特异性表达于神经系统。LncRNA不但参与了神经系统的发育和功能的成熟，还参与调解突触连接，轴突生长以及神经系统的损伤后修复等过程。然而，对于LncRNA，由于技术方法所限而研究较少，许多LncRNA的功能尚不清楚。之前的研究表明，在LncRNA在调节大脑发育过程中有着重要的功能，比如促进神经干细胞向神经元或胶质细胞分化。在疾病损伤修复过程中LncRNA也具有重要的功能，有研究发现BACE1-AS与阿尔兹海默症有关，MALAT1与帕金森病的发生和发展有关。然而，目前为止没有有关LncRNA与胶质细胞转分化的研究。
随着老龄化进程的发展，神经退行性疾病逐渐成为除癌症以外的第二大疾病，病人数量众多，然而目前能用于治疗神经退行性疾病的药物非常少，而且大部分药物只能延缓疾病的进程，并不能达到逆转疾病进程的效果。而神经再生技术的出现，无疑为这些重大神经退行性疾病的治疗带来了希望。科学家们将胶质细胞转分化为功能性神经元，期待能治疗神经退行性疾病或者中风等重大脑疾病。因此，寻找高效的神经转分化靶点就尤为重要。
本研究通过AAV介导的基因递送技术，在神经系统中将胶质细胞转分化为神经元神经元，或在视网膜中将穆勒胶质细胞转分化为RGC细胞。实验结果表明，Pnky、Tuna、Let-7b和miR137等miRNA或LncRNA可以在体内将星形胶质细胞转分化为神经元。这些结果说明，miRNA和LncRNA也可以作为胶质细胞向神经元转分化的靶点，而且为治疗多种神经退行性疾病奠定基础。
与神经元功能缺失或死亡相关的疾病
在本公开内容中，与神经元功能缺失或死亡相关的疾病主要包括与多巴胺神经元功能缺失或死亡相关的疾病，以及与视神经节或感光细胞缺失或死亡相关的视力障碍。
在一个优选的实施方案中，所述与神经元功能缺失或死亡相关的疾病选自：帕金森病、阿尔茨海默病、脑卒中(中风)、精神分裂症、亨廷顿舞蹈症、抑郁症、运动神经元病、脑缺血、脑损伤、肌萎缩性侧索硬化(ALS)、脊髓性肌萎缩症、Pick病、睡眠失调、癫痫、共济失调、PloyQ疾病、成瘾、RGC细胞功能缺失或死亡导致的失明或视力损伤、感光细胞功能缺失或死亡导致的失明或视力损伤、青光眼、年龄相关的RGC病变、视神经损伤、视网膜缺血或出血、Leber遗传性视神经病变、损伤或退行性病变导致的感光细胞变性或死亡、黄斑变性、视网膜色素变性、糖尿病有关的失明、夜盲症、色盲、遗传性失明、先天性黑蒙症、耳蜗螺旋神经节细胞死亡导致的耳聋或听觉减退、或其组合，优选帕金森病和RGC或感光细胞功能缺失或死亡导致的视觉系统疾病。
星形胶质细胞
星形胶质细胞，是哺乳动物脑内数量最多的一类细胞。它们执行许多功能，包括生化支撑(例如形成血-脑屏障)，为神经元提供营养，维持细胞外离子平衡，并参与脑和脊髓损伤后的修复和瘢痕形成。根据胶质丝的含量以及胞突的形状可将星形胶质细胞分为两种：纤维性星形胶质细胞(fibrous astrocyte)多分布在脑和脊髓的白质，突起细长，分支较少，胞质中含大量胶质丝；原浆性星形胶质细胞(protoplasmic astrocyte)，多分布在灰质，细胞突起粗短，分支多。
可用于本公开内容的星形胶质细胞没有特别限制，包括哺乳动物中枢神经系统来源的各种星形胶质细胞，例如来源于纹状体、中脑腹侧被盖区、下丘脑、脊髓、背侧中脑或大脑皮层，优选地，来源于纹状体或黑质。
神经元
在本公开内容中，神经元可以指能够通过化学或电信号发送或接收信息的神经元。在一些实施方案中，神经元展现出存在于正常神经系统中的成熟神经元的一种或多种功能特性，包括但不限于：兴奋性(例如，表现出动作电位的能力，例如快速上升和随后的下降)(跨细胞膜的电压或膜电位)，与其他神经元形成突触连接，突触前神经递质释放和突触后反应(例如，兴奋性突触后电流或抑制性突触后电流)。
在一些实施方案中，神经元的特征在于其表达功能神经元的一种或多种标记，包括但不限于突触蛋白，突触素，谷氨酸脱羧酶67(GAD67)，谷氨酸脱羧酶65(GAD65)，小白蛋白，多巴胺-和cAMP调节的神经元磷蛋白32(DARPP32)，囊泡谷氨酸转运蛋白1(vGLUT1)，囊泡谷氨酸转运蛋白2(vGLUT2)，乙酰胆碱，酪氨酸羟化酶(TH)，多巴胺，囊泡GABA转运蛋白(VGAT)和γ-氨基丁酸(GABA)。
多巴胺神经元
多巴胺能神经元(dopaminergic neuron)含有并释放多巴胺(dopamine，DA)作为神经递质的神经元。多巴胺属于儿茶酚胺类神经递质，在中枢神经系统中发挥重要的生物学作用，大脑内的多巴胺能神经元主要集中在中脑的黑质致密区(substantria nigrapars compacta,SNc)、腹侧被盖区(ventral tegmental area,VTA)、下丘脑和脑室周围。很多实验证实多巴胺能神经元与人体的多种疾病密切相关，最典型的就是帕金森病。
腺相关病毒
因腺相关病毒(Adeno-associated virus，AAV)较其他病毒载体小，无致病性，可转染正在分裂和未分裂的细胞等特性，基于AAV载体的针对遗传性疾病的基因治疗方法受到了广泛的关注。
腺相关病毒(AAV),也称腺伴随病毒，属于微小病毒科依赖病毒属,是目前发现的一类结构最简单的单链DNA缺陷型病毒，需要辅助病毒(通常为腺病毒)参与复制。它编码两个末端的反向重复序列(ITR)中的cap和rep基因。ITRs对于病毒的复制和包装具有决定性作用。cap基因编码病毒衣壳蛋白，rep基因参与病毒的复制和整合。AAV能感染多种细胞。
重组腺相关病毒载体(rAAV)源于非致病的野生型腺相关病毒，由于其安全性好、宿主细胞范围广(分裂和非分裂细胞)、免疫源性低，在体内表达外源基因时间长等特点，被视为最有前途的基因转移载体之一，在世界范围内的基因治疗和疫苗研究中得到广泛应用。经过10余年的研究，重组腺相关病毒的生物学特性己被深入了解，尤其是其在各种细胞、组织和体内实验中的应用效果方面已经积累了许多资料。在医学研究中，rAAV被用于多种疾病的基因治疗的研究(包括体内、体外实验)；同时作为一种有特点的基因转移载体，还广泛用于基因功能研究、构建疾病模型、制备基因敲除鼠等方面。
在本公开内容一个优选的实施例中，载体为重组AAV载体。AAV是相对较小的DNA病毒，其可以稳定和位点特异性方式整合到它们所感染的细胞的基因组中。它们能够感染一大系列的细胞而不对细胞生长、形态或分化产生任何影响，并且它们似乎并不涉及人体病理学。AAV基因组己被克隆、测序及表征。AAV在每个末端包含约145个碱基的反向末端重复序列(ITR)区域，其作为病毒的复制起点。该基因组的其余被分成两个带有衣壳化功能的重要区域：包含涉及病毒复制和病毒基因表达的rep基因的基因组左边部分；以及包含编码病毒衣壳蛋白的cap基因的基因组右边部分。
AAV载体可采用本领域的标准方法制备。任何血清型的腺相关病毒均是合适的。用于纯化载体的方法可见于例如美国专利No.6566118、6989264和6995006，它们的公开内容整体以引用方式并入本文。杂合载体的制备在例如PCT申请No.PCT/US2005/027091中有所描述，该申请的公开内容整体以引用方式并入本文。用于体外和体内转运基因的衍生自AAV的载体的使用己有描述(参见例如国际专利申请公布No.WO91/18088和WO93/09239；美国专利No.4,797,368、6,596,535和5,139,941，以及欧洲专利No.0488528，它们均整体以引用方式并入本文)。这些专利公布描述了其中rep和/或cap基因缺失并被所关注的基因替换的各种来源于AAV的构建体，以及这些构建体在体外(进入培养的细胞中)或体内(直接进入生物体)转运所关注的基因的用途。复制缺陷重组AAV可通过将以下质粒共转染进被人类辅助病毒(例如腺病毒)感染的细胞系而制备：所含的所关注核酸序列的侧翼为两个AAV反向末端重复序列(ITR)区域的质粒，和携带AAV衣壳化基因(rep和cap基因)的质粒。然后通过标准技术纯化所产生的AAV重组体。
在一些实施方案中，重组载体被衣壳化到病毒粒子(例如包括但不限于AAV1、AAV2、AAV3、AAV4、AAV5、AAV6、AAV7、AAV8、AAV9、AAV10、AAV11、AAV12、AAV13、AAV14、AAV15和AAV16的AAV病毒粒子)中。因此，本公开包括含有本文所述任何载体的重组病毒粒子(因其包含重组多核苷酸而为重组的)。产生这样的粒子的方法是本领域己知的，并在美国专利No.6,596,535中有所描述。
通用方法
动物伦理：
本研究中动物的饲养和使用是在中国科学院脑科学与智能技术卓越创新中心生物医学研究伦理委员会的指导原则指导下完成。
质粒构建：
本研究中的质粒均为本实验室自己构建，AAV骨架载体用限制性内切酶进行酶切，并进行琼脂糖凝胶电泳，回收骨架载体。插入DNA片段为以细胞cDNA或基因组为模板进行PCR，琼脂糖凝胶电泳后回收PCR片段。按照诺唯赞生物科技有限公司的ClonExpressMultiS One Step Cloning Kit(Vazyme,C113-02)标准操作步骤将骨架载体与片段连接。连接后转化到DH5a大肠杆菌中。经测序验证正确的克隆进行扩大培养，并提取质粒。构建质粒如下：AAV-GFAP-mCherry,AAV-GFAP-CasRx，AAV-GFAP-CasRx-gRNA(Pnky),CAG-Pnky-WPRE；CAG-CasRx,CMV-mCherry-U6-gRNA(Pnky)，AAV-GFAP-Pnky,AAV-GFAP-Let-7b,AAV-GFAP-miRNA-137。
细胞培养和转染
293T细胞培养于DMEM+10％胎牛血清+青/链霉素培养基中，在37℃，5％CO2浓度的的培养箱中培养。待细胞生长到铺满培养皿底70％左右进行转染。按照EZ Trans细胞转染试剂(上海李记生物，AC04L092)标准操作步骤进行细胞转染。实验组转染质粒为CAG-Pnky-WPRE+CAG-CasRx-EGFP+CMV-mCherry-U6-gRNA(Pnky)，对照组转染质粒为CAG-CasRx+CMV-mCherry-U6-gRNA(Pnky)。转染后48h进行流式分选，每个样品收集30000个细胞，实验组收取GFP和mCherry双阳性细胞，对照组分选GFP阳性细胞。收集的细胞使用Trizol(Ambion)提取RNA，并使用逆转录试剂盒(用于qPCR的HiScript Q RT SuperMix，诺唯赞)进行其反转录。QPCR检测使用AceQ qPCR SYBR Green Master Mix(诺唯赞)。qPCR引物为：5’-aggcagtgtgcggaggacat-3’和5’-gccattgtcctagcaagtgc-3’。
小鼠脑部AAV注射：
利用瑞沃德立体定位注射系统进行注射，对于需要下调表达的RNA，对照组注GFAP-mCherry+GFAP-CasRx，实验组注射GFAP-mCherry+GFAP-CasRx-gRNA(Pnky)。对于需要上调表达的RNA，对照组注射GFAP-mCherry，实验组注射GFAP-mCherry+GFAP-miRNA/LncRNA，本实验中miRNA/LncRNA具体为GFAP-Tuna,GFAP-Let-7b和GFAP-miRNA-137。各组AAV混合液的滴度大于5×1012vg/ml(每次注射1-3μl)。将AAV注入纹状体(AP+0.8mm，ML±1.6mm和DV-2.8mm)或黑质(AP–3.0mm，ML±1.25mm和DV-4.5mm)。
小鼠组织免疫荧光染色：
注射AAV后1-2个月取材、切片并进行免疫荧光染色。大概步骤为:先用生理盐水进行灌流，再用4％PFA灌流，取出目的组织并用4％多聚甲醛(PFA)固定过夜，然后在30％蔗糖中脱水至少12小时以上，待组织沉入蔗糖溶液底部再进行切片。用OCT进行包埋后进行冷冻切片，切片厚度为30μm或40μm。免疫荧光染色之时，用0.1M磷酸盐缓冲液(PBS)清洗脑片三次，每次5-10分钟。然后加上一抗4℃孵育过夜，用PBS清洗3-4次，每次10-15分钟。清洗结束后加入二抗稀释液稀释后的二抗进行孵育，室温孵育2-3个小时，孵育结束后再用PBS洗3-4次，每次10-15分钟。最后用抗荧光淬灭封片剂(Life Technology)进行封片。
本研究中使用的抗体信息如下：
本研究中所用一抗包括：荷兰猪抗NeuN(1:500,ABN90,Millipore),兔抗TH(1:500,AB152,Millipore),大鼠抗DAT(1:100,MAB369,Millipore)和鼠抗Flag(1:2000,F3165,Sigma),。该研究中使用的二抗为:Cy5-AffiniPure Donkey Anti-Guinea Pig IgG(H+L)(1:500,706-175-148,Jackson ImmunoResearch)，Alexa Fluora-488 AffiniPureDonkey Anti-Rabbit IgG(H+L)(1:500,711-545-152,Jackson ImmunoResearch)，AlexaFluora-488 AffiniPure Donkey Anti-Mouse IgG(H+L)(1:500,715-545-150,JacksonImmunoResearch)和Cy5 AffiniPure Donkey Anti-Rabbit IgG(H+L)(1:500,711-175-152,Jackson ImmunoResearch)。
电生理记录：
AAV注射后1-3个月进行电生理学记录。首先将小鼠麻醉并用预冷的NMDA灌流，然后把脑子放入充有二氧化碳的NMDG人工脑脊液(ACSF)[NMDG ACSF(mM)：NMDG 92，氯化钾2.5，磷酸二氢钠1.25，碳酸氢钠30，HEPES 20，葡萄糖25，硫脲2，抗坏血酸钠5)在室温下，丙酮酸钠3，氯化钙0.5，硫酸镁10]中。灌注后提取脑并将其置于冰冷的NMDG ACSF溶液中30秒。用震动切片机以0.04-0.05mm/s的速度切成厚度为250-350μm的厚脑片。将脑切片移入充满二氧化碳NMDG ACSF的培养皿中，并在32-34℃保持≤12分钟。在室温下将切片转移到充二氧化碳的HEPES ACSF的新的培养皿中[HEPES，其中含有ACSF(mM)：氯化钠92，氯化钾2.5，磷酸二氢钠1.25，碳酸氢钠30，HEPES 20，葡萄糖25，硫脲2，抗坏血酸钠5，丙酮酸钠3，氯化钙2，硫酸镁2]。1小时后将切片转移到含有记录缓冲液[记录ACSF(mM)：氯化钠119，氯化钾2.5，磷酸二氢钠1.25，碳酸氢钠24，葡萄糖12.5，氯化钙2，硫酸镁2]的记录皿中。在显微镜(Olympus BX51WI)下记录具有红色荧光信号的神经元样细胞，并使用Clampex 10捕获转分化细胞的电活动。
6-OHDA PD小鼠模型
本实验所使用的的小鼠为成年C57BL/6小鼠(7-10周)小鼠。在麻醉前半小时腹腔注射25mg/kg盐酸地昔帕明(D3900，Sigma-Aldrich)。麻醉后，向小鼠右侧内侧前脑束注射3μg6-OHDA(H116，Sigma-Aldrich)或生理盐水：前后位(A/P)＝-1.2mm，内外侧(M/L)＝-1.1mm，背腹(D/V)＝-5mm。手术后1小时，给小鼠皮下注射1ml 4％的葡萄糖-盐水溶液。
NMDA造模，AAV注射和切片
为研究在受损视网膜中是否可以再生RGC，用PBS中配制200mM的NMDA溶液，然后通过玻璃体内注射，在4-8周龄的Ai9小鼠玻璃体腔中注射1.5μl NMDA溶液注。NMDA注射后2-3周，对照组和实验组AAV混合液通过视网膜下注射递送至视网膜下。针对需要下调表达的miRNA/LncRNA，对照组注射GFAP-GFP-Cre(0.1ul)+GFAP-CasRx，实验组注射GFAP-GFP-Cre(0.1ul)+GFAP-CasRx-gRNA；针对需要上调表达的miRNA/LncRNA，对照组注射GFAP-GFP-Cre(0.1ul)+PBS(0.9ul)，实验组注射GFAP-GFP-Cre(0.1μl)+GFAP-miRNA/LncRNA。在体视显微镜(Olympus)下用Hamilton注射器(32G针)向眼睛注射AAV混合液(>1×1013vg/ml)。AAV注射1-3个月后，取眼睛，视神经，用4％多聚甲醛(PFA)固定2小时，然后在30％蔗糖溶液中脱水2h，视神经直接用PBS清洗后封片观察。然后用OCT进行包埋，将眼睛进行切片，厚度为30μm。
视网膜免疫荧光染色：
用于免疫荧光染色的一抗：兔抗RBPMS(1：500，Proteintech,15187-1-AP)，小鼠抗Brn3a(1：100，MAB1585，Millipore)。二抗为：CyTM5AffiniPure Donkey小鼠抗IgG(H+L)(1：500,715-175-150，Jackson ImmunoResearch)和Cy TM 5AffiniPure Donkey兔抗IgG(H+L)(1：500,711-175-152，Jackson ImmunoResearch)。一抗4℃孵育12小时后用PBS清洗3遍，每次10分钟。加入二抗室温孵育3h，再用PBS清洗3遍，每次10分钟。最后用抗荧光淬灭剂封片(Life technology),并使用共聚焦显微镜进行成像。
黑白盒偏好测试
用于黑白偏好测试的箱体包含两个部分，三分之一的暗箱部分和三分之二明箱部分(550-600流明)。小鼠可以在两个隔室之间自由移动，放入小鼠后用摄像头记录10分钟。统计小鼠在明室和暗室中的时间，并使用Ethovision XT软件进行分析。每次试验后，用70％乙醇擦拭箱体以避免嗅觉干扰。
序列信息
miRNA的序列信息
Let-7a的核苷酸序列
人Let-7a编码序列：5’-tgaggtagtaggttgtatagtt-3’(SEQ ID NO:1)
人Let-7a*编码序列：5’-ctatacaatctactgtctttc-3’(SEQ ID NO:2)
人Let-7a-2*编码序列：5’-ctatacaatctactgtctttc-3’(SEQ ID NO:3)
人Let-7a Per-miRNA全长(人有3个Let-7a的Pre-miRNA)
Let-7a-1：
tgggatgaggtagtaggttgtatagttttagggtcacacccaccactgggagataactatacaatctactgtctttccta(SEQ ID NO:4)
Let-7a-2：
aggttgaggtagtaggttgtatagtttagaattacatcaagggagataactgtacagcctcctagctttcct(SEQ ID NO:5)
Let-7a-3：
gggtgaggtagtaggttgtatagtttggggctctgccctgctatgggataactatacaatctactgtctttcct(SEQ ID NO:6)
人和鼠Let-7a(Let-7a-1/2)核心序列，在DNA水平的相似性为100％。
Let-7b的核苷酸序列
人Let-7b编码序列：5’-tgaggtagtaggttgtgtggtt-3’(SEQ ID NO:7)
人Let-7b*编码序列：5’-ctatacaacctactgccttccc-3’(SEQ ID NO:8)
人Let-7b Per-miRNA全长
cggggtgaggtagtaggttgtgtggtttcagggcagtgatgttgcccctcggaagataactatacaacctactgccttccctg(SEQ ID NO:9)
人和鼠Let-7b核心序列，在DNA水平的相似性为100％。
miR-18的核苷酸序列
人miR-18a编码序列：5’-taaggtgcatctagtgcagatag-3’(SEQ ID NO:10)
人miR-18a*编码序列：5’-actgccctaagtgctccttctgg-3’(SEQ ID NO:11)
人miR-18b*编码序列：5’-taaggtgcatctagtgcagttag-3’(SEQ ID NO:12)
人miR-18Per-miRNA全长
miR-18a
tgttctaaggtgcatctagtgcagatagtgaagtagattagcatctactgccctaagtgctccttctggca(SEQ ID NO:13)
miR-18b
tgtgttaaggtgcatctagtgcagttagtgaagcagcttagaatctactgccctaaatgccccttctggca(SEQ ID NO:14)
人和鼠miR-18a核心序列，在DNA水平的相似性为100％；
miR-24-3p的核苷酸序列
人miR-24-3p编码序列：5’-tggctcagttcagcaggaacag-3’(SEQ ID NO:15)
人miR-24-3p Per-miRNA全长(人有2个编码序列)
miR-24-1
ctccggtgcctactgagctgatatcagttctcattttacacactggctcagttcagcaggaacaggag(SEQ ID NO:16)
miR-24-2
ctctgcctcccgtgcctactgagctgaaacacagttggtttgtgtacactggctcagttcagcaggaacaggg(SEQ ID NO:17)
人和鼠miR-24-3p核心序列，在DNA水平的相似性为100％；
miR-34a的核苷酸序列
人miR-34a编码序列：5’-tggcagtgtcttagctggttgt-3’(SEQ ID NO:18)
人miR-34a*编码序列：5’-caatcagcaagtatactgccct-3’(SEQ ID NO:19)
人miR-34a Per-miRNA全长
ggccagctgtgagtgtttctttggcagtgtcttagctggttgttgtgagcaatagtaaggaagcaatcagcaagtatactgccctagaagtgctgcacgttgtggggccc(SEQ ID NO:20)
人和鼠miR-34a核心序列，在DNA水平的相似性为100％；
miR-92b的核苷酸序列
人miR-92b编码序列：5’-agggacgggacgcggtgcagtg-3’(SEQ ID NO:21)
人miR-92b*编码序列：5’-tattgcactcgtcccggcctcc-3’(SEQ ID NO:22)
人miR-92b Per-miRNA全长
cgggccccgggcgggcgggagggacgggacgcggtgcagtgttgttttttcccccgccaatattgcactcgtcccggcctccggcccccccggccc(SEQ ID NO:23)
人和鼠miR-92b核心序列，在DNA水平的相似性为95.45％；
miR-96的核苷酸序列
人miR-96编码序列：5’-tttggcactagcacatttttgct-3’(SEQ ID NO:24)
人miR-96*编码序列：5’-aatcatgtgcagtgccaatatg-3’(SEQ ID NO:25)
人miR-96Per-miRNA全长
tggccgattttggcactagcacatttttgcttgtgtctctccgctctgagcaatcatgtgcagtgccaatatgggaaa(SEQ ID NO:26)
人和鼠miR-96核心序列，在DNA水平的相似性为100％；
miR-106的核苷酸序列
人miR-106编码序列：5’-aaaagtgcttacagtgcaggtag-3’(SEQ ID NO:27)
人miR-106*编码序列：5’-ctgcaatgtaagcacttcttac-3’(SEQ ID NO:28)
人miR-106Per-miRNA全长
ccttggccatgtaaaagtgcttacagtgcaggtagctttttgagatctactgcaatgtaagcacttcttacattaccatgg(SEQ ID NO:29)
人和鼠miR-106核心序列，在DNA水平的相似性为91.3％；
miR-128的核苷酸序列
人miR-128编码序列：5’-cggggccgtagcactgtctgaga-3’(SEQ ID NO:30)
人miR-128*编码序列：5’-tcacagtgaaccggtctcttt-3’(SEQ ID NO:31)
人miR-128Per-miRNA全长
tgagctgttggattcggggccgtagcactgtctgagaggtttacatttctcacagtgaaccggtctctttttcagctgcttc(SEQ ID NO:32)
人和鼠miR-128核心序列，在DNA水平的相似性为100％；
miR-134的核苷酸序列
人miR-134编码序列：5’-tgtgactggttgaccagagggg-3’(SEQ ID NO:33)
人miR-134*编码序列：5’-cctgtgggccacctagtcaccaa-3’(SEQ ID NO:34)
人miR-134Per-miRNA全长
cagggtgtgtgactggttgaccagaggggcatgcactgtgttcaccctgtgggccacctagtcaccaaccctc(SEQ ID NO:35)
人和鼠miR-134核心序列，在DNA水平的相似性为100％；
miR-135的核苷酸序列
人miR-135编码序列：5’-tatggctttttattcctatgtga-3’(SEQ ID NO:36)
人miR-135*编码序列：5’-tatagggattggagccgtggcg-3’(SEQ ID NO:37)
人miR-135Per-miRNA全长
aggcctcgctgttctctatggctttttattcctatgtgattctactgctcactcatatagggattggagccgtggcgcacggcggggaca(SEQ ID NO:38)
人和鼠miR-135核心序列，在DNA水平的相似性为100％；
miR-137的核苷酸序列
人miR-137编码序列：5’-acgggtattcttgggtggataat-3’(SEQ ID NO:39)
人miR-137*编码序列：5’-ttattgcttaagaatacgcgtag-3’(SEQ ID NO:40)
人miR-137Per-miRNA全长
ggtcctctgactctcttcggtgacgggtattcttgggtggataatacggattacgttgttattgcttaagaatacgcgtagtcgaggagagtaccagcggca(SEQ ID NO:41)
人和鼠miR-137核心序列，在DNA水平的相似性为100％；
miR-141的核苷酸序列
人miR-141编码序列：5’-catcttccagtacagtgttgga-3’(SEQ ID NO:42)
人miR-141*编码序列：5’-taacactgtctggtaaagatgg-3’(SEQ ID NO:43)
人miR-141Per-miRNA全长
cggccggccctgggtccatcttccagtacagtgttggatggtctaattgtgaagctcctaacactgtctggtaaagatggctcccgggtgggttc(SEQ ID NO:44)
人和鼠miR-141核心序列，在DNA水平的相似性为95.45％；
miR-143的核苷酸序列
人miR-143编码序列：5’-ggtgcagtgctgcatctctggt-3’(SEQ ID NO:45)
人miR-143*编码序列：5’-tgagatgaagcactgtagctc-3’(SEQ ID NO:46)
人miR-143Per-miRNA全长
gcgcagcgccctgtctcccagcctgaggtgcagtgctgcatctctggtcagttgggagtctgagatgaagcactgtagctcaggaagagagaagttgttctgcagc(SEQ ID NO:47)
人和鼠miR-143核心序列，在DNA水平的相似性为100％；
miR-184的核苷酸序列
人miR-184编码序列：5’-ccttatcacttttccagcccagc-3’(SEQ ID NO:48)
人miR-184*编码序列：5’-tggacggagaactgataagggt-3’(SEQ ID NO:49)
人miR-184Per-miRNA全长
ccagtcacgtccccttatcacttttccagcccagctttgtgactgtaagtgttggacggagaactgataagggtaggtgattga(SEQ ID NO:50)
人和鼠miR-184核心序列，在DNA水平的相似性为95.45％；
miR-200的核苷酸序列
人miR-200编码序列
miR-200a:5’-catcttaccggacagtgctgga-3’(SEQ ID NO:51)
miR-200b:5’-catcttactgggcagcattgga-3’(SEQ ID NO:52)
miR-200c:5’-cgtcttacccagcagtgtttgg-3’(SEQ ID NO:53)
人miR-200编码序列
miR-200a:5’-taacactgtctggtaacgatgt-3’(SEQ ID NO:54)
miR-200b:5’-taatactgcctggtaatgatga-3’(SEQ ID NO:55)
miR-200c:5’-taatactgccgggtaatgatgga-3’(SEQ ID NO:56)
人miR-200Per-miRNA全长
miR-200a:
ccgggcccctgtgagcatcttaccggacagtgctggatttcccagcttgactctaacactgtctggtaacgatgttcaaaggtgacccgc(SEQ ID NO:57)
miR-200b:
ccagctcgggcagccgtggccatcttactgggcagcattggatggagtcaggtctctaatactgcctggtaatgatgacggcggagccctgcacg(SEQ ID NO:58)
miR-200c:
ccctcgtcttacccagcagtgtttgggtgcggttgggagtctctaatactgccgggtaatgatggagg(SEQ ID NO:59)
人和鼠miR-200a/b/c核心序列，在DNA水平的相似性为100％；
miR-218的核苷酸序列
人miR-218-1编码序列：5’-ttgtgcttgatctaaccatgt-3’(SEQ ID NO:60)
人miR-218-1*编码序列：5’-atggttccgtcaagcaccatgg-3’(SEQ ID NO:61)
人miR-218-2*编码序列：5’-catggttctgtcaagcaccgcg-3’(SEQ ID NO:62)
人miR-218Per-miRNA全长
miR-218-1:
gtgataatgtagcgagattttctgttgtgcttgatctaaccatgtggttgcgaggtatgagtaaaacatggttccgtcaagcaccatggaacgtcacgcagctttctaca(SEQ ID NO:63)
miR-218-2:
gaccagtcgctgcggggctttcctttgtgcttgatctaaccatgtggtggaacgatggaaacggaacatggttctgtcaagcaccgcggaaagcaccgtgctctcctgca(SEQ ID NO:64)
人和鼠miR-218-1/2核心序列，在DNA水平的相似性为100％；
miR-219的核苷酸序列
人miR-219-1编码序列：5’-tgattgtccaaacgcaattct-3’(SEQ ID NO:65)
人miR-219-1*编码序列：5’-agagttgagtctggacgtcccg-3’(SEQ ID NO:66)
人miR-219-2编码序列：5’-tgattgtccaaacgcaattct-3’(SEQ ID NO:67)
人miR-219-2*编码序列：5’-agaattgtggctggacatctgt-3’(SEQ ID NO:68)
人miR-219Per-miRNA全长
miR-219-1:
ccgccccgggccgcggctcctgattgtccaaacgcaattctcgagtctatggctccggccgagagttgagtctggacgtcccgagccgccgcccccaaacctcgagcggg(SEQ ID NO:69)
miR-219-2:
actcaggggcttcgccactgattgtccaaacgcaattcttgtacgagtctgcggccaaccgagaattgtggctggacatctgtggctgagctccggg(SEQ ID NO:70)
人和鼠miR-219-1/2核心序列，在DNA水平的相似性为100％；
miR-429的核苷酸序列
人miR-429编码序列：5’-gtcttaccagacatggttaga-3’(SEQ ID NO:71)
人miR-429*编码序列：5’-taatactgtctggtaaaaccgt-3’(SEQ ID NO:72)
人miR-429Per-miRNA全长
cgccggccgatgggcgtcttaccagacatggttagacctggccctctgtctaatactgtctggtaaaaccgtccatccgctgc(SEQ ID NO:73)
人和鼠miR-429核心序列，在DNA水平的相似性为100％；
miR-430的核苷酸序列
人miR-430编码序列：5’-acttaaacgtggatgtacttgct-3’(SEQ ID NO:74)
人miR-430*编码序列：5’-taagtgcttccatgttttggtga-3’(SEQ ID NO:75)
人miR-430Per-miRNA全长
ccaccacttaaacgtggatgtacttgctttgaaactaaagaagtaagtgcttccatgttttggtgatgg(SEQ ID NO:76)
miR-7a的核苷酸序列
人miR-7a编码序列：5’-tggaagactagtgattttgttgtt-3’(SEQ ID NO:77)
人miR-7a*编码序列：5’-caacaaatcacagtctgccata-3’(SEQ ID NO:78)
人miR-7a Per-miRNA全长
ttggatgttggcctagttctgtgtggaagactagtgattttgttgtttttagataactaaatcgacaacaaatcacagtctgccatatggcacaggccatgcctctacag(SEQ ID NO:79)
3.人和鼠miR-7a核心序列，在DNA水平的相似性为100％；
miR-15的核苷酸序列
人miR-15-1编码序列：5’-tagcagcacataatggtttgtg-3’(SEQ ID NO:80)
人miR-15-1*编码序列：5’-caggccatattgtgctgcctca-3’(SEQ ID NO:81)
人miR-15-2编码序列：5’-tagcagcacatcatggtttaca-3’(SEQ ID NO:82)
人miR-15-2*编码序列：5’-cgaatcattatttgctgctcta-3’(SEQ ID NO:83)
人miR-15Per-miRNA全长
miR-15-1:ccttggagtaaagtagcagcacataatggtttgtggattttgaaaaggtgcaggccatattgtgctgcctcaaaaatacaagg(SEQ ID NO:84)
miR-15-2:
ttgaggccttaaagtactgtagcagcacatcatggtttacatgctacagtcaagatgcgaatcattatttgctgctctagaaatttaaggaaattcat(SEQ ID NO:85)
人和鼠miR-15核心序列，在DNA水平的相似性为100％；
miR-23的核苷酸序列
人miR-23编码序列：5’-ggggttcctggggatgggattt-3’(SEQ ID NO:86)
人miR-23*编码序列：5’-atcacattgccagggatttcc-3’(SEQ ID NO:87)
人miR-23Per-miRNA全长
ggccggctggggttcctggggatgggatttgcttcctgtcacaaatcacattgccagggatttccaaccgacc(SEQ ID NO:88)
人和鼠miR-23核心序列，在DNA水平的相似性为100％；
miR-25的核苷酸序列
人miR-25编码序列：5’-aggcggagacttgggcaattg-3’(SEQ ID NO:89)
人miR-25*编码序列：5’-cattgcacttgtctcggtctga-3’(SEQ ID NO:90)
人miR-25Per-miRNA全长
ggccagtgttgagaggcggagacttgggcaattgctggacgctgccctgggcattgcacttgtctcggtctgacagtgccggcc(SEQ ID NO:91)
人和鼠miR-25核心序列，在DNA水平的相似性为100％；
miR-29a的核苷酸序列
人miR-29a编码序列：5’-actgatttcttttggtgttcag-3’(SEQ ID NO:92)
人miR-29a*编码序列：5’-tagcaccatctgaaatcggtta-3’(SEQ ID NO:93)
人miR-29a Per-miRNA全长
atgactgatttcttttggtgttcagagtcaatataattttctagcaccatctgaaatcggttat(SEQID NO:94)
人和鼠miR-29a核心序列，在DNA水平的相似性为100％；
miR-129的核苷酸序列
人miR-129-1编码序列：5’-ctttttgcggtctgggcttgc-3’(SEQ ID NO:95)
人miR-129-1*编码序列：5’-aagcccttaccccaaaaagtat-3’(SEQ ID NO:96)
人miR-129-2编码序列：5’-ctttttgcggtctgggcttgc-3’(SEQ ID NO:97)
人miR-129-2*编码序列：5’-aagcccttaccccaaaaagcat-3’(SEQ ID NO:98)
人miR-129Per-miRNA全长
miR-129-1:
ggatctttttgcggtctgggcttgctgttcctctcaacagtagtcaggaagcccttaccccaaaaagtatct(SEQ ID NO:99)
miR-129-2:
tgcccttcgcgaatctttttgcggtctgggcttgctgtacataactcaatagccggaagcccttaccccaaaaagcatttgcggagggcg(SEQ ID NO:100)
人和鼠miR-129-1/2核心序列，在DNA水平的相似性为100％；
miR-137的核苷酸序列
人miR-137编码序列：5’-acgggtattcttgggtggataat-3’(SEQ ID NO:101)
人miR-137*编码序列：5’-ttattgcttaagaatacgcgtag-3’(SEQ ID NO:102)
人miR-137Per-miRNA全长
ggtcctctgactctcttcggtgacgggtattcttgggtggataatacggattacgttgttattgcttaagaatacgcgtagtcgaggagagtaccagcggca(SEQ ID NO:103)
人和鼠miR-137核心序列，在DNA水平的相似性为100％；
miR-138的核苷酸序列
人miR-138-1编码序列：5’-agctggtgttgtgaatcaggccg-3’(SEQ ID NO:104)
人miR-138-1*编码序列：5’-gctacttcacaacaccagggcc-3’(SEQ ID NO:105)
人miR-138-2编码序列：5’-agctggtgttgtgaatcaggccg-3’(SEQ ID NO:106)
人miR-138-2*编码序列：5’-gctatttcacgacaccagggtt-3’(SEQ ID NO:107)
人miR-138Per-miRNA全长
miR-138-1:
ccctggcatggtgtggtggggcagctggtgttgtgaatcaggccgttgccaatcagagaacggctacttcacaacaccagggccacaccacactacagg(SEQ ID NO:108)
miR-138-2:
cgttgctgcagctggtgttgtgaatcaggccgacgagcagcgcatcctcttacccggctatttcacgacaccagggttgcatca(SEQ ID NO:109)
人和鼠miR-138-1/2核心序列，在DNA水平的相似性为100％；
miR-155的核苷酸序列
人miR-155编码序列：5’-ttaatgctaatcgtgataggggtt-3’(SEQ ID NO:110)
人miR-155*编码序列：5’-ctcctacatattagcattaaca-3’(SEQ ID NO:111)
人miR-155Per-miRNA全长
ctgttaatgctaatcgtgataggggtttttgcctccaactgactcctacatattagcattaacag(SEQID NO:112)
人和鼠miR-155核心序列，在DNA水平的相似性为95.8％；
miR-195的核苷酸序列
人miR-195编码序列：5’-tagcagcacagaaatattggc-3’(SEQ ID NO:113)
人miR-195*编码序列：5’-ccaatattggctgtgctgctcc-3’(SEQ ID NO:114)
人miR-195Per-miRNA全长
agcttccctggctctagcagcacagaaatattggcacagggaagcgagtctgccaatattggctgtgctgctccaggcagggtggtg(SEQ ID NO:115)
人和鼠miR-195核心序列，在DNA水平的相似性为100％；
miR-214的核苷酸序列
人miR-214编码序列：5’-tgcctgtctacacttgctgtgc-3’(SEQ ID NO:116)
人miR-214*编码序列：5’-acagcaggcacagacaggcagt-3’(SEQ ID NO:117)
人miR-214Per-miRNA全长
ggcctggctggacagagttgtcatgtgtctgcctgtctacacttgctgtgcagaacatccgctcacctgtacagcaggcacagacaggcagtcacatgacaacccagcct(SEQ ID NO:118)
人和鼠miR-214核心序列，在DNA水平的相似性为100％；
miR-222的核苷酸序列
人miR-222编码序列：5’-ctcagtagccagtgtagatcct-3’(SEQ ID NO:119)
人miR-222*编码序列：5’-agctacatctggctactgggt-3’(SEQ ID NO:120)
人miR-222Per-miRNA全长
gctgctggaaggtgtaggtaccctcaatggctcagtagccagtgtagatcctgtctttcgtaatcagcagctacatctggctactgggtctctgatggcatcttctagct(SEQ ID NO:121)
人和鼠miR-222核心序列，在DNA水平的相似性为100％；
miR-223的核苷酸序列
人miR-223编码序列：5’-cgtgtatttgacaagctgagtt-3’(SEQ ID NO:122)
人miR-223*编码序列：5’-tgtcagtttgtcaaatacccca-3’(SEQ ID NO:123)
人miR-223Per-miRNA全长
cctggcctcctgcagtgccacgctccgtgtatttgacaagctgagttggacactccatgtggtagagtgtcagtttgtcaaataccccaagtgcggcacatgcttaccag(SEQ ID NO:124)
人和鼠miR-223核心序列，在DNA水平的相似性为100％；
miR-132的核苷酸序列
人miR-132编码序列：5’-accgtggctttcgattgttact-3’(SEQ ID NO:125)
人miR-132*编码序列：5’-taacagtctacagccatggtcg-3’(SEQ ID NO:126)
人miR-132Per-miRNA全长
ccgcccccgcgtctccagggcaaccgtggctttcgattgttactgtgggaactggaggtaacagtctacagccatggtcgccccgcagcacgcccacgcgc(SEQ ID NO:127)
人和鼠miR-132核心序列，在DNA水平的相似性为100％；
miR-133的核苷酸序列
人miR-133编码序列：5’-agctggtaaaatggaaccaaat-3’(SEQ ID NO:128)
人miR-133*编码序列：5’-tttggtccccttcaaccagctg-3’(SEQ ID NO:129)
人miR-133Per-miRNA全长
acaatgctttgctagagctggtaaaatggaaccaaatcgcctcttcaatggatttggtccccttcaaccagctgtagctatgcattga(SEQ ID NO:130)
人和鼠miR-133核心序列，在DNA水平的相似性为100％。
lncRNA的序列信息
Human-Pnky
aggcgccaggggcccggttggcgcgaacgccgggttccgagcaccctgggcttccttgtctgcctcccagcgcggcacctcttcggggctcccgaaacctgagctctcgctggttttaggtccagactggggcctctccaccggttcctcccccgccccgggctctggggcccattctttgggctgaccctgtcagggcagagtccgcgcgtctgcctgccattctccgcccgcataaaagcacgttgaaggtgtctcgggcagacacctccaggttttgaatcagtttattccctttcactgttcaaagcagctgttcaaatacacaggctgcttacgttgacgtggagaggatttcaaacaacgctaaaatgctttgaactgacaaggtgtcttgatatctccctcactccatccagcacagctcctcgagatcactcgctaggacaatggctgagcaggcgattcgtgcgggcctcgccacctcggggcgcggactgcggggtgtcctaagccccttccgcaaggacaggatggaggcacctgtaaggagatgctggcgccaccccagcttctcccaggtccggaggaacctctactcagtcaataccctgagctggacttgtctgaagaaacggagccgactccctcttgccggggtgcgctgagtggaggggaaacatcctcgaataacagaactacaccaaaaagacacccatgttatctctcacactttcacactcctcgagatagtgagccggacctgggtcttagtagcacccagtaccttgacacaaacctcccaaatttccacctgagtaacagttatggggtcagtccatgcactgtaacttgaactctaatttattaactatttcatctagtaaacacactcacaccatatataaaatagcatttatttatttctatataccaggagttggcagaaaacccaccgtgaccactcccatacattgagctggaggcacacaattactaaaacagaggtgaaatggtattcatttgatcttaattttttcttatttatgtagtcccaggataatagaaatcaggaaacaaaagaaaacaaagaattttctgaggagatggccattgggggagtggaggtagcagctggtttaaacctaagtaaaactagaaaaagaaactgctgtttcctttttcttatatccaccttagaggatcatgtttgaacgtccctactcctcctcctctttttaaaaagccttgtctcagtcattcattcctgtgcttcctgctcttctgctagaccccagcagctgtttgatttggtgaggcccccctccaacctctgagtggaacttcttttctaagggcctgcagaatgtcaaaactgaggctctggcttcggagctagagctttgaacagccaatccacacaaaaaggcagctggctgctttaatgaaaactgctataaagcttcaagaactttagccttgggggatgcatttataaggaacatggaaaatgcatttccaagttgctggttcttgggagagacataataaacatttacc(SEQ ID NO:131)
Human-Paupar
aaaggtaccggaataaaaatttgactaaagtttgggataaattaatcggtggcttgaagaacagtagcacatttctgattatgtaggctccagccaggatttaag
ttttgtgtcatgattgttttcatatttctttgacatctattgatttggaggcagctgcaagcctttgtcacaggagagaagagcagtcacaatatattagcttgatggcataactcgaaccggagaagcgaggggagcctgagtgactggggcgcacatgacccccctcctggggcctttgggctcaacccttacttttaacttgttctaacaggaataatggagtagtactactaatgcatggtcagaaggggcttttctgtctagaacgcaggcggcgggagttgcaccgccacagcccgggagaccaaagagtctccactccccgctcccggcgcctcctcgccgaccggagccccgagcccagtgagcccagccggtcccacgtcgagaggcgctgggttgggagaagttctgctggtcgtgggctcggcccccaggcgccaggccgagtgcccacctcggcttctttagggggcctacagcgggcagccgagcggctggcggacccggagcttgggaggcgaccgccaggctggtgcccggcctgacccggcgttcgcggccgcccgctcgcccgccgcgggccgggagcgtacaggagtgtgacgcagattgtgaaaacagaagggagggagttgggtcatttccttcgctaatcatcgccccctcctgctcctcctccccacccccatcccatcctcgccgccacccagcctcgaactctcttccttgccagagtctgcctcactttgagccagtggctgcactttatggagaaaatatatgtgcccatcactcacccatctatttgcagcgtccatggagcgcctcggggaacacgcatggacaattaaacacacccacttacggcgggatgatgaggctttctgttaaccacatgtgttcagaaatggatacagccctaattttgacacggaatgcagctaatgcaccttgctatagatgtacgtccgttggaaaagtgtgtgatgggcacctgatctacaccaagagaacagggctgtctgcagaagacccagcggcctgacaccttttcttgttgccggggaaggaaagtttttcttttgatttgtcctctcacgatttttcccttttcctttgcattacagtttcagagaggaatgtaaatattttgactagacctctgcaggggccttttaaacaccaggcacaatcatctgtggaatactgtagttcatactttcaaaacttgggtgttaaagagtctgtcttgctgaggaaacccatagaactagtggcgacctttcaactccctatttgtgtgatgaaatgaagtatgccctagtgattgtcgaattttaaggacttgttctgtcactgctactttccgatcgtttgcagggaagaaaaatcaatcaaacagacctttgatggggttgtggcaaggtcacatttcactgtgctccaggcttacctcttcttaacgcccctccctgctgtggagcgtgtgcaggtagtatgcaaaactctagaaataatatttgaaaaaattaacaccttgtttatctcttctgtgtatttgatataggggtttctttcttttcctgttttggtgtttaatacaaggctgatatattggaacagaatgcagacttcaaagaaactaaaattaggaggcaaatagcgtcaaggtttcctcggtttctgtatgtagtacaaatagtatagcgtcttttcatccaaaaagaagcaaaaattgccaggaggcataaagcatctctgaatatccgttttttttaaagaaacaaacatttcccaaatattgatgtacgcatggttttatagtctgaaaatatttctaggcacaaatatggcatacaaacattcgtttcaactctgtcgttgttgttaaaatgacagtaaattatagtttattttaagatacctccctgttaatgtcagttgaggttattttagggcctggatgctctaggaagaccacctaaaatgtgtttatttctctgcccaattcacctatagtgtaaggagcattttattttattttattttattttattttattttattatactttaagttttagggtacatgtgcacaatgtgcaggtttgttacatgtgtatacttgtgccatgttggtgtgatgcacccattaactcgtcatttagcattaggtatatctcctaatgctatccctcccctccccccatcccacaacagtccccagagtgtcatgtaaggagcattttaaataaaatattttgggcatccttaagtccttttttaaaaatccaacattctacaattgtgacaaataggctgaaaaattttgttttgtttataccaaattcattttaataaagcatttgctgagattttaatacaacaaatgccaacaaaatgcatcagagtagaaaaaagaaaatattttcagaattgcctataatattgcttgtgatcctaaattttttgatgcaaggaacttgaatttttcagctaatattattctgttttcttattctgtgtttctattagaacactcacctatgctctgcttcccttgctgtcttcccatagcttatgtgtgcactatgaatttcaataaatataaattactgcttaaaagaaaaaaaaaaaaaaaaaa(SEQID NO:132)
human-HOTAIRM1
aaaagtttgccggcttccgcagtgatggatcaccgttttagtggcatttaaatccccggcgctccgccgtctaggtgacgcgcagtcgcccccccaggcagcctaggcggcggcagctgctgcggcgactgcaaaggccgatttggagtgctggagcgaagaagagcaaaagctgcgttctgcgcgcgcccgactccgctgcccgccccgccaggcctccgggaggtgggggctgggaggcgtcccccgctcccgccccctccccaccgttcaatgaaagatgaactggcgagaggacgaatcgcatccaggagctgcgcagccctggccgctgccgggacgccctgctccgcgctgagcttggggccagaaaccagccatagtccccacactccgccgccgcagctgagatttagcggaggaaggggcgagggaaggtagggagcaaacctatgaagaaacatcgcgttgtcattggaacttccaagcctttgctgttaagagccaggttcttaaatcaacccgccccacacacatgttgcttacatgctgcgttttctcacggtctgttttgcctgaacccatcaacagctgggagattaatcaaccacactgaaaatgtggagggatttatgggggagggggttgaaatgtgggtgtttgaaacaaaagtgtataaacaaatgaattgttgataacttagttattgacctggagactggtagcttattaaagaaactccgtgttactcattcctggagttgggggtttctgtaggcactttatttctccactttcaagagcttgggcttggcccaaatcttagactgtccaattctgcctctattaccaatttaaatctatggcttgaacctgtgcactgaaaatcaaatcctttaaaaagaaagaggagaagaagaagcaaaaaagaaagaaaaaacacttattagaagccctagtcattttttggctttctgttttgttgctgtccattgaagactttgaacatgccgccttaataaatgtattaaaattgaaaaaagaaaaaaaaa(SEQID NO:133)
human-TUG1
gagcgacgcagccgggacggtagctgcggtgcggaccggaggagccatcttgtctcgtcgccggggagtcaggcccctaaatcgaagaagccctggcgcgccctccccccctcccgggtctgatagcagactccttgaaagcagggtccttgtttagtgcatctttgcccacatacaccacaacatatcaagatgcatttattaggaaggaggagtttagagagcaggctatcagaataaccactcatcctgtgcctcctgattgctgagtgttcacctggaccttctgactaccttccctgtgctattccatcagcctacagacctggtacctggatttttgcccgagatgattcctaccaccttactactgacgaagacacccattccagtggaccactgtgacccaggaggcattcagccatcatgatgtggcctttacctccactcctgtcttgttctacccagattcagcacagccctttatagtgaagtcagagtcctcaagccaaatagctaaagctgttttatcacaacaaaggcctagtttgttccatgagtgtgcatttcatttcttcagttaaagccttcagagacacacaataaatttggaccaggggattttttagttattaatgctctctgaagaaaggcaacatctttttgagagcagcattggaccacaccccacaatctcaaatgattgaaattcatgaacatctaggatcccgtgaaggtcactggaccctgttttttctacttcaaatcctgtagtagcctactgaatgagaaaacatattctgacccattgggatcaaatcaaaggcacagtgaactcctcatagcatcttctttggaattactcaggaaccagaactttttacacaaatgtaagaaattctaccaaggagtccccttacctaacagcatctcacaaggctgcaccagattccagaaaaggcttctcttgatacatcaagcattttgtgaccgacttattcttagatcattggttttccaaaggctttgtggccatgaagccctttgagtgaaaactgtgcagaagcccagagtaaaagtgaagctgctctggatgaagtagtgaagcaagagtaggggcctgaatcctgctacaactatcttcctttaccaccgtggtgacacctaaggggacttccttacaacaccttgaactcttccgaacacagtttgaaaaccactgccccagacagcaatatgtttgacctgaatggcattccaatcttttctgtacctccactcagcacagttcatgttcagtagatgctgaacattcttagaaatactgtgtgtgaacttagaaaagtgcaagaagacaggcatgtctttgaccccaggaatgatcatttgctgaagatggtgtcaagtgaacctagattaacagccctccactccagatggatatccagtgattcctagaatgggatatagccagagaacaattctatgcaccctacactgacagactcccttaagcaacaccagatgctctactggtacttgaagtacatgactttgaagtcttgaccctccatgaatacctgaattatcagcaagcgggttttgaagctggtgcctcattgaggccatattagagcaacttgtacatttgacctcttgttatcagccatggtactctacttcgtgtgcaagagataactatgaaagccaaattcaaatactggcaacatttcctaaaggggctcaatatctatcattcgtcttcttttccaaactacacatcactgtatgactcaaccagtagcagttatattgccccttggtttttattcagtttaactactgtttccaagataaatgagctaataagctttaaaaaaaaaaaaaaaaaaggctgaattcttttttcttcatcactggcatatctgcctattctccagaattattatgactattcagctcactttaacagttgaacttcaagcgacaatctttgaacaccccttctcatgtgatttaaaatgaaaccatttggaaaagtttcttctagccagtaatagattttttttttaattgctctgccttgtgccgagagatgttcttttaagatgaatcttttgatgtctgataccaccaaatataggtggtagggagagttggaggctggccctttgagcaggccattagcttacttgctgggcatttccgatagcttattgcctacctttttgctggaaacaaactgatttgaaaaacaaaatctatgaagactgcagctaaggattttatcggtagacttaagagcttttgtccttgtggatattttagtggaaccacatcagtctcaatactgtcattttacactgactcagagcagctgacttcattccttgccatgatatatatttaaggcaggcattgtaacagacataaagacaacttatctgtttcagcaggaaggattcagtttatgaactctcagaccagatcatgttgaacaaggagactttgatgtgtgtcatgagaaaactcattctttacttcccagtcaatttaaaggccagctatcctgagctactcgaatgaatgcactggttaaacattggaaatagtttgtttatatccttgtctctctctaggccaattgtgattacatgactcgactctacatctcgtcaaacaaggcctaggtctggttgctgtagactgctcgccctcaacaaataaaatctggttgactagcctccttgtatatacaactattatttgttaagaagaaattatcgtcaattttctactaccttccaattgtcagctctttttttcctctctggtttttcctatactttacagaaaaagacattgatctatactgccattccctctaatcctgccatactcagtcaaaaggaatgacttaagatgaagatgatcatctgctcgagtctaaaatatacattgtatataagaattggtgattagaaaagcaaaaaacctaaaacttaaatctaggagtctgtatactgtctccatgtctccatgcctcagatctcatctaaatctttgaacagcaccattcaaccaatctgaggccttgacttgcttgtaagatgattctcagagatcggctgagttaaaaaagatgacgacttgattaccaaagaaagtagggccaactttgacaaatctggctctgctgaccctgtcactcccagatgtagcatagactcctaaacagaacctcaagtctgattgaggataaggccttctcctgagctgaaagttctttggcagatgagcaagaaactgaaagctgatgtacctgactggctctgtaagatcagaaaactgtatccagaataagccctatggattaacccctgagtacccagagtaaaaactaatttacagaacttccttattgatctgctggttcttccagatcatattctggctattggtatggctggcctttctgaaggtaccctgcttgtctattttcctgactcagctcttgcctgcctttttcacatgttgctgcaattagactcaccgtgaggactacagtcaatttcagtctatcttgtgcccaatacaacaaggatttttaatagtaacaacccacacctcacccactaggactcaatgttcacaacaggaaggaccattgctgcatactccttgaccagcaacttttttgaagatatttttaagtgcagagtaggcctctattcctgtatgtaattgttcattttcagcacctggaacctcatctatcgggtctggaaggaatacagcagttcgaaagccgcgtccatttctctccttcagtagtgcagaaatgagtccgattcaccagtacacacagaactgtaccagttcaacctagcaaaagaagaaaagtttccactgtacttaaaatttacagctgactcaaattgcctcacagaattatttgatgtagaaggctagttgtcttacttcagatcagcaggacagttgggctctcagactcatgaccactgagtttgcttgtgttgaaactgtggtttcatccaacatatgctattggacatgattattattccattcaaatggattacagacttcttgaggacaggacaaacttatctctcatggtgtttttttagaatacttttataaccaaggaagaaaccatgccagctgttaccattcaacttcttaagcagagattaagctttttcatatctgttcttatcctggacatcagtagtttttaattgcccagcatccgttccatcttgtaacaactccctgatgtttcttaaaaccacctcttcctattttcagtctgtggtttggacagtctgacccaaccttgagctttgtgggtgaacatgtaattcagacctcatcaatcagcaaatccatctgaactgtggaggagaagctctctttactgagggtgctttagctttgtaggatgaaaacctcaaactaacagggcctaccatgtagagaatgaagccagtgcaggggaaagcagagccaaaatatggagagacttgaatcctgatgacagcgtttgtgcccctggatccaaccgtgcctgaagctagaatatcccctggacttttcagttatgtgaaccaataaatacccttttttgcttaagttactttgagttgggtttctgttacttgaaattgaatccacactaatatatctaccaacattgagacttgacagatccaagtatttattaagctagaggtcatggtcactgaaattactttccaaagtggaagacaaaatgaaacaggaactgagggaatatttaagatcccacagaagcgtaaaaatgacatggtagaaagtaatagaaaacctaaatgtctgtcattaaaggataggttaaggtgtggttcagccatataggaatatctcgtatctgttaaaatgaataaagtacattcattgtgtatggaaaaatggccatgatacattaggtgaaacaagttattaatagaaaagtgtacagtgtgaactcattttaaaatgtgtgtgcttatgtttataaatgcatagaaaggtctattcacagctttctttgaacagtgtagatcacatgaaactttcaactttatacatttctgtattaatattttacactacccacattatttttaaactttattttaaataaagaatttttaaaattaaa(SEQ ID NO:134)
Human-RMST
atttcatttgtgattcggatgatgcagctctaggtggattgactatgaaaggcgctgaatatcttcaggaaaatgggttccatgagaagtgacatcctcctcgaatcaaaagattctcaggatgatggagtgagtgatggaataggttgccaactgtagttactccactcagcacagaatggctgcggggaaatataatcagacatgcccaaagaagtctgcttagggtgaaacaaatacctttgaggtttaaatcaggaaggagagactgtttctacaggtgtcatacaaaaatcaatactgagccaaggattattggatcccatagaaccacggagacttggtagtgaaattcttccaaagcattccatccgtgcaggcagatggtgttcctaggtttggaaatataaatcccatgggaagtcagctgaagaccattttatgcatcactcatcctgttagagccctgtgctgttctgtctctctataagactggctgaaaccaccacggttgtttacaatttatgctctaactttggatcacctagttaatactctaactccgattattaccaaagacaatgttctataaaagatattgtctattagaaggatgcttctgcattattaataaaatcacagggaaaatgcaacattttggatgtcacatctgataagttggcagttaaagaacagaaacagcaataagactgcgtggctacattttcccagtgccaccaactgggatttaagctgactaacattttgaaagcccagcccatttcattcacagcaggatggcagtgggtgactgatcgtacccgccagctggctaatgtcataattaacaaagttgctactacatctgcaaagtttaatcgaaaaatttgccagtgatatgatggccttgtcacagagatcacaagggacacggagttgacttttgctcaaggtggaacgacagagctgtgtaggcaagatgagaaattgcgaacttgttcggccaaaggattatctcctgagatgtgtagaaatgaactcttgtcagagtttcaaaggaattaacgttttttggtaaaatgtgctaatgtaaagagtgagaagattagtgatacataatgaaagcaatgcattctttcacatggaaatgggaatataataaatgtcctgcaggtgattggggctgtagcaattttattgaagattaaagtttgattgacctttgttagggtgattaacccttctgaaattaaaagccagagctgaattattctgctcaatttaaatgcaaacatcgagcaggtcgtatgtcattcaaataataataagaagaaaatcttcctattttaattttcatttttgcacttctgagtggtatgctgctttagaaggaccatagctctcgcaaaagcattctggtggcagagaatatacaataacgttacagataattgggagcatataggaagagtcccaagcactactgcctgcattcgaaacatcaaaaccaccatcccaacaaaagcacggagcatgaagccaatctctgtacactgaaaatgcatgctcccaatagaaaaacaacctagggatgtcctgaaggggttaggaataaataacaatgacatctctattctagttcagtgccaaccaccgaaattgcatatcatatccatgttaaatctacatgatgtctcctggaaatgcgtgctttttggtacagttgcttatgaagcagtttctaaaagttgattatttctgatgtctggaatttcattctccatgatctctggcagtttctgaatatattcagtattttcattaagttcaaaaatgctgtaggagaagctaacgaattatttgcaatgccatttaatggtttagttttatttttctctgttaaattttctaagccttggtgaaaagttgtgtattcacatttcttcaaaaaactgtttccatttttcatatcatgttaattttgtttagttctaagtcagtgaatatttttagtcttaggtcccaccacatagtgaatgtgtctgccttttatgtatctgtgaactattaaaatgataataaaggttctcttccttccat(SEQ ID NO:135)
Mouse-RMST
aggtacctatattctgcacgggcttctgggcaggcagcactaacactcaggagaaggtctgcctctgtctgcgccttcctggttcaatgcaggcagatgagtgtcacagatgtaactgaggcactgaataatcaacatatcggagccaattcccaggacggcaagagggggaaccggcagagatgactgaccctggaggacaagagcattcttctgacaagttttagcatggactatcctcaggaaaatgagatccaggaagagtgacgccctcctcgaactgaaagatactcaggttgatggagtcagggacgaagtggcttatcaacaacacaggatgtctgcagggaacagaacttattcagacatggcccagattgtctgcccgtggggactgagggacctctgagggttacatcaggaaggaaggagaggctgtttctacaggtgccacagaaaaatcgatgctgagcctcggattattggatcccatagaaccgtggagacttggcagtgaaattcttccaaaggcaggcagaggttttcctggtttgggaagtataaatcccgtgggaagtcaactggaggacattttacgcgtcactcatcctattatgagcctgctgctcctccgtctcttgacaaggccaccaactagaagggcacagaattgttcataaaacagctgaatgtgaatgtctttggattcccatttaatgagggtgtcttaatgagatgactgaagagtacaaccgccaaggctgagatgatgcaaaggctacgtgtgggtacagttcccggtgcctgtgcacaccattcattggcagctaaaggacaggagcagcaataaggcttcctggctacattttcatggtgccaccaactgcgagttaagctgacaaacattttgagagctcggcccatttcattcccagcaggatggcaggagttaactaaaacagaataaactaaaaattgtgccttcattgcacatttgcactgattatcagcactgaaaatggctaagttctgcttatcaagagcgggtgactgattgtccctgccagctggctaatatcataattagcaaagttgctaccacatctgcaaagtttaatcgaaaaatttaccagtggtatgatggcattgtcaccgcgatcctgagggaatcagagtcgacttctgcttcaactggaatggcaaggctgtagagctgagatgagaaactgtaaacttgctcagccaaaggttatgcttcacatcacccaccagggaggatcatctctcatgaaaactttcaaatttgattttgaaaatttattcagaaaaatttaagccacgctctttcccaacacaggaaataatatgctccagagaatcctctaattcaccgaaaatggacttggataacatttgggttctcatactaccacagtcctcttgagaaggacagccaggcttgggtggcagtggtgaggaaggttcctttctgtcaagggagctgatgccttaaagaagctatctccagataaagggagatctaaggaaggaagccaacgaaagacaccatgtaccagaaagccaagcaggattttgacatttataaccataatctctataaacaagatgaattatggctggggattcagttagtaaatcaacgaaaataaatcctggtaaggtaatgatacaattttatcattttttgttgaaatctaacagtgtatagtatgctttgctgcaatcaaagacctgcagtattttgtgtgctaaactccaatgacccatcatttattttctctttattccacctacttacctgtgataataaccaaatagcctcacatttcccctttcaaagttgtatctcaagaggaaagctcactgaccccacacattagccctccagtagctccagctgagaagtactctctcctccatttttttcagtgcataattcaaagataacccaaataagaacagaaagttgtgtgtcatagtcactggcatctatccggtgcttctgaaccatgaaccacatgacctgattaaagaggttgctgtgagtgtgttgtactcttcgtgaactaaattccatgatgacagaaaacaaacctgaaaacaagagttatttcacaactctagagctccacagagtcggctgcaattggttgagttgaggtgaattttcagtggacctggatcagtgtagaagggcaggaacattggcccagcacagccccaggctgtgcagcattcaatgtgacttgggactggccttcctggctctgccttgccggtgaaacatggattggaagctttgaatgttggaagaaataaacaagtcttggttggagtcccagtttcaataaccacatattttcaaacctagacaaatattctggtctcatctcctcatttggattacttcaatcctcggagagaacggaataggactctgtatttctttggatgttcaacacagtgtttaactaatgggtgctatttgaaatattatcgtctattatcattgctattctaataaggatgatacttgctataaatattattgagaaaaaaaacttggaagtgttcttgagcaacataaacagtacaaaatgacagatattaaacaccgttcttttttgcacgtaaaactatacaaataaaaatatagaaaagcttgc(SEQ ID NO:136)
human-tuna
gtgctgctggcgcccggcccccgcggggtgcagctctgcgcgttctcatgctgtctctctctctttccctccgcgctgcctctccgaggtcctcccgccgagccccggcgcggggcatgaggagcccccgggtgccgcccagagaccagcaggctgcgcgcacacctagccagcggcagacggggacatgagcagcgcgcacggggtcccgcgcccggcggccagccctatccggcggcggccagcgggtcaacgctgcccgggagaatgaggcaggagccggcggcagcctcctttttttccttctcctcgccttcctgcggctccggcgctccgggtccgggccgggctgcggctctgctgcgtgccccgcgcgcccctcaaccgcctccggatgcgcttctcgatctcagcccgctgtcgccttctctctgaccctggtcccttccactgcaggctgttgctccggtgtctctgggctgctccaccacgtggtgcctgcccatcatggcatccaccaccaggtggcctttttcttggttagcctggcaaggaagataaagacatttgcaaccaagatggtaatcactagtgaaaatgatgaagacagaggaggtcaagaaaaagaaagtaaagaggagagtgtcttggcaatgctggggattatcgggaccattctgaacctgattgtgatcatatttgtctacatatacaccaccctgtgaatggcccagagcgtcctcagaggcctcagaatggccaaagacggaagtcctgcgtgtcggcgcatcactgaccagaccctgcgagaacaagcaggcttgacccgcacataccacccaatcaaatgcaccttcaaactttacaaaaggtcacacaaatagaccgatcctgctgcagggagcagacactaaagcacaatgattccaacaaaactcattcacagcactaggaactcaacgtctttggcagggggcccagaagaatgcttggaagaccagcctctgacaccatcagtgagcggatgggtgcagaaattcattattccagatcgctgacagatatcacatatttgaaaagatgaatagggcggacatggctcagatgtgtgtctcccaggacaagtgtttcatcttcacttgacgagctatttagtggaaaaaccacaggcgcagccctttgacaggcatcccattcatcaaaagtgtctaactatttgatactggggagataacttatttttcttttttcattggcttgacatgtgtatctgttcatgtcaaggtttataaatatatatttttaataaatgtgctctattttttagcatgaaccaaatacttggagaggcactcccagatccatagagctttccttagttttatctgctttgtcccctcctcccccaactacagatgttctgttgtggagccattctagtccttttgtctcatcttgagtcttttaccttgcgcttttgttctctctctctcctctctctctgcctctttggtctgaaggacattttcccatactgtcagccatggttttgggtgcatgttttaagattgtccattgagtggctttttgttgttatctcggagatataaaatgattgtgggcatgcagaccttagatgcaccctatctttactgagaattatgcatgaataagggctgagtgatagatcagcttaaaattaaaaggactacctttgaggaagaagagcgtggctatatttgcagatgaacttttgaacagaatattcagcttcttaccggcagcgttattgtttcattcttgtgaccattcgtttatcagattttgattttagcggtcatgtaccgcgagagttgggaagaacaagggggaaagctcgggattaggtgcattactccttcctttgcaagatacctgggatcctcctcaaaagcgggtggggtataaatgacacaagaactcccccaggagatctcatggtgattcaggctgtgaggacagccctgtgacaggtgacttttcagggacatgaggaggggatttaatgattgccctaaaggacttctgtatttttaaagcccctggtttacacccacatgaagctatttcctctctggcagggatggttgcataaaaacaaattagctcccttctggctccctgaaatgggcccttgcctggctacagtggcatggccttaaagagagggttagtattccttctgccattgccagctgtattagtctgttttcacactgctgaaaaagacatccccaagactgggcaatttacaaagaaagaggtttattggacttacagttccacgtggctgaggaggcctcacaattacggtggaaggtgaaaggcacgtctcacatggtggcagacaagagaagtgaacatgtgcaaggagactcccatttttaaaacagatctcgtgagactttttcactatcatgcaaacagcatgggaaacctgcccccgtgattcagttacctcccaccgggtccctcccacaacacatgggtattcaagatgagatttgggtggggttacagccaaactctatcaccagccttgcccctgggcagaagcagcagcagtctgcctggctggattcaaatgattctgaggcttctatagtctatgcctgcagatctctccctcacccatgctatagtgtctgaaattccaccattagagagtcatttcttgggctctgttaaatggaccaggctcttttataaagaaaatgcccctgagcagctggctctggcattgatttatgatatcttctcttccctgccagaaggaaggaagctaaggtgcatgtagggcgtactgtgtgcccaggcactgtgccagatgctttggatacttggagtcattgaattcttgtagtaaccctgtgagagagggagtcttttctccacattgtagaagaaggaaaaagggctcagagaggtcaagaaatgtccctgagatcacatggcttctagtggagtcaagatccaaacccaatgtgtctgattccttagcccttgggggtccggaggctgctgaacaagaaaggaggtggagaggagagaaagctgcaggcataccaccgcacacccttctccctcccctgtaaaaacaaccctgggaactccctggacactagcagaatatcatacactaaggataagggatgagaggaggctggttagaaataaagcagtgtcagggggaaggagctactcagtaggctctgtgtgattctagaaagactgtatgaaaattctgaacagtgaacagaataaacaataaaggtgcaatggaaaaaaataaaaaaaaaaaaaaaaaa(SEQ ID NO:137)
mouse-tuna
tcattcccctccttatccctcctcttctctccccttccctccccgcccttcccctctgccgcagcccagctcctagcgcgtcagcgtgggcttcccggagcgagtcgctaggtaacagggctagctccgcagacccgggccagggaagcccgcgcgcgtcgtcagcatctgcgccgaggggcggggaacgcactgacactcccctatcggagcctgcagacccttcagctggttctcagtcccctccctggatgccttaagggtggctattgccaccgcggagttgcccctcccctgcggggaccccgacgtcgccgcccccttctcctcccacgctggtccgcaccactctccgcaccgccagccaccctccgagatcttcccgccgagcccaggcgtggggcatgaggagcccctgggtgtcgcctgcagacaacccagcctcgcgcacacctcgccagtcgctgacagggacatgaacagcatgattgggttccggtgtccggcggccagcctcagccggaggcggccagtgggtctgcgctgtttgggagaatgaggcaggaacccacggcaacctctctctcctccttctcctcgccttcctctggctcccgctccccggacccgggccgggctgtggctctgctgcgtgccctgcgcgccccccacctgcctccggatgctcttctcggttagcctggagaggaagataaagacatttgcaaccaagatggtaatcacgagtggaaacgatgaagaccggggaggccaagagaaagagagcaaagaggagagcgtgttggccatgctgggcatcatcgggaccatcctgaacctgatcgttatcatctttgtatacatatataccactctatgaaaggccccattcagacctcggtggcctcaggatggccacgagacaagggtcctgtgcatccgtctatcagcgaccacacactgcggggggaccagcaggtttgaagaccacacaatgctccatcaatgcaccttcgaactttctgacgggtcacctgatggacccgtccttctgtgaggagcagacactctgaagcacaatgaatccagtgggactccttcaggccacaaggaactcccacaggggacccagcgggatgctggaaaggccagccttctgcaccggcggtgagcacgagggtgaggaagtgcttcaccctggagtgctgaccacatctcacactggaaagaggatgcgtggggtagtcgcagctccgctgacctcctcccaggactggcaagataaataagctctaggtgcggttcgttgacaggcattgcattcatcaaatgtttccagctgtttgatatgggagataacttatttttcctttttcattggcttgatatgtgtatctgttcatatcgaggtttataaatctatatttttaataaatgtgctctattttttagcatgaaccaaatatttggagaagcacttctggacccatagctcttcttggttttaatcgcttttgctccatcagctgcaagacgtctttgtctgtagtcatccggttgcctcagctcatctcaagccttgtcgtacctcaggttcttcttccttcccatccctgcccctcccttctctcctctctctttcccctgtctctcccttccatctcttaattcccctatccttccccatctccccaccccccatctcctctctcccctcctcctcacctcttgtctagaggacattttcccataataccagctgtggtcttggctggtgtgtgcttcaagattgtcgagcggcttttcattgttctgtcagagatataaaccgattgtgggcatgcagaccttagatgcaccctgtctttattgagaattatgcatgaacaagggctgagtggcaggccagcatctccagtttttaaagggactaccaaggaggaagatgagcagccctgcctgcaggccacccttgggacagagcagtcaccagctcaagtgcagtattgcttatttgctcctgtaaccatccaattatcagattctgatttatttatttatttatttatttatttatttatttatttatttatttttgtgaccatgagagatggaaacggggcgagctcgatgttcagtgcaccagccgtcatcccttccttggtgagctgcctggggaggtggagggtgggatctcttcagaagtcagtgggatatgagggaagtgagacctccccgctgtgagaatgcacacacagttcctgctgtaaaaacactgctgggacgagtgacccttcaagggcattgggaggggacttaatggtctctgttaaggagccctgcacattttaaagctgtttttccactcacacaaagctctttttttctctgaggggatggttgaataaatacaaatttgccctgctctctggctccgtaacacagccccaacctggatgcagtgtacagctttaaggagagggtccgcattcattctgccaagggcagaagtggcagcagccccccctttggattcagatgacactaagggggggcatgtctcagcttgcccccttccttaaatggcaccatgaaggagtcatttcttgggcttcactaagggaccagtctcttttataaatcaaatacccatgagcacctggctctgcccagagatgtctcctcttccccaccagaaggacagataccgtgtacacaagtaaccaggctttcatagttgctggtgagagggagagtctttctctctcacctgtgtggtagaaggaagaagaaaggacagctcggaccaggaatcttccctgaggtttcctggcacccagtggagtcagattctagcctcacctggccagttccttatcccagcgaggacttggatgctgttgtgggatgctgatgaggatagtgactgtggctggaaagcctgtcgctttgctgaggatcaacccagcacacacacacacacacacacacacacacacacaccacaccacaccacaccacaacaggaaacaaccttagaactccttggacactggcagaatttgacacaaataaaagacagtagagaggctggttaggaaggtgggaggcaccccggggcgagcactacctaccaggctgtgtgattcttgacaaactgtaattctgcacagtggactaaacaaacaataaaggtgcagtgggggaaactattggtgtcgccaacttcctcgtgagcccgtgtgtaattgtttgatttaataaaacttgaccgtggctgtaaaaaaaaaaaaaaaaaaaaa(SEQ ID NO:138)
human-Linc-Brn1b
gcgagtgcgtccccaccagcctggccgccgcgggaactcggggaccgggagggcgggggttagcgggaggaaagggtaagctgaagaggggctgggaacgggagggaggctcggggcgaacgggccgtcgcgttcatttccataagaaagctgaaatcgcagttggaagcaggatttctcgcccctgcagcccttcccccatacccggttttctgcaagaagcgggctccagagctcagagcccgaagtgtgtgctctggtctttgatgatgttgataaaatgtggtttcaaatgttgtcccgaagaggccggtttcctgtctgtatgtggaatggaaggaccgtgccggagttgtgttctcaccacccactttgtcggcggaggagaaacactgctgcctgatgcttgcactgctgcactgttcttgcacctgctcctagccctgaactcgggccctgagctcctcactgccgcccgctctgcgctgagccccactcctgagaccgcgaggtgccagagcagcgcctctcccaccaactcctagacgcctgtaggagctgcgccggagccttcagaaccccatgggggtgtgggggtgaagttggaggtcatccgggtgatttttttcttactttttcctaattgttctcctgcgttgatttcaactcttccagtctcccggtgctggggcgccaatcctttcccaacaattcctacccaccagctggaggtcggggcccagggttaccccagagttctatggtggcagggggcgccgagtagaggggcgggaggagctgggtcctcgggaaccaaaggggacctcagcgggggcggagtgcgcagccttggctgctgggaaatgcccaactagccgctgtgagtgcccacagcgcgtcgtgggggcgtccgttctgcagctcgggtgactcagacgccctgccaaccccaccagctcccggcttctcgaacgctcttctgatcgcccagcggggagacttcagggcctgcctcgtcaggccagattgcagcccgcgaccttcccggattaaccaagggcggggcctgttgcccagcaaggctgctgcctaactgagcctcccggggaacagccatgaccaaagccccgcgggcccaggcgcgggcacctacccctacccgctcaggcctgtgggagcgcaggggcagaggccgagacgctggacttccagccccacacctctgacaacccgggcacgtctgcggagcccgggggaacagtcagcgggctctgcgtcccgggagctggggacacgcctgcaaggtgtgtgatcctttaaagatccttagtactagttttgtagggagcctttgttatagctttgtcagcctgcgcgccttcagcagctccccctcccgggcccctcggttccctccgggctcgcccccagcggagagggcccggcgcaggggatctgcccaggatcaactgccctcttccagatccccttctgcgagattcttttcctttggttacaatctcccctccgtgcctggggcagataaacacggttcgccccgcctgcagtattggggcgatgctgtcctggaagaacgggctttctgaatgtgacctcgggatgctgcagcggcgcaatgctgctactgctgaatgagtagctctcctgccaccgcagggcgactgcggtgggcacagcagggcgcacagaggagggggtaatctgcccacccaggctaaggatttgagggttctgacaaaaaagagctggttgaggatgacacagttgtgaactaacctggctcctactaccccacagggcagccaggtcccagtagtcttgggtaccactgcccccaccataccaccattgtaaagtatggactcctgcttagccaacgtgcagctctaggcaggatctctgaaggatgctctggcacacagatggtgcaggtatgactttacctgcacacaagcttacatgtgccctgtcatatatggctacacgtttccccatttccccacagtcttcctatttaactggtcttcaatcctcctttctagggctttccgcctgcacacagtcatttggagaaaatcaagtgagtgcacttctccccacagaggattctgtatgttatgtaacacactcacactgggattcctcaagttaccattttgccccaactcagccagcacttggttttctggcgggggtgtcaggatgatgcaaatggaggtggaagcttcattccctgggggcttttattcccctccttgaagccccagttcaaggcccaggaacaaaggggaaaggtaactgatctctcttttggtctttctctcccctcacttccaccccttcacctgcaggccctcctctttgataaatagaggaaagcccgtgggatcaggtacatatgtaaatactgctgacctcggccgcccctcctcaccgaaaagcagaaagcccgtttcaggtgcaggctgctccgtgcctttgagtgtccaccacttctattcccccagactgcttgggactcaaggccactcacttaatacccgtctcttgttaaaaacattcaggacaactattaaatagttattggaagagttaaagaccttctttcaggagtgaaacgtttttaaagctgtgcttggcataagtctttaaggcgtacaaagtagaatcagtagacttgcctgagcgattttgaaatttgaaagatttctccccatgaaatggtaatttaaaatagtttgtagatgttgttttgttctgtgatggctttttcaccattgtcacctaaagattctcaagaccaagctactaagacatttcatttggttagtttctgggtgatactgtgctttctgattagacctatttaatttatttttaactctgcaggagagttttcaaccttggaaatgtaagtgaaacacagactcaccctccttctgagaccttgataggggcagaaaggaacaaatctggctagcccccctcacacctggaagtttccctgtctaaacctgggtacaatgagcgtggtgggttttgtcaccttttattttattgctggctcaaggaaaattctttgaaatgaacatctattctatttcagtgtgcaatgttccagccgacttaatgggcttgccttatgcggagaggcagtcctgcaggacagagctaatgtgtggtctcccaggaagctcatcagaacacctcttgtcccttttcttt(SEQ ID NO:139)
mouse-Linc-Brn1b
ctaggcgactggtgtggattggtgttgatgagatgtggcttccagcgttgcccgactcagacctgtttccagtctggatggagcggaccgactgtgtgggatggggtgagaggaacaagtgaaactcaacagctaaggagaaaatgaagaactagtgctacgttttccacgttctttttgctccggggttgacatggcatttggcctttctacctggagaaaatcaagagtatgtaactttccctgcagatggtctgtctgtaagagctgacacaggaacctttgggagccagtatctattttgtttccgactgcaaagttccagccaatgatttggaggggggccggcaccttctgctgggagctagtctgggagggaacaactcattcctgagttctctttcgcaaacatatctcttgtctattaaaataatagtaataaaaataagaataataattaaaa(SEQ ID NO:140)
Mouse-Dali
tttgttttttaaatcaagattatagattttggggaggtgactcaggagttaagagcatttgcaactctccaaggaggcttggattcagttcctagtacccacatggtggctcacaatcatctataacttgagtttcaggaaatccaatactctcttctgacctctacataaaccaggcatgcacatgatgcacataaatattgtgcaggcaaacaccgtcccccagacactcaaaatacataaaataaaaataagtattttttaaaagttggaatttggtatgattagctttatagctttagctatttatattagttttatggcaacttgacactacccagagtcattttggaagagggaacctcagttgagaaaaatcctccaccatattgatctatgagcaagccagtaagcagcactccttcatggcctctgcatcagctcctgcttccaggttcctgccctggttgagttcctgccttgactttccctcagtgatagagtgttcttgggagtgtagatgaagtaaaccctcgcctcctaaactgcccttggtcatgatcttttatcatagcaatggaacccctacttaagacaattatctttgaagcacatattttgacatttaggcatatcaataaatgattgatggttagtttcttaaaatgccccttgaccacaaagacagtgaattttctcccttgctccctagcatagattataggtctgagccatcagatctggcttgaggttcaaagcttgtgaccacctgttccaaggacaaatgagctgcctagaactcttccactggcctgcctgtagccgggaatggtggagttccctgtgactgtgggattctatatgagctactgatgagacataagcaagtaaggaaagttgatcttgggatcaacactcatcaagaataagatgggtcccccactctctagctgtgcttccagacaggtttgcttcagtgtggcttcagcaaagccttcctagtggtctacagtagagaatgcaagagtccatccctagcctgaacactgcacacagacaccaattatgctaaaatatttaatttcattccataaataattaagcctaaataataatacctagatataacttggaacttgtgacaatctacctgcctctgtctctgtgtaccaggattataggcctgggcacacattcttcttcaggactgattataatacattttgtatattgatttaaaaaaatgatgcttaggtagttatggcctgtgagtaattctataaagtagactaagtggatatcatcagtctatactctaagacattcctttaatttttttaaatttttttttaaagttctactttttaaagattcctagagagccagatgggtgatgaaaagccaggtttcacatgtaacactaatattgggggaaaaaaaacctgacgctagaaattatttagttattctgaaagctgtcacttcttgaaagcagagtcagaattagaaaagaattaacagtgtatcgttgtgttctcacatttccaatgtggctggtgaatcatgaagcaaaaatttcctcaaaactggagccccagagtcttagtctgagcccatcctcctgcctgagaatctccaaattgcctagtgaaggaaaagctatgtccatggtcccacctgttccaaagtccctttggaaatctaggcagaagtaggtttgctagagtcttacttatgacaacctgggaaacaaagaaggctcttcatacaagggtgtgtatccacacaagaggcagcatcctgaaggaaaccttcaggagcctccgatcctgcagttagctgactgtttcctgccctccttggtccaactcgttatggccccaggtgttccttcttgctgctgaactgctgtctctaccagctgagcccactcctgtggtctgcactcactgccctggctgcaggttgaacagggtcaggctacttctcagatgcttcccaccagccgcagtgaactccattttgacatgaagccatttaaatggaaatccagttttacaaagctcaagtgactggtaatgaagatgtgaatgatgcttatgaggtttttatttaattttaaatcaattgtgtattctaattcattaataaaggggaaaggaaagaatacaggaaaaaaaaaaaaaaaaa(SEQ IDNO:141)
human-miat
cagctacaaagacgacgccggctgcgctcgcgggaccagagggagggaggctgcggacgagtgcggggaggagtttgagatgggaggcgcttgcaggggctcccccagttctgcgctgtgagccggggcacaaagagccctctgcactagcgccgcaggaccgcggacccgagttggaggcatctgtccacccatgtggttccagacacgttcatgtggccaccatgaccccgtcggcatcacaggggtaaccaaggtccacagaacgaggggaaagggtcactgtggatcaagccaggctcctctgagcagtccagggtctatttacagagagcagcaagttcctgggacagaggagacagaagggaatttccaggttcttcaggacgttcacaaccacactgagaagcatctttgcagataagtatttaaacttaccagcccatagcctaccagcctgccctcttctggtctgtgcaggaaagtgtagtatcctagaatgccaaagtgggaggggaaatgggtgatgtagctcattctcttttctacctctatggaagaaagaaagagcctgtccccattttgtggggtcccagaaagggtgattttcacacttcacatttggcgttagggctagtatttcacaaacattaccgtctggaacttttgaaggctgagttaaatgacttcatcttgtgtacttgtagaactgctattagaaggaggctggggactccctgatgatgtgaaccagcccttctcttctcagtttcagcactttgtgatcatatttataaaccttggacagggctccttggccttagagttaagtgaagagttaacactgtgactttagatgcatttttctcagtgtaagtgtctgagctcatctccagttctggactcgtgcccccactcccgggtgctgacagcaagctctgaagatatgctgagagagctccctgactctcctgactcaggtctgccagttgatgaagacagcacagttgttaccaaaaacaaaacctggcagatggtcctaggtcaggattagtggtcattctctggtcttctccagactggtgacacagggtggtcttaaaagagtcctagtccagcctctggctccccgaatttcctctggtgcatggggcatcaggaaagggcaggggagaaggagggggagcagaaaaataactgaggctgggcagaagggtcccttccatttcccatccattgcttcaaacaatgggtgattaccgtgcaccttgagtgaatgtcaaggcaggaagggttccagggccacccagtgtggcaggagcagagctgggatcagaattctggattcctgactctccgttcagctgctattcagctatcaccaagctgctgagtttgtcctactttctcctgggtcacattctgctgttgttgggaaacagggagtgagtgaagggaacctgggaacccttctcccctcaccttttaaggatgttctggggtggaataaagagaggtggagggtggggtgcctgggcccagcctccctggctcctggtccttctttcttcagcagggagttctggcaaggcctgggcctggggagggggcctgggtgcagttttctcctgcggtgtggttggctcttttgtcttccaggatgggcctgtggggtctgtgtggggaaggaaggagctgggagcctgggctgcctgtgtgtcggctggatgctgccagcaccggcatggaccaagcaacttctctgagccagatgctggggacgcagaggtgaacccagagacatgatcccatctgctcagatcttcatgtcagaacacgctttattacagtctcggcaagggggtggctccatctgggccgcatctccaggactcctggcctggacttctctttggacctcgggtgaccttggattctggccacagtgacttagcggtcagactccggtggttttctagcccgctgggtgactccctgaagatctcatcctcttcacacctgttgggatggagcctcccatggataggaactcttcctggttgatgctcagcagatgactgatctggctctggaggacagctccaggggtatgagggaggcctggcagcccactactccctcctcacctgctcgggccctgcctgctgggccctattgtctgggtctgggggccctttcctgccccatgtgaacttgattcctcctcgcgtttctgccggtgaccagacagagcctggcctgggccaagtccccactgaccacactttccccaaggctgggtctcaaaggaccctacaggatggggacaggaacaaggatgggagtcggggaggggctgtcaggcagagggcagatgcagctcctcgggtgccgctggctggagtcctttgtctccatttgctcagtgcgtaattgtcattttgtgggggacttccttggtggggcttttccatgcttttcctctccctgatggttacaaagaggagacagtcaggatctgggaggagctggagccttccccctgtgctgttgaactctgggaggggcagccagaggggctgagagtgcaccatcctgaaaagagagggtctttaagagataagatttaggctagggaaattcactagaaagagacaggtggccctgggttttttttcctgccatccaaagggaaccagtcttacccaaaggcttaaggggtcaccttagcccagtctcaggacactcttctccaatcagatcgctgcttctagttgcactgctcctggattctgttcttggggaacagaaggtggcaggacaggccccacaatctgcaattccagctccctccagaggagacagtcccagcgtttgcaagagagcagcttgtggcctcccttaggcaagtttaaaagccagatgtcctttttcccagaatgcggagtggtgtgtactattcatcagcttgggctgccacagcaccatgccagactggatggcttaaacatcaggaatttattttctgccagttctggaggctggaaagtccagatcaaggtgttaagacttggtttctggtgaggcctctctccttggcttgcaggtggcaccttctcactatgtcctcacatggccttttctctgtggagagggacagagagcatgagcaggctctggtgtctcctcctcttcttataaagacactaatatcaccatattagggcttaaacctatgacctcatttaaccttaaccccttaaaggtcccatctccaaaaacagtcacatagcaggctactgcttcaacatatgcatttgggggaggggacaccattcagttcttaacagggtggtcaccgcaaacatggaaagtcagagccttctccccttcagaattcccgcccccacccagggatggggaggaggagcagagaggtatgggaagcagacacggagagtggcaggtaccatgctggggtggctcaggagtgcttcggaggacatatggaactggcagggctcagtgcagggaggcggaggccctgggagagccgtgtcctgagaagggcctgggctacaaccctgggcaagttacttcacctctgagcctccgatgctctgtgaaatggaaggaatgtgcttgcctgtcaggtgcagggagaattcagtgagattgtgtgcctagcacagtgcctgactcccagtaggtgctcagcaaatgctcccatccatctgggagtatagacttagggtttatctatttttttttttttttggctctctggactttaaaactcagcatcttctgaaccagaggcatttctgattagcccttccctacctattttcctagtatcactctttaatcagcttggggaggtggcagcatttcatggcctccgtagtaactcacaatgcttcctggggtatttaaattctactctctcatcagcactgagcacctactttgggccctttcccgtgctagccatttgggggaaatataggtgaagagtggctggggtttgaacctttaggatttcacagccatgctggatgggataaaaccagctcacatggagaatcagagaatgggacagtgccacaaaacagtctactgaggcacaagttctgagtgcctgggaagtggtagagagaccccagagagggctgctgcagtctggaacagcttcctagcaagctgtaccaaacagggccttgaaggatgagaaagatctggctgagatgatacccgaccctctagggaaattcttaaagtaacttctaggaaatgtcattgctccttaaaaaaaaaaaaaaaaaaaaaaaagcaggttctaattcaaattccgctgcactactgaagtagtgcaggacttatcagaacctttaaaatgctaatggcaatttcaaatactcagggacagggcataggatgaagtgttccttgacttttatggccgtagaatctttttctcatggaacatcgtttagaactgtgggagatgctaggctggggtttctatgggaaaagtacagcagtgatagaagatggcataattagggtacacttaggtgctttgtagcattggctgaaaaggaagcagaccgggtgggcgtgggggagtctcaacttggttccaggagccaggccagcttgatgcgttttttttttttctaatggtgggagggcaggccaatagttggagaaactagaggcctgacagtcggtgatggaagagatgtctactaagcacggttgtcagatcttttgcggagagatgcgggtgtgcgtgtgtctgtcagagtgtaacaggatccagccctctgggaaggggctgaccagaaccaggcagggggtttctgtctaggacaagtagggtccattttcaggggagctgaaatatttgcagggggtgctctgagacccacagccaataaatagggaagcaacatgcttttgggcagggtccatgtggttagggttgattttgatggggctggggggcttagagttagaccccctgccctggtcaggccccactccctggctggtgggggcgggaggcctctgaagctgcagctggaggggccggggcagtgttgcatggtgtgattaacctactaacccagggctcagccgggacgctgtggcgtgtgacgaggtgcctggccttctgccaaccaactaacccactaaccaggcccgagcatgccctactaaccacccccccgcagccagatcctactaactgtgcagctcatgggcctttcaaggggctgggatatgggggcagccaaggctccagaaggctctgcctatgggctgggatctttgtgcagacccacgttccaggacagagaatgcaaataagactcaccaactctgccacttcctgttgagtgagtttgagtaagtcacctcacttctctcaacctcagtttcctcagtggtagaatgcgagttctgataccttacaggttgcagtgaggattcccgtcaatataagggtctcagcacatggcagacacctaaaaaaaaaaaaagtatgaggatggaggaaggcccctcaaacctggttgaacacgtctgctgcctaggccctggcctctctgggtgttctgcacacagatccttctgcctggggcaagacacttggctttgaatccatgtcacttccccacattcttcctccgtctcagctttcttttctgtaggcagctcttttgttcgattactaacccgtctaacccctggggtgcctcaactgcaccccgatcatcccttaacaaactaacggacctgcgtgcgttcttccttttctcttagcgactcctgtgtgtgtctgctgaggtgccctgtccgctggtgctgtgctctgacttactaacccagcccctactaaccctgttttctcttcttactaaccccagccctgccgagctctgggctccccccgggggctggtccccctccttttggcaagcagatgacctggggctactggccctgtagacagatgtcccactttgctgccccatattggctgtaagatcagagtccactgggccaggtctaaggcaggggatggccctattaacaagactcagaggaggaagaggtggtcctgtggatgtgggaggctggactctgagtatgacatctctcctatgtgcagaagtctggttgccactgggagtaggtgggaccagggaaatctctgggacgtgagtgtggaggcctgttggtctagactctagactgtggagctctgagcttttgtgtcctctggaaggaagctggggaagaatcctctccattgttaagtgacggggatagaagctgtcctgcacaggaagtcacgaggggggcgtatcccacgaggaaggcaggagggggcgtgcccctcaccggaaattagcagaggggcgtgtcccacaccggaagtcagaaagcggagcctttcttacaccggaagtcaatgaagcgggtctttcctacgctaaaaaccactgagtggagtatttagtacacaggaagtcggccagagaaacatttctcatatttgaaggccggaaagagggacatttctgacaccggaagtcagtgagaggactctttcccacacaggaagtcagctagagagccgtctcccctctctggagccgagagaggccggtttcccccaccgtaagtagacgtggggccgtgaccggaagtccttgggaaagatccgtcccattcccggaagctagagggcgttagttgtcgggttgaaaaggggtgtggggaggggaagcagctttaccccgggctcggagtttgcaggagagagaagtggggagcaagaagtgaacctcaggggctcacagggttcccgcagatgctcaggccggccaggaatgcatctctggctctctgttcccacggacgtcactgcctcagccagcctcccccagagcccgccagccgctaagccggggccacacctgggggtgatttcatgcctcacctccagtaggcaccttggtttctttgggctaatctctggctcccttgcgctaactcttgctctcacccagctaatccctgcctcaccctgactgccccaggggctgaccactaacaaccaacctggccctgtctgggggttccaggctcctggcctggccctgaccggttcttaattaacctttccttcaccttgactaactcctgccttcctggtctgttcctttcagcagaaactaatggtttgtggatttttttctgactaacaacaggtctaacattcctcgttactgttaacagcttggatgtcggcatggctgggaaggggctaacacagctttgaacttggctaacacaggtttgaacttggctaacacaggtttgaacttgactaacacagggaaaagcatagctaacaattttgggcgtggtggctgctctgagtcagaacaatcagaagtcggtaaagatggtagttttctaaaggaggtgccagggctctggtgtggaccaggcctgatggagcagtggtacccaccaaggtggggtcagaagtatagccagtcttgcaaggttttggccattgggcatatcttcactcctcatagtctgcatttggtttcagttcttaaaaaaatatagccttatagctacagtagtttgcacaagtagatgcagctcttataaaccttaaaatacctgtctggtgtctacagagcatatgccattttgtatagagtcacccttccccaggccagggcctagagtcttcattttggggactttgtgttttggaagttctaggacataaagctttagatcagagtattcagaagggttataactccgtcagtcatttacatgttagtagtataaattatctgagcttcctgttctaacttttagctcttctagcataaactcttctgtgcaatttagctgcaccgaggaaacgggagtttttctggaagggacttttgatctctttagactgagggaacgtcctttgggagtagaggggcagggagcatacgcaagggattccaggtgcaggtaaaaggtggcactagttcaaggttttgctgactcagtctggtagtcagagtctgcaggagaagacagttcaaggcagggcctggaggattggatcagtttagggacaggtcaaaggctggcttacagaccttagaggcaggttgcttgggtcgttgaatgctagtctggtgctgagagcccttttctctggcaactgtggactcagagctaaccaattgtagttggcagtgggggtgaagggtgatccagaggcctgagctgcagagggcacaagagagaaaagatgtcttagaaagagctttgagaacatgccttggctgctggcagggaccttggatggggtagtctacacccggaagtgcctgcctgccatcctctagtggctgccttgctccatttcactcaaagcaggaagctcacacctcctattcctgaaactcctctttgtttaactgcaaagacttgatgctgctaaggatctactatgtgccaggcactgctctgggcgctgggacctgcacctgggctttttcgtcatggtgcttttatagcctagtgggagagttggtgaagtagatagtgattcagtgagatgggtgttatgattggtcaggggtctgtgggagcaccaaggagacagacaagattgatgtgcacctactctgtgccaggcgtgtgccaggcattggggatgtagtggtagttaaacaccatttggtcttcaggagctttaattctagtgtgttgggtgcaggggggtggaatggggacagagagacacctaatccaccctgtggtggctttctggagagggaggcatctaagctgagctgtggctgggtggagtgtgggtggggatgagttccgggcagcgagagtggtggacaccagtttctggggatcagagaggatccaaagaggttctggaaggttcatgtggaatgtagcaagagataggagacatggacatggtgccgggtctggttgccaagaagtttagattttatccttaggccttggggagcgacggatatgatctgagaaagggagttagtggatttgagttttaggctggccatttggcttttccagcccaggtggaactcagaggagtttgcaatggcctctggccacattttagacaactgagcagaactttttgaaactaggaagaccctttggtccatcttttgataaacagaatccatacatgtctaccccagttggaagtatctctgcaatgactggaaagtaaagaggaccaaggtgaaaataaaggctcggaaggggagcaatcttgaaaacatgtcatcccatggtggtgggaagtccctggagaagatcaggggaaacacagtcataggctgcaagtctataagataattccattggggagggagcccatttgtcatgcatggctgcaaggggcagatacaagtgtggagtaagcttgcaagagctgatcctggtcccagagagggaaaaatatgccttggtgggtaatgaaccttttgttcccagaggcagaaggattgggactaggccaacatagagattggcgatggttgtgagattctaagagtgtgtgtgcatcttgacaatattagaggaggctgagcccaagcaggcacattctcttcgacccctccctcattcagtctgctttggagtctactgaacatcaagcttgctatgagcaggatcttagagctgaggaattggcctcccaatccgaacaggtgttataatcctttcttaataggttgtgctgtggacccaatgtgagggctgtgctggtgtaaatggtgacatgttgagctggggggatgctttcggggtggggggactggttccattccatcaaaggccctcttgagagtctatccagggacccattgttttactttaacagaccagaaaagatgtttgttttccatgtcattacccccaggggataccgaatgtgtgggtagaaatttctctgtagattaaaaatcagatttttacatggattcaacaaaggagcgtcacttggatttttgttttcatccatgaatgtagctgcttctgtgtaaaatgccattttgctattaaaaatcaattcacgctggaaaaaaaaaaaaa(SEQ ID NO:142)
mouse-miat
tttgttttttaaatcaagattatagattttggggaggtgactcaggagttaagagcatttgcaactctccaaggaggcttggattcagttcctagtacccacatggtggctcacaatcatctataacttgagtttcaggaaatccaatactctcttctgacctctacataaaccaggcatgcacatgatgcacataaatattgtgcaggcaaacaccgtcccccagacactcaaaatacataaaataaaaataagtattttttaaaagttggaatttggtatgattagctttatagctttagctatttatattagttttatggcaacttgacactacccagagtcattttggaagagggaacctcagttgagaaaaatcctccaccatattgatctatgagcaagccagtaagcagcactccttcatggcctctgcatcagctcctgcttccaggttcctgccctggttgagttcctgccttgactttccctcagtgatagagtgttcttgggagtgtagatgaagtaaaccctcgcctcctaaactgcccttggtcatgatcttttatcatagcaatggaacccctacttaagacaattatctttgaagcacatattttgacatttaggcatatcaataaatgattgatggttagtttcttaaaatgccccttgaccacaaagacagtgaattttctcccttgctccctagcatagattataggtctgagccatcagatctggcttgaggttcaaagcttgtgaccacctgttccaaggacaaatgagctgcctagaactcttccactggcctgcctgtagccgggaatggtggagttccctgtgactgtgggattctatatgagctactgatgagacataagcaagtaaggaaagttgatcttgggatcaacactcatcaagaataagatgggtcccccactctctagctgtgcttccagacaggtttgcttcagtgtggcttcagcaaagccttcctagtggtctacagtagagaatgcaagagtccatccctagcctgaacactgcacacagacaccaattatgctaaaatatttaatttcattccataaataattaagcctaaataataatacctagatataacttggaacttgtgacaatctacctgcctctgtctctgtgtaccaggattataggcctgggcacacattcttcttcaggactgattataatacattttgtatattgatttaaaaaaatgatgcttaggtagttatggcctgtgagtaattctataaagtagactaagtggatatcatcagtctatactctaagacattcctttaatttttttaaatttttttttaaagttctactttttaaagattcctagagagccagatgggtgatgaaaagccaggtttcacatgtaacactaatattgggggaaaaaaaacctgacgctagaaattatttagttattctgaaagctgtcacttcttgaaagcagagtcagaattagaaaagaattaacagtgtatcgttgtgttctcacatttccaatgtggctggtgaatcatgaagcaaaaatttcctcaaaactggagccccagagtcttagtctgagcccatcctcctgcctgagaatctccaaattgcctagtgaaggaaaagctatgtccatggtcccacctgttccaaagtccctttggaaatctaggcagaagtaggtttgctagagtcttacttatgacaacctgggaaacaaagaaggctcttcatacaagggtgtgtatccacacaagaggcagcatcctgaaggaaaccttcaggagcctccgatcctgcagttagctgactgtttcctgccctccttggtccaactcgttatggccccaggtgttccttcttgctgctgaactgctgtctctaccagctgagcccactcctgtggtctgcactcactgccctggctgcaggttgaacagggtcaggctacttctcagatgcttcccaccagccgcagtgaactccattttgacatgaagccatttaaatggaaatccagttttacaaagctcaagtgactggtaatgaagatgtgaatgatgcttatgaggtttttatttaattttaaatcaattgtgtattctaattcattaataaaggggaaaggaaagaatacaggaaaaaaaaaaaaaaaaa(SEQ IDNO:143)
human-NBAT-1
ctagaatgagaatgcacagcaagcggcagacaatcacccggcattcggcatctctttcttttcacgcgctccctcgctccgcctttctccagctctgccttctcaggcagatacatcagataccttgtttatccatcttcagctccactctgagggcgcagacgcacgattccgggatcgggtgcaccacggcgaagcccaggcgggagacggcaggagcagctcagatgaagaaactgaaacccacagagatgaagtaacatcctcaagatcaaaaggtaacaaacgattgaggcaggatttggatattgctctacatgacgggaaagcctgtgctcttggaattacagtcatagtacaacagatcaagttcaaagcatcatctaagtcaaggaaaaccagtaaagaggtttggagagacaaacagggtcaactccaggcatttgggtcagcagaaacggcacgattgagcagcactgtgactataggatcatggatcagaggctgcttcctctttggttctgggcatcagcctcatgtccactcaaagtaagtggcccctctgattggaatcggaggtgcctgggtcatctcacagagccaaacaaatacaattagctattgcaaagccttttgggaattattcccagtgtaaataaacacataaccatatagcaagagccttgataaagtccaaaaacatgcaaacttggagtatctaagagaaaagaccacaatgtaaatgaaaaaccaaataaactcgggcaaaccataggatagggccctgtctgtgatggcctgcatatgatgagccatagaaaaaggatggtgaattctggataataagaaatgtcaatgagatgcaagaaccacctgttttatgtaaagctccaaataaccagatcacagtggacagccactcaaataatgccttcataatacagagtattattgagaataactcagttcacagagagcttaaggcagccaatatttgatagcctgtcagaaaaaaacagaacagtaattatagaaaagaatcatatcctcggaaaaacaaaaattaatcaaactaagtttgtaaagtctatcttacagacacattgtctggactggtcctctcaaaaatactgtttttttttaatgccaatttgtttagttaatgatttttgtcttattacttcaaaactggaaatatcctatgactcataatatcttacaacctttctactttcttaaagaatctcaagtttataatcacaggggatcggattatttttcaaaaattaaatggtgatgtaatgatttctgtgtctattgtagaaaagtcaaccttattacagctgcaacaatggcattaagaaatatgagtaattccaatcaacttgagataatgtctaatcaaacacaaatacaactggtaaatttcattaaatagcatggagattaaattaaaacactattatgtaataaaaacctttagtggtactaaaattttagaatagttcagatatacagaaaaatttcaaagatacacagagttcccatttttttcctattactaacctctcatatttgtcacaactaatgaatattcaatagagtattattaactaaagcctatacatttatttagatttccttagtttttagctaacattctttttctttgttccaggatcccatccgggccaccacattgaatttatttgtcattttaggtacctcttggctgtgagtttcttagactttccttgtttttggtgaccctgacagtttgagggagtactagtcagtcagttatttttgcagaatgccctaaatttgagtttggctgatgtttttcttagggtttgactggggttatgggttttggggaggaagaccacagaggtgaagtaccattctcaccaaattatattaaaggtacataccatcagcatgccttatactattgatgtgaactttgattgcctggctgtggtagtgtttgtcatgtttcttcactgtaaagttactcttctcatcacccacttttctgtactgtactctttggaagaaagtcactatatgcatcccaaatttaaggagtgggaagttatgctccacccatttgtaagcagaaaatctacataatttgtttggcattcttctgcataggaaaatcatctcactctcccagttatttatttatttgatctttttttatatcagtatggactcatgggtatttcttttatactttgggttataatccaatactaacacaataaagaaatttttaatggagatgcaaaaaaaaaaaaaa(SEQ ID NO:144)
human-Malat1
cgcagcctgcagcccgagacttctgtaaaggactggggccccgcaactggcctctcctgccctcttaagcgcagcgccattttagcaacgcagaagcccggcgccgggaagcctcagctcgcctgaaggcaggtcccctctgacgcctccgggagcccaggtttcccagagtccttgggacgcagcgacgagttgtgctgctatcttagctgtccttataggctggccattccaggtggtggtatttagataaaaccactcaaactctgcagtttggtcttggggtttggaggaaagcttttatttttcttcctgctccggttcagaaggtctgaagctcatacctaaccaggcataacacagaatctgcaaaacaaaaacccctaaaaaagcagacccagagcagtgtaaacacttctgggtgtgtccctgactggctgcccaaggtctctgtgtcttcggagacaaagccattcgcttagttggtctactttaaaaggccacttgaactcgctttccatggcgatttgccttgtgagcactttcaggagagcctggaagctgaaaaacggtagaaaaatttccgtgcgggccgtggggggctggcggcaactggggggccgcagatcagagtgggccactggcagccaacggcccccggggctcaggcggggagcagctctgtggtgtgggattgaggcgttttccaagagtgggttttcacgtttctaagatttcccaagcagacagcccgtgctgctccgatttctcgaacaaaaaagcaaaacgtgtggctgtcttgggagcaagtcgcaggactgcaagcagttgggggagaaagtccgccattttgccacttctcaaccgtccctgcaaggctggggctcagttgcgtaatggaaagtaaagccctgaactatcacactttaatcttccttcaaaaggtggtaaactatacctactgtccctcaagagaacacaagaagtgctttaagaggtattttaaaagttccgggggttttgtgaggtgtttgatgacccgtttaaaatatgatttccatgtttcttttgtctaaagtttgcagctcaaatctttccacacgctagtaatttaagtatttctgcatgtgtagtttgcattcaagttccataagctgttaagaaaaatctagaaaagtaaaactagaacctatttttaaccgaagaactactttttgcctccctcacaaaggcggcggaaggtgatcgaattccggtgatgcgagttgttctccgtctataaatacgcctcgcccgagctgtgcggtaggcattgaggcagccagcgcaggggcttctgctgagggggcaggcggagcttgaggaaaccgcagataagtttttttctctttgaaagatagagattaatacaactacttaaaaaatatagtcaataggttactaagatattgcttagcgttaagtttttaacgtaattttaatagcttaagattttaagagaaaatatgaagacttagaagagtagcatgaggaaggaaaagataaaaggtttctaaaacatgacggaggttgagatgaagcttcttcatggagtaaaaaatgtatttaaaagaaaattgagagaaaggactacagagccccgaattaataccaatagaagggcaatgcttttagattaaaatgaaggtgacttaaacagcttaaagtttagtttaaaagttgtaggtgattaaaataatttgaaggcgatcttttaaaaagagattaaaccgaaggtgattaaaagaccttgaaatccatgacgcagggagaattgcgtcatttaaagcctagttaacgcatttactaaacgcagacgaaaatggaaagattaattgggagtggtaggatgaaacaatttggagaagatagaagtttgaagtggaaaactggaagacagaagtacgggaaggcgaagaaaagaatagagaagatagggaaattagaagataaaaacatacttttagaagaaaaaagataaatttaaacctgaaaagtaggaagcagaagaaaaaagacaagctaggaaacaaaaagctaagggcaaaatgtacaaacttagaagaaaattggaagatagaaacaagatagaaaatgaaaatattgtcaagagtttcagatagaaaatgaaaaacaagctaagacaagtattggagaagtatagaagatagaaaaatataaagccaaaaattggataaaatagcactgaaaaaatgaggaaattattggtaaccaatttattttaaaagcccatcaatttaatttctggtggtgcagaagttagaaggtaaagcttgagaagatgagggtgtttacgtagaccagaaccaatttagaagaatacttgaagctagaaggggaagttggttaaaaatcacatcaaaaagctactaaaaggactggtgtaatttaaaaaaaactaaggcagaaggcttttggaagagttagaagaatttggaaggccttaaatatagtagcttagtttgaaaaatgtgaaggactttcgtaacggaagtaattcaagatcaagagtaattaccaacttaatgtttttgcattggactttgagttaagattattttttaaatcctgaggactagcattaattgacagctgacccaggtgctacacagaagtggattcagtgaatctaggaagacagcagcagacaggattccaggaaccagtgtttgatgaagctaggactgaggagcaagcgagcaagcagcagttcgtggtgaagataggaaaagagtccaggagccagtgcgatttggtgaaggaagctaggaagaaggaaggagcgctaacgatttggtggtgaagctaggaaaaaggattccaggaaggagcgagtgcaatttggtgatgaaggtagcaggcggcttggcttggcaaccacacggaggaggcgagcaggcgttgtgcgtagaggatcctagaccagcatgccagtgtgccaaggccacagggaaagcgagtggttggtaaaaatccgtgaggtcggcaatatgttgtttttctggaacttacttatggtaaccttttatttattttctaatataatgggggagtttcgtactgaggtgtaaagggatttatatggggacgtaggccgatttccgggtgttgtaggtttctctttttcaggcttatactcatgaatcttgtctgaagcttttgagggcagactgccaagtcctggagaaatagtagatggcaagtttgtgggttttttttttttacacgaatttgaggaaaaccaaatgaatttgatagccaaattgagacaatttcagcaaatctgtaagcagtttgtatgtttagttggggtaatgaagtatttcagttttgtgaatagatgacctgtttttacttcctcaccctgaattcgttttgtaaatgtagagtttggatgtgtaactgaggcgggggggagttttcagtatttttttttgtgggggtgggggcaaaatatgttttcagttctttttcccttaggtctgtctagaatcctaaaggcaaatgactcaaggtgtaacagaaaacaagaaaatccaatatcaggataatcagaccaccacaggtttacagtttatagaaactagagcagttctcacgttgaggtctgtggaagagatgtccattggagaaatggctggtagttactcttttttccccccacccccttaatcagactttaaaagtgcttaaccccttaaacttgttattttttacttgaagcattttgggatggtcttaacagggaagagagagggtgggggagaaaatgtttttttctaagattttccacagatgctatagtactattgacaaactgggttagagaaggagtgtaccgctgtgctgttggcacgaacaccttcagggactggagctgcttttatccttggaagagtattcccagttgaagctgaaaagtacagcacagtgcagctttggttcatattcagtcatctcaggagaacttcagaagagcttgagtaggccaaatgttgaagttaagttttccaataatgtgacttcttaaaagttttattaaaggggaggggcaaatattggcaattagttggcagtggcctgttacggttgggattggtggggtgggtttaggtaattgtttagtttatgattgcagataaactcatgccagagaacttaaagtcttagaatggaaaaagtaaagaaatatcaacttccaagttggcaagtaactcccaatgatttagtttttttccccccagtttgaattgggaagctgggggaagttaaatatgagccactgggtgtaccagtgcattaatttgggcaaggaaagtgtcataatttgatactgtatctgttttccttcaaagtatagagcttttggggaaggaaagtattgaactgggggttggtctggcctactgggctgacattaactacaattatgggaaatgcaaaagttgtttggatatggtagtgtgtggttctcttttggaatttttttcaggtgatttaataataatttaaaactactatagaaactgcagagcaaaggaagtggcttaatgatcctgaagggatttcttctgatggtagcttttgtattatcaagtaagattctattttcagttgtgtgtaagcaagtttttttttagtgtaggagaaatacttttccattgtttaactgcaaaacaagatgttaaggtatgcttcaaaaattttgtaaattgtttattttaaacttatctgtttgtaaattgtaactgattaagaattgtgatagttcagcttgaatgtctcttagagggtgggcttttgttgatgagggaggggaaactttttttttttctatagacttttttcagataacatcttctgagtcataaccagcctggcagtatgatggcctagatgcagagaaaacagctccttggtgaattgataagtaaaggcagaaaagattatatgtcatacctccattggggaataagcataaccctgagattcttactactgatgagaacattatctgcatatgccaaaaaattttaagcaaatgaaagctaccaatttaaagttacggaatctaccattttaaagttaattgcttgtcaagctataaccacaaaaataatgaattgatgagaaatacaatgaagaggcaatgtccatctcaaaatactgcttttacaaaagcagaataaaagcgaaaagaaatgaaaatgttacactacattaatcctggaataaaagaagccgaaataaatgagagatgagttgggatcaagtggattgaggaggctgtgctgtgtgccaatgtttcgtttgcctcagacaggtatctcttcgttatcagaagagttgcttcatttcatctgggagcagaaaacagcaggcagctgttaacagataagtttaacttgcatctgcagtattgcatgttagggataagtgcttatttttaagagctgtggagttcttaaatatcaaccatggcactttctcctgaccccttccctaggggatttcaggattgagaaatttttccatcgagcctttttaaaattgtaggacttgttcctgtgggcttcagtgatgggatagtacacttcactcagaggcatttgcatctttaaataatttcttaaaagcctctaaagtgatcagtgccttgatgccaactaaggaaatttgtttagcattgaatctctgaaggctctatgaaaggaatagcatgatgtgctgttagaatcagatgttactgctaaaatttacatgttgtgatgtaaattgtgtagaaaaccattaaatcattcaaaataataaactatttttattagagaatgtatacttttagaaagctgtctccttatttaaataaaatagtgtttgtctgtagttcagtgttggggcaatcttgggggggattcttctctaatctttcagaaactttgtctgcgaacactctttaatggaccagatcaggatttgagcggaagaacgaatgtaactttaaggcaggaaagacaaattttattcttcataaagtgatgagcatataataattccaggcacatggcaatagaggccctctaaataaggaataaataacctcttagacaggtgggagattatgatcagagtaaaaggtaattacacattttatttccagaaagtcaggggtctataaattgacagtgattagagtaatactttttcacatttccaaagtttgcatgttaactttaaatgcttacaatcttagagtggtaggcaatgttttacactattgaccttatatagggaagggagggggtgcctgtggggttttaaagaattttcctttgcagaggcatttcatccttcatgaagccattcaggattttgaattgcatatgagtgcttggctcttccttctgttctagtgagtgtatgagaccttgcagtgagtttatcagcatactcaaaatttttttcctggaatttggagggatgggaggagggggtggggcttacttgttgtagctttttttttttttacagacttcacagagaatgcagttgtcttgacttcaggtctgtctgttctgttggcaagtaaatgcagtactgttctgatcccgctgctattagaatgcattgtgaaacgactggagtatgattaaaagttgtgttccccaatgcttggagtagtgattgttgaaggaaaaaatccagctgagtgataaaggctgagtgttgaggaaatttctgcagttttaagcagtcgtatttgtgattgaagctgagtacattttgctggtgtatttttaggtaaaatgctttttgttcatttctggtggtgggaggggactgaagcctttagtcttttccagatgcaaccttaaaatcagtgacaagaaacattccaaacaagcaacagtcttcaagaaattaaactggcaagtggaaatgtttaaacagttcagtgatctttagtgcattgtttatgtgtgggtttctctctcccctcccttggtcttaattcttacatgcaggaacactcagcagacacacgtatgcgaagggccagagaagccagacccagtaagaaaaaatagcctatttactttaaataaaccaaacattccattttaaatgtggggattgggaaccactagttctttcagatggtattcttcagactatagaaggagcttccagttgaattcaccagtggacaaaatgaggaaaacaggtgaacaagctttttctgtatttacatacaaagtcagatcagttatgggacaatagtattgaatagatttcagctttatgctggagtaactggcatgtgagcaaactgtgttggcgtgggggtggaggggtgaggtgggcgctaagcctttttttaagatttttcaggtacccctcactaaaggcaccgaaggcttaaagtaggacaaccatggagccttcctgtggcaggagagacaacaaagcgctattatcctaaggtcaagagaagtgtcagcctcacctgatttttattagtaatgaggacttgcctcaactccctctttctggagtgaagcatccgaaggaatgcttgaagtacccctgggcttctcttaacatttaagcaagctgtttttatagcagctcttaataataaagcccaaatctcaagcggtgcttgaaggggagggaaagggggaaagcgggcaaccacttttccctagcttttccagaagcctgttaaaagcaaggtctccccacaagcaacttctctgccacatcgccaccccgtgccttttgatctagcacagacccttcacccctcacctcgatgcagccagtagcttggatccttgtgggcatgatccataatcggtttcaaggtaacgatggtgtcgaggtctttggtgggttgaactatgttagaaaaggccattaatttgcctgcaaattgttaacagaagggtattaaaaccacagctaagtagctctattataatacttatccagtgactaaaaccaacttaaaccagtaagtggagaaataacatgttcaagaactgtaatgctgggtgggaacatgtaacttgtagactggagaagataggcatttgagtggctgagagggcttttgggtgggaatgcaaaaattctctgctaagactttttcaggtgaacataacagacttggccaagctagcatcttagcggaagctgatctccaatgctcttcagtagggtcatgaaggtttttcttttcctgagaaaacaacacgtattgttttctcaggttttgctttttggcctttttctagcttaaaaaaaaaaaaagcaaaagatgctggtggttggcactcctggtttccaggacggggttcaaatccctgcggcgtctttgctttgactactaatctgtcttcaggactctttctgtatttctccttttctctgcaggtgctagttcttggagttttggggaggtgggaggtaacagcacaatatctttgaactatatacatccttgatgtataatttgtcaggagcttgacttgattgtatattcatatttacacgagaacctaatataactgccttgtctttttcaggtaatagcctgcagctggtgttttgagaagccctactgctgaaaacttaacaattttgtgtaataaaaatggagaagctctaaattgttgtggttcttttgtgaataaaaaaatcttgattggggaaaaaa(SEQ ID NO:145)
mouse-Malat1
caggcattcaggcagcgagagcagagcagcgtagagcagcacagctgagctcgtgaggcaggagactcagcccgaggaaatcgcagataagtttttaattaaaaagattgagcagtaaaaagaattagaactctaaacttaagctaatagagtagcttatcgaaatattacttagtcttaataatctaagaagatcttaagagataacatgaaggcttatttaaacagtttgaaaaaggaaatgaggagaaaagtatttgtactgtataatggaggctgaccagagcagtttaggagattgtaaagggaggttttgtgaagttctaaaaggttctagtttgaaggtcggccttgtagattaaaacgaaggttacctaaatagaatctaagtggcatttaaaacagtaaagttgtagagaatagtttgaaaatgaggtgtagttttaaaagattgagaaaagtaggttaagttgacggccgttataaaaatccttcgactggcgcatgtacgtttgaaggcatgagttggaaacagggaagatggaagtgttaggctagccgggcgatggtggcgcacgcctttaatcctagcacttgggaggcagaggcaggcggatttctgagttcgaggccagcctggtctacagagtgagttccaggacagccagggctacacagagaaaccctgtcttgaaaaaacaaaaaggttaggctagtatttggagaaagaagattagaaaatggaagtgaaagacgaagaagacatacaggaaggtgaagaaaaagctgttagagaagataggaaaatagaagacaaagcatctttagaagacagaaaaggtacttaaaggcacaggtagtaggaagccgaagaatagaagatagaaagaagcaagatagaaaaacaaaatggaagttaagacaactttggatgccagcattcaagataggcaaagaagataagattgaggccaaaaggttggataagatataaagtcagaaggaaattatctttaaagccataagttcaaatttctgatggagcgagcagtttagaagagtctttagacagccacatacaagattgaagctagcaatcaaagctactaggactgaagtaaaaagttaaggcagaatgcctttgaagagttagaagaatattaaaagccttaacttgtagcttaattttgcttgatgacaaaaggacttttgataacagtttcaagattgtcagcattttgcattggacttgagctgaggtgcttttaaaatcctaacgactagcattggcagctgacccaggtctacacagaagtgcattcagtgaactaggaagacaggagcggcagacaggagtcccgaagccagtttggtgaagctaggaaggactgaggagccagcagcagcagtgcatggtgaagatagcccaggaaagagtgcggttcggtggaggaagctaggaagaaggagccatacggatgtggtggtgaagctgggaaagggttccaggatggtggagcgagagcgagttggtgatgaagctagctggcggcttggcttgtcaactgcgcggaggaggcgagcaggcattgtggagaggatagatagcggctcctagaccagcatgccagtgtgcaagaaaggctgcagggagagcatgcggtgcggtaacattccttgaggtcggcaacatggtggtggttttctgtaacttggatggtaacttgtttactttgtcttaatagttatgggggagttgtaggcttctgtgtaaagagatatatctggggctgtatgtaggcctttgcgggtgttgtaggtttttctttttcagggttatgtcctcttgcatcttgtcagaagcttttgagggctgactgccaaggcccagaaagaagaatggtagatggcaagttgtctttaaccgctcagaggggaatgaatggtagagccagcacaacctcccagttttgtaagacgttgtagtttgaacagatgacctaccacaagcctcactcctgtgtaggggaggtaattgggcaaagtgcttttgggggaatgggggcaaaatatattttgagttcttttccccttaggtctgtctagaatcctaaaggcagatgactcaagggaaccagaaaaaaggaaatccactctcaggataagcagagctcgccaggtttacagtttgtaggaagtagaggatggatgctagctttcacactgagtgtggaggagctggccatggcggaattgctggtagtttactctttccccctcccttaatgagatttgtaaaatcctaaacacttttacttgaaatatttgggagtggtcttaacagggaggagtgggtgggggaaacgttttttttctaagattttccacagatgctatagttgtgttgacacactgggttagagaaggcgtgtactgctatgctgttggcacgacaccttcagggactggagctgccttttgtccttggaagagttttcccagttgccgctgaagtcagcacagtgcggctttggttcacagtcacctcaggagaacctcaggagcttggctaggccagaggttgaagttaagttttacagcaccgtgatttaaaatatttcattaaaggggaggggtaaaacttagttggctgtggccttgtgtttgggtgggtgggggtgttaggtaattgtttagtttatgatttcagataatcataccagagaacttaaatatttggaaaaacaggaaatctcagctttcaagttggcaagtaactcccaatccagtttttgcttcttttttcctttttctttttttgaggcgggcagctaaggaaggttggttcctctgccggtccctcgaaagcgtagggcttgggggttggtctggtccactgggatgatgtgatgctacagtggggactcttctgaagctgttggatgaatatagattgtagtgtgtggttctcttttgaaatttttttcaggtgacttaatgtatcttaataactactataggaacaaaggaagtggctttaatgaccctgaaggaatttcttctggtgatagcttttatattatcaagtaagagatactatctcagttttgtataagcaagtctttttcctagtgtaggagaaatgattttccttgtgactaaacaagatgtaaaggtatgctttttttcttcttgtgcattgtatacttgtgtttatttgtaacttataatttaagaattatgataattcagcctgaatgtcttttagagggtgggcttttgttgatgagggaggggaaacctttttttttctgtagacctttttcagataacaccatctgagtcataaccagcctggcagtgtgatgacgtagatgcagagggagcagctccttggtgaatgagtgataagtaaaggcagaaaaaataatgtcatgtctccatggggaatgagcatgagccagagattgttcctactgatgaaaagctgcatatgcaaaaatttaagcaaatgaaagcaaccagtataaagttatggcaatacctttaaaagttatggcttatctaccaagctttatccacaaaagtaaagaattgatgaaaaacagtgaagatcaaatgttcatctcaaaactgcttttacaaaagcagaatagaaatgaagtgaaaatgctgcattaagcctggagtaaaaagaagctgagcttgttgagatgagtgggatcgagcggctgcgaggcggtgcagtgtgccaatgtttcgtttgcctcagacaggtttctcttcataagcagaagagttgcttcattccatctcggagcaggaaacagcagactgctgttgacagataagtgtaacttggatctgcagtattgcatgttagggatagataagtgccttttttctctttttccaaaaagacctgtagagctgttgaatgtttgcagctggcccctcttaggcagttcagaattttgagtagttttcccatccagcctcttaaaaattcctaagccttgcaccgatgggctttcatgatgggatagctaataggcttttgcatcgtaaacttcaacacaaaagcctacatgattaatgcctactttaattacattgcttacaagattaaggaatctttatcttgaagaccccatgaaagggatcattatgtgctgaaaattagatgttcatattgctaaaatttaaatgtgctccaatgtacttgtgcttaaaatcattaaattatacaaattaataaaatacttcactagagaatgtatgtatttagaaggctgtctccttatttaaataaagtcttgtttgttgtctgtagttagtgtgggcaattttggggggatgttcttctctaatcttttcagaaacttgacttcgaacacttaagtggaccagatcaggatttgagccagaagaccgaaattaactttaaggcaggaaagacaaattttattctccatgcagtgatgagcatttaataattgcaggcctggcatagaggccgtctaactaaggactaagtaccttaggcaggtgggagatgatggtcagagtaaaaggtaactacatattttgtttccagaaagtcaggggtctaatttgaccatggctaaacatctagggtaagacacttttcccccacatttccaaatatgcatgttgagtttaaatgcttacgatcatctcatccactttagccttttgtcacctcacttgagccacgagtggggtcaggcatgtgggtttaaagagttttcctttgcagagcctcatttcatccttcatggagctgctcaggactttgcatataagcgcttgcctctgtcttctgttctgctagtgagtgtgtgatgtgagaccttgcagtgagtttgtttttcctggaatgtggagggagggggggatggggcttacttgttctagctttttttttacagaccacacagaatgcaggtgtcttgacttcaggtcatgtctgttctttggcaagtaatatgtgcagtactgttccaatctgctgctattagaatgcattgtgacgcgactggagtatgattaaagaaagttgtgtttccccaagtgtttggagtagtggttgttggaggaaaagccatgagtaacaggctgagtgttgaggaaatggctctctgcagctttaagtaacccgtgtttgtgattggagccgagtccctttgctgtgctgccttaggtaaatgtttttgttcatttctggtgaggggggttgggagcactgaagcctttagtctcttccagattcaacttaaaatctgacaagaaataaatcagacaagcaacattcttgaagaaattttaactggcaagtggaaatgttttgaacagttccgtggtctttagtgcattatctttgtgtaggtgttctctctcccctcccttggtcttaattcttacatgcaggaacattgacaacagcagacatctatctattcaaggggccagagaatccagacccagtaaggaaaaatagcccatttactttaaatcgataagtgaagcagacatgccattttcagtgtggggattgggaagccctagttctttcagatgtacttcagactgtagaaggagcttccagttgaattgaaattcaccagtggacaaaatgaggacaacaggtgaacgagccttttcttgtttaagattagctactggtaatctagtgttgaatcctctccagcttcatgctggagcagctagcatgtgatgtaatgttggccttggggtggaggggtgaggtgggcgctaagcctttttttaagatttttcaggtacccctcactaaaggcactgaaggcttaatgtaggacagcggagccttcctgtgtggcaagaatcaagcaagcagtattgtatcgagaccaaagtggtatcatggtcggttttgattagcagtggggactaccctaccgtaacaccttgttggaattgaagcatccaaagaaaatacttgagaggccctgggcttgttttaacatctggaaaaaaggctgtttttatagcagcggttaccagcccaaacctcaagttgtgcttgcaggggagggaaaagggggaaagcgggcaaccagtttccccagcttttccagaatcctgttacaaggtctccccacaagtgatttctctgccacatcgccaccatgggcctttggcctaatcacagacccttcacccctcaccttgatgcagccagtagctggatccttgaggtcacgttgcatatcggtttcaaggtaaccatggtgccaaggtcctgtgggttgcaccagaaaaggccatcaattttccccttgcctgtaatttaacattaaaaccatagctaagatgttttatacatagcacctatgcagagtaaacaaaccagtatgggtatagtatgtttgataccagtgctgggtgggaatgtaggaagtcggatgaaaagcaagcctttgtaggaagttgttggggtgggattgcaaaaattctctgctaagactttttcaggtggacataacagacttggccaagctagcatcttagtggaagcagattcgtcagtagggttgtaaaggtttttcttttcctgagaaaacaaccttttgttttctcaggttttgctttttggcctttccctagctttaaaaaaaaaaaagcaaaagacgctggtggctggcactcctggtttccaggacggggttcaagtccctgcggtgtctttgcttgactcttatatcatgaggccattacatttttcttggagggttctaaaggctctgggtatggtagctgatatcactggaacactccccagcctcagtgttgaactcttgataattaactgcattgtctttcaggttatgcccaattcgtcttattacctctgagtcgacacacctcctactatttattgaatactttgattttatgaaataaaaactaaatatctctca(SEQ ID NO:146)
mouse-Dlx1as
agctcagagatgcaaaaagcctgcggcgctctggaggcgcctggtcctggggacctctttcctccactctgttctcagcataggaagatggggctggggaattctttttggttttctggttttgttttgctctggttttggtcggggttttgtatttttctattcttccttggttttattttttcctttttttcctttttttttttcttttgctttcctgtcattctcccagccaaaagccgccttcgacccttttgatttgatgtagcaaagagtgtgtgtccagattatctgaaatagacactgaagaagctacatagatggtcaagcagggcccggaagaagaccattcaggaaaaagtggtccaggactcggtggatgggctgccggcagaccggtgtggctcagacctggtgactttttggagaggtcgtagaatgaggacagcagacacacgaggaccttgacttcggcgcacagacagtgcaaaaaggagacaaagacggacagaatcaaaaaagagcgtatttccccctcctacgtatttgtttttcctgatagtctcacaaagatgagagtctggtccggtccagcgggttatcttgtggcactggctgtctccagtggctgtgcctgcgctttgaggccactctgctgttcaccgtggcccaaaccagattcgggctgaaaggtcgctgagtcagacttttaggggctccgagaagcagcaagccctctgccttcactgttcctttttcttttatttttagctccccacccccacccctgctcccgctcgtgggctcttctcctcctggcccagggcgtgcgaaaaggtggatgaacctggaggcgggaggggccgggccaagggagacgggcaggaagcgggtgagtgcgaactgataacctcacatcagttgaggctgctgcatagcttcttggtgcgctgagggataccatgatgtatagctggggacgtaggagccagcgctgctgccggagcccttcccagatgaggagttcggattccagccgggtggtaccggtggggagccggcagacaaggctctgccgttcgccagcgcgctgccctccagagctgccccgccttgcttcatcagcttcttgaacttggagcgtttgttctggaaccatatcttgacctgcaggatcgggcgacaacgtgactggactatgaccattgagcctacccaggtccaaggagaaaagggacgggtggacaacaatacccgccctccttgctttgggaaagctgacagctccaggacagaggggcagagaccaccgcctccccacaccccatgagggccaaaggccagaaaattgagccccaggtccagccgctgttggcaacttttagagcagctatcagagccgggaataagagaacaggggagagccaggccttggcttgcaaatgagacgatgccacctgggcgacgtttatggaagacctcatgcagcacaatgcaataacaataaagaaaatttaaaacctagataggaacggggtggggggcgggggcatttgttaaaattagatctcctttcctcgtaggactattggaagaggctacagcgtctttgttaaactctttagactcaaaccaattctcccccccacccccaacggtgtatttgctttccccagctccaacctaaatctagagacagactggccctcgttcgaatgcctaggaactgcccagggtcttagagaagtgcaggaagaaaaaagaaaaatctcactttttttttcccccttcttcttaaggatctggaacttgggaagtgaagggccagagggaaggatctgcctctgccacctcgcaagaagaaggaggtgggggaagcaggcttaggcccaggacctgagtgattagtggcacactttaaaggctaaggaagattaaatcccccttctattgttccagttgttcaggcacgtgtgacctcagaacctccaaacaaaacgtctggggaaatccttccagttccctgcctggtcagaagaccaggtagcctgcaggtcagagagtagggtccgagctagggcaaacagtttgagggaggaagaggagacgctgaaagtcagaggtggatacacacacacacacacacacacacacacacacacgggttggggggcggactgtgacacctagaaccagaggcccagcgaacaaaaaatgtgaagcctggggctggagcccagctcccgaggcttgtttggcagagcggccaggtacctgcgtctgtgtgagtcccaaggaggccgccagctccgccctctcaggcagagctaagtactgagtttgttggaacctccggttcaaagcctgcaactgcaaactggaataaattgtcctgggtttacggatctttttccctttgccgttaaagcgcacctcgccgccttccaccaccgtactcttctcggagtccgcccctggagggacaacagaagcagagacccttgttaatgctgcactgcctttagtgaggagggacgagaatgaatgtctatggatgggttggcagaagtagggtccggaaaagaacgttcaagaaaccctgaaagactgcgaaggtccctcaaggtccgagcgcacgtccctggctgctgcagacagaattgggtcgttcccaagagcgcagctattgcctttgcagagaaagtttgctattttttgcaggcggtagttgaggtttaattacccttaattgcatacattgtttatagcgctacgcaataaataattaccgag(SEQ ID NO:147)
human-Six3os
ttttttttatctttgcaactcttaatctcgctacctccccctcctctcttctctcttctccctctctctcctcttttctctaccgctgtctctgagacttcttcttccctttttcctaaagaagttgatccagaaattcgaaaagccctgggcagagttgttgaatgggatgtgcaattagagaggggattttgttgggaggcaagagggtcccccaggctccacatagtccaggtcggcaggcaaggaaagacggctgaccagcccagcgggcgcggtttgcacatggtttgcacgtcgggccgcctctttctgcctataattcagctgcctctctgaggagtggtggaggagctgcgggagccgagaagcccaagagccctctggacccagaaaagtcctacagatgcccactcctcaccacacaacagaaggagctctggtcctgcctgccagccccagagggcactcaaactttggaggccagccacccggatgaagtgaataaggcctgaaaattgcttgtttgctcgtattgtaaaataataataattaccattattatttttaaactgtctaatttctctagggaaagtaacatcgaaagcctaaaacagacgccaaaaggcccatagaacacagagggccctctctgcctctggccaccacagcccctaggccaggcatgggtatttattcttaggtatgttgcttttaagaagctgtaatcagcatcttgagccgggcctccctttgtgaggcttctgtaactatggaagtgtgatttacgcagatttgtcggggtcagagacgtctttccctgagcactgtgtatatttagacaggactcggtttggtgttaaaaagtgtatatgttgaatggattcacacacagtagccaacaatgaccacattgtcggcccgtgtacaacgcgtattgaaacgcagcgcccagacttcaactaatctgccctcaataaagctgaaataattatcctaa(SEQ ID NO:148)
mouse-Six3os
aaaaccctcgccactcatgaagaactgaggcaaaaggatcacagatgctgctcggggccagccctatactccctccagtgcctggtctccggtggacccgcggggctctgcagttctctggcggccgcgccttgtaagcgctaagccgggaggagggcgcaggcagggcgcacagctctgagcgcgaccctacccggctcgggcccgcagcaaccccgactgtccgagagcctctccccaagcaaggctctgcgccgccctctgagcccacctcctggccacaacgctgcctgcgcttctccagcccaggccggaagccctatgctgcctcccgaagccggactttctggaagcccatcttcgtatgctcaccagcccaccctcctacgctggtcagagtgagattgctaacctcaagaccccattcaatgccagctttcaactactgctgaagaccaatgtaggtcctggaatagaagaactgcagagtatccggagctggccgaccccagactgattctcaacaggtggctgggtagtgccccccaccctgtgttggtcgtgcgggacccatcgcacacagagaagccaccttacccctcacctcaccccgtcggccaaagactgaccacccgcgcccgagtgtggggaggggtgggaattccggatcacacacacacacacacacacacacacacaccagggtaggggaacagggaagatcttacctgcagaaaggtaagagaagccgggagcgtgtagcagcggcggataaatattcattaggaagtgtaagtcctttcaaagggctccgcgcgcgcgctctagctcctgtctctctttctctccctccctctgtcctccaggaaggcttcccctcctctagctatctcaacgcccccccccccttcctgcgaaataccgggtggatcctaggctagctaacctgttgggaagcctgaactgcggtagcgcctctgcagctagcagtttgctttcgctcctggggcgcgcgtccccccccatcccctcccctccttcctttcgcccagcccctcacccctcctaaatcactacatcattagctttattgggcggggggggggcgggtaacggagcagccagacgcacctctccatagaagggtgaatagttggtgccctgcgatgcaaccccaactccatctccacctcattctcacccatctgcacatcctcatccaatcttgcttctttttcttcgctctttccacctccacctccatcctgtgtcaacctaactccctcagcagccctcccacccgccgccgccaatccggatcacagattgggttgggagtgagattgcaaggctgttaggtccgaaggtcctgtgtgtcgaggttagaactcctccctggcgtgagtacggggtggttatcaagatctccttctccttcctgaccctgcaaggttaccaaacagcctggacttttgaatcagatctctggagcaagcattaagaactccagccacacagatctcagggcctggccctttcactcagccgcggaggctgcttgagggatggggagaggtgatttcactcagcgccaacgcgcaggaaaaactcatagacgacagtcggactaatactcgtcccttaagaatgcactacctgaagttagtcgcaagtcatcttcaatcgaggaaaggaaaaaaaaaatcctcacatctagaagcttcgccgaagccacttccaacagcacgcgaacatgttcgcgcacacccttctctgtgcacgccccaaagcctgctctctcgcgggcaggtgaaaatacaggctgcccaggccagaggagagaaggcggcggaggaatacatcgcttagggttgttgagaaactaggaataactgttttcaatactctgctctgctaccaggaccttaggtccctcttgggaccctgaaaagtggctttgccccacgatggggggtgggggggcagtgactctagctctggccctcctactgggagcttaaagttggggtgaagggtttaaggaggagccgagggggcgggccctgttagtttgcagttgtaagtgcagctgtgcctgggacaccaagaaggagagtctcgccccctaatgctcacggtgcttgcttagaggacccccgaggttaactaccggagcttctgctctctcctgagccccaggccaacacaggacgatggtggccgggatgccagccgggatgcctaaacacagtaagacttcagttgcctctcatttggctgttcagagctaatgtctaccagaggaggttttagaagtgggtcgcacccgtcctgaatccatcctgtgaggtggcagagggtcagagggtcactccttcttgttaaaggttagcataataagtattattattactagggtagaggaagatgtggaggaaaaaaaaagcctagggtgcctaggacactaaccaaccttacagcttacccaaagtccagaacctcccattgtacaccttctctccccaacacagatccctaaggtctcctcttcatctggcatgtgtgttcacagaaggtacagtgtgcgagaacacacttaggaaattttaggaacgctaaccacagtactggaggaataaagatgtgtcgaaggaatggatggaatgcatgaacacatacaccttgttgtccagatgcagacaaaagctaccatgtccgcttggagtgacgcccagacacgcacagagatgtacaggaagccaaggagagtgggatccaccagagtacagtacaagtacagagtacagtgcaagatgcccagtggccctggagaaaaaccttcgttgactcttctgtatggaaagtttctgaagaaagggccaaggaatgatctgccccagaggctgcctttaggctcccatacctgctctgtttggagacacccagaagaggccagtacagcaaagactctttttggtttggttatttctgttgcttgttgtctttttttcatcctttgcctgggaaattgtgctctggaatagggcttgagtagacagcacaggcctccagtagataacaagagattctcaatctccaatgaggacattccgttctaaggaagcttccagataggggaaagccctgttttgtcccccttttctcctctgagatctgaaaaaatagaaagaaaaaaaaagaaaaacaaaacaaatataaaaactatagcccaatcccatgtacatcaaataaatccacaaggaatatgctagatcaagctaaattatgtatttaactcattttcttttgtgagatactgagaagtcttcaacttcctctattccaggcagggatcgaggacctggcctggcagaggttccaccaccagggtttcccacagtggttctgggactaggcgtaaggtgtcctgacttgttttctctgtcacctcttctggggaactggggaactgtcccagacaatggctgccccagttccctctagaagagacagcccccacccccagaacccgttgccctccaacctcacctcattttctcttgagctcattctccgagctcttaaagtagtaggtgtgagtcttggaccatttctttaaaagaaacaactaaggaaagggagggaggggaggagggaggaggggagcgggaaggagagctacctcctagactaacgcgtccaggaaccactctctaaggagcaaaagagagcctgtgttgtaaagtagaagtgatcccccgacattgctgcagggcgccttgcaacagatgtaactgtccactgaagagacagagggtgggcatggggaagattttttttcctcccttttgtgaacagctcttacacttttccaagacacattgagttcctggacatttttgtgaatttgttcttgattgtgttttgaacaataaactgtgaaaatcaacttcaagcccacacaatcagaatctttcttgggagggcaggttctttcagcgctgtttttctccaggtcgcttttatcttacccccaatgggagtcacctgctgatgctcctcgggaggagactgtaactgaaagacggaagtgaatgcagacacagcatcctctgagccaaaccgttgctttggttccttctagcttaggatgccgaacactggctggctttgaacaccctctacttcgctaagaagtttagagcctttctcacaacaaaccacagcgttttagaactggaaatgtttcttctgattttccagtcttaggacaattttcgaactctaacttaaaaaaaaatttgtttatgggggtttagctagaacacttgtagcattcgcttctcaaggaaagatcaactgttttctcataaccccaactgctccacacacttcataggatataatgtattttctttacttatccttgtgccttctgcccaggacatagaactaggggcaaaactttggaggtctatgacctcttgatagcacctgtaattgttaggcttttgttcttgtgccttgtaaatctctcatgtacgtctatgaaaatatgcattgcatgggtgtgatcctatcaagttgtccacactttctcaacaaccactgatgagtgaaaccatttctattgcccagggcaaagggctaatcgccttgtgggtctagagttgtcataggataatatccggtgtgtgtgtgatatgacagttattactttcaagaataaattaaaataaccagatacccctttaatactttcctcaacagcgtcaatgctctagagatgggacctcgccttccaaggtgtcttcactatcacagggcccgggctctctgcctcagcccaaccctgggcttgcgctcagagaggaggtattccgacggaaaaaaatcccatacatttttaactacagtgattactaaattaatagcaggcaccaagacagatgtcaaaacgtcttgaaaatgtttatctgtgaataattgagaaggtagtgggacgcattatctgattgtgtaatgaaatatgtatgaggaacagctgtttgcagcagccccttccccttgccgccttagccagggcccttctctcgcaagctttcttctactttcttccacctttttcttccttctactttctagttcgctctcttcttccttaactgctcgcacggctttggctgcagtgaacccagagtcgcctggttctctgatgaaggttagccacaaggtttcctctaagccttgctggattggcgttccgtagtgggatgaggcttcgttgtctgctgttctggccatcgcgccttccggccaggctgcccgctgggtctccatggagtctgcggg(SEQ ID NO:149)
human-Evf2
atttcacacctggatgtgctcactcaaccaagaatatagagaaagagcttctgccctgagactcagaaaaatattctcctgtgctttggttcagtatagatttctaaaccctgatcattgcttaagagatattcactgaggacagagtcttgctctattgcccaggctgcaactggtgtgatctcggctcactacaacctctgcctcctgggttcaagcgattctcctgcctcaagctcccaagtagctgggattacaagcatgcaccaccatgcctggctaatttttgtatttttagtggagacggggtttcgccacattggccagggtggtcttgaactcctgacctcaagtgatccacctgccttggcctcccaaagtgctgggattataagcatgagccactgcacccagccttatactgaactttcaatgggttcaattccactaggagcataaaggccactgcatatgagttgtggaaagaagagattagaagaaggaagaacttgagatgagttcctcccttcaacattctgtctcctcctacctagcatcttctttcttttagtctttctagaatgtccatctgtttttggccattgcggagagagaagctgagctttaaaggagtaggagcttcaaaggcgtaggagcttcaaaattcttgtttcttcatgtttgatcacccttctaaacctgtcttctgttccttctgctattcttttttcttagagcataggaaaggggagcttttaaattaatacttaaagcatggaaaaaaagaacttgagaagaaagtaaaacaagggagatgaggctagtaaagtaaggaaaatgaagaggaagaggaggaagggttagcttctaaattccaagtcaaattgatatggaacaggcaagccgcttgtcttacttaaacttcagaaaaggatctgctgaaacttgatagaaatggaaagggaaatccttggggtggggaacctccaaacattagtaatgatattgaacaactcaaagtattgaggaaatctgcaggctacatgcctgaagattacccatgcagatagaccaaaaggattagaattatctgttgatattagtaatatttattgacatctagctagtattggtaattttaagttttagattaatttctttggtaatagctatgatatattttatagacaagaattatatctataggcttgctatcataggctcttttaatcagcattaatttagtctactgatttttagcacatttgaatcattcacttatgctaggtaactcattgcaaaataaaaagatgattcctgtatgtatggcagctatacattaaggaggagtctaccagaatatgaaaaagtcagctgacctaaatattgctgagacaaaggaaaacccactcccttggaggagcatgaccttttcctgtaattcttcccactgctgttgttgagctccttggatcctggctcctggacaccatcatcaagaagactttatggatgggctgtccacccactgagagaagaggagcatcagctacagtttctctctagattgccttcttcattttgagtaatgactgtcagcagggtcagattaaacacaaaacaactggacaattgcttggaggactaaactataagggcactaacatgtcaatagtaggctaacacatccatggaaaatatatttaccagctcttctctcagggaggattctgtgtggggttggaagtaatgatttgttaaattccttaggggtagaaagtagggcataatcagaatatagaggaatatgctgtttgacttcagggtttctgtttttcttactaggatatataaaacagggactctagctagattgtttatgaccacagagggtaggctgagtgctcccatgatcttcctgcttggttcttgcccatacagaggtcagcctttcctctaataaagattgaacaagtagtggtctgaggga(SEQ ID NO:150)
mouse-Evf2
gcttcaaattggatggcactgcagctggaggctttgttcagaattgatcctggggagctacgaacccaaagtttcacagtaggaagggggaaaaaagaaaagaaaacatttttcctaatgtaacaatgcgaatgctagaaaatgacaagactgatcggttttaaaccattctgaagactgactgagcgtggaagttgctcaacaaaaaagggaacggggatattgaaccagagagaaacctacgcccagaagaacatgtccctggattgctttcccactgctgtggagtgtcttgaacactggtccctggacaccaacttcaagaagacttcatggatggctgtccagtcttatgagccacagtttcccctctacattttcttcactccagcgaggctcttatcagggtcagatcagagatgaaccagctggacgacagattggagcgctgacctcttagagtgctaacagtgaacagtgtggggtcagatctatagaaagataataataagaaaacaccctatatgcaagggagagggatggttcataatttcttaaagattgaaatcaaggaacaatcaaaatatagaagaatgtggacgtgttttgctgcaggacttctgttttgtccccattggaatatgtattatggtattcctgttggatcaggactcaggggcaaggctaagcattccagtggtcctcctacttagctcttgtcctttcgtaagaaacaccaactcattagtctctatattacttctctgtactgtagatctgcattcttgatctgagagatattggcaatgacactcttgtatgataaagctcaatgataagagtacttcaaacccccttgaactttttgtttatacatcaagtggtgacattgtgtattgagctaattagatcaatggagtcacagggtgatactgaactcttttaaaatatttggctgaaacatgacattgtagttatttgtagaagagaacattatggaatatgaaaaacatcacagaacacagaactagcagcagaaactagcagcaggtagacatttttccttttccatagagctttcaaccaaatgtctctgtagaaaatagtggctatcgtgtatatatatagccacatagatgtccttgagtgtaccctgtagtcagtgggagagttcctactgccacagtcatggccatggctatgttctctaagcctacattttataaacactctgtgaatcttgactacttttctttagcaagcattgcaaagtcctgggatgtcagagaagtgcctggggttggcagggtttctagagaggaaattgttaaatgatttgaaccagaaaacaaacaggggatggggttcagaaccaacaattacctctattctatgtaggaaaccacaacatgaaatatgctgggcatggaaactttgataccttggtttttcattctttttaaaaattaatactaaagagctatgcgactgtaggcaagccatttcccatcccctgtgaatatctcccagatgactttaaatcccttctagttctgaaaggcttttaacatcagggcccaggctccagtggccagtttcaaaataccctcccttttgatgttaggttacataaacattgttcttttttagggagggtctcttttatcaacttttaaaaacacacatcaggttctctggtattaaaaagatgccatctctgagtcccctactatctgtgctgcctgcctttcctcctgttctttccttattcccatccctattgaacttgtgctatgcagtatgcatcaggtatgtgttagctttggggatacatgatagataaactggacacacagggtcttcccattctcttctggaattttctttggagggagcctcttgtatctagacagaccgtgctgtggtaccccagaggtaaccacctacaggcttcactctgcctaagcaattttgctgtgcactaagatacacattcaagtaactttagattaccacaataactttctccaggtatgaggaaaagagataatttacttctgagatgtgtataggatagccctccatcctgggaagaacagtgactactccctgcatcccgaccttgcccagggaaagctaatgtttctctgtgttatccctgtgacttgccacttctttaaaaaggaatgggcaaacaataaacagacaaaaatgttgtctgacctcattggaaatccttttaagaattaatcctttctatctccttcattatcaacaaatctattgaatacttatctctgagtccagggcatattttataatacataaaacaatggaatttcaaaattggagcactgacatacaatattggttttgagtatttttattatagggaatgactttagacattgcaatttatgacttaactgataaaatggatgactcttgactttcaattttcattttcagttcagtcgaggaatagcttcctccaggtaatgtctatactttcctatgactaagggctctaactatctctgttgcttttctttatgtaggcatatgttagtatttattttctatatgacaaatgtattaaagaaagcatgaaattaatgagataaacttttcagataggagtttagaaaatcaaggggccaagataaataaatgaaaaatcaacttaaataattaacatattccagatatattggaataaatgtttattgtacccttttggttttgtcttgggttatttttttcttatctcactgatttttttttctttcctttttagcttttttgtcttttttgatttttgttgttgcgtttctcctttttttttttcttgttgatgttgtttgtttgtttgtttgtttgttttttgagaaagaacagaaggttggttggatagggaggtggggaagatctatctggatggagttgggaggagggaaaatacacgatcaaaatatattttgtgatgggcagggcatagtggtacatgtctttaatctcagcactctggaggcagaggcaggtggatctctatgagatggaggctagcctgatatacaaagtgagaccagaacatagggctgcctcaaaaactttatatatatattaaaaatgtttgctttttgagacagtcacagataaccaaaactgatcttgtaatgatgtaaacatgtccagctaattttcaaatattgtagggcagcatttctccctttgtgcacacgtggagtcagcaaatccatataattctaaccattctggtgaaaaggagaacactcggccaagcatctcacacttccaagtgtgaagccttgtttgaaagctccgagtatctaaatagtagccctgtgaaaggtaaatttatgaatggtctggtgtgttcttattccagccattgaccttaaagcaacttatatatgttttctttatccttcaagagaaaagaaaaatcatatttttccaagcaattaaaattcttctgcttcaggtaggaagaaggaattaggagttatgtctccttgtatataattgcaagtttcatttttcttgttttaatgattgacagaaaactgataaactgagacatctccttattagggttgaatgtactctcttggtggccccattgctaatttgtttgactattttccatgatttcttactctgtaatggaaaggtttattaaatatgagggttgcaaagctttctgaatactaatgaacttatttgccaaaatttaaatgttcttcttgtcagtgaatgcctgtctcacttaacaggcaccaaattgaataatgaagaaaattagactctatcgtaccctcaagagaaatcgcgtgtgaattgtaatagaaaattgagggagaaaagggtcatattgtagcaataacactagataatttggattattttaaaaaaggatgaacttagggaagctcaggtcttttcaaagaaacacacatttggttaattcatgcaaaacgctggtttcccctcaacccaggtggtctatacctatcgccagtttacagaaaaaggaagccaggtggatggaaaacgtgtgccaagtttctgtgcttacaatccactaaactcattctcatatgaggactttatatacctgtgatggagtgggaaaatcaataacctggaaaaaatgagtaccattttccaaagaagttcaataaagagatggaatttgggaaactgctgcagttcttcctataagcataaaaaaaaaaaaaaaaa(SEQ ID NO:151)
human-lncRNA_N1
attccggcgtggagttctctgagttcggtggcacttgggatattccacttcagtgccatgggaagaaaatggtaagcaaaaagcaaaaggaataatgcaaaaaaaaaaaaaaaattataatgttgtggtatccaattgctcctgcttcagccttttatccaaagccttgagatggatctgcctcatccaggaagttttcctgcttcgttagagtatcttcgttttctttatcagacgctggctggcactccacgccagtgcacggctccatggaatgcctgctgttggacacttgcagagctctgccaccaagcaacctcctgcattggaaatcgggggactactccaggatcttatgcgtgcttgctgtttgaagctgcagaaaagtgaataatcaattaagtattgatttcttgtaagatttggtaaatttcaaaggcaagacaaagaggatggcttaaggaaacactgcagggacttggcgtaaattagacaactaacggaagcgcagaataaaataacacctcaactgaagatttccttggaagaattagcactagctattggaagacaatggtggatttaatcaaaacagcaggcatgcaagaattttacccgtgaaccagaaaaaggagctaattataaccacctttttaatggagctaatttgactgaatggatgcaaatgtgctttatttatggatgaagaagcaagccttactgcatgatcttgggatcatcggatctgctaagctttgcagctcctgttaccttcagtacattttttatttccggagaaggtatttgtatgtaaacaacaactaaccatgcaaaagattcatcggaacaatatactgtggtatatgagatataatcataattttgcagcctctcaggatttcctctaacttggaggttttgcaacctttgtgtgcaatgggttatggtaaacaataaatgaatgatgctaaa(SEQ IDNO:152)
human-lncRNA_N2
ggggagccgccggagggcagctggggctgcggaattttggaagcgcagaagttttctcctcctgtcctgtaactggttttcactcactcaactgagagatttctttgttgcaatgatggggtctaagataacacttctggaggctgcaggcgagaaacacagctgatatcatcttttattgtgtgttgttatttgcctagcattataaattaaggaggaatagtaacaaagagcttgaagacatgcacagctcacaggccccgggtggaggctggcgacatcagacagacagaaccaagacatctgaggggcaaccaggaggtgcgtgtggctgcagagcacacagacttgtctttggacaaaattgagaagaactcataaacttggcttcctcgcttctgctcctcagacgcgcgtggatgatttgaagatattagcctaacaagatggaagcaggtttaaaattttacataagaagttacctttttcagttgtgttgatgttcctttcagctggtcctatagtacccctcctcaggaatgtctccccagtgcaaggacaaagactgaagagactgctatattgatggactctcaagccaactatgaagttgaaacaaagaaagtgatcacctgaagacacctcctctgctaagaaacacccccaaattgtgcagcttctgccactagaactctcagaacaagagacaatcttttcaagaaacagaaaaactcaataatgacatctagattttcatgagccaagaactttcccttcctcatgtgtattcctctgtttgtacttaaattcatgtgacattcatttttttcctagtatggatatgcttattaatgcacttgtttcaaaatcccaaattgcacaaatgtgttaatattttaagaaacaaaatgaatcctacaaggagaatgatttttagccacacatagggttggatcttgagagtgacctacagaataaaagtacttttaaaataaagtagtcagaggctattcaaagggtaaaataatcatagtaccacattggtccacttgacactaaccaatcgatcatttttttttaatcaagaaagctagattctatcagataaaatcactgcttctaaagagtttaaatctagttagaaaaagttatagaaatgtttgcaaagataagtaacagatagagtcagtagaggataagatcaaaaacaaaaccaagcaaaagatgagttcaggggagtttgccatcaagttggcaaaactgacttacttagggaagaaagttataaaacaggaaaatatgagatgaaccttgagtgatgtggaagatttagataaatggaaaggaaggagaaaatggagttctttaggtggttgtaattggaggaggaaatgaatacacacatcttgttgacttaaacccagacattcagcagctctctatacatatctggaaaagactgcacagtcacctcctgtctctcaccccaggtattacttagaattattatcatatttcccttcctttaaagtaagtaagggtgattggtgacaatatggagaactatgatttttccattaacctaataataattggtatttattgagttctgttaagcattttacatattaactcacttaagcctttcaacagccttgcaaaataggtattattatccccattttacaggcaagaaaactgaggtttaagtaacttgccgaagtgccatatacagggctcacattcagtattgcagttgcaaagctcatgatctatagtgccaagttgcaatattgtagtcaatgtcacaattattacccctttttatattccttgatatttttccatggcaaacaattagctatttcatttaataatcacctaaaacttttcagtcttctgattaaaattacgctggagtgatagaatgtattttcatgatagaaattgggaaaaaaaatggggaatgaagtttatcagcatttcagacttgttttttttttttttttttgcaagactttgatgagattgttcacttttgtctatgtaaaatcccaaatccttgagaataaaaaagggggaggtttaagtcacttgttgcaatgccctttttaatagaggcaataaatctaaaggccataaatttagagtgacttacagaagatcgaactttggagtgtggcagagtaagggatggaaaccgggccctccagttcactatcagtagcttttgcactggtctgcccttcctaaattaagtatgcacttcaatttgatgagtggaaacagtctatctgggcagtaaccagggagctttgtgcctagtagattgcttctgttctgcacttctttggtttcccacctcaatgtaaaaaatagctagcaatgaagtccagaagttgtcaatggttcatccccagaagaatgcataatgtccaaagttgtatgtgtatgatgtcttcaatggtattaagttatttcaaattcttagttcacctacataaatcatttctaacaagcatcttcttaaccaactttatgcacagtgtatgtttgtaagtgcttctgcacgaatgtttatacatgactgtttccatagtacttatgtttttaaaaatattcagtcatttcctactataatcctcatgtatccatgtaactgactcaaaaatacttcagccacagaaagctaaaactgagcaaatctcattcttcttttccatcccctttgcatgtggctggcatttagtaatgattaataatatggccagctgaataacagaggtttgagacacaattctttctcaaaggagtcagctaagctgggtctacttatggacaaacatctaaatgtgtggaagtatctgatatttgacaatggtaaatttccacttagctagctagcattgtcagacttcaatctcctcatggctctggccgtcctgttttaagcatgataattgttggccacatctcacatagttctcattgagtgagttcataaataaacagggtttttttttttttttaaagagcagccaagcacaaagtgtgactttgttgacattttatgtgactttgtcatatgttcctaacccccaataaaagcaatgttgcatcaactgtgaa(SEQ ID NO:153)
统计分析：
由s.e.m.设置误差线，以非成对双尾t检验或单因素方差分析计算统计学显着性(p<0.05)。所有实验均随机制定，未使用统计学方法预确定样本量。假设数据分布正常但未经正式检验。数据收集和分析并未在盲实验条件下进行。
实施例
下面结合具体实施例，进一步阐述本公开内容。应理解，这些实施例仅用于举例说明本公开内容而不用于限制本公开内容的范围。
实施例1.敲低Pnky介导的胶质细胞向神经元转分化
为了研究CasRx敲低Pnky的效率，我们在293T细胞中分别转染对照组质粒和实验组质粒，Q-PCR结果表明在人类细胞中可以利用CasRx高效敲低Pnky的表达，Pnky敲低实验组的Pnky表达只有对照组的0.5％(图1A)。为了进一步在体内利用CasRx对Pnky进行编辑，我们构建了一套AAV表达系统，用胶质细胞特异性启动子GFAP来启动mCherry的表达，以特异性标记星形胶质细胞，同时用GFAP启动CasRx的表达，实现特异性在星形胶质细胞中表达CasRX(图1B)。在小鼠大脑中注射不同的AAV组合，对照组注射GFAP-mCherry+GFAP-CasRx，实验组注射GFAP-mCherry+GFAP-CasRx-gRNA(Pnky)，其中GFAP-mCherry标记星形胶质细胞，在注射后1-2个月进行取材分析(图1C)。
实施例2.miRNA和lncRNA介导的胶质细胞向神经元转分化
为了在体内探究miRNA和lncRNA是否可以将胶质细胞转分化为神经元，我们构建了AAV系统，利用AAV-GFAP-mCherry标记胶质细胞，并利用胶质细胞特异性启动子GFAP启动miRNA/LncRNA的在胶质细胞中表达(图2A)。为了探究Tuna,Let-7b和miRNA-137的功能，我们分别构建了AAV-GFAP-Tuna，AAV-GFAP-Let-7b和AAV-GFAP-miRNA-137的AAV表达载体(图2B)。将AAV注射到小鼠脑部纹状体中，在注射后的1-2个月分析，并用神经元特异性标志物NeuN进行免疫荧光染色，GFAP-mCherry标记的胶质细胞转分化为神经元后会与NeuN共标(图2C)。在对照组中，注射了GFAP-mCherry后1个月的结果显示，胶质细胞依然保持着胶质细胞的典型特征，并且不与神经元特异性标志物NeuN共标(图2D)。而在GFAP-Tuna组，红色荧光标记的细胞已经明显具有神经元的形态，胞体变圆，同时具有一些较长的而且较细的突起，进一步用神经元特异性标志物NeuN进行染色，发现红色细胞与NeuN重叠，这表明这些红色的细胞已经从胶质细胞转分化为神经元(图2E)。与此类似，在GFAP-Let-7b组和GFAP-miRNA-137组有一部分红色细胞具有典型神经元形态，而且与神经元特异性标志物NeuN共标。与此同时我们在GFAP-Let-7b组和GFAP-miRNA-137组也观察到有一部分红色细胞依然保持胶质细胞形态，这表明有一部分胶质细胞转分化为神经元，有一部分细胞并未发生转分化，依然是星形胶质细胞(图2F和G)。
在本公开内容提及的所有文献都在本申请中引用作为参考，就如同每一篇文献被单独引用作为参考那样。此外应理解，在阅读了本公开内容的上述讲授内容之后，本领域技术人员可以对本公开内容作各种改动或修改，这些等价形式同样落于本申请所附权利要求书所限定的范围。
序列表
<110> 中国科学院脑科学与智能技术卓越创新中心
<120> 编码RNA介导的神经性疾病治疗
<160> 153
<170> SIPOSequenceListing 1.0
<210> 1
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 1
tgaggtagta ggttgtatag tt 22
<210> 2
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 2
ctatacaatc tactgtcttt c 21
<210> 3
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 3
ctatacaatc tactgtcttt c 21
<210> 4
<211> 80
<212> DNA
<213> 智人(Homo sapiens)
<400> 4
tgggatgagg tagtaggttg tatagtttta gggtcacacc caccactggg agataactat 60
acaatctact gtctttccta 80
<210> 5
<211> 72
<212> DNA
<213> 智人(Homo sapiens)
<400> 5
aggttgaggt agtaggttgt atagtttaga attacatcaa gggagataac tgtacagcct 60
cctagctttc ct 72
<210> 6
<211> 74
<212> DNA
<213> 智人(Homo sapiens)
<400> 6
gggtgaggta gtaggttgta tagtttgggg ctctgccctg ctatgggata actatacaat 60
ctactgtctt tcct 74
<210> 7
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 7
tgaggtagta ggttgtgtgg tt 22
<210> 8
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 8
ctatacaacc tactgccttc cc 22
<210> 9
<211> 83
<212> DNA
<213> 智人(Homo sapiens)
<400> 9
cggggtgagg tagtaggttg tgtggtttca gggcagtgat gttgcccctc ggaagataac 60
tatacaacct actgccttcc ctg 83
<210> 10
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 10
taaggtgcat ctagtgcaga tag 23
<210> 11
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 11
actgccctaa gtgctccttc tgg 23
<210> 12
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 12
taaggtgcat ctagtgcagt tag 23
<210> 13
<211> 71
<212> DNA
<213> 智人(Homo sapiens)
<400> 13
tgttctaagg tgcatctagt gcagatagtg aagtagatta gcatctactg ccctaagtgc 60
tccttctggc a 71
<210> 14
<211> 71
<212> DNA
<213> 智人(Homo sapiens)
<400> 14
tgtgttaagg tgcatctagt gcagttagtg aagcagctta gaatctactg ccctaaatgc 60
cccttctggc a 71
<210> 15
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 15
tggctcagtt cagcaggaac ag 22
<210> 16
<211> 68
<212> DNA
<213> 智人(Homo sapiens)
<400> 16
ctccggtgcc tactgagctg atatcagttc tcattttaca cactggctca gttcagcagg 60
aacaggag 68
<210> 17
<211> 73
<212> DNA
<213> 智人(Homo sapiens)
<400> 17
ctctgcctcc cgtgcctact gagctgaaac acagttggtt tgtgtacact ggctcagttc 60
agcaggaaca ggg 73
<210> 18
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 18
tggcagtgtc ttagctggtt gt 22
<210> 19
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 19
caatcagcaa gtatactgcc ct 22
<210> 20
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 20
ggccagctgt gagtgtttct ttggcagtgt cttagctggt tgttgtgagc aatagtaagg 60
aagcaatcag caagtatact gccctagaag tgctgcacgt tgtggggccc 110
<210> 21
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 21
agggacggga cgcggtgcag tg 22
<210> 22
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 22
tattgcactc gtcccggcct cc 22
<210> 23
<211> 96
<212> DNA
<213> 智人(Homo sapiens)
<400> 23
cgggccccgg gcgggcggga gggacgggac gcggtgcagt gttgtttttt cccccgccaa 60
tattgcactc gtcccggcct ccggcccccc cggccc 96
<210> 24
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 24
tttggcacta gcacattttt gct 23
<210> 25
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 25
aatcatgtgc agtgccaata tg 22
<210> 26
<211> 78
<212> DNA
<213> 智人(Homo sapiens)
<400> 26
tggccgattt tggcactagc acatttttgc ttgtgtctct ccgctctgag caatcatgtg 60
cagtgccaat atgggaaa 78
<210> 27
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 27
aaaagtgctt acagtgcagg tag 23
<210> 28
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 28
ctgcaatgta agcacttctt ac 22
<210> 29
<211> 81
<212> DNA
<213> 智人(Homo sapiens)
<400> 29
ccttggccat gtaaaagtgc ttacagtgca ggtagctttt tgagatctac tgcaatgtaa 60
gcacttctta cattaccatg g 81
<210> 30
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 30
cggggccgta gcactgtctg aga 23
<210> 31
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 31
tcacagtgaa ccggtctctt t 21
<210> 32
<211> 82
<212> DNA
<213> 智人(Homo sapiens)
<400> 32
tgagctgttg gattcggggc cgtagcactg tctgagaggt ttacatttct cacagtgaac 60
cggtctcttt ttcagctgct tc 82
<210> 33
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 33
tgtgactggt tgaccagagg gg 22
<210> 34
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 34
cctgtgggcc acctagtcac caa 23
<210> 35
<211> 73
<212> DNA
<213> 智人(Homo sapiens)
<400> 35
cagggtgtgt gactggttga ccagaggggc atgcactgtg ttcaccctgt gggccaccta 60
gtcaccaacc ctc 73
<210> 36
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 36
tatggctttt tattcctatg tga 23
<210> 37
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 37
tatagggatt ggagccgtgg cg 22
<210> 38
<211> 90
<212> DNA
<213> 智人(Homo sapiens)
<400> 38
aggcctcgct gttctctatg gctttttatt cctatgtgat tctactgctc actcatatag 60
ggattggagc cgtggcgcac ggcggggaca 90
<210> 39
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 39
acgggtattc ttgggtggat aat 23
<210> 40
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 40
ttattgctta agaatacgcg tag 23
<210> 41
<211> 102
<212> DNA
<213> 智人(Homo sapiens)
<400> 41
ggtcctctga ctctcttcgg tgacgggtat tcttgggtgg ataatacgga ttacgttgtt 60
attgcttaag aatacgcgta gtcgaggaga gtaccagcgg ca 102
<210> 42
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 42
catcttccag tacagtgttg ga 22
<210> 43
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 43
taacactgtc tggtaaagat gg 22
<210> 44
<211> 95
<212> DNA
<213> 智人(Homo sapiens)
<400> 44
cggccggccc tgggtccatc ttccagtaca gtgttggatg gtctaattgt gaagctccta 60
acactgtctg gtaaagatgg ctcccgggtg ggttc 95
<210> 45
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 45
ggtgcagtgc tgcatctctg gt 22
<210> 46
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 46
tgagatgaag cactgtagct c 21
<210> 47
<211> 106
<212> DNA
<213> 智人(Homo sapiens)
<400> 47
gcgcagcgcc ctgtctccca gcctgaggtg cagtgctgca tctctggtca gttgggagtc 60
tgagatgaag cactgtagct caggaagaga gaagttgttc tgcagc 106
<210> 48
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 48
ccttatcact tttccagccc agc 23
<210> 49
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 49
tggacggaga actgataagg gt 22
<210> 50
<211> 84
<212> DNA
<213> 智人(Homo sapiens)
<400> 50
ccagtcacgt ccccttatca cttttccagc ccagctttgt gactgtaagt gttggacgga 60
gaactgataa gggtaggtga ttga 84
<210> 51
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 51
catcttaccg gacagtgctg ga 22
<210> 52
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 52
catcttactg ggcagcattg ga 22
<210> 53
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 53
cgtcttaccc agcagtgttt gg 22
<210> 54
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 54
taacactgtc tggtaacgat gt 22
<210> 55
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 55
taatactgcc tggtaatgat ga 22
<210> 56
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 56
taatactgcc gggtaatgat gga 23
<210> 57
<211> 90
<212> DNA
<213> 智人(Homo sapiens)
<400> 57
ccgggcccct gtgagcatct taccggacag tgctggattt cccagcttga ctctaacact 60
gtctggtaac gatgttcaaa ggtgacccgc 90
<210> 58
<211> 95
<212> DNA
<213> 智人(Homo sapiens)
<400> 58
ccagctcggg cagccgtggc catcttactg ggcagcattg gatggagtca ggtctctaat 60
actgcctggt aatgatgacg gcggagccct gcacg 95
<210> 59
<211> 68
<212> DNA
<213> 智人(Homo sapiens)
<400> 59
ccctcgtctt acccagcagt gtttgggtgc ggttgggagt ctctaatact gccgggtaat 60
gatggagg 68
<210> 60
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 60
ttgtgcttga tctaaccatg t 21
<210> 61
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 61
atggttccgt caagcaccat gg 22
<210> 62
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 62
catggttctg tcaagcaccg cg 22
<210> 63
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 63
gtgataatgt agcgagattt tctgttgtgc ttgatctaac catgtggttg cgaggtatga 60
gtaaaacatg gttccgtcaa gcaccatgga acgtcacgca gctttctaca 110
<210> 64
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 64
gaccagtcgc tgcggggctt tcctttgtgc ttgatctaac catgtggtgg aacgatggaa 60
acggaacatg gttctgtcaa gcaccgcgga aagcaccgtg ctctcctgca 110
<210> 65
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 65
tgattgtcca aacgcaattc t 21
<210> 66
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 66
agagttgagt ctggacgtcc cg 22
<210> 67
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 67
tgattgtcca aacgcaattc t 21
<210> 68
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 68
agaattgtgg ctggacatct gt 22
<210> 69
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 69
ccgccccggg ccgcggctcc tgattgtcca aacgcaattc tcgagtctat ggctccggcc 60
gagagttgag tctggacgtc ccgagccgcc gcccccaaac ctcgagcggg 110
<210> 70
<211> 97
<212> DNA
<213> 智人(Homo sapiens)
<400> 70
actcaggggc ttcgccactg attgtccaaa cgcaattctt gtacgagtct gcggccaacc 60
gagaattgtg gctggacatc tgtggctgag ctccggg 97
<210> 71
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 71
gtcttaccag acatggttag a 21
<210> 72
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 72
taatactgtc tggtaaaacc gt 22
<210> 73
<211> 83
<212> DNA
<213> 智人(Homo sapiens)
<400> 73
cgccggccga tgggcgtctt accagacatg gttagacctg gccctctgtc taatactgtc 60
tggtaaaacc gtccatccgc tgc 83
<210> 74
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 74
acttaaacgt ggatgtactt gct 23
<210> 75
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 75
taagtgcttc catgttttgg tga 23
<210> 76
<211> 69
<212> DNA
<213> 智人(Homo sapiens)
<400> 76
ccaccactta aacgtggatg tacttgcttt gaaactaaag aagtaagtgc ttccatgttt 60
tggtgatgg 69
<210> 77
<211> 24
<212> DNA
<213> 智人(Homo sapiens)
<400> 77
tggaagacta gtgattttgt tgtt 24
<210> 78
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 78
caacaaatca cagtctgcca ta 22
<210> 79
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 79
ttggatgttg gcctagttct gtgtggaaga ctagtgattt tgttgttttt agataactaa 60
atcgacaaca aatcacagtc tgccatatgg cacaggccat gcctctacag 110
<210> 80
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 80
tagcagcaca taatggtttg tg 22
<210> 81
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 81
caggccatat tgtgctgcct ca 22
<210> 82
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 82
tagcagcaca tcatggttta ca 22
<210> 83
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 83
cgaatcatta tttgctgctc ta 22
<210> 84
<211> 83
<212> DNA
<213> 智人(Homo sapiens)
<400> 84
ccttggagta aagtagcagc acataatggt ttgtggattt tgaaaaggtg caggccatat 60
tgtgctgcct caaaaataca agg 83
<210> 85
<211> 98
<212> DNA
<213> 智人(Homo sapiens)
<400> 85
ttgaggcctt aaagtactgt agcagcacat catggtttac atgctacagt caagatgcga 60
atcattattt gctgctctag aaatttaagg aaattcat 98
<210> 86
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 86
ggggttcctg gggatgggat tt 22
<210> 87
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 87
atcacattgc cagggatttc c 21
<210> 88
<211> 73
<212> DNA
<213> 智人(Homo sapiens)
<400> 88
ggccggctgg ggttcctggg gatgggattt gcttcctgtc acaaatcaca ttgccaggga 60
tttccaaccg acc 73
<210> 89
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 89
aggcggagac ttgggcaatt g 21
<210> 90
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 90
cattgcactt gtctcggtct ga 22
<210> 91
<211> 84
<212> DNA
<213> 智人(Homo sapiens)
<400> 91
ggccagtgtt gagaggcgga gacttgggca attgctggac gctgccctgg gcattgcact 60
tgtctcggtc tgacagtgcc ggcc 84
<210> 92
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 92
actgatttct tttggtgttc ag 22
<210> 93
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 93
tagcaccatc tgaaatcggt ta 22
<210> 94
<211> 64
<212> DNA
<213> 智人(Homo sapiens)
<400> 94
atgactgatt tcttttggtg ttcagagtca atataatttt ctagcaccat ctgaaatcgg 60
ttat 64
<210> 95
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 95
ctttttgcgg tctgggcttg c 21
<210> 96
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 96
aagcccttac cccaaaaagt at 22
<210> 97
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 97
ctttttgcgg tctgggcttg c 21
<210> 98
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 98
aagcccttac cccaaaaagc at 22
<210> 99
<211> 72
<212> DNA
<213> 智人(Homo sapiens)
<400> 99
ggatcttttt gcggtctggg cttgctgttc ctctcaacag tagtcaggaa gcccttaccc 60
caaaaagtat ct 72
<210> 100
<211> 90
<212> DNA
<213> 智人(Homo sapiens)
<400> 100
tgcccttcgc gaatcttttt gcggtctggg cttgctgtac ataactcaat agccggaagc 60
ccttacccca aaaagcattt gcggagggcg 90
<210> 101
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 101
acgggtattc ttgggtggat aat 23
<210> 102
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 102
ttattgctta agaatacgcg tag 23
<210> 103
<211> 102
<212> DNA
<213> 智人(Homo sapiens)
<400> 103
ggtcctctga ctctcttcgg tgacgggtat tcttgggtgg ataatacgga ttacgttgtt 60
attgcttaag aatacgcgta gtcgaggaga gtaccagcgg ca 102
<210> 104
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 104
agctggtgtt gtgaatcagg ccg 23
<210> 105
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 105
gctacttcac aacaccaggg cc 22
<210> 106
<211> 23
<212> DNA
<213> 智人(Homo sapiens)
<400> 106
agctggtgtt gtgaatcagg ccg 23
<210> 107
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 107
gctatttcac gacaccaggg tt 22
<210> 108
<211> 99
<212> DNA
<213> 智人(Homo sapiens)
<400> 108
ccctggcatg gtgtggtggg gcagctggtg ttgtgaatca ggccgttgcc aatcagagaa 60
cggctacttc acaacaccag ggccacacca cactacagg 99
<210> 109
<211> 84
<212> DNA
<213> 智人(Homo sapiens)
<400> 109
cgttgctgca gctggtgttg tgaatcaggc cgacgagcag cgcatcctct tacccggcta 60
tttcacgaca ccagggttgc atca 84
<210> 110
<211> 24
<212> DNA
<213> 智人(Homo sapiens)
<400> 110
ttaatgctaa tcgtgatagg ggtt 24
<210> 111
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 111
ctcctacata ttagcattaa ca 22
<210> 112
<211> 65
<212> DNA
<213> 智人(Homo sapiens)
<400> 112
ctgttaatgc taatcgtgat aggggttttt gcctccaact gactcctaca tattagcatt 60
aacag 65
<210> 113
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 113
tagcagcaca gaaatattgg c 21
<210> 114
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 114
ccaatattgg ctgtgctgct cc 22
<210> 115
<211> 87
<212> DNA
<213> 智人(Homo sapiens)
<400> 115
agcttccctg gctctagcag cacagaaata ttggcacagg gaagcgagtc tgccaatatt 60
ggctgtgctg ctccaggcag ggtggtg 87
<210> 116
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 116
tgcctgtcta cacttgctgt gc 22
<210> 117
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 117
acagcaggca cagacaggca gt 22
<210> 118
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 118
ggcctggctg gacagagttg tcatgtgtct gcctgtctac acttgctgtg cagaacatcc 60
gctcacctgt acagcaggca cagacaggca gtcacatgac aacccagcct 110
<210> 119
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 119
ctcagtagcc agtgtagatc ct 22
<210> 120
<211> 21
<212> DNA
<213> 智人(Homo sapiens)
<400> 120
agctacatct ggctactggg t 21
<210> 121
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 121
gctgctggaa ggtgtaggta ccctcaatgg ctcagtagcc agtgtagatc ctgtctttcg 60
taatcagcag ctacatctgg ctactgggtc tctgatggca tcttctagct 110
<210> 122
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 122
cgtgtatttg acaagctgag tt 22
<210> 123
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 123
tgtcagtttg tcaaataccc ca 22
<210> 124
<211> 110
<212> DNA
<213> 智人(Homo sapiens)
<400> 124
cctggcctcc tgcagtgcca cgctccgtgt atttgacaag ctgagttgga cactccatgt 60
ggtagagtgt cagtttgtca aataccccaa gtgcggcaca tgcttaccag 110
<210> 125
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 125
accgtggctt tcgattgtta ct 22
<210> 126
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 126
taacagtcta cagccatggt cg 22
<210> 127
<211> 101
<212> DNA
<213> 智人(Homo sapiens)
<400> 127
ccgcccccgc gtctccaggg caaccgtggc tttcgattgt tactgtggga actggaggta 60
acagtctaca gccatggtcg ccccgcagca cgcccacgcg c 101
<210> 128
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 128
agctggtaaa atggaaccaa at 22
<210> 129
<211> 22
<212> DNA
<213> 智人(Homo sapiens)
<400> 129
tttggtcccc ttcaaccagc tg 22
<210> 130
<211> 88
<212> DNA
<213> 智人(Homo sapiens)
<400> 130
acaatgcttt gctagagctg gtaaaatgga accaaatcgc ctcttcaatg gatttggtcc 60
ccttcaacca gctgtagcta tgcattga 88
<210> 131
<211> 1560
<212> DNA
<213> 智人(Homo sapiens)
<400> 131
aggcgccagg ggcccggttg gcgcgaacgc cgggttccga gcaccctggg cttccttgtc 60
tgcctcccag cgcggcacct cttcggggct cccgaaacct gagctctcgc tggttttagg 120
tccagactgg ggcctctcca ccggttcctc ccccgccccg ggctctgggg cccattcttt 180
gggctgaccc tgtcagggca gagtccgcgc gtctgcctgc cattctccgc ccgcataaaa 240
gcacgttgaa ggtgtctcgg gcagacacct ccaggttttg aatcagttta ttccctttca 300
ctgttcaaag cagctgttca aatacacagg ctgcttacgt tgacgtggag aggatttcaa 360
acaacgctaa aatgctttga actgacaagg tgtcttgata tctccctcac tccatccagc 420
acagctcctc gagatcactc gctaggacaa tggctgagca ggcgattcgt gcgggcctcg 480
ccacctcggg gcgcggactg cggggtgtcc taagcccctt ccgcaaggac aggatggagg 540
cacctgtaag gagatgctgg cgccacccca gcttctccca ggtccggagg aacctctact 600
cagtcaatac cctgagctgg acttgtctga agaaacggag ccgactccct cttgccgggg 660
tgcgctgagt ggaggggaaa catcctcgaa taacagaact acaccaaaaa gacacccatg 720
ttatctctca cactttcaca ctcctcgaga tagtgagccg gacctgggtc ttagtagcac 780
ccagtacctt gacacaaacc tcccaaattt ccacctgagt aacagttatg gggtcagtcc 840
atgcactgta acttgaactc taatttatta actatttcat ctagtaaaca cactcacacc 900
atatataaaa tagcatttat ttatttctat ataccaggag ttggcagaaa acccaccgtg 960
accactccca tacattgagc tggaggcaca caattactaa aacagaggtg aaatggtatt 1020
catttgatct taattttttc ttatttatgt agtcccagga taatagaaat caggaaacaa 1080
aagaaaacaa agaattttct gaggagatgg ccattggggg agtggaggta gcagctggtt 1140
taaacctaag taaaactaga aaaagaaact gctgtttcct ttttcttata tccaccttag 1200
aggatcatgt ttgaacgtcc ctactcctcc tcctcttttt aaaaagcctt gtctcagtca 1260
ttcattcctg tgcttcctgc tcttctgcta gaccccagca gctgtttgat ttggtgaggc 1320
ccccctccaa cctctgagtg gaacttcttt tctaagggcc tgcagaatgt caaaactgag 1380
gctctggctt cggagctaga gctttgaaca gccaatccac acaaaaaggc agctggctgc 1440
tttaatgaaa actgctataa agcttcaaga actttagcct tgggggatgc atttataagg 1500
aacatggaaa atgcatttcc aagttgctgg ttcttgggag agacataata aacatttacc 1560
<210> 132
<211> 2754
<212> DNA
<213> 智人(Homo sapiens)
<400> 132
aaaggtaccg gaataaaaat ttgactaaag tttgggataa attaatcggt ggcttgaaga 60
acagtagcac atttctgatt atgtaggctc cagccaggat ttaagttttg tgtcatgatt 120
gttttcatat ttctttgaca tctattgatt tggaggcagc tgcaagcctt tgtcacagga 180
gagaagagca gtcacaatat attagcttga tggcataact cgaaccggag aagcgagggg 240
agcctgagtg actggggcgc acatgacccc cctcctgggg cctttgggct caacccttac 300
ttttaacttg ttctaacagg aataatggag tagtactact aatgcatggt cagaaggggc 360
ttttctgtct agaacgcagg cggcgggagt tgcaccgcca cagcccggga gaccaaagag 420
tctccactcc ccgctcccgg cgcctcctcg ccgaccggag ccccgagccc agtgagccca 480
gccggtccca cgtcgagagg cgctgggttg ggagaagttc tgctggtcgt gggctcggcc 540
cccaggcgcc aggccgagtg cccacctcgg cttctttagg gggcctacag cgggcagccg 600
agcggctggc ggacccggag cttgggaggc gaccgccagg ctggtgcccg gcctgacccg 660
gcgttcgcgg ccgcccgctc gcccgccgcg ggccgggagc gtacaggagt gtgacgcaga 720
ttgtgaaaac agaagggagg gagttgggtc atttccttcg ctaatcatcg ccccctcctg 780
ctcctcctcc ccacccccat cccatcctcg ccgccaccca gcctcgaact ctcttccttg 840
ccagagtctg cctcactttg agccagtggc tgcactttat ggagaaaata tatgtgccca 900
tcactcaccc atctatttgc agcgtccatg gagcgcctcg gggaacacgc atggacaatt 960
aaacacaccc acttacggcg ggatgatgag gctttctgtt aaccacatgt gttcagaaat 1020
ggatacagcc ctaattttga cacggaatgc agctaatgca ccttgctata gatgtacgtc 1080
cgttggaaaa gtgtgtgatg ggcacctgat ctacaccaag agaacagggc tgtctgcaga 1140
agacccagcg gcctgacacc ttttcttgtt gccggggaag gaaagttttt cttttgattt 1200
gtcctctcac gatttttccc ttttcctttg cattacagtt tcagagagga atgtaaatat 1260
tttgactaga cctctgcagg ggccttttaa acaccaggca caatcatctg tggaatactg 1320
tagttcatac tttcaaaact tgggtgttaa agagtctgtc ttgctgagga aacccataga 1380
actagtggcg acctttcaac tccctatttg tgtgatgaaa tgaagtatgc cctagtgatt 1440
gtcgaatttt aaggacttgt tctgtcactg ctactttccg atcgtttgca gggaagaaaa 1500
atcaatcaaa cagacctttg atggggttgt ggcaaggtca catttcactg tgctccaggc 1560
ttacctcttc ttaacgcccc tccctgctgt ggagcgtgtg caggtagtat gcaaaactct 1620
agaaataata tttgaaaaaa ttaacacctt gtttatctct tctgtgtatt tgatataggg 1680
gtttctttct tttcctgttt tggtgtttaa tacaaggctg atatattgga acagaatgca 1740
gacttcaaag aaactaaaat taggaggcaa atagcgtcaa ggtttcctcg gtttctgtat 1800
gtagtacaaa tagtatagcg tcttttcatc caaaaagaag caaaaattgc caggaggcat 1860
aaagcatctc tgaatatccg ttttttttaa agaaacaaac atttcccaaa tattgatgta 1920
cgcatggttt tatagtctga aaatatttct aggcacaaat atggcataca aacattcgtt 1980
tcaactctgt cgttgttgtt aaaatgacag taaattatag tttattttaa gatacctccc 2040
tgttaatgtc agttgaggtt attttagggc ctggatgctc taggaagacc acctaaaatg 2100
tgtttatttc tctgcccaat tcacctatag tgtaaggagc attttatttt attttatttt 2160
attttatttt attttattat actttaagtt ttagggtaca tgtgcacaat gtgcaggttt 2220
gttacatgtg tatacttgtg ccatgttggt gtgatgcacc cattaactcg tcatttagca 2280
ttaggtatat ctcctaatgc tatccctccc ctccccccat cccacaacag tccccagagt 2340
gtcatgtaag gagcatttta aataaaatat tttgggcatc cttaagtcct tttttaaaaa 2400
tccaacattc tacaattgtg acaaataggc tgaaaaattt tgttttgttt ataccaaatt 2460
cattttaata aagcatttgc tgagatttta atacaacaaa tgccaacaaa atgcatcaga 2520
gtagaaaaaa gaaaatattt tcagaattgc ctataatatt gcttgtgatc ctaaattttt 2580
tgatgcaagg aacttgaatt tttcagctaa tattattctg ttttcttatt ctgtgtttct 2640
attagaacac tcacctatgc tctgcttccc ttgctgtctt cccatagctt atgtgtgcac 2700
tatgaatttc aataaatata aattactgct taaaagaaaa aaaaaaaaaa aaaa 2754
<210> 133
<211> 1052
<212> DNA
<213> 智人(Homo sapiens)
<400> 133
aaaagtttgc cggcttccgc agtgatggat caccgtttta gtggcattta aatccccggc 60
gctccgccgt ctaggtgacg cgcagtcgcc cccccaggca gcctaggcgg cggcagctgc 120
tgcggcgact gcaaaggccg atttggagtg ctggagcgaa gaagagcaaa agctgcgttc 180
tgcgcgcgcc cgactccgct gcccgccccg ccaggcctcc gggaggtggg ggctgggagg 240
cgtcccccgc tcccgccccc tccccaccgt tcaatgaaag atgaactggc gagaggacga 300
atcgcatcca ggagctgcgc agccctggcc gctgccggga cgccctgctc cgcgctgagc 360
ttggggccag aaaccagcca tagtccccac actccgccgc cgcagctgag atttagcgga 420
ggaaggggcg agggaaggta gggagcaaac ctatgaagaa acatcgcgtt gtcattggaa 480
cttccaagcc tttgctgtta agagccaggt tcttaaatca acccgcccca cacacatgtt 540
gcttacatgc tgcgttttct cacggtctgt tttgcctgaa cccatcaaca gctgggagat 600
taatcaacca cactgaaaat gtggagggat ttatggggga gggggttgaa atgtgggtgt 660
ttgaaacaaa agtgtataaa caaatgaatt gttgataact tagttattga cctggagact 720
ggtagcttat taaagaaact ccgtgttact cattcctgga gttgggggtt tctgtaggca 780
ctttatttct ccactttcaa gagcttgggc ttggcccaaa tcttagactg tccaattctg 840
cctctattac caatttaaat ctatggcttg aacctgtgca ctgaaaatca aatcctttaa 900
aaagaaagag gagaagaaga agcaaaaaag aaagaaaaaa cacttattag aagccctagt 960
cattttttgg ctttctgttt tgttgctgtc cattgaagac tttgaacatg ccgccttaat 1020
aaatgtatta aaattgaaaa aagaaaaaaa aa 1052
<210> 134
<211> 5206
<212> DNA
<213> 智人(Homo sapiens)
<400> 134
gagcgacgca gccgggacgg tagctgcggt gcggaccgga ggagccatct tgtctcgtcg 60
ccggggagtc aggcccctaa atcgaagaag ccctggcgcg ccctcccccc ctcccgggtc 120
tgatagcaga ctccttgaaa gcagggtcct tgtttagtgc atctttgccc acatacacca 180
caacatatca agatgcattt attaggaagg aggagtttag agagcaggct atcagaataa 240
ccactcatcc tgtgcctcct gattgctgag tgttcacctg gaccttctga ctaccttccc 300
tgtgctattc catcagccta cagacctggt acctggattt ttgcccgaga tgattcctac 360
caccttacta ctgacgaaga cacccattcc agtggaccac tgtgacccag gaggcattca 420
gccatcatga tgtggccttt acctccactc ctgtcttgtt ctacccagat tcagcacagc 480
cctttatagt gaagtcagag tcctcaagcc aaatagctaa agctgtttta tcacaacaaa 540
ggcctagttt gttccatgag tgtgcatttc atttcttcag ttaaagcctt cagagacaca 600
caataaattt ggaccagggg attttttagt tattaatgct ctctgaagaa aggcaacatc 660
tttttgagag cagcattgga ccacacccca caatctcaaa tgattgaaat tcatgaacat 720
ctaggatccc gtgaaggtca ctggaccctg ttttttctac ttcaaatcct gtagtagcct 780
actgaatgag aaaacatatt ctgacccatt gggatcaaat caaaggcaca gtgaactcct 840
catagcatct tctttggaat tactcaggaa ccagaacttt ttacacaaat gtaagaaatt 900
ctaccaagga gtccccttac ctaacagcat ctcacaaggc tgcaccagat tccagaaaag 960
gcttctcttg atacatcaag cattttgtga ccgacttatt cttagatcat tggttttcca 1020
aaggctttgt ggccatgaag ccctttgagt gaaaactgtg cagaagccca gagtaaaagt 1080
gaagctgctc tggatgaagt agtgaagcaa gagtaggggc ctgaatcctg ctacaactat 1140
cttcctttac caccgtggtg acacctaagg ggacttcctt acaacacctt gaactcttcc 1200
gaacacagtt tgaaaaccac tgccccagac agcaatatgt ttgacctgaa tggcattcca 1260
atcttttctg tacctccact cagcacagtt catgttcagt agatgctgaa cattcttaga 1320
aatactgtgt gtgaacttag aaaagtgcaa gaagacaggc atgtctttga ccccaggaat 1380
gatcatttgc tgaagatggt gtcaagtgaa cctagattaa cagccctcca ctccagatgg 1440
atatccagtg attcctagaa tgggatatag ccagagaaca attctatgca ccctacactg 1500
acagactccc ttaagcaaca ccagatgctc tactggtact tgaagtacat gactttgaag 1560
tcttgaccct ccatgaatac ctgaattatc agcaagcggg ttttgaagct ggtgcctcat 1620
tgaggccata ttagagcaac ttgtacattt gacctcttgt tatcagccat ggtactctac 1680
ttcgtgtgca agagataact atgaaagcca aattcaaata ctggcaacat ttcctaaagg 1740
ggctcaatat ctatcattcg tcttcttttc caaactacac atcactgtat gactcaacca 1800
gtagcagtta tattgcccct tggtttttat tcagtttaac tactgtttcc aagataaatg 1860
agctaataag ctttaaaaaa aaaaaaaaaa aaggctgaat tcttttttct tcatcactgg 1920
catatctgcc tattctccag aattattatg actattcagc tcactttaac agttgaactt 1980
caagcgacaa tctttgaaca ccccttctca tgtgatttaa aatgaaacca tttggaaaag 2040
tttcttctag ccagtaatag attttttttt taattgctct gccttgtgcc gagagatgtt 2100
cttttaagat gaatcttttg atgtctgata ccaccaaata taggtggtag ggagagttgg 2160
aggctggccc tttgagcagg ccattagctt acttgctggg catttccgat agcttattgc 2220
ctaccttttt gctggaaaca aactgatttg aaaaacaaaa tctatgaaga ctgcagctaa 2280
ggattttatc ggtagactta agagcttttg tccttgtgga tattttagtg gaaccacatc 2340
agtctcaata ctgtcatttt acactgactc agagcagctg acttcattcc ttgccatgat 2400
atatatttaa ggcaggcatt gtaacagaca taaagacaac ttatctgttt cagcaggaag 2460
gattcagttt atgaactctc agaccagatc atgttgaaca aggagacttt gatgtgtgtc 2520
atgagaaaac tcattcttta cttcccagtc aatttaaagg ccagctatcc tgagctactc 2580
gaatgaatgc actggttaaa cattggaaat agtttgttta tatccttgtc tctctctagg 2640
ccaattgtga ttacatgact cgactctaca tctcgtcaaa caaggcctag gtctggttgc 2700
tgtagactgc tcgccctcaa caaataaaat ctggttgact agcctccttg tatatacaac 2760
tattatttgt taagaagaaa ttatcgtcaa ttttctacta ccttccaatt gtcagctctt 2820
tttttcctct ctggtttttc ctatacttta cagaaaaaga cattgatcta tactgccatt 2880
ccctctaatc ctgccatact cagtcaaaag gaatgactta agatgaagat gatcatctgc 2940
tcgagtctaa aatatacatt gtatataaga attggtgatt agaaaagcaa aaaacctaaa 3000
acttaaatct aggagtctgt atactgtctc catgtctcca tgcctcagat ctcatctaaa 3060
tctttgaaca gcaccattca accaatctga ggccttgact tgcttgtaag atgattctca 3120
gagatcggct gagttaaaaa agatgacgac ttgattacca aagaaagtag ggccaacttt 3180
gacaaatctg gctctgctga ccctgtcact cccagatgta gcatagactc ctaaacagaa 3240
cctcaagtct gattgaggat aaggccttct cctgagctga aagttctttg gcagatgagc 3300
aagaaactga aagctgatgt acctgactgg ctctgtaaga tcagaaaact gtatccagaa 3360
taagccctat ggattaaccc ctgagtaccc agagtaaaaa ctaatttaca gaacttcctt 3420
attgatctgc tggttcttcc agatcatatt ctggctattg gtatggctgg cctttctgaa 3480
ggtaccctgc ttgtctattt tcctgactca gctcttgcct gcctttttca catgttgctg 3540
caattagact caccgtgagg actacagtca atttcagtct atcttgtgcc caatacaaca 3600
aggattttta atagtaacaa cccacacctc acccactagg actcaatgtt cacaacagga 3660
aggaccattg ctgcatactc cttgaccagc aacttttttg aagatatttt taagtgcaga 3720
gtaggcctct attcctgtat gtaattgttc attttcagca cctggaacct catctatcgg 3780
gtctggaagg aatacagcag ttcgaaagcc gcgtccattt ctctccttca gtagtgcaga 3840
aatgagtccg attcaccagt acacacagaa ctgtaccagt tcaacctagc aaaagaagaa 3900
aagtttccac tgtacttaaa atttacagct gactcaaatt gcctcacaga attatttgat 3960
gtagaaggct agttgtctta cttcagatca gcaggacagt tgggctctca gactcatgac 4020
cactgagttt gcttgtgttg aaactgtggt ttcatccaac atatgctatt ggacatgatt 4080
attattccat tcaaatggat tacagacttc ttgaggacag gacaaactta tctctcatgg 4140
tgttttttta gaatactttt ataaccaagg aagaaaccat gccagctgtt accattcaac 4200
ttcttaagca gagattaagc tttttcatat ctgttcttat cctggacatc agtagttttt 4260
aattgcccag catccgttcc atcttgtaac aactccctga tgtttcttaa aaccacctct 4320
tcctattttc agtctgtggt ttggacagtc tgacccaacc ttgagctttg tgggtgaaca 4380
tgtaattcag acctcatcaa tcagcaaatc catctgaact gtggaggaga agctctcttt 4440
actgagggtg ctttagcttt gtaggatgaa aacctcaaac taacagggcc taccatgtag 4500
agaatgaagc cagtgcaggg gaaagcagag ccaaaatatg gagagacttg aatcctgatg 4560
acagcgtttg tgcccctgga tccaaccgtg cctgaagcta gaatatcccc tggacttttc 4620
agttatgtga accaataaat accctttttt gcttaagtta ctttgagttg ggtttctgtt 4680
acttgaaatt gaatccacac taatatatct accaacattg agacttgaca gatccaagta 4740
tttattaagc tagaggtcat ggtcactgaa attactttcc aaagtggaag acaaaatgaa 4800
acaggaactg agggaatatt taagatccca cagaagcgta aaaatgacat ggtagaaagt 4860
aatagaaaac ctaaatgtct gtcattaaag gataggttaa ggtgtggttc agccatatag 4920
gaatatctcg tatctgttaa aatgaataaa gtacattcat tgtgtatgga aaaatggcca 4980
tgatacatta ggtgaaacaa gttattaata gaaaagtgta cagtgtgaac tcattttaaa 5040
atgtgtgtgc ttatgtttat aaatgcatag aaaggtctat tcacagcttt ctttgaacag 5100
tgtagatcac atgaaacttt caactttata catttctgta ttaatatttt acactaccca 5160
cattattttt aaactttatt ttaaataaag aatttttaaa attaaa 5206
<210> 135
<211> 2100
<212> DNA
<213> 智人(Homo sapiens)
<400> 135
atttcatttg tgattcggat gatgcagctc taggtggatt gactatgaaa ggcgctgaat 60
atcttcagga aaatgggttc catgagaagt gacatcctcc tcgaatcaaa agattctcag 120
gatgatggag tgagtgatgg aataggttgc caactgtagt tactccactc agcacagaat 180
ggctgcgggg aaatataatc agacatgccc aaagaagtct gcttagggtg aaacaaatac 240
ctttgaggtt taaatcagga aggagagact gtttctacag gtgtcataca aaaatcaata 300
ctgagccaag gattattgga tcccatagaa ccacggagac ttggtagtga aattcttcca 360
aagcattcca tccgtgcagg cagatggtgt tcctaggttt ggaaatataa atcccatggg 420
aagtcagctg aagaccattt tatgcatcac tcatcctgtt agagccctgt gctgttctgt 480
ctctctataa gactggctga aaccaccacg gttgtttaca atttatgctc taactttgga 540
tcacctagtt aatactctaa ctccgattat taccaaagac aatgttctat aaaagatatt 600
gtctattaga aggatgcttc tgcattatta ataaaatcac agggaaaatg caacattttg 660
gatgtcacat ctgataagtt ggcagttaaa gaacagaaac agcaataaga ctgcgtggct 720
acattttccc agtgccacca actgggattt aagctgacta acattttgaa agcccagccc 780
atttcattca cagcaggatg gcagtgggtg actgatcgta cccgccagct ggctaatgtc 840
ataattaaca aagttgctac tacatctgca aagtttaatc gaaaaatttg ccagtgatat 900
gatggccttg tcacagagat cacaagggac acggagttga cttttgctca aggtggaacg 960
acagagctgt gtaggcaaga tgagaaattg cgaacttgtt cggccaaagg attatctcct 1020
gagatgtgta gaaatgaact cttgtcagag tttcaaagga attaacgttt tttggtaaaa 1080
tgtgctaatg taaagagtga gaagattagt gatacataat gaaagcaatg cattctttca 1140
catggaaatg ggaatataat aaatgtcctg caggtgattg gggctgtagc aattttattg 1200
aagattaaag tttgattgac ctttgttagg gtgattaacc cttctgaaat taaaagccag 1260
agctgaatta ttctgctcaa tttaaatgca aacatcgagc aggtcgtatg tcattcaaat 1320
aataataaga agaaaatctt cctattttaa ttttcatttt tgcacttctg agtggtatgc 1380
tgctttagaa ggaccatagc tctcgcaaaa gcattctggt ggcagagaat atacaataac 1440
gttacagata attgggagca tataggaaga gtcccaagca ctactgcctg cattcgaaac 1500
atcaaaacca ccatcccaac aaaagcacgg agcatgaagc caatctctgt acactgaaaa 1560
tgcatgctcc caatagaaaa acaacctagg gatgtcctga aggggttagg aataaataac 1620
aatgacatct ctattctagt tcagtgccaa ccaccgaaat tgcatatcat atccatgtta 1680
aatctacatg atgtctcctg gaaatgcgtg ctttttggta cagttgctta tgaagcagtt 1740
tctaaaagtt gattatttct gatgtctgga atttcattct ccatgatctc tggcagtttc 1800
tgaatatatt cagtattttc attaagttca aaaatgctgt aggagaagct aacgaattat 1860
ttgcaatgcc atttaatggt ttagttttat ttttctctgt taaattttct aagccttggt 1920
gaaaagttgt gtattcacat ttcttcaaaa aactgtttcc atttttcata tcatgttaat 1980
tttgtttagt tctaagtcag tgaatatttt tagtcttagg tcccaccaca tagtgaatgt 2040
gtctgccttt tatgtatctg tgaactatta aaatgataat aaaggttctc ttccttccat 2100
<210> 136
<211> 2687
<212> DNA
<213> 小鼠(Mus musculus)
<400> 136
aggtacctat attctgcacg ggcttctggg caggcagcac taacactcag gagaaggtct 60
gcctctgtct gcgccttcct ggttcaatgc aggcagatga gtgtcacaga tgtaactgag 120
gcactgaata atcaacatat cggagccaat tcccaggacg gcaagagggg gaaccggcag 180
agatgactga ccctggagga caagagcatt cttctgacaa gttttagcat ggactatcct 240
caggaaaatg agatccagga agagtgacgc cctcctcgaa ctgaaagata ctcaggttga 300
tggagtcagg gacgaagtgg cttatcaaca acacaggatg tctgcaggga acagaactta 360
ttcagacatg gcccagattg tctgcccgtg gggactgagg gacctctgag ggttacatca 420
ggaaggaagg agaggctgtt tctacaggtg ccacagaaaa atcgatgctg agcctcggat 480
tattggatcc catagaaccg tggagacttg gcagtgaaat tcttccaaag gcaggcagag 540
gttttcctgg tttgggaagt ataaatcccg tgggaagtca actggaggac attttacgcg 600
tcactcatcc tattatgagc ctgctgctcc tccgtctctt gacaaggcca ccaactagaa 660
gggcacagaa ttgttcataa aacagctgaa tgtgaatgtc tttggattcc catttaatga 720
gggtgtctta atgagatgac tgaagagtac aaccgccaag gctgagatga tgcaaaggct 780
acgtgtgggt acagttcccg gtgcctgtgc acaccattca ttggcagcta aaggacagga 840
gcagcaataa ggcttcctgg ctacattttc atggtgccac caactgcgag ttaagctgac 900
aaacattttg agagctcggc ccatttcatt cccagcagga tggcaggagt taactaaaac 960
agaataaact aaaaattgtg ccttcattgc acatttgcac tgattatcag cactgaaaat 1020
ggctaagttc tgcttatcaa gagcgggtga ctgattgtcc ctgccagctg gctaatatca 1080
taattagcaa agttgctacc acatctgcaa agtttaatcg aaaaatttac cagtggtatg 1140
atggcattgt caccgcgatc ctgagggaat cagagtcgac ttctgcttca actggaatgg 1200
caaggctgta gagctgagat gagaaactgt aaacttgctc agccaaaggt tatgcttcac 1260
atcacccacc agggaggatc atctctcatg aaaactttca aatttgattt tgaaaattta 1320
ttcagaaaaa tttaagccac gctctttccc aacacaggaa ataatatgct ccagagaatc 1380
ctctaattca ccgaaaatgg acttggataa catttgggtt ctcatactac cacagtcctc 1440
ttgagaagga cagccaggct tgggtggcag tggtgaggaa ggttcctttc tgtcaaggga 1500
gctgatgcct taaagaagct atctccagat aaagggagat ctaaggaagg aagccaacga 1560
aagacaccat gtaccagaaa gccaagcagg attttgacat ttataaccat aatctctata 1620
aacaagatga attatggctg gggattcagt tagtaaatca acgaaaataa atcctggtaa 1680
ggtaatgata caattttatc attttttgtt gaaatctaac agtgtatagt atgctttgct 1740
gcaatcaaag acctgcagta ttttgtgtgc taaactccaa tgacccatca tttattttct 1800
ctttattcca cctacttacc tgtgataata accaaatagc ctcacatttc ccctttcaaa 1860
gttgtatctc aagaggaaag ctcactgacc ccacacatta gccctccagt agctccagct 1920
gagaagtact ctctcctcca tttttttcag tgcataattc aaagataacc caaataagaa 1980
cagaaagttg tgtgtcatag tcactggcat ctatccggtg cttctgaacc atgaaccaca 2040
tgacctgatt aaagaggttg ctgtgagtgt gttgtactct tcgtgaacta aattccatga 2100
tgacagaaaa caaacctgaa aacaagagtt atttcacaac tctagagctc cacagagtcg 2160
gctgcaattg gttgagttga ggtgaatttt cagtggacct ggatcagtgt agaagggcag 2220
gaacattggc ccagcacagc cccaggctgt gcagcattca atgtgacttg ggactggcct 2280
tcctggctct gccttgccgg tgaaacatgg attggaagct ttgaatgttg gaagaaataa 2340
acaagtcttg gttggagtcc cagtttcaat aaccacatat tttcaaacct agacaaatat 2400
tctggtctca tctcctcatt tggattactt caatcctcgg agagaacgga ataggactct 2460
gtatttcttt ggatgttcaa cacagtgttt aactaatggg tgctatttga aatattatcg 2520
tctattatca ttgctattct aataaggatg atacttgcta taaatattat tgagaaaaaa 2580
aacttggaag tgttcttgag caacataaac agtacaaaat gacagatatt aaacaccgtt 2640
cttttttgca cgtaaaacta tacaaataaa aatatagaaa agcttgc 2687
<210> 137
<211> 3347
<212> DNA
<213> 智人(Homo sapiens)
<400> 137
gtgctgctgg cgcccggccc ccgcggggtg cagctctgcg cgttctcatg ctgtctctct 60
ctctttccct ccgcgctgcc tctccgaggt cctcccgccg agccccggcg cggggcatga 120
ggagcccccg ggtgccgccc agagaccagc aggctgcgcg cacacctagc cagcggcaga 180
cggggacatg agcagcgcgc acggggtccc gcgcccggcg gccagcccta tccggcggcg 240
gccagcgggt caacgctgcc cgggagaatg aggcaggagc cggcggcagc ctcctttttt 300
tccttctcct cgccttcctg cggctccggc gctccgggtc cgggccgggc tgcggctctg 360
ctgcgtgccc cgcgcgcccc tcaaccgcct ccggatgcgc ttctcgatct cagcccgctg 420
tcgccttctc tctgaccctg gtcccttcca ctgcaggctg ttgctccggt gtctctgggc 480
tgctccacca cgtggtgcct gcccatcatg gcatccacca ccaggtggcc tttttcttgg 540
ttagcctggc aaggaagata aagacatttg caaccaagat ggtaatcact agtgaaaatg 600
atgaagacag aggaggtcaa gaaaaagaaa gtaaagagga gagtgtcttg gcaatgctgg 660
ggattatcgg gaccattctg aacctgattg tgatcatatt tgtctacata tacaccaccc 720
tgtgaatggc ccagagcgtc ctcagaggcc tcagaatggc caaagacgga agtcctgcgt 780
gtcggcgcat cactgaccag accctgcgag aacaagcagg cttgacccgc acataccacc 840
caatcaaatg caccttcaaa ctttacaaaa ggtcacacaa atagaccgat cctgctgcag 900
ggagcagaca ctaaagcaca atgattccaa caaaactcat tcacagcact aggaactcaa 960
cgtctttggc agggggccca gaagaatgct tggaagacca gcctctgaca ccatcagtga 1020
gcggatgggt gcagaaattc attattccag atcgctgaca gatatcacat atttgaaaag 1080
atgaataggg cggacatggc tcagatgtgt gtctcccagg acaagtgttt catcttcact 1140
tgacgagcta tttagtggaa aaaccacagg cgcagccctt tgacaggcat cccattcatc 1200
aaaagtgtct aactatttga tactggggag ataacttatt tttctttttt cattggcttg 1260
acatgtgtat ctgttcatgt caaggtttat aaatatatat ttttaataaa tgtgctctat 1320
tttttagcat gaaccaaata cttggagagg cactcccaga tccatagagc tttccttagt 1380
tttatctgct ttgtcccctc ctcccccaac tacagatgtt ctgttgtgga gccattctag 1440
tccttttgtc tcatcttgag tcttttacct tgcgcttttg ttctctctct ctcctctctc 1500
tctgcctctt tggtctgaag gacattttcc catactgtca gccatggttt tgggtgcatg 1560
ttttaagatt gtccattgag tggctttttg ttgttatctc ggagatataa aatgattgtg 1620
ggcatgcaga ccttagatgc accctatctt tactgagaat tatgcatgaa taagggctga 1680
gtgatagatc agcttaaaat taaaaggact acctttgagg aagaagagcg tggctatatt 1740
tgcagatgaa cttttgaaca gaatattcag cttcttaccg gcagcgttat tgtttcattc 1800
ttgtgaccat tcgtttatca gattttgatt ttagcggtca tgtaccgcga gagttgggaa 1860
gaacaagggg gaaagctcgg gattaggtgc attactcctt cctttgcaag atacctggga 1920
tcctcctcaa aagcgggtgg ggtataaatg acacaagaac tcccccagga gatctcatgg 1980
tgattcaggc tgtgaggaca gccctgtgac aggtgacttt tcagggacat gaggagggga 2040
tttaatgatt gccctaaagg acttctgtat ttttaaagcc cctggtttac acccacatga 2100
agctatttcc tctctggcag ggatggttgc ataaaaacaa attagctccc ttctggctcc 2160
ctgaaatggg cccttgcctg gctacagtgg catggcctta aagagagggt tagtattcct 2220
tctgccattg ccagctgtat tagtctgttt tcacactgct gaaaaagaca tccccaagac 2280
tgggcaattt acaaagaaag aggtttattg gacttacagt tccacgtggc tgaggaggcc 2340
tcacaattac ggtggaaggt gaaaggcacg tctcacatgg tggcagacaa gagaagtgaa 2400
catgtgcaag gagactccca tttttaaaac agatctcgtg agactttttc actatcatgc 2460
aaacagcatg ggaaacctgc ccccgtgatt cagttacctc ccaccgggtc cctcccacaa 2520
cacatgggta ttcaagatga gatttgggtg gggttacagc caaactctat caccagcctt 2580
gcccctgggc agaagcagca gcagtctgcc tggctggatt caaatgattc tgaggcttct 2640
atagtctatg cctgcagatc tctccctcac ccatgctata gtgtctgaaa ttccaccatt 2700
agagagtcat ttcttgggct ctgttaaatg gaccaggctc ttttataaag aaaatgcccc 2760
tgagcagctg gctctggcat tgatttatga tatcttctct tccctgccag aaggaaggaa 2820
gctaaggtgc atgtagggcg tactgtgtgc ccaggcactg tgccagatgc tttggatact 2880
tggagtcatt gaattcttgt agtaaccctg tgagagaggg agtcttttct ccacattgta 2940
gaagaaggaa aaagggctca gagaggtcaa gaaatgtccc tgagatcaca tggcttctag 3000
tggagtcaag atccaaaccc aatgtgtctg attccttagc ccttgggggt ccggaggctg 3060
ctgaacaaga aaggaggtgg agaggagaga aagctgcagg cataccaccg cacacccttc 3120
tccctcccct gtaaaaacaa ccctgggaac tccctggaca ctagcagaat atcatacact 3180
aaggataagg gatgagagga ggctggttag aaataaagca gtgtcagggg gaaggagcta 3240
ctcagtaggc tctgtgtgat tctagaaaga ctgtatgaaa attctgaaca gtgaacagaa 3300
taaacaataa aggtgcaatg gaaaaaaata aaaaaaaaaa aaaaaaa 3347
<210> 138
<211> 3302
<212> DNA
<213> 小鼠(Mus musculus)
<400> 138
tcattcccct ccttatccct cctcttctct ccccttccct ccccgccctt cccctctgcc 60
gcagcccagc tcctagcgcg tcagcgtggg cttcccggag cgagtcgcta ggtaacaggg 120
ctagctccgc agacccgggc cagggaagcc cgcgcgcgtc gtcagcatct gcgccgaggg 180
gcggggaacg cactgacact cccctatcgg agcctgcaga cccttcagct ggttctcagt 240
cccctccctg gatgccttaa gggtggctat tgccaccgcg gagttgcccc tcccctgcgg 300
ggaccccgac gtcgccgccc ccttctcctc ccacgctggt ccgcaccact ctccgcaccg 360
ccagccaccc tccgagatct tcccgccgag cccaggcgtg gggcatgagg agcccctggg 420
tgtcgcctgc agacaaccca gcctcgcgca cacctcgcca gtcgctgaca gggacatgaa 480
cagcatgatt gggttccggt gtccggcggc cagcctcagc cggaggcggc cagtgggtct 540
gcgctgtttg ggagaatgag gcaggaaccc acggcaacct ctctctcctc cttctcctcg 600
ccttcctctg gctcccgctc cccggacccg ggccgggctg tggctctgct gcgtgccctg 660
cgcgcccccc acctgcctcc ggatgctctt ctcggttagc ctggagagga agataaagac 720
atttgcaacc aagatggtaa tcacgagtgg aaacgatgaa gaccggggag gccaagagaa 780
agagagcaaa gaggagagcg tgttggccat gctgggcatc atcgggacca tcctgaacct 840
gatcgttatc atctttgtat acatatatac cactctatga aaggccccat tcagacctcg 900
gtggcctcag gatggccacg agacaagggt cctgtgcatc cgtctatcag cgaccacaca 960
ctgcgggggg accagcaggt ttgaagacca cacaatgctc catcaatgca ccttcgaact 1020
ttctgacggg tcacctgatg gacccgtcct tctgtgagga gcagacactc tgaagcacaa 1080
tgaatccagt gggactcctt caggccacaa ggaactccca caggggaccc agcgggatgc 1140
tggaaaggcc agccttctgc accggcggtg agcacgaggg tgaggaagtg cttcaccctg 1200
gagtgctgac cacatctcac actggaaaga ggatgcgtgg ggtagtcgca gctccgctga 1260
cctcctccca ggactggcaa gataaataag ctctaggtgc ggttcgttga caggcattgc 1320
attcatcaaa tgtttccagc tgtttgatat gggagataac ttatttttcc tttttcattg 1380
gcttgatatg tgtatctgtt catatcgagg tttataaatc tatattttta ataaatgtgc 1440
tctatttttt agcatgaacc aaatatttgg agaagcactt ctggacccat agctcttctt 1500
ggttttaatc gcttttgctc catcagctgc aagacgtctt tgtctgtagt catccggttg 1560
cctcagctca tctcaagcct tgtcgtacct caggttcttc ttccttccca tccctgcccc 1620
tcccttctct cctctctctt tcccctgtct ctcccttcca tctcttaatt cccctatcct 1680
tccccatctc cccacccccc atctcctctc tcccctcctc ctcacctctt gtctagagga 1740
cattttccca taataccagc tgtggtcttg gctggtgtgt gcttcaagat tgtcgagcgg 1800
cttttcattg ttctgtcaga gatataaacc gattgtgggc atgcagacct tagatgcacc 1860
ctgtctttat tgagaattat gcatgaacaa gggctgagtg gcaggccagc atctccagtt 1920
tttaaaggga ctaccaagga ggaagatgag cagccctgcc tgcaggccac ccttgggaca 1980
gagcagtcac cagctcaagt gcagtattgc ttatttgctc ctgtaaccat ccaattatca 2040
gattctgatt tatttattta tttatttatt tatttattta tttatttatt tatttttgtg 2100
accatgagag atggaaacgg ggcgagctcg atgttcagtg caccagccgt catcccttcc 2160
ttggtgagct gcctggggag gtggagggtg ggatctcttc agaagtcagt gggatatgag 2220
ggaagtgaga cctccccgct gtgagaatgc acacacagtt cctgctgtaa aaacactgct 2280
gggacgagtg acccttcaag ggcattggga ggggacttaa tggtctctgt taaggagccc 2340
tgcacatttt aaagctgttt ttccactcac acaaagctct ttttttctct gaggggatgg 2400
ttgaataaat acaaatttgc cctgctctct ggctccgtaa cacagcccca acctggatgc 2460
agtgtacagc tttaaggaga gggtccgcat tcattctgcc aagggcagaa gtggcagcag 2520
cccccccttt ggattcagat gacactaagg gggggcatgt ctcagcttgc ccccttcctt 2580
aaatggcacc atgaaggagt catttcttgg gcttcactaa gggaccagtc tcttttataa 2640
atcaaatacc catgagcacc tggctctgcc cagagatgtc tcctcttccc caccagaagg 2700
acagataccg tgtacacaag taaccaggct ttcatagttg ctggtgagag ggagagtctt 2760
tctctctcac ctgtgtggta gaaggaagaa gaaaggacag ctcggaccag gaatcttccc 2820
tgaggtttcc tggcacccag tggagtcaga ttctagcctc acctggccag ttccttatcc 2880
cagcgaggac ttggatgctg ttgtgggatg ctgatgagga tagtgactgt ggctggaaag 2940
cctgtcgctt tgctgaggat caacccagca cacacacaca cacacacaca cacacacaca 3000
caccacacca caccacacca caacaggaaa caaccttaga actccttgga cactggcaga 3060
atttgacaca aataaaagac agtagagagg ctggttagga aggtgggagg caccccgggg 3120
cgagcactac ctaccaggct gtgtgattct tgacaaactg taattctgca cagtggacta 3180
aacaaacaat aaaggtgcag tgggggaaac tattggtgtc gccaacttcc tcgtgagccc 3240
gtgtgtaatt gtttgattta ataaaacttg accgtggctg taaaaaaaaa aaaaaaaaaa 3300
aa 3302
<210> 139
<211> 3246
<212> DNA
<213> 智人(Homo sapiens)
<400> 139
gcgagtgcgt ccccaccagc ctggccgccg cgggaactcg gggaccggga gggcgggggt 60
tagcgggagg aaagggtaag ctgaagaggg gctgggaacg ggagggaggc tcggggcgaa 120
cgggccgtcg cgttcatttc cataagaaag ctgaaatcgc agttggaagc aggatttctc 180
gcccctgcag cccttccccc atacccggtt ttctgcaaga agcgggctcc agagctcaga 240
gcccgaagtg tgtgctctgg tctttgatga tgttgataaa atgtggtttc aaatgttgtc 300
ccgaagaggc cggtttcctg tctgtatgtg gaatggaagg accgtgccgg agttgtgttc 360
tcaccaccca ctttgtcggc ggaggagaaa cactgctgcc tgatgcttgc actgctgcac 420
tgttcttgca cctgctccta gccctgaact cgggccctga gctcctcact gccgcccgct 480
ctgcgctgag ccccactcct gagaccgcga ggtgccagag cagcgcctct cccaccaact 540
cctagacgcc tgtaggagct gcgccggagc cttcagaacc ccatgggggt gtgggggtga 600
agttggaggt catccgggtg atttttttct tactttttcc taattgttct cctgcgttga 660
tttcaactct tccagtctcc cggtgctggg gcgccaatcc tttcccaaca attcctaccc 720
accagctgga ggtcggggcc cagggttacc ccagagttct atggtggcag ggggcgccga 780
gtagaggggc gggaggagct gggtcctcgg gaaccaaagg ggacctcagc gggggcggag 840
tgcgcagcct tggctgctgg gaaatgccca actagccgct gtgagtgccc acagcgcgtc 900
gtgggggcgt ccgttctgca gctcgggtga ctcagacgcc ctgccaaccc caccagctcc 960
cggcttctcg aacgctcttc tgatcgccca gcggggagac ttcagggcct gcctcgtcag 1020
gccagattgc agcccgcgac cttcccggat taaccaaggg cggggcctgt tgcccagcaa 1080
ggctgctgcc taactgagcc tcccggggaa cagccatgac caaagccccg cgggcccagg 1140
cgcgggcacc tacccctacc cgctcaggcc tgtgggagcg caggggcaga ggccgagacg 1200
ctggacttcc agccccacac ctctgacaac ccgggcacgt ctgcggagcc cgggggaaca 1260
gtcagcgggc tctgcgtccc gggagctggg gacacgcctg caaggtgtgt gatcctttaa 1320
agatccttag tactagtttt gtagggagcc tttgttatag ctttgtcagc ctgcgcgcct 1380
tcagcagctc cccctcccgg gcccctcggt tccctccggg ctcgccccca gcggagaggg 1440
cccggcgcag gggatctgcc caggatcaac tgccctcttc cagatcccct tctgcgagat 1500
tcttttcctt tggttacaat ctcccctccg tgcctggggc agataaacac ggttcgcccc 1560
gcctgcagta ttggggcgat gctgtcctgg aagaacgggc tttctgaatg tgacctcggg 1620
atgctgcagc ggcgcaatgc tgctactgct gaatgagtag ctctcctgcc accgcagggc 1680
gactgcggtg ggcacagcag ggcgcacaga ggagggggta atctgcccac ccaggctaag 1740
gatttgaggg ttctgacaaa aaagagctgg ttgaggatga cacagttgtg aactaacctg 1800
gctcctacta ccccacaggg cagccaggtc ccagtagtct tgggtaccac tgcccccacc 1860
ataccaccat tgtaaagtat ggactcctgc ttagccaacg tgcagctcta ggcaggatct 1920
ctgaaggatg ctctggcaca cagatggtgc aggtatgact ttacctgcac acaagcttac 1980
atgtgccctg tcatatatgg ctacacgttt ccccatttcc ccacagtctt cctatttaac 2040
tggtcttcaa tcctcctttc tagggctttc cgcctgcaca cagtcatttg gagaaaatca 2100
agtgagtgca cttctcccca cagaggattc tgtatgttat gtaacacact cacactggga 2160
ttcctcaagt taccattttg ccccaactca gccagcactt ggttttctgg cgggggtgtc 2220
aggatgatgc aaatggaggt ggaagcttca ttccctgggg gcttttattc ccctccttga 2280
agccccagtt caaggcccag gaacaaaggg gaaaggtaac tgatctctct tttggtcttt 2340
ctctcccctc acttccaccc cttcacctgc aggccctcct ctttgataaa tagaggaaag 2400
cccgtgggat caggtacata tgtaaatact gctgacctcg gccgcccctc ctcaccgaaa 2460
agcagaaagc ccgtttcagg tgcaggctgc tccgtgcctt tgagtgtcca ccacttctat 2520
tcccccagac tgcttgggac tcaaggccac tcacttaata cccgtctctt gttaaaaaca 2580
ttcaggacaa ctattaaata gttattggaa gagttaaaga ccttctttca ggagtgaaac 2640
gtttttaaag ctgtgcttgg cataagtctt taaggcgtac aaagtagaat cagtagactt 2700
gcctgagcga ttttgaaatt tgaaagattt ctccccatga aatggtaatt taaaatagtt 2760
tgtagatgtt gttttgttct gtgatggctt tttcaccatt gtcacctaaa gattctcaag 2820
accaagctac taagacattt catttggtta gtttctgggt gatactgtgc tttctgatta 2880
gacctattta atttattttt aactctgcag gagagttttc aaccttggaa atgtaagtga 2940
aacacagact caccctcctt ctgagacctt gataggggca gaaaggaaca aatctggcta 3000
gcccccctca cacctggaag tttccctgtc taaacctggg tacaatgagc gtggtgggtt 3060
ttgtcacctt ttattttatt gctggctcaa ggaaaattct ttgaaatgaa catctattct 3120
atttcagtgt gcaatgttcc agccgactta atgggcttgc cttatgcgga gaggcagtcc 3180
tgcaggacag agctaatgtg tggtctccca ggaagctcat cagaacacct cttgtccctt 3240
ttcttt 3246
<210> 140
<211> 463
<212> DNA
<213> 小鼠(Mus musculus)
<400> 140
ctaggcgact ggtgtggatt ggtgttgatg agatgtggct tccagcgttg cccgactcag 60
acctgtttcc agtctggatg gagcggaccg actgtgtggg atggggtgag aggaacaagt 120
gaaactcaac agctaaggag aaaatgaaga actagtgcta cgttttccac gttctttttg 180
ctccggggtt gacatggcat ttggcctttc tacctggaga aaatcaagag tatgtaactt 240
tccctgcaga tggtctgtct gtaagagctg acacaggaac ctttgggagc cagtatctat 300
tttgtttccg actgcaaagt tccagccaat gatttggagg ggggccggca ccttctgctg 360
ggagctagtc tgggagggaa caactcattc ctgagttctc tttcgcaaac atatctcttg 420
tctattaaaa taatagtaat aaaaataaga ataataatta aaa 463
<210> 141
<211> 2190
<212> DNA
<213> 小鼠(Mus musculus)
<400> 141
tttgtttttt aaatcaagat tatagatttt ggggaggtga ctcaggagtt aagagcattt 60
gcaactctcc aaggaggctt ggattcagtt cctagtaccc acatggtggc tcacaatcat 120
ctataacttg agtttcagga aatccaatac tctcttctga cctctacata aaccaggcat 180
gcacatgatg cacataaata ttgtgcaggc aaacaccgtc ccccagacac tcaaaataca 240
taaaataaaa ataagtattt tttaaaagtt ggaatttggt atgattagct ttatagcttt 300
agctatttat attagtttta tggcaacttg acactaccca gagtcatttt ggaagaggga 360
acctcagttg agaaaaatcc tccaccatat tgatctatga gcaagccagt aagcagcact 420
ccttcatggc ctctgcatca gctcctgctt ccaggttcct gccctggttg agttcctgcc 480
ttgactttcc ctcagtgata gagtgttctt gggagtgtag atgaagtaaa ccctcgcctc 540
ctaaactgcc cttggtcatg atcttttatc atagcaatgg aacccctact taagacaatt 600
atctttgaag cacatatttt gacatttagg catatcaata aatgattgat ggttagtttc 660
ttaaaatgcc ccttgaccac aaagacagtg aattttctcc cttgctccct agcatagatt 720
ataggtctga gccatcagat ctggcttgag gttcaaagct tgtgaccacc tgttccaagg 780
acaaatgagc tgcctagaac tcttccactg gcctgcctgt agccgggaat ggtggagttc 840
cctgtgactg tgggattcta tatgagctac tgatgagaca taagcaagta aggaaagttg 900
atcttgggat caacactcat caagaataag atgggtcccc cactctctag ctgtgcttcc 960
agacaggttt gcttcagtgt ggcttcagca aagccttcct agtggtctac agtagagaat 1020
gcaagagtcc atccctagcc tgaacactgc acacagacac caattatgct aaaatattta 1080
atttcattcc ataaataatt aagcctaaat aataatacct agatataact tggaacttgt 1140
gacaatctac ctgcctctgt ctctgtgtac caggattata ggcctgggca cacattcttc 1200
ttcaggactg attataatac attttgtata ttgatttaaa aaaatgatgc ttaggtagtt 1260
atggcctgtg agtaattcta taaagtagac taagtggata tcatcagtct atactctaag 1320
acattccttt aattttttta aatttttttt taaagttcta ctttttaaag attcctagag 1380
agccagatgg gtgatgaaaa gccaggtttc acatgtaaca ctaatattgg gggaaaaaaa 1440
acctgacgct agaaattatt tagttattct gaaagctgtc acttcttgaa agcagagtca 1500
gaattagaaa agaattaaca gtgtatcgtt gtgttctcac atttccaatg tggctggtga 1560
atcatgaagc aaaaatttcc tcaaaactgg agccccagag tcttagtctg agcccatcct 1620
cctgcctgag aatctccaaa ttgcctagtg aaggaaaagc tatgtccatg gtcccacctg 1680
ttccaaagtc cctttggaaa tctaggcaga agtaggtttg ctagagtctt acttatgaca 1740
acctgggaaa caaagaaggc tcttcataca agggtgtgta tccacacaag aggcagcatc 1800
ctgaaggaaa ccttcaggag cctccgatcc tgcagttagc tgactgtttc ctgccctcct 1860
tggtccaact cgttatggcc ccaggtgttc cttcttgctg ctgaactgct gtctctacca 1920
gctgagccca ctcctgtggt ctgcactcac tgccctggct gcaggttgaa cagggtcagg 1980
ctacttctca gatgcttccc accagccgca gtgaactcca ttttgacatg aagccattta 2040
aatggaaatc cagttttaca aagctcaagt gactggtaat gaagatgtga atgatgctta 2100
tgaggttttt atttaatttt aaatcaattg tgtattctaa ttcattaata aaggggaaag 2160
gaaagaatac aggaaaaaaa aaaaaaaaaa 2190
<210> 142
<211> 10194
<212> DNA
<213> 智人(Homo sapiens)
<400> 142
cagctacaaa gacgacgccg gctgcgctcg cgggaccaga gggagggagg ctgcggacga 60
gtgcggggag gagtttgaga tgggaggcgc ttgcaggggc tcccccagtt ctgcgctgtg 120
agccggggca caaagagccc tctgcactag cgccgcagga ccgcggaccc gagttggagg 180
catctgtcca cccatgtggt tccagacacg ttcatgtggc caccatgacc ccgtcggcat 240
cacaggggta accaaggtcc acagaacgag gggaaagggt cactgtggat caagccaggc 300
tcctctgagc agtccagggt ctatttacag agagcagcaa gttcctggga cagaggagac 360
agaagggaat ttccaggttc ttcaggacgt tcacaaccac actgagaagc atctttgcag 420
ataagtattt aaacttacca gcccatagcc taccagcctg ccctcttctg gtctgtgcag 480
gaaagtgtag tatcctagaa tgccaaagtg ggaggggaaa tgggtgatgt agctcattct 540
cttttctacc tctatggaag aaagaaagag cctgtcccca ttttgtgggg tcccagaaag 600
ggtgattttc acacttcaca tttggcgtta gggctagtat ttcacaaaca ttaccgtctg 660
gaacttttga aggctgagtt aaatgacttc atcttgtgta cttgtagaac tgctattaga 720
aggaggctgg ggactccctg atgatgtgaa ccagcccttc tcttctcagt ttcagcactt 780
tgtgatcata tttataaacc ttggacaggg ctccttggcc ttagagttaa gtgaagagtt 840
aacactgtga ctttagatgc atttttctca gtgtaagtgt ctgagctcat ctccagttct 900
ggactcgtgc ccccactccc gggtgctgac agcaagctct gaagatatgc tgagagagct 960
ccctgactct cctgactcag gtctgccagt tgatgaagac agcacagttg ttaccaaaaa 1020
caaaacctgg cagatggtcc taggtcagga ttagtggtca ttctctggtc ttctccagac 1080
tggtgacaca gggtggtctt aaaagagtcc tagtccagcc tctggctccc cgaatttcct 1140
ctggtgcatg gggcatcagg aaagggcagg ggagaaggag ggggagcaga aaaataactg 1200
aggctgggca gaagggtccc ttccatttcc catccattgc ttcaaacaat gggtgattac 1260
cgtgcacctt gagtgaatgt caaggcagga agggttccag ggccacccag tgtggcagga 1320
gcagagctgg gatcagaatt ctggattcct gactctccgt tcagctgcta ttcagctatc 1380
accaagctgc tgagtttgtc ctactttctc ctgggtcaca ttctgctgtt gttgggaaac 1440
agggagtgag tgaagggaac ctgggaaccc ttctcccctc accttttaag gatgttctgg 1500
ggtggaataa agagaggtgg agggtggggt gcctgggccc agcctccctg gctcctggtc 1560
cttctttctt cagcagggag ttctggcaag gcctgggcct ggggaggggg cctgggtgca 1620
gttttctcct gcggtgtggt tggctctttt gtcttccagg atgggcctgt ggggtctgtg 1680
tggggaagga aggagctggg agcctgggct gcctgtgtgt cggctggatg ctgccagcac 1740
cggcatggac caagcaactt ctctgagcca gatgctgggg acgcagaggt gaacccagag 1800
acatgatccc atctgctcag atcttcatgt cagaacacgc tttattacag tctcggcaag 1860
ggggtggctc catctgggcc gcatctccag gactcctggc ctggacttct ctttggacct 1920
cgggtgacct tggattctgg ccacagtgac ttagcggtca gactccggtg gttttctagc 1980
ccgctgggtg actccctgaa gatctcatcc tcttcacacc tgttgggatg gagcctccca 2040
tggataggaa ctcttcctgg ttgatgctca gcagatgact gatctggctc tggaggacag 2100
ctccaggggt atgagggagg cctggcagcc cactactccc tcctcacctg ctcgggccct 2160
gcctgctggg ccctattgtc tgggtctggg ggccctttcc tgccccatgt gaacttgatt 2220
cctcctcgcg tttctgccgg tgaccagaca gagcctggcc tgggccaagt ccccactgac 2280
cacactttcc ccaaggctgg gtctcaaagg accctacagg atggggacag gaacaaggat 2340
gggagtcggg gaggggctgt caggcagagg gcagatgcag ctcctcgggt gccgctggct 2400
ggagtccttt gtctccattt gctcagtgcg taattgtcat tttgtggggg acttccttgg 2460
tggggctttt ccatgctttt cctctccctg atggttacaa agaggagaca gtcaggatct 2520
gggaggagct ggagccttcc ccctgtgctg ttgaactctg ggaggggcag ccagaggggc 2580
tgagagtgca ccatcctgaa aagagagggt ctttaagaga taagatttag gctagggaaa 2640
ttcactagaa agagacaggt ggccctgggt tttttttcct gccatccaaa gggaaccagt 2700
cttacccaaa ggcttaaggg gtcaccttag cccagtctca ggacactctt ctccaatcag 2760
atcgctgctt ctagttgcac tgctcctgga ttctgttctt ggggaacaga aggtggcagg 2820
acaggcccca caatctgcaa ttccagctcc ctccagagga gacagtccca gcgtttgcaa 2880
gagagcagct tgtggcctcc cttaggcaag tttaaaagcc agatgtcctt tttcccagaa 2940
tgcggagtgg tgtgtactat tcatcagctt gggctgccac agcaccatgc cagactggat 3000
ggcttaaaca tcaggaattt attttctgcc agttctggag gctggaaagt ccagatcaag 3060
gtgttaagac ttggtttctg gtgaggcctc tctccttggc ttgcaggtgg caccttctca 3120
ctatgtcctc acatggcctt ttctctgtgg agagggacag agagcatgag caggctctgg 3180
tgtctcctcc tcttcttata aagacactaa tatcaccata ttagggctta aacctatgac 3240
ctcatttaac cttaacccct taaaggtccc atctccaaaa acagtcacat agcaggctac 3300
tgcttcaaca tatgcatttg ggggagggga caccattcag ttcttaacag ggtggtcacc 3360
gcaaacatgg aaagtcagag ccttctcccc ttcagaattc ccgcccccac ccagggatgg 3420
ggaggaggag cagagaggta tgggaagcag acacggagag tggcaggtac catgctgggg 3480
tggctcagga gtgcttcgga ggacatatgg aactggcagg gctcagtgca gggaggcgga 3540
ggccctggga gagccgtgtc ctgagaaggg cctgggctac aaccctgggc aagttacttc 3600
acctctgagc ctccgatgct ctgtgaaatg gaaggaatgt gcttgcctgt caggtgcagg 3660
gagaattcag tgagattgtg tgcctagcac agtgcctgac tcccagtagg tgctcagcaa 3720
atgctcccat ccatctggga gtatagactt agggtttatc tatttttttt tttttttggc 3780
tctctggact ttaaaactca gcatcttctg aaccagaggc atttctgatt agcccttccc 3840
tacctatttt cctagtatca ctctttaatc agcttgggga ggtggcagca tttcatggcc 3900
tccgtagtaa ctcacaatgc ttcctggggt atttaaattc tactctctca tcagcactga 3960
gcacctactt tgggcccttt cccgtgctag ccatttgggg gaaatatagg tgaagagtgg 4020
ctggggtttg aacctttagg atttcacagc catgctggat gggataaaac cagctcacat 4080
ggagaatcag agaatgggac agtgccacaa aacagtctac tgaggcacaa gttctgagtg 4140
cctgggaagt ggtagagaga ccccagagag ggctgctgca gtctggaaca gcttcctagc 4200
aagctgtacc aaacagggcc ttgaaggatg agaaagatct ggctgagatg atacccgacc 4260
ctctagggaa attcttaaag taacttctag gaaatgtcat tgctccttaa aaaaaaaaaa 4320
aaaaaaaaaa aagcaggttc taattcaaat tccgctgcac tactgaagta gtgcaggact 4380
tatcagaacc tttaaaatgc taatggcaat ttcaaatact cagggacagg gcataggatg 4440
aagtgttcct tgacttttat ggccgtagaa tctttttctc atggaacatc gtttagaact 4500
gtgggagatg ctaggctggg gtttctatgg gaaaagtaca gcagtgatag aagatggcat 4560
aattagggta cacttaggtg ctttgtagca ttggctgaaa aggaagcaga ccgggtgggc 4620
gtgggggagt ctcaacttgg ttccaggagc caggccagct tgatgcgttt tttttttttc 4680
taatggtggg agggcaggcc aatagttgga gaaactagag gcctgacagt cggtgatgga 4740
agagatgtct actaagcacg gttgtcagat cttttgcgga gagatgcggg tgtgcgtgtg 4800
tctgtcagag tgtaacagga tccagccctc tgggaagggg ctgaccagaa ccaggcaggg 4860
ggtttctgtc taggacaagt agggtccatt ttcaggggag ctgaaatatt tgcagggggt 4920
gctctgagac ccacagccaa taaataggga agcaacatgc ttttgggcag ggtccatgtg 4980
gttagggttg attttgatgg ggctgggggg cttagagtta gaccccctgc cctggtcagg 5040
ccccactccc tggctggtgg gggcgggagg cctctgaagc tgcagctgga ggggccgggg 5100
cagtgttgca tggtgtgatt aacctactaa cccagggctc agccgggacg ctgtggcgtg 5160
tgacgaggtg cctggccttc tgccaaccaa ctaacccact aaccaggccc gagcatgccc 5220
tactaaccac ccccccgcag ccagatccta ctaactgtgc agctcatggg cctttcaagg 5280
ggctgggata tgggggcagc caaggctcca gaaggctctg cctatgggct gggatctttg 5340
tgcagaccca cgttccagga cagagaatgc aaataagact caccaactct gccacttcct 5400
gttgagtgag tttgagtaag tcacctcact tctctcaacc tcagtttcct cagtggtaga 5460
atgcgagttc tgatacctta caggttgcag tgaggattcc cgtcaatata agggtctcag 5520
cacatggcag acacctaaaa aaaaaaaaag tatgaggatg gaggaaggcc cctcaaacct 5580
ggttgaacac gtctgctgcc taggccctgg cctctctggg tgttctgcac acagatcctt 5640
ctgcctgggg caagacactt ggctttgaat ccatgtcact tccccacatt cttcctccgt 5700
ctcagctttc ttttctgtag gcagctcttt tgttcgatta ctaacccgtc taacccctgg 5760
ggtgcctcaa ctgcaccccg atcatccctt aacaaactaa cggacctgcg tgcgttcttc 5820
cttttctctt agcgactcct gtgtgtgtct gctgaggtgc cctgtccgct ggtgctgtgc 5880
tctgacttac taacccagcc cctactaacc ctgttttctc ttcttactaa ccccagccct 5940
gccgagctct gggctccccc cgggggctgg tccccctcct tttggcaagc agatgacctg 6000
gggctactgg ccctgtagac agatgtccca ctttgctgcc ccatattggc tgtaagatca 6060
gagtccactg ggccaggtct aaggcagggg atggccctat taacaagact cagaggagga 6120
agaggtggtc ctgtggatgt gggaggctgg actctgagta tgacatctct cctatgtgca 6180
gaagtctggt tgccactggg agtaggtggg accagggaaa tctctgggac gtgagtgtgg 6240
aggcctgttg gtctagactc tagactgtgg agctctgagc ttttgtgtcc tctggaagga 6300
agctggggaa gaatcctctc cattgttaag tgacggggat agaagctgtc ctgcacagga 6360
agtcacgagg ggggcgtatc ccacgaggaa ggcaggaggg ggcgtgcccc tcaccggaaa 6420
ttagcagagg ggcgtgtccc acaccggaag tcagaaagcg gagcctttct tacaccggaa 6480
gtcaatgaag cgggtctttc ctacgctaaa aaccactgag tggagtattt agtacacagg 6540
aagtcggcca gagaaacatt tctcatattt gaaggccgga aagagggaca tttctgacac 6600
cggaagtcag tgagaggact ctttcccaca caggaagtca gctagagagc cgtctcccct 6660
ctctggagcc gagagaggcc ggtttccccc accgtaagta gacgtggggc cgtgaccgga 6720
agtccttggg aaagatccgt cccattcccg gaagctagag ggcgttagtt gtcgggttga 6780
aaaggggtgt ggggagggga agcagcttta ccccgggctc ggagtttgca ggagagagaa 6840
gtggggagca agaagtgaac ctcaggggct cacagggttc ccgcagatgc tcaggccggc 6900
caggaatgca tctctggctc tctgttccca cggacgtcac tgcctcagcc agcctccccc 6960
agagcccgcc agccgctaag ccggggccac acctgggggt gatttcatgc ctcacctcca 7020
gtaggcacct tggtttcttt gggctaatct ctggctccct tgcgctaact cttgctctca 7080
cccagctaat ccctgcctca ccctgactgc cccaggggct gaccactaac aaccaacctg 7140
gccctgtctg ggggttccag gctcctggcc tggccctgac cggttcttaa ttaacctttc 7200
cttcaccttg actaactcct gccttcctgg tctgttcctt tcagcagaaa ctaatggttt 7260
gtggattttt ttctgactaa caacaggtct aacattcctc gttactgtta acagcttgga 7320
tgtcggcatg gctgggaagg ggctaacaca gctttgaact tggctaacac aggtttgaac 7380
ttggctaaca caggtttgaa cttgactaac acagggaaaa gcatagctaa caattttggg 7440
cgtggtggct gctctgagtc agaacaatca gaagtcggta aagatggtag ttttctaaag 7500
gaggtgccag ggctctggtg tggaccaggc ctgatggagc agtggtaccc accaaggtgg 7560
ggtcagaagt atagccagtc ttgcaaggtt ttggccattg ggcatatctt cactcctcat 7620
agtctgcatt tggtttcagt tcttaaaaaa atatagcctt atagctacag tagtttgcac 7680
aagtagatgc agctcttata aaccttaaaa tacctgtctg gtgtctacag agcatatgcc 7740
attttgtata gagtcaccct tccccaggcc agggcctaga gtcttcattt tggggacttt 7800
gtgttttgga agttctagga cataaagctt tagatcagag tattcagaag ggttataact 7860
ccgtcagtca tttacatgtt agtagtataa attatctgag cttcctgttc taacttttag 7920
ctcttctagc ataaactctt ctgtgcaatt tagctgcacc gaggaaacgg gagtttttct 7980
ggaagggact tttgatctct ttagactgag ggaacgtcct ttgggagtag aggggcaggg 8040
agcatacgca agggattcca ggtgcaggta aaaggtggca ctagttcaag gttttgctga 8100
ctcagtctgg tagtcagagt ctgcaggaga agacagttca aggcagggcc tggaggattg 8160
gatcagttta gggacaggtc aaaggctggc ttacagacct tagaggcagg ttgcttgggt 8220
cgttgaatgc tagtctggtg ctgagagccc ttttctctgg caactgtgga ctcagagcta 8280
accaattgta gttggcagtg ggggtgaagg gtgatccaga ggcctgagct gcagagggca 8340
caagagagaa aagatgtctt agaaagagct ttgagaacat gccttggctg ctggcaggga 8400
ccttggatgg ggtagtctac acccggaagt gcctgcctgc catcctctag tggctgcctt 8460
gctccatttc actcaaagca ggaagctcac acctcctatt cctgaaactc ctctttgttt 8520
aactgcaaag acttgatgct gctaaggatc tactatgtgc caggcactgc tctgggcgct 8580
gggacctgca cctgggcttt ttcgtcatgg tgcttttata gcctagtggg agagttggtg 8640
aagtagatag tgattcagtg agatgggtgt tatgattggt caggggtctg tgggagcacc 8700
aaggagacag acaagattga tgtgcaccta ctctgtgcca ggcgtgtgcc aggcattggg 8760
gatgtagtgg tagttaaaca ccatttggtc ttcaggagct ttaattctag tgtgttgggt 8820
gcaggggggt ggaatgggga cagagagaca cctaatccac cctgtggtgg ctttctggag 8880
agggaggcat ctaagctgag ctgtggctgg gtggagtgtg ggtggggatg agttccgggc 8940
agcgagagtg gtggacacca gtttctgggg atcagagagg atccaaagag gttctggaag 9000
gttcatgtgg aatgtagcaa gagataggag acatggacat ggtgccgggt ctggttgcca 9060
agaagtttag attttatcct taggccttgg ggagcgacgg atatgatctg agaaagggag 9120
ttagtggatt tgagttttag gctggccatt tggcttttcc agcccaggtg gaactcagag 9180
gagtttgcaa tggcctctgg ccacatttta gacaactgag cagaactttt tgaaactagg 9240
aagacccttt ggtccatctt ttgataaaca gaatccatac atgtctaccc cagttggaag 9300
tatctctgca atgactggaa agtaaagagg accaaggtga aaataaaggc tcggaagggg 9360
agcaatcttg aaaacatgtc atcccatggt ggtgggaagt ccctggagaa gatcagggga 9420
aacacagtca taggctgcaa gtctataaga taattccatt ggggagggag cccatttgtc 9480
atgcatggct gcaaggggca gatacaagtg tggagtaagc ttgcaagagc tgatcctggt 9540
cccagagagg gaaaaatatg ccttggtggg taatgaacct tttgttccca gaggcagaag 9600
gattgggact aggccaacat agagattggc gatggttgtg agattctaag agtgtgtgtg 9660
catcttgaca atattagagg aggctgagcc caagcaggca cattctcttc gacccctccc 9720
tcattcagtc tgctttggag tctactgaac atcaagcttg ctatgagcag gatcttagag 9780
ctgaggaatt ggcctcccaa tccgaacagg tgttataatc ctttcttaat aggttgtgct 9840
gtggacccaa tgtgagggct gtgctggtgt aaatggtgac atgttgagct ggggggatgc 9900
tttcggggtg gggggactgg ttccattcca tcaaaggccc tcttgagagt ctatccaggg 9960
acccattgtt ttactttaac agaccagaaa agatgtttgt tttccatgtc attaccccca 10020
ggggataccg aatgtgtggg tagaaatttc tctgtagatt aaaaatcaga tttttacatg 10080
gattcaacaa aggagcgtca cttggatttt tgttttcatc catgaatgta gctgcttctg 10140
tgtaaaatgc cattttgcta ttaaaaatca attcacgctg gaaaaaaaaa aaaa 10194
<210> 143
<211> 2190
<212> DNA
<213> 小鼠(Mus musculus)
<400> 143
tttgtttttt aaatcaagat tatagatttt ggggaggtga ctcaggagtt aagagcattt 60
gcaactctcc aaggaggctt ggattcagtt cctagtaccc acatggtggc tcacaatcat 120
ctataacttg agtttcagga aatccaatac tctcttctga cctctacata aaccaggcat 180
gcacatgatg cacataaata ttgtgcaggc aaacaccgtc ccccagacac tcaaaataca 240
taaaataaaa ataagtattt tttaaaagtt ggaatttggt atgattagct ttatagcttt 300
agctatttat attagtttta tggcaacttg acactaccca gagtcatttt ggaagaggga 360
acctcagttg agaaaaatcc tccaccatat tgatctatga gcaagccagt aagcagcact 420
ccttcatggc ctctgcatca gctcctgctt ccaggttcct gccctggttg agttcctgcc 480
ttgactttcc ctcagtgata gagtgttctt gggagtgtag atgaagtaaa ccctcgcctc 540
ctaaactgcc cttggtcatg atcttttatc atagcaatgg aacccctact taagacaatt 600
atctttgaag cacatatttt gacatttagg catatcaata aatgattgat ggttagtttc 660
ttaaaatgcc ccttgaccac aaagacagtg aattttctcc cttgctccct agcatagatt 720
ataggtctga gccatcagat ctggcttgag gttcaaagct tgtgaccacc tgttccaagg 780
acaaatgagc tgcctagaac tcttccactg gcctgcctgt agccgggaat ggtggagttc 840
cctgtgactg tgggattcta tatgagctac tgatgagaca taagcaagta aggaaagttg 900
atcttgggat caacactcat caagaataag atgggtcccc cactctctag ctgtgcttcc 960
agacaggttt gcttcagtgt ggcttcagca aagccttcct agtggtctac agtagagaat 1020
gcaagagtcc atccctagcc tgaacactgc acacagacac caattatgct aaaatattta 1080
atttcattcc ataaataatt aagcctaaat aataatacct agatataact tggaacttgt 1140
gacaatctac ctgcctctgt ctctgtgtac caggattata ggcctgggca cacattcttc 1200
ttcaggactg attataatac attttgtata ttgatttaaa aaaatgatgc ttaggtagtt 1260
atggcctgtg agtaattcta taaagtagac taagtggata tcatcagtct atactctaag 1320
acattccttt aattttttta aatttttttt taaagttcta ctttttaaag attcctagag 1380
agccagatgg gtgatgaaaa gccaggtttc acatgtaaca ctaatattgg gggaaaaaaa 1440
acctgacgct agaaattatt tagttattct gaaagctgtc acttcttgaa agcagagtca 1500
gaattagaaa agaattaaca gtgtatcgtt gtgttctcac atttccaatg tggctggtga 1560
atcatgaagc aaaaatttcc tcaaaactgg agccccagag tcttagtctg agcccatcct 1620
cctgcctgag aatctccaaa ttgcctagtg aaggaaaagc tatgtccatg gtcccacctg 1680
ttccaaagtc cctttggaaa tctaggcaga agtaggtttg ctagagtctt acttatgaca 1740
acctgggaaa caaagaaggc tcttcataca agggtgtgta tccacacaag aggcagcatc 1800
ctgaaggaaa ccttcaggag cctccgatcc tgcagttagc tgactgtttc ctgccctcct 1860
tggtccaact cgttatggcc ccaggtgttc cttcttgctg ctgaactgct gtctctacca 1920
gctgagccca ctcctgtggt ctgcactcac tgccctggct gcaggttgaa cagggtcagg 1980
ctacttctca gatgcttccc accagccgca gtgaactcca ttttgacatg aagccattta 2040
aatggaaatc cagttttaca aagctcaagt gactggtaat gaagatgtga atgatgctta 2100
tgaggttttt atttaatttt aaatcaattg tgtattctaa ttcattaata aaggggaaag 2160
gaaagaatac aggaaaaaaa aaaaaaaaaa 2190
<210> 144
<211> 2308
<212> DNA
<213> 智人(Homo sapiens)
<400> 144
ctagaatgag aatgcacagc aagcggcaga caatcacccg gcattcggca tctctttctt 60
ttcacgcgct ccctcgctcc gcctttctcc agctctgcct tctcaggcag atacatcaga 120
taccttgttt atccatcttc agctccactc tgagggcgca gacgcacgat tccgggatcg 180
ggtgcaccac ggcgaagccc aggcgggaga cggcaggagc agctcagatg aagaaactga 240
aacccacaga gatgaagtaa catcctcaag atcaaaaggt aacaaacgat tgaggcagga 300
tttggatatt gctctacatg acgggaaagc ctgtgctctt ggaattacag tcatagtaca 360
acagatcaag ttcaaagcat catctaagtc aaggaaaacc agtaaagagg tttggagaga 420
caaacagggt caactccagg catttgggtc agcagaaacg gcacgattga gcagcactgt 480
gactatagga tcatggatca gaggctgctt cctctttggt tctgggcatc agcctcatgt 540
ccactcaaag taagtggccc ctctgattgg aatcggaggt gcctgggtca tctcacagag 600
ccaaacaaat acaattagct attgcaaagc cttttgggaa ttattcccag tgtaaataaa 660
cacataacca tatagcaaga gccttgataa agtccaaaaa catgcaaact tggagtatct 720
aagagaaaag accacaatgt aaatgaaaaa ccaaataaac tcgggcaaac cataggatag 780
ggccctgtct gtgatggcct gcatatgatg agccatagaa aaaggatggt gaattctgga 840
taataagaaa tgtcaatgag atgcaagaac cacctgtttt atgtaaagct ccaaataacc 900
agatcacagt ggacagccac tcaaataatg ccttcataat acagagtatt attgagaata 960
actcagttca cagagagctt aaggcagcca atatttgata gcctgtcaga aaaaaacaga 1020
acagtaatta tagaaaagaa tcatatcctc ggaaaaacaa aaattaatca aactaagttt 1080
gtaaagtcta tcttacagac acattgtctg gactggtcct ctcaaaaata ctgttttttt 1140
ttaatgccaa tttgtttagt taatgatttt tgtcttatta cttcaaaact ggaaatatcc 1200
tatgactcat aatatcttac aacctttcta ctttcttaaa gaatctcaag tttataatca 1260
caggggatcg gattattttt caaaaattaa atggtgatgt aatgatttct gtgtctattg 1320
tagaaaagtc aaccttatta cagctgcaac aatggcatta agaaatatga gtaattccaa 1380
tcaacttgag ataatgtcta atcaaacaca aatacaactg gtaaatttca ttaaatagca 1440
tggagattaa attaaaacac tattatgtaa taaaaacctt tagtggtact aaaattttag 1500
aatagttcag atatacagaa aaatttcaaa gatacacaga gttcccattt ttttcctatt 1560
actaacctct catatttgtc acaactaatg aatattcaat agagtattat taactaaagc 1620
ctatacattt atttagattt ccttagtttt tagctaacat tctttttctt tgttccagga 1680
tcccatccgg gccaccacat tgaatttatt tgtcatttta ggtacctctt ggctgtgagt 1740
ttcttagact ttccttgttt ttggtgaccc tgacagtttg agggagtact agtcagtcag 1800
ttatttttgc agaatgccct aaatttgagt ttggctgatg tttttcttag ggtttgactg 1860
gggttatggg ttttggggag gaagaccaca gaggtgaagt accattctca ccaaattata 1920
ttaaaggtac ataccatcag catgccttat actattgatg tgaactttga ttgcctggct 1980
gtggtagtgt ttgtcatgtt tcttcactgt aaagttactc ttctcatcac ccacttttct 2040
gtactgtact ctttggaaga aagtcactat atgcatccca aatttaagga gtgggaagtt 2100
atgctccacc catttgtaag cagaaaatct acataatttg tttggcattc ttctgcatag 2160
gaaaatcatc tcactctccc agttatttat ttatttgatc tttttttata tcagtatgga 2220
ctcatgggta tttcttttat actttgggtt ataatccaat actaacacaa taaagaaatt 2280
tttaatggag atgcaaaaaa aaaaaaaa 2308
<210> 145
<211> 8779
<212> DNA
<213> 智人(Homo sapiens)
<400> 145
cgcagcctgc agcccgagac ttctgtaaag gactggggcc ccgcaactgg cctctcctgc 60
cctcttaagc gcagcgccat tttagcaacg cagaagcccg gcgccgggaa gcctcagctc 120
gcctgaaggc aggtcccctc tgacgcctcc gggagcccag gtttcccaga gtccttggga 180
cgcagcgacg agttgtgctg ctatcttagc tgtccttata ggctggccat tccaggtggt 240
ggtatttaga taaaaccact caaactctgc agtttggtct tggggtttgg aggaaagctt 300
ttatttttct tcctgctccg gttcagaagg tctgaagctc atacctaacc aggcataaca 360
cagaatctgc aaaacaaaaa cccctaaaaa agcagaccca gagcagtgta aacacttctg 420
ggtgtgtccc tgactggctg cccaaggtct ctgtgtcttc ggagacaaag ccattcgctt 480
agttggtcta ctttaaaagg ccacttgaac tcgctttcca tggcgatttg ccttgtgagc 540
actttcagga gagcctggaa gctgaaaaac ggtagaaaaa tttccgtgcg ggccgtgggg 600
ggctggcggc aactgggggg ccgcagatca gagtgggcca ctggcagcca acggcccccg 660
gggctcaggc ggggagcagc tctgtggtgt gggattgagg cgttttccaa gagtgggttt 720
tcacgtttct aagatttccc aagcagacag cccgtgctgc tccgatttct cgaacaaaaa 780
agcaaaacgt gtggctgtct tgggagcaag tcgcaggact gcaagcagtt gggggagaaa 840
gtccgccatt ttgccacttc tcaaccgtcc ctgcaaggct ggggctcagt tgcgtaatgg 900
aaagtaaagc cctgaactat cacactttaa tcttccttca aaaggtggta aactatacct 960
actgtccctc aagagaacac aagaagtgct ttaagaggta ttttaaaagt tccgggggtt 1020
ttgtgaggtg tttgatgacc cgtttaaaat atgatttcca tgtttctttt gtctaaagtt 1080
tgcagctcaa atctttccac acgctagtaa tttaagtatt tctgcatgtg tagtttgcat 1140
tcaagttcca taagctgtta agaaaaatct agaaaagtaa aactagaacc tatttttaac 1200
cgaagaacta ctttttgcct ccctcacaaa ggcggcggaa ggtgatcgaa ttccggtgat 1260
gcgagttgtt ctccgtctat aaatacgcct cgcccgagct gtgcggtagg cattgaggca 1320
gccagcgcag gggcttctgc tgagggggca ggcggagctt gaggaaaccg cagataagtt 1380
tttttctctt tgaaagatag agattaatac aactacttaa aaaatatagt caataggtta 1440
ctaagatatt gcttagcgtt aagtttttaa cgtaatttta atagcttaag attttaagag 1500
aaaatatgaa gacttagaag agtagcatga ggaaggaaaa gataaaaggt ttctaaaaca 1560
tgacggaggt tgagatgaag cttcttcatg gagtaaaaaa tgtatttaaa agaaaattga 1620
gagaaaggac tacagagccc cgaattaata ccaatagaag ggcaatgctt ttagattaaa 1680
atgaaggtga cttaaacagc ttaaagttta gtttaaaagt tgtaggtgat taaaataatt 1740
tgaaggcgat cttttaaaaa gagattaaac cgaaggtgat taaaagacct tgaaatccat 1800
gacgcaggga gaattgcgtc atttaaagcc tagttaacgc atttactaaa cgcagacgaa 1860
aatggaaaga ttaattggga gtggtaggat gaaacaattt ggagaagata gaagtttgaa 1920
gtggaaaact ggaagacaga agtacgggaa ggcgaagaaa agaatagaga agatagggaa 1980
attagaagat aaaaacatac ttttagaaga aaaaagataa atttaaacct gaaaagtagg 2040
aagcagaaga aaaaagacaa gctaggaaac aaaaagctaa gggcaaaatg tacaaactta 2100
gaagaaaatt ggaagataga aacaagatag aaaatgaaaa tattgtcaag agtttcagat 2160
agaaaatgaa aaacaagcta agacaagtat tggagaagta tagaagatag aaaaatataa 2220
agccaaaaat tggataaaat agcactgaaa aaatgaggaa attattggta accaatttat 2280
tttaaaagcc catcaattta atttctggtg gtgcagaagt tagaaggtaa agcttgagaa 2340
gatgagggtg tttacgtaga ccagaaccaa tttagaagaa tacttgaagc tagaagggga 2400
agttggttaa aaatcacatc aaaaagctac taaaaggact ggtgtaattt aaaaaaaact 2460
aaggcagaag gcttttggaa gagttagaag aatttggaag gccttaaata tagtagctta 2520
gtttgaaaaa tgtgaaggac tttcgtaacg gaagtaattc aagatcaaga gtaattacca 2580
acttaatgtt tttgcattgg actttgagtt aagattattt tttaaatcct gaggactagc 2640
attaattgac agctgaccca ggtgctacac agaagtggat tcagtgaatc taggaagaca 2700
gcagcagaca ggattccagg aaccagtgtt tgatgaagct aggactgagg agcaagcgag 2760
caagcagcag ttcgtggtga agataggaaa agagtccagg agccagtgcg atttggtgaa 2820
ggaagctagg aagaaggaag gagcgctaac gatttggtgg tgaagctagg aaaaaggatt 2880
ccaggaagga gcgagtgcaa tttggtgatg aaggtagcag gcggcttggc ttggcaacca 2940
cacggaggag gcgagcaggc gttgtgcgta gaggatccta gaccagcatg ccagtgtgcc 3000
aaggccacag ggaaagcgag tggttggtaa aaatccgtga ggtcggcaat atgttgtttt 3060
tctggaactt acttatggta accttttatt tattttctaa tataatgggg gagtttcgta 3120
ctgaggtgta aagggattta tatggggacg taggccgatt tccgggtgtt gtaggtttct 3180
ctttttcagg cttatactca tgaatcttgt ctgaagcttt tgagggcaga ctgccaagtc 3240
ctggagaaat agtagatggc aagtttgtgg gttttttttt tttacacgaa tttgaggaaa 3300
accaaatgaa tttgatagcc aaattgagac aatttcagca aatctgtaag cagtttgtat 3360
gtttagttgg ggtaatgaag tatttcagtt ttgtgaatag atgacctgtt tttacttcct 3420
caccctgaat tcgttttgta aatgtagagt ttggatgtgt aactgaggcg ggggggagtt 3480
ttcagtattt ttttttgtgg gggtgggggc aaaatatgtt ttcagttctt tttcccttag 3540
gtctgtctag aatcctaaag gcaaatgact caaggtgtaa cagaaaacaa gaaaatccaa 3600
tatcaggata atcagaccac cacaggttta cagtttatag aaactagagc agttctcacg 3660
ttgaggtctg tggaagagat gtccattgga gaaatggctg gtagttactc ttttttcccc 3720
ccaccccctt aatcagactt taaaagtgct taacccctta aacttgttat tttttacttg 3780
aagcattttg ggatggtctt aacagggaag agagagggtg ggggagaaaa tgtttttttc 3840
taagattttc cacagatgct atagtactat tgacaaactg ggttagagaa ggagtgtacc 3900
gctgtgctgt tggcacgaac accttcaggg actggagctg cttttatcct tggaagagta 3960
ttcccagttg aagctgaaaa gtacagcaca gtgcagcttt ggttcatatt cagtcatctc 4020
aggagaactt cagaagagct tgagtaggcc aaatgttgaa gttaagtttt ccaataatgt 4080
gacttcttaa aagttttatt aaaggggagg ggcaaatatt ggcaattagt tggcagtggc 4140
ctgttacggt tgggattggt ggggtgggtt taggtaattg tttagtttat gattgcagat 4200
aaactcatgc cagagaactt aaagtcttag aatggaaaaa gtaaagaaat atcaacttcc 4260
aagttggcaa gtaactccca atgatttagt ttttttcccc ccagtttgaa ttgggaagct 4320
gggggaagtt aaatatgagc cactgggtgt accagtgcat taatttgggc aaggaaagtg 4380
tcataatttg atactgtatc tgttttcctt caaagtatag agcttttggg gaaggaaagt 4440
attgaactgg gggttggtct ggcctactgg gctgacatta actacaatta tgggaaatgc 4500
aaaagttgtt tggatatggt agtgtgtggt tctcttttgg aatttttttc aggtgattta 4560
ataataattt aaaactacta tagaaactgc agagcaaagg aagtggctta atgatcctga 4620
agggatttct tctgatggta gcttttgtat tatcaagtaa gattctattt tcagttgtgt 4680
gtaagcaagt ttttttttag tgtaggagaa atacttttcc attgtttaac tgcaaaacaa 4740
gatgttaagg tatgcttcaa aaattttgta aattgtttat tttaaactta tctgtttgta 4800
aattgtaact gattaagaat tgtgatagtt cagcttgaat gtctcttaga gggtgggctt 4860
ttgttgatga gggaggggaa actttttttt tttctataga cttttttcag ataacatctt 4920
ctgagtcata accagcctgg cagtatgatg gcctagatgc agagaaaaca gctccttggt 4980
gaattgataa gtaaaggcag aaaagattat atgtcatacc tccattgggg aataagcata 5040
accctgagat tcttactact gatgagaaca ttatctgcat atgccaaaaa attttaagca 5100
aatgaaagct accaatttaa agttacggaa tctaccattt taaagttaat tgcttgtcaa 5160
gctataacca caaaaataat gaattgatga gaaatacaat gaagaggcaa tgtccatctc 5220
aaaatactgc ttttacaaaa gcagaataaa agcgaaaaga aatgaaaatg ttacactaca 5280
ttaatcctgg aataaaagaa gccgaaataa atgagagatg agttgggatc aagtggattg 5340
aggaggctgt gctgtgtgcc aatgtttcgt ttgcctcaga caggtatctc ttcgttatca 5400
gaagagttgc ttcatttcat ctgggagcag aaaacagcag gcagctgtta acagataagt 5460
ttaacttgca tctgcagtat tgcatgttag ggataagtgc ttatttttaa gagctgtgga 5520
gttcttaaat atcaaccatg gcactttctc ctgacccctt ccctagggga tttcaggatt 5580
gagaaatttt tccatcgagc ctttttaaaa ttgtaggact tgttcctgtg ggcttcagtg 5640
atgggatagt acacttcact cagaggcatt tgcatcttta aataatttct taaaagcctc 5700
taaagtgatc agtgccttga tgccaactaa ggaaatttgt ttagcattga atctctgaag 5760
gctctatgaa aggaatagca tgatgtgctg ttagaatcag atgttactgc taaaatttac 5820
atgttgtgat gtaaattgtg tagaaaacca ttaaatcatt caaaataata aactattttt 5880
attagagaat gtatactttt agaaagctgt ctccttattt aaataaaata gtgtttgtct 5940
gtagttcagt gttggggcaa tcttgggggg gattcttctc taatctttca gaaactttgt 6000
ctgcgaacac tctttaatgg accagatcag gatttgagcg gaagaacgaa tgtaacttta 6060
aggcaggaaa gacaaatttt attcttcata aagtgatgag catataataa ttccaggcac 6120
atggcaatag aggccctcta aataaggaat aaataacctc ttagacaggt gggagattat 6180
gatcagagta aaaggtaatt acacatttta tttccagaaa gtcaggggtc tataaattga 6240
cagtgattag agtaatactt tttcacattt ccaaagtttg catgttaact ttaaatgctt 6300
acaatcttag agtggtaggc aatgttttac actattgacc ttatataggg aagggagggg 6360
gtgcctgtgg ggttttaaag aattttcctt tgcagaggca tttcatcctt catgaagcca 6420
ttcaggattt tgaattgcat atgagtgctt ggctcttcct tctgttctag tgagtgtatg 6480
agaccttgca gtgagtttat cagcatactc aaaatttttt tcctggaatt tggagggatg 6540
ggaggagggg gtggggctta cttgttgtag cttttttttt ttttacagac ttcacagaga 6600
atgcagttgt cttgacttca ggtctgtctg ttctgttggc aagtaaatgc agtactgttc 6660
tgatcccgct gctattagaa tgcattgtga aacgactgga gtatgattaa aagttgtgtt 6720
ccccaatgct tggagtagtg attgttgaag gaaaaaatcc agctgagtga taaaggctga 6780
gtgttgagga aatttctgca gttttaagca gtcgtatttg tgattgaagc tgagtacatt 6840
ttgctggtgt atttttaggt aaaatgcttt ttgttcattt ctggtggtgg gaggggactg 6900
aagcctttag tcttttccag atgcaacctt aaaatcagtg acaagaaaca ttccaaacaa 6960
gcaacagtct tcaagaaatt aaactggcaa gtggaaatgt ttaaacagtt cagtgatctt 7020
tagtgcattg tttatgtgtg ggtttctctc tcccctccct tggtcttaat tcttacatgc 7080
aggaacactc agcagacaca cgtatgcgaa gggccagaga agccagaccc agtaagaaaa 7140
aatagcctat ttactttaaa taaaccaaac attccatttt aaatgtgggg attgggaacc 7200
actagttctt tcagatggta ttcttcagac tatagaagga gcttccagtt gaattcacca 7260
gtggacaaaa tgaggaaaac aggtgaacaa gctttttctg tatttacata caaagtcaga 7320
tcagttatgg gacaatagta ttgaatagat ttcagcttta tgctggagta actggcatgt 7380
gagcaaactg tgttggcgtg ggggtggagg ggtgaggtgg gcgctaagcc tttttttaag 7440
atttttcagg tacccctcac taaaggcacc gaaggcttaa agtaggacaa ccatggagcc 7500
ttcctgtggc aggagagaca acaaagcgct attatcctaa ggtcaagaga agtgtcagcc 7560
tcacctgatt tttattagta atgaggactt gcctcaactc cctctttctg gagtgaagca 7620
tccgaaggaa tgcttgaagt acccctgggc ttctcttaac atttaagcaa gctgttttta 7680
tagcagctct taataataaa gcccaaatct caagcggtgc ttgaagggga gggaaagggg 7740
gaaagcgggc aaccactttt ccctagcttt tccagaagcc tgttaaaagc aaggtctccc 7800
cacaagcaac ttctctgcca catcgccacc ccgtgccttt tgatctagca cagacccttc 7860
acccctcacc tcgatgcagc cagtagcttg gatccttgtg ggcatgatcc ataatcggtt 7920
tcaaggtaac gatggtgtcg aggtctttgg tgggttgaac tatgttagaa aaggccatta 7980
atttgcctgc aaattgttaa cagaagggta ttaaaaccac agctaagtag ctctattata 8040
atacttatcc agtgactaaa accaacttaa accagtaagt ggagaaataa catgttcaag 8100
aactgtaatg ctgggtggga acatgtaact tgtagactgg agaagatagg catttgagtg 8160
gctgagaggg cttttgggtg ggaatgcaaa aattctctgc taagactttt tcaggtgaac 8220
ataacagact tggccaagct agcatcttag cggaagctga tctccaatgc tcttcagtag 8280
ggtcatgaag gtttttcttt tcctgagaaa acaacacgta ttgttttctc aggttttgct 8340
ttttggcctt tttctagctt aaaaaaaaaa aaagcaaaag atgctggtgg ttggcactcc 8400
tggtttccag gacggggttc aaatccctgc ggcgtctttg ctttgactac taatctgtct 8460
tcaggactct ttctgtattt ctccttttct ctgcaggtgc tagttcttgg agttttgggg 8520
aggtgggagg taacagcaca atatctttga actatataca tccttgatgt ataatttgtc 8580
aggagcttga cttgattgta tattcatatt tacacgagaa cctaatataa ctgccttgtc 8640
tttttcaggt aatagcctgc agctggtgtt ttgagaagcc ctactgctga aaacttaaca 8700
attttgtgta ataaaaatgg agaagctcta aattgttgtg gttcttttgt gaataaaaaa 8760
atcttgattg gggaaaaaa 8779
<210> 146
<211> 6983
<212> DNA
<213> 小鼠(Mus musculus)
<400> 146
caggcattca ggcagcgaga gcagagcagc gtagagcagc acagctgagc tcgtgaggca 60
ggagactcag cccgaggaaa tcgcagataa gtttttaatt aaaaagattg agcagtaaaa 120
agaattagaa ctctaaactt aagctaatag agtagcttat cgaaatatta cttagtctta 180
ataatctaag aagatcttaa gagataacat gaaggcttat ttaaacagtt tgaaaaagga 240
aatgaggaga aaagtatttg tactgtataa tggaggctga ccagagcagt ttaggagatt 300
gtaaagggag gttttgtgaa gttctaaaag gttctagttt gaaggtcggc cttgtagatt 360
aaaacgaagg ttacctaaat agaatctaag tggcatttaa aacagtaaag ttgtagagaa 420
tagtttgaaa atgaggtgta gttttaaaag attgagaaaa gtaggttaag ttgacggccg 480
ttataaaaat ccttcgactg gcgcatgtac gtttgaaggc atgagttgga aacagggaag 540
atggaagtgt taggctagcc gggcgatggt ggcgcacgcc tttaatccta gcacttggga 600
ggcagaggca ggcggatttc tgagttcgag gccagcctgg tctacagagt gagttccagg 660
acagccaggg ctacacagag aaaccctgtc ttgaaaaaac aaaaaggtta ggctagtatt 720
tggagaaaga agattagaaa atggaagtga aagacgaaga agacatacag gaaggtgaag 780
aaaaagctgt tagagaagat aggaaaatag aagacaaagc atctttagaa gacagaaaag 840
gtacttaaag gcacaggtag taggaagccg aagaatagaa gatagaaaga agcaagatag 900
aaaaacaaaa tggaagttaa gacaactttg gatgccagca ttcaagatag gcaaagaaga 960
taagattgag gccaaaaggt tggataagat ataaagtcag aaggaaatta tctttaaagc 1020
cataagttca aatttctgat ggagcgagca gtttagaaga gtctttagac agccacatac 1080
aagattgaag ctagcaatca aagctactag gactgaagta aaaagttaag gcagaatgcc 1140
tttgaagagt tagaagaata ttaaaagcct taacttgtag cttaattttg cttgatgaca 1200
aaaggacttt tgataacagt ttcaagattg tcagcatttt gcattggact tgagctgagg 1260
tgcttttaaa atcctaacga ctagcattgg cagctgaccc aggtctacac agaagtgcat 1320
tcagtgaact aggaagacag gagcggcaga caggagtccc gaagccagtt tggtgaagct 1380
aggaaggact gaggagccag cagcagcagt gcatggtgaa gatagcccag gaaagagtgc 1440
ggttcggtgg aggaagctag gaagaaggag ccatacggat gtggtggtga agctgggaaa 1500
gggttccagg atggtggagc gagagcgagt tggtgatgaa gctagctggc ggcttggctt 1560
gtcaactgcg cggaggaggc gagcaggcat tgtggagagg atagatagcg gctcctagac 1620
cagcatgcca gtgtgcaaga aaggctgcag ggagagcatg cggtgcggta acattccttg 1680
aggtcggcaa catggtggtg gttttctgta acttggatgg taacttgttt actttgtctt 1740
aatagttatg ggggagttgt aggcttctgt gtaaagagat atatctgggg ctgtatgtag 1800
gcctttgcgg gtgttgtagg tttttctttt tcagggttat gtcctcttgc atcttgtcag 1860
aagcttttga gggctgactg ccaaggccca gaaagaagaa tggtagatgg caagttgtct 1920
ttaaccgctc agaggggaat gaatggtaga gccagcacaa cctcccagtt ttgtaagacg 1980
ttgtagtttg aacagatgac ctaccacaag cctcactcct gtgtagggga ggtaattggg 2040
caaagtgctt ttgggggaat gggggcaaaa tatattttga gttcttttcc ccttaggtct 2100
gtctagaatc ctaaaggcag atgactcaag ggaaccagaa aaaaggaaat ccactctcag 2160
gataagcaga gctcgccagg tttacagttt gtaggaagta gaggatggat gctagctttc 2220
acactgagtg tggaggagct ggccatggcg gaattgctgg tagtttactc tttccccctc 2280
ccttaatgag atttgtaaaa tcctaaacac ttttacttga aatatttggg agtggtctta 2340
acagggagga gtgggtgggg gaaacgtttt ttttctaaga ttttccacag atgctatagt 2400
tgtgttgaca cactgggtta gagaaggcgt gtactgctat gctgttggca cgacaccttc 2460
agggactgga gctgcctttt gtccttggaa gagttttccc agttgccgct gaagtcagca 2520
cagtgcggct ttggttcaca gtcacctcag gagaacctca ggagcttggc taggccagag 2580
gttgaagtta agttttacag caccgtgatt taaaatattt cattaaaggg gaggggtaaa 2640
acttagttgg ctgtggcctt gtgtttgggt gggtgggggt gttaggtaat tgtttagttt 2700
atgatttcag ataatcatac cagagaactt aaatatttgg aaaaacagga aatctcagct 2760
ttcaagttgg caagtaactc ccaatccagt ttttgcttct tttttccttt ttcttttttt 2820
gaggcgggca gctaaggaag gttggttcct ctgccggtcc ctcgaaagcg tagggcttgg 2880
gggttggtct ggtccactgg gatgatgtga tgctacagtg gggactcttc tgaagctgtt 2940
ggatgaatat agattgtagt gtgtggttct cttttgaaat ttttttcagg tgacttaatg 3000
tatcttaata actactatag gaacaaagga agtggcttta atgaccctga aggaatttct 3060
tctggtgata gcttttatat tatcaagtaa gagatactat ctcagttttg tataagcaag 3120
tctttttcct agtgtaggag aaatgatttt ccttgtgact aaacaagatg taaaggtatg 3180
ctttttttct tcttgtgcat tgtatacttg tgtttatttg taacttataa tttaagaatt 3240
atgataattc agcctgaatg tcttttagag ggtgggcttt tgttgatgag ggaggggaaa 3300
cctttttttt tctgtagacc tttttcagat aacaccatct gagtcataac cagcctggca 3360
gtgtgatgac gtagatgcag agggagcagc tccttggtga atgagtgata agtaaaggca 3420
gaaaaaataa tgtcatgtct ccatggggaa tgagcatgag ccagagattg ttcctactga 3480
tgaaaagctg catatgcaaa aatttaagca aatgaaagca accagtataa agttatggca 3540
atacctttaa aagttatggc ttatctacca agctttatcc acaaaagtaa agaattgatg 3600
aaaaacagtg aagatcaaat gttcatctca aaactgcttt tacaaaagca gaatagaaat 3660
gaagtgaaaa tgctgcatta agcctggagt aaaaagaagc tgagcttgtt gagatgagtg 3720
ggatcgagcg gctgcgaggc ggtgcagtgt gccaatgttt cgtttgcctc agacaggttt 3780
ctcttcataa gcagaagagt tgcttcattc catctcggag caggaaacag cagactgctg 3840
ttgacagata agtgtaactt ggatctgcag tattgcatgt tagggataga taagtgcctt 3900
ttttctcttt ttccaaaaag acctgtagag ctgttgaatg tttgcagctg gcccctctta 3960
ggcagttcag aattttgagt agttttccca tccagcctct taaaaattcc taagccttgc 4020
accgatgggc tttcatgatg ggatagctaa taggcttttg catcgtaaac ttcaacacaa 4080
aagcctacat gattaatgcc tactttaatt acattgctta caagattaag gaatctttat 4140
cttgaagacc ccatgaaagg gatcattatg tgctgaaaat tagatgttca tattgctaaa 4200
atttaaatgt gctccaatgt acttgtgctt aaaatcatta aattatacaa attaataaaa 4260
tacttcacta gagaatgtat gtatttagaa ggctgtctcc ttatttaaat aaagtcttgt 4320
ttgttgtctg tagttagtgt gggcaatttt ggggggatgt tcttctctaa tcttttcaga 4380
aacttgactt cgaacactta agtggaccag atcaggattt gagccagaag accgaaatta 4440
actttaaggc aggaaagaca aattttattc tccatgcagt gatgagcatt taataattgc 4500
aggcctggca tagaggccgt ctaactaagg actaagtacc ttaggcaggt gggagatgat 4560
ggtcagagta aaaggtaact acatattttg tttccagaaa gtcaggggtc taatttgacc 4620
atggctaaac atctagggta agacactttt cccccacatt tccaaatatg catgttgagt 4680
ttaaatgctt acgatcatct catccacttt agccttttgt cacctcactt gagccacgag 4740
tggggtcagg catgtgggtt taaagagttt tcctttgcag agcctcattt catccttcat 4800
ggagctgctc aggactttgc atataagcgc ttgcctctgt cttctgttct gctagtgagt 4860
gtgtgatgtg agaccttgca gtgagtttgt ttttcctgga atgtggaggg agggggggat 4920
ggggcttact tgttctagct ttttttttac agaccacaca gaatgcaggt gtcttgactt 4980
caggtcatgt ctgttctttg gcaagtaata tgtgcagtac tgttccaatc tgctgctatt 5040
agaatgcatt gtgacgcgac tggagtatga ttaaagaaag ttgtgtttcc ccaagtgttt 5100
ggagtagtgg ttgttggagg aaaagccatg agtaacaggc tgagtgttga ggaaatggct 5160
ctctgcagct ttaagtaacc cgtgtttgtg attggagccg agtccctttg ctgtgctgcc 5220
ttaggtaaat gtttttgttc atttctggtg aggggggttg ggagcactga agcctttagt 5280
ctcttccaga ttcaacttaa aatctgacaa gaaataaatc agacaagcaa cattcttgaa 5340
gaaattttaa ctggcaagtg gaaatgtttt gaacagttcc gtggtcttta gtgcattatc 5400
tttgtgtagg tgttctctct cccctccctt ggtcttaatt cttacatgca ggaacattga 5460
caacagcaga catctatcta ttcaaggggc cagagaatcc agacccagta aggaaaaata 5520
gcccatttac tttaaatcga taagtgaagc agacatgcca ttttcagtgt ggggattggg 5580
aagccctagt tctttcagat gtacttcaga ctgtagaagg agcttccagt tgaattgaaa 5640
ttcaccagtg gacaaaatga ggacaacagg tgaacgagcc ttttcttgtt taagattagc 5700
tactggtaat ctagtgttga atcctctcca gcttcatgct ggagcagcta gcatgtgatg 5760
taatgttggc cttggggtgg aggggtgagg tgggcgctaa gccttttttt aagatttttc 5820
aggtacccct cactaaaggc actgaaggct taatgtagga cagcggagcc ttcctgtgtg 5880
gcaagaatca agcaagcagt attgtatcga gaccaaagtg gtatcatggt cggttttgat 5940
tagcagtggg gactacccta ccgtaacacc ttgttggaat tgaagcatcc aaagaaaata 6000
cttgagaggc cctgggcttg ttttaacatc tggaaaaaag gctgttttta tagcagcggt 6060
taccagccca aacctcaagt tgtgcttgca ggggagggaa aagggggaaa gcgggcaacc 6120
agtttcccca gcttttccag aatcctgtta caaggtctcc ccacaagtga tttctctgcc 6180
acatcgccac catgggcctt tggcctaatc acagaccctt cacccctcac cttgatgcag 6240
ccagtagctg gatccttgag gtcacgttgc atatcggttt caaggtaacc atggtgccaa 6300
ggtcctgtgg gttgcaccag aaaaggccat caattttccc cttgcctgta atttaacatt 6360
aaaaccatag ctaagatgtt ttatacatag cacctatgca gagtaaacaa accagtatgg 6420
gtatagtatg tttgatacca gtgctgggtg ggaatgtagg aagtcggatg aaaagcaagc 6480
ctttgtagga agttgttggg gtgggattgc aaaaattctc tgctaagact ttttcaggtg 6540
gacataacag acttggccaa gctagcatct tagtggaagc agattcgtca gtagggttgt 6600
aaaggttttt cttttcctga gaaaacaacc ttttgttttc tcaggttttg ctttttggcc 6660
tttccctagc tttaaaaaaa aaaaagcaaa agacgctggt ggctggcact cctggtttcc 6720
aggacggggt tcaagtccct gcggtgtctt tgcttgactc ttatatcatg aggccattac 6780
atttttcttg gagggttcta aaggctctgg gtatggtagc tgatatcact ggaacactcc 6840
ccagcctcag tgttgaactc ttgataatta actgcattgt ctttcaggtt atgcccaatt 6900
cgtcttatta cctctgagtc gacacacctc ctactattta ttgaatactt tgattttatg 6960
aaataaaaac taaatatctc tca 6983
<210> 147
<211> 2793
<212> DNA
<213> 小鼠(Mus musculus)
<400> 147
agctcagaga tgcaaaaagc ctgcggcgct ctggaggcgc ctggtcctgg ggacctcttt 60
cctccactct gttctcagca taggaagatg gggctgggga attctttttg gttttctggt 120
tttgttttgc tctggttttg gtcggggttt tgtatttttc tattcttcct tggttttatt 180
ttttcctttt tttccttttt ttttttcttt tgctttcctg tcattctccc agccaaaagc 240
cgccttcgac ccttttgatt tgatgtagca aagagtgtgt gtccagatta tctgaaatag 300
acactgaaga agctacatag atggtcaagc agggcccgga agaagaccat tcaggaaaaa 360
gtggtccagg actcggtgga tgggctgccg gcagaccggt gtggctcaga cctggtgact 420
ttttggagag gtcgtagaat gaggacagca gacacacgag gaccttgact tcggcgcaca 480
gacagtgcaa aaaggagaca aagacggaca gaatcaaaaa agagcgtatt tccccctcct 540
acgtatttgt ttttcctgat agtctcacaa agatgagagt ctggtccggt ccagcgggtt 600
atcttgtggc actggctgtc tccagtggct gtgcctgcgc tttgaggcca ctctgctgtt 660
caccgtggcc caaaccagat tcgggctgaa aggtcgctga gtcagacttt taggggctcc 720
gagaagcagc aagccctctg ccttcactgt tcctttttct tttattttta gctccccacc 780
cccacccctg ctcccgctcg tgggctcttc tcctcctggc ccagggcgtg cgaaaaggtg 840
gatgaacctg gaggcgggag gggccgggcc aagggagacg ggcaggaagc gggtgagtgc 900
gaactgataa cctcacatca gttgaggctg ctgcatagct tcttggtgcg ctgagggata 960
ccatgatgta tagctgggga cgtaggagcc agcgctgctg ccggagccct tcccagatga 1020
ggagttcgga ttccagccgg gtggtaccgg tggggagccg gcagacaagg ctctgccgtt 1080
cgccagcgcg ctgccctcca gagctgcccc gccttgcttc atcagcttct tgaacttgga 1140
gcgtttgttc tggaaccata tcttgacctg caggatcggg cgacaacgtg actggactat 1200
gaccattgag cctacccagg tccaaggaga aaagggacgg gtggacaaca atacccgccc 1260
tccttgcttt gggaaagctg acagctccag gacagagggg cagagaccac cgcctcccca 1320
caccccatga gggccaaagg ccagaaaatt gagccccagg tccagccgct gttggcaact 1380
tttagagcag ctatcagagc cgggaataag agaacagggg agagccaggc cttggcttgc 1440
aaatgagacg atgccacctg ggcgacgttt atggaagacc tcatgcagca caatgcaata 1500
acaataaaga aaatttaaaa cctagatagg aacggggtgg ggggcggggg catttgttaa 1560
aattagatct cctttcctcg taggactatt ggaagaggct acagcgtctt tgttaaactc 1620
tttagactca aaccaattct cccccccacc cccaacggtg tatttgcttt ccccagctcc 1680
aacctaaatc tagagacaga ctggccctcg ttcgaatgcc taggaactgc ccagggtctt 1740
agagaagtgc aggaagaaaa aagaaaaatc tcactttttt tttccccctt cttcttaagg 1800
atctggaact tgggaagtga agggccagag ggaaggatct gcctctgcca cctcgcaaga 1860
agaaggaggt gggggaagca ggcttaggcc caggacctga gtgattagtg gcacacttta 1920
aaggctaagg aagattaaat cccccttcta ttgttccagt tgttcaggca cgtgtgacct 1980
cagaacctcc aaacaaaacg tctggggaaa tccttccagt tccctgcctg gtcagaagac 2040
caggtagcct gcaggtcaga gagtagggtc cgagctaggg caaacagttt gagggaggaa 2100
gaggagacgc tgaaagtcag aggtggatac acacacacac acacacacac acacacacac 2160
acgggttggg gggcggactg tgacacctag aaccagaggc ccagcgaaca aaaaatgtga 2220
agcctggggc tggagcccag ctcccgaggc ttgtttggca gagcggccag gtacctgcgt 2280
ctgtgtgagt cccaaggagg ccgccagctc cgccctctca ggcagagcta agtactgagt 2340
ttgttggaac ctccggttca aagcctgcaa ctgcaaactg gaataaattg tcctgggttt 2400
acggatcttt ttccctttgc cgttaaagcg cacctcgccg ccttccacca ccgtactctt 2460
ctcggagtcc gcccctggag ggacaacaga agcagagacc cttgttaatg ctgcactgcc 2520
tttagtgagg agggacgaga atgaatgtct atggatgggt tggcagaagt agggtccgga 2580
aaagaacgtt caagaaaccc tgaaagactg cgaaggtccc tcaaggtccg agcgcacgtc 2640
cctggctgct gcagacagaa ttgggtcgtt cccaagagcg cagctattgc ctttgcagag 2700
aaagtttgct attttttgca ggcggtagtt gaggtttaat tacccttaat tgcatacatt 2760
gtttatagcg ctacgcaata aataattacc gag 2793
<210> 148
<211> 1000
<212> DNA
<213> 智人(Homo sapiens)
<400> 148
ttttttttat ctttgcaact cttaatctcg ctacctcccc ctcctctctt ctctcttctc 60
cctctctctc ctcttttctc taccgctgtc tctgagactt cttcttccct ttttcctaaa 120
gaagttgatc cagaaattcg aaaagccctg ggcagagttg ttgaatggga tgtgcaatta 180
gagaggggat tttgttggga ggcaagaggg tcccccaggc tccacatagt ccaggtcggc 240
aggcaaggaa agacggctga ccagcccagc gggcgcggtt tgcacatggt ttgcacgtcg 300
ggccgcctct ttctgcctat aattcagctg cctctctgag gagtggtgga ggagctgcgg 360
gagccgagaa gcccaagagc cctctggacc cagaaaagtc ctacagatgc ccactcctca 420
ccacacaaca gaaggagctc tggtcctgcc tgccagcccc agagggcact caaactttgg 480
aggccagcca cccggatgaa gtgaataagg cctgaaaatt gcttgtttgc tcgtattgta 540
aaataataat aattaccatt attattttta aactgtctaa tttctctagg gaaagtaaca 600
tcgaaagcct aaaacagacg ccaaaaggcc catagaacac agagggccct ctctgcctct 660
ggccaccaca gcccctaggc caggcatggg tatttattct taggtatgtt gcttttaaga 720
agctgtaatc agcatcttga gccgggcctc cctttgtgag gcttctgtaa ctatggaagt 780
gtgatttacg cagatttgtc ggggtcagag acgtctttcc ctgagcactg tgtatattta 840
gacaggactc ggtttggtgt taaaaagtgt atatgttgaa tggattcaca cacagtagcc 900
aacaatgacc acattgtcgg cccgtgtaca acgcgtattg aaacgcagcg cccagacttc 960
aactaatctg ccctcaataa agctgaaata attatcctaa 1000
<210> 149
<211> 5352
<212> DNA
<213> 小鼠(Mus musculus)
<400> 149
aaaaccctcg ccactcatga agaactgagg caaaaggatc acagatgctg ctcggggcca 60
gccctatact ccctccagtg cctggtctcc ggtggacccg cggggctctg cagttctctg 120
gcggccgcgc cttgtaagcg ctaagccggg aggagggcgc aggcagggcg cacagctctg 180
agcgcgaccc tacccggctc gggcccgcag caaccccgac tgtccgagag cctctcccca 240
agcaaggctc tgcgccgccc tctgagccca cctcctggcc acaacgctgc ctgcgcttct 300
ccagcccagg ccggaagccc tatgctgcct cccgaagccg gactttctgg aagcccatct 360
tcgtatgctc accagcccac cctcctacgc tggtcagagt gagattgcta acctcaagac 420
cccattcaat gccagctttc aactactgct gaagaccaat gtaggtcctg gaatagaaga 480
actgcagagt atccggagct ggccgacccc agactgattc tcaacaggtg gctgggtagt 540
gccccccacc ctgtgttggt cgtgcgggac ccatcgcaca cagagaagcc accttacccc 600
tcacctcacc ccgtcggcca aagactgacc acccgcgccc gagtgtgggg aggggtggga 660
attccggatc acacacacac acacacacac acacacacac cagggtaggg gaacagggaa 720
gatcttacct gcagaaaggt aagagaagcc gggagcgtgt agcagcggcg gataaatatt 780
cattaggaag tgtaagtcct ttcaaagggc tccgcgcgcg cgctctagct cctgtctctc 840
tttctctccc tccctctgtc ctccaggaag gcttcccctc ctctagctat ctcaacgccc 900
cccccccctt cctgcgaaat accgggtgga tcctaggcta gctaacctgt tgggaagcct 960
gaactgcggt agcgcctctg cagctagcag tttgctttcg ctcctggggc gcgcgtcccc 1020
ccccatcccc tcccctcctt cctttcgccc agcccctcac ccctcctaaa tcactacatc 1080
attagcttta ttgggcgggg ggggggcggg taacggagca gccagacgca cctctccata 1140
gaagggtgaa tagttggtgc cctgcgatgc aaccccaact ccatctccac ctcattctca 1200
cccatctgca catcctcatc caatcttgct tctttttctt cgctctttcc acctccacct 1260
ccatcctgtg tcaacctaac tccctcagca gccctcccac ccgccgccgc caatccggat 1320
cacagattgg gttgggagtg agattgcaag gctgttaggt ccgaaggtcc tgtgtgtcga 1380
ggttagaact cctccctggc gtgagtacgg ggtggttatc aagatctcct tctccttcct 1440
gaccctgcaa ggttaccaaa cagcctggac ttttgaatca gatctctgga gcaagcatta 1500
agaactccag ccacacagat ctcagggcct ggccctttca ctcagccgcg gaggctgctt 1560
gagggatggg gagaggtgat ttcactcagc gccaacgcgc aggaaaaact catagacgac 1620
agtcggacta atactcgtcc cttaagaatg cactacctga agttagtcgc aagtcatctt 1680
caatcgagga aaggaaaaaa aaaatcctca catctagaag cttcgccgaa gccacttcca 1740
acagcacgcg aacatgttcg cgcacaccct tctctgtgca cgccccaaag cctgctctct 1800
cgcgggcagg tgaaaataca ggctgcccag gccagaggag agaaggcggc ggaggaatac 1860
atcgcttagg gttgttgaga aactaggaat aactgttttc aatactctgc tctgctacca 1920
ggaccttagg tccctcttgg gaccctgaaa agtggctttg ccccacgatg gggggtgggg 1980
gggcagtgac tctagctctg gccctcctac tgggagctta aagttggggt gaagggttta 2040
aggaggagcc gagggggcgg gccctgttag tttgcagttg taagtgcagc tgtgcctggg 2100
acaccaagaa ggagagtctc gccccctaat gctcacggtg cttgcttaga ggacccccga 2160
ggttaactac cggagcttct gctctctcct gagccccagg ccaacacagg acgatggtgg 2220
ccgggatgcc agccgggatg cctaaacaca gtaagacttc agttgcctct catttggctg 2280
ttcagagcta atgtctacca gaggaggttt tagaagtggg tcgcacccgt cctgaatcca 2340
tcctgtgagg tggcagaggg tcagagggtc actccttctt gttaaaggtt agcataataa 2400
gtattattat tactagggta gaggaagatg tggaggaaaa aaaaagccta gggtgcctag 2460
gacactaacc aaccttacag cttacccaaa gtccagaacc tcccattgta caccttctct 2520
ccccaacaca gatccctaag gtctcctctt catctggcat gtgtgttcac agaaggtaca 2580
gtgtgcgaga acacacttag gaaattttag gaacgctaac cacagtactg gaggaataaa 2640
gatgtgtcga aggaatggat ggaatgcatg aacacataca ccttgttgtc cagatgcaga 2700
caaaagctac catgtccgct tggagtgacg cccagacacg cacagagatg tacaggaagc 2760
caaggagagt gggatccacc agagtacagt acaagtacag agtacagtgc aagatgccca 2820
gtggccctgg agaaaaacct tcgttgactc ttctgtatgg aaagtttctg aagaaagggc 2880
caaggaatga tctgccccag aggctgcctt taggctccca tacctgctct gtttggagac 2940
acccagaaga ggccagtaca gcaaagactc tttttggttt ggttatttct gttgcttgtt 3000
gtcttttttt catcctttgc ctgggaaatt gtgctctgga atagggcttg agtagacagc 3060
acaggcctcc agtagataac aagagattct caatctccaa tgaggacatt ccgttctaag 3120
gaagcttcca gataggggaa agccctgttt tgtccccctt ttctcctctg agatctgaaa 3180
aaatagaaag aaaaaaaaag aaaaacaaaa caaatataaa aactatagcc caatcccatg 3240
tacatcaaat aaatccacaa ggaatatgct agatcaagct aaattatgta tttaactcat 3300
tttcttttgt gagatactga gaagtcttca acttcctcta ttccaggcag ggatcgagga 3360
cctggcctgg cagaggttcc accaccaggg tttcccacag tggttctggg actaggcgta 3420
aggtgtcctg acttgttttc tctgtcacct cttctgggga actggggaac tgtcccagac 3480
aatggctgcc ccagttccct ctagaagaga cagcccccac ccccagaacc cgttgccctc 3540
caacctcacc tcattttctc ttgagctcat tctccgagct cttaaagtag taggtgtgag 3600
tcttggacca tttctttaaa agaaacaact aaggaaaggg agggagggga ggagggagga 3660
ggggagcggg aaggagagct acctcctaga ctaacgcgtc caggaaccac tctctaagga 3720
gcaaaagaga gcctgtgttg taaagtagaa gtgatccccc gacattgctg cagggcgcct 3780
tgcaacagat gtaactgtcc actgaagaga cagagggtgg gcatggggaa gatttttttt 3840
cctccctttt gtgaacagct cttacacttt tccaagacac attgagttcc tggacatttt 3900
tgtgaatttg ttcttgattg tgttttgaac aataaactgt gaaaatcaac ttcaagccca 3960
cacaatcaga atctttcttg ggagggcagg ttctttcagc gctgtttttc tccaggtcgc 4020
ttttatctta cccccaatgg gagtcacctg ctgatgctcc tcgggaggag actgtaactg 4080
aaagacggaa gtgaatgcag acacagcatc ctctgagcca aaccgttgct ttggttcctt 4140
ctagcttagg atgccgaaca ctggctggct ttgaacaccc tctacttcgc taagaagttt 4200
agagcctttc tcacaacaaa ccacagcgtt ttagaactgg aaatgtttct tctgattttc 4260
cagtcttagg acaattttcg aactctaact taaaaaaaaa tttgtttatg ggggtttagc 4320
tagaacactt gtagcattcg cttctcaagg aaagatcaac tgttttctca taaccccaac 4380
tgctccacac acttcatagg atataatgta ttttctttac ttatccttgt gccttctgcc 4440
caggacatag aactaggggc aaaactttgg aggtctatga cctcttgata gcacctgtaa 4500
ttgttaggct tttgttcttg tgccttgtaa atctctcatg tacgtctatg aaaatatgca 4560
ttgcatgggt gtgatcctat caagttgtcc acactttctc aacaaccact gatgagtgaa 4620
accatttcta ttgcccaggg caaagggcta atcgccttgt gggtctagag ttgtcatagg 4680
ataatatccg gtgtgtgtgt gatatgacag ttattacttt caagaataaa ttaaaataac 4740
cagatacccc tttaatactt tcctcaacag cgtcaatgct ctagagatgg gacctcgcct 4800
tccaaggtgt cttcactatc acagggcccg ggctctctgc ctcagcccaa ccctgggctt 4860
gcgctcagag aggaggtatt ccgacggaaa aaaatcccat acatttttaa ctacagtgat 4920
tactaaatta atagcaggca ccaagacaga tgtcaaaacg tcttgaaaat gtttatctgt 4980
gaataattga gaaggtagtg ggacgcatta tctgattgtg taatgaaata tgtatgagga 5040
acagctgttt gcagcagccc cttccccttg ccgccttagc cagggccctt ctctcgcaag 5100
ctttcttcta ctttcttcca cctttttctt ccttctactt tctagttcgc tctcttcttc 5160
cttaactgct cgcacggctt tggctgcagt gaacccagag tcgcctggtt ctctgatgaa 5220
ggttagccac aaggtttcct ctaagccttg ctggattggc gttccgtagt gggatgaggc 5280
ttcgttgtct gctgttctgg ccatcgcgcc ttccggccag gctgcccgct gggtctccat 5340
ggagtctgcg gg 5352
<210> 150
<211> 1990
<212> DNA
<213> 智人(Homo sapiens)
<400> 150
atttcacacc tggatgtgct cactcaacca agaatataga gaaagagctt ctgccctgag 60
actcagaaaa atattctcct gtgctttggt tcagtataga tttctaaacc ctgatcattg 120
cttaagagat attcactgag gacagagtct tgctctattg cccaggctgc aactggtgtg 180
atctcggctc actacaacct ctgcctcctg ggttcaagcg attctcctgc ctcaagctcc 240
caagtagctg ggattacaag catgcaccac catgcctggc taatttttgt atttttagtg 300
gagacggggt ttcgccacat tggccagggt ggtcttgaac tcctgacctc aagtgatcca 360
cctgccttgg cctcccaaag tgctgggatt ataagcatga gccactgcac ccagccttat 420
actgaacttt caatgggttc aattccacta ggagcataaa ggccactgca tatgagttgt 480
ggaaagaaga gattagaaga aggaagaact tgagatgagt tcctcccttc aacattctgt 540
ctcctcctac ctagcatctt ctttctttta gtctttctag aatgtccatc tgtttttggc 600
cattgcggag agagaagctg agctttaaag gagtaggagc ttcaaaggcg taggagcttc 660
aaaattcttg tttcttcatg tttgatcacc cttctaaacc tgtcttctgt tccttctgct 720
attctttttt cttagagcat aggaaagggg agcttttaaa ttaatactta aagcatggaa 780
aaaaagaact tgagaagaaa gtaaaacaag ggagatgagg ctagtaaagt aaggaaaatg 840
aagaggaaga ggaggaaggg ttagcttcta aattccaagt caaattgata tggaacaggc 900
aagccgcttg tcttacttaa acttcagaaa aggatctgct gaaacttgat agaaatggaa 960
agggaaatcc ttggggtggg gaacctccaa acattagtaa tgatattgaa caactcaaag 1020
tattgaggaa atctgcaggc tacatgcctg aagattaccc atgcagatag accaaaagga 1080
ttagaattat ctgttgatat tagtaatatt tattgacatc tagctagtat tggtaatttt 1140
aagttttaga ttaatttctt tggtaatagc tatgatatat tttatagaca agaattatat 1200
ctataggctt gctatcatag gctcttttaa tcagcattaa tttagtctac tgatttttag 1260
cacatttgaa tcattcactt atgctaggta actcattgca aaataaaaag atgattcctg 1320
tatgtatggc agctatacat taaggaggag tctaccagaa tatgaaaaag tcagctgacc 1380
taaatattgc tgagacaaag gaaaacccac tcccttggag gagcatgacc ttttcctgta 1440
attcttccca ctgctgttgt tgagctcctt ggatcctggc tcctggacac catcatcaag 1500
aagactttat ggatgggctg tccacccact gagagaagag gagcatcagc tacagtttct 1560
ctctagattg ccttcttcat tttgagtaat gactgtcagc agggtcagat taaacacaaa 1620
acaactggac aattgcttgg aggactaaac tataagggca ctaacatgtc aatagtaggc 1680
taacacatcc atggaaaata tatttaccag ctcttctctc agggaggatt ctgtgtgggg 1740
ttggaagtaa tgatttgtta aattccttag gggtagaaag tagggcataa tcagaatata 1800
gaggaatatg ctgtttgact tcagggtttc tgtttttctt actaggatat ataaaacagg 1860
gactctagct agattgttta tgaccacaga gggtaggctg agtgctccca tgatcttcct 1920
gcttggttct tgcccataca gaggtcagcc tttcctctaa taaagattga acaagtagtg 1980
gtctgaggga 1990
<210> 151
<211> 4266
<212> DNA
<213> 小鼠(Mus musculus)
<400> 151
gcttcaaatt ggatggcact gcagctggag gctttgttca gaattgatcc tggggagcta 60
cgaacccaaa gtttcacagt aggaaggggg aaaaaagaaa agaaaacatt tttcctaatg 120
taacaatgcg aatgctagaa aatgacaaga ctgatcggtt ttaaaccatt ctgaagactg 180
actgagcgtg gaagttgctc aacaaaaaag ggaacgggga tattgaacca gagagaaacc 240
tacgcccaga agaacatgtc cctggattgc tttcccactg ctgtggagtg tcttgaacac 300
tggtccctgg acaccaactt caagaagact tcatggatgg ctgtccagtc ttatgagcca 360
cagtttcccc tctacatttt cttcactcca gcgaggctct tatcagggtc agatcagaga 420
tgaaccagct ggacgacaga ttggagcgct gacctcttag agtgctaaca gtgaacagtg 480
tggggtcaga tctatagaaa gataataata agaaaacacc ctatatgcaa gggagaggga 540
tggttcataa tttcttaaag attgaaatca aggaacaatc aaaatataga agaatgtgga 600
cgtgttttgc tgcaggactt ctgttttgtc cccattggaa tatgtattat ggtattcctg 660
ttggatcagg actcaggggc aaggctaagc attccagtgg tcctcctact tagctcttgt 720
cctttcgtaa gaaacaccaa ctcattagtc tctatattac ttctctgtac tgtagatctg 780
cattcttgat ctgagagata ttggcaatga cactcttgta tgataaagct caatgataag 840
agtacttcaa acccccttga actttttgtt tatacatcaa gtggtgacat tgtgtattga 900
gctaattaga tcaatggagt cacagggtga tactgaactc ttttaaaata tttggctgaa 960
acatgacatt gtagttattt gtagaagaga acattatgga atatgaaaaa catcacagaa 1020
cacagaacta gcagcagaaa ctagcagcag gtagacattt ttccttttcc atagagcttt 1080
caaccaaatg tctctgtaga aaatagtggc tatcgtgtat atatatagcc acatagatgt 1140
ccttgagtgt accctgtagt cagtgggaga gttcctactg ccacagtcat ggccatggct 1200
atgttctcta agcctacatt ttataaacac tctgtgaatc ttgactactt ttctttagca 1260
agcattgcaa agtcctggga tgtcagagaa gtgcctgggg ttggcagggt ttctagagag 1320
gaaattgtta aatgatttga accagaaaac aaacagggga tggggttcag aaccaacaat 1380
tacctctatt ctatgtagga aaccacaaca tgaaatatgc tgggcatgga aactttgata 1440
ccttggtttt tcattctttt taaaaattaa tactaaagag ctatgcgact gtaggcaagc 1500
catttcccat cccctgtgaa tatctcccag atgactttaa atcccttcta gttctgaaag 1560
gcttttaaca tcagggccca ggctccagtg gccagtttca aaataccctc ccttttgatg 1620
ttaggttaca taaacattgt tcttttttag ggagggtctc ttttatcaac ttttaaaaac 1680
acacatcagg ttctctggta ttaaaaagat gccatctctg agtcccctac tatctgtgct 1740
gcctgccttt cctcctgttc tttccttatt cccatcccta ttgaacttgt gctatgcagt 1800
atgcatcagg tatgtgttag ctttggggat acatgataga taaactggac acacagggtc 1860
ttcccattct cttctggaat tttctttgga gggagcctct tgtatctaga cagaccgtgc 1920
tgtggtaccc cagaggtaac cacctacagg cttcactctg cctaagcaat tttgctgtgc 1980
actaagatac acattcaagt aactttagat taccacaata actttctcca ggtatgagga 2040
aaagagataa tttacttctg agatgtgtat aggatagccc tccatcctgg gaagaacagt 2100
gactactccc tgcatcccga ccttgcccag ggaaagctaa tgtttctctg tgttatccct 2160
gtgacttgcc acttctttaa aaaggaatgg gcaaacaata aacagacaaa aatgttgtct 2220
gacctcattg gaaatccttt taagaattaa tcctttctat ctccttcatt atcaacaaat 2280
ctattgaata cttatctctg agtccagggc atattttata atacataaaa caatggaatt 2340
tcaaaattgg agcactgaca tacaatattg gttttgagta tttttattat agggaatgac 2400
tttagacatt gcaatttatg acttaactga taaaatggat gactcttgac tttcaatttt 2460
cattttcagt tcagtcgagg aatagcttcc tccaggtaat gtctatactt tcctatgact 2520
aagggctcta actatctctg ttgcttttct ttatgtaggc atatgttagt atttattttc 2580
tatatgacaa atgtattaaa gaaagcatga aattaatgag ataaactttt cagataggag 2640
tttagaaaat caaggggcca agataaataa atgaaaaatc aacttaaata attaacatat 2700
tccagatata ttggaataaa tgtttattgt acccttttgg ttttgtcttg ggttattttt 2760
ttcttatctc actgattttt ttttctttcc tttttagctt ttttgtcttt tttgattttt 2820
gttgttgcgt ttctcctttt tttttttctt gttgatgttg tttgtttgtt tgtttgtttg 2880
ttttttgaga aagaacagaa ggttggttgg atagggaggt ggggaagatc tatctggatg 2940
gagttgggag gagggaaaat acacgatcaa aatatatttt gtgatgggca gggcatagtg 3000
gtacatgtct ttaatctcag cactctggag gcagaggcag gtggatctct atgagatgga 3060
ggctagcctg atatacaaag tgagaccaga acatagggct gcctcaaaaa ctttatatat 3120
atattaaaaa tgtttgcttt ttgagacagt cacagataac caaaactgat cttgtaatga 3180
tgtaaacatg tccagctaat tttcaaatat tgtagggcag catttctccc tttgtgcaca 3240
cgtggagtca gcaaatccat ataattctaa ccattctggt gaaaaggaga acactcggcc 3300
aagcatctca cacttccaag tgtgaagcct tgtttgaaag ctccgagtat ctaaatagta 3360
gccctgtgaa aggtaaattt atgaatggtc tggtgtgttc ttattccagc cattgacctt 3420
aaagcaactt atatatgttt tctttatcct tcaagagaaa agaaaaatca tatttttcca 3480
agcaattaaa attcttctgc ttcaggtagg aagaaggaat taggagttat gtctccttgt 3540
atataattgc aagtttcatt tttcttgttt taatgattga cagaaaactg ataaactgag 3600
acatctcctt attagggttg aatgtactct cttggtggcc ccattgctaa tttgtttgac 3660
tattttccat gatttcttac tctgtaatgg aaaggtttat taaatatgag ggttgcaaag 3720
ctttctgaat actaatgaac ttatttgcca aaatttaaat gttcttcttg tcagtgaatg 3780
cctgtctcac ttaacaggca ccaaattgaa taatgaagaa aattagactc tatcgtaccc 3840
tcaagagaaa tcgcgtgtga attgtaatag aaaattgagg gagaaaaggg tcatattgta 3900
gcaataacac tagataattt ggattatttt aaaaaaggat gaacttaggg aagctcaggt 3960
cttttcaaag aaacacacat ttggttaatt catgcaaaac gctggtttcc cctcaaccca 4020
ggtggtctat acctatcgcc agtttacaga aaaaggaagc caggtggatg gaaaacgtgt 4080
gccaagtttc tgtgcttaca atccactaaa ctcattctca tatgaggact ttatatacct 4140
gtgatggagt gggaaaatca ataacctgga aaaaatgagt accattttcc aaagaagttc 4200
aataaagaga tggaatttgg gaaactgctg cagttcttcc tataagcata aaaaaaaaaa 4260
aaaaaa 4266
<210> 152
<211> 972
<212> DNA
<213> 智人(Homo sapiens)
<400> 152
attccggcgt ggagttctct gagttcggtg gcacttggga tattccactt cagtgccatg 60
ggaagaaaat ggtaagcaaa aagcaaaagg aataatgcaa aaaaaaaaaa aaaattataa 120
tgttgtggta tccaattgct cctgcttcag ccttttatcc aaagccttga gatggatctg 180
cctcatccag gaagttttcc tgcttcgtta gagtatcttc gttttcttta tcagacgctg 240
gctggcactc cacgccagtg cacggctcca tggaatgcct gctgttggac acttgcagag 300
ctctgccacc aagcaacctc ctgcattgga aatcggggga ctactccagg atcttatgcg 360
tgcttgctgt ttgaagctgc agaaaagtga ataatcaatt aagtattgat ttcttgtaag 420
atttggtaaa tttcaaaggc aagacaaaga ggatggctta aggaaacact gcagggactt 480
ggcgtaaatt agacaactaa cggaagcgca gaataaaata acacctcaac tgaagatttc 540
cttggaagaa ttagcactag ctattggaag acaatggtgg atttaatcaa aacagcaggc 600
atgcaagaat tttacccgtg aaccagaaaa aggagctaat tataaccacc tttttaatgg 660
agctaatttg actgaatgga tgcaaatgtg ctttatttat ggatgaagaa gcaagcctta 720
ctgcatgatc ttgggatcat cggatctgct aagctttgca gctcctgtta ccttcagtac 780
attttttatt tccggagaag gtatttgtat gtaaacaaca actaaccatg caaaagattc 840
atcggaacaa tatactgtgg tatatgagat ataatcataa ttttgcagcc tctcaggatt 900
tcctctaact tggaggtttt gcaacctttg tgtgcaatgg gttatggtaa acaataaatg 960
aatgatgcta aa 972
<210> 153
<211> 3129
<212> DNA
<213> 智人(Homo sapiens)
<400> 153
ggggagccgc cggagggcag ctggggctgc ggaattttgg aagcgcagaa gttttctcct 60
cctgtcctgt aactggtttt cactcactca actgagagat ttctttgttg caatgatggg 120
gtctaagata acacttctgg aggctgcagg cgagaaacac agctgatatc atcttttatt 180
gtgtgttgtt atttgcctag cattataaat taaggaggaa tagtaacaaa gagcttgaag 240
acatgcacag ctcacaggcc ccgggtggag gctggcgaca tcagacagac agaaccaaga 300
catctgaggg gcaaccagga ggtgcgtgtg gctgcagagc acacagactt gtctttggac 360
aaaattgaga agaactcata aacttggctt cctcgcttct gctcctcaga cgcgcgtgga 420
tgatttgaag atattagcct aacaagatgg aagcaggttt aaaattttac ataagaagtt 480
acctttttca gttgtgttga tgttcctttc agctggtcct atagtacccc tcctcaggaa 540
tgtctcccca gtgcaaggac aaagactgaa gagactgcta tattgatgga ctctcaagcc 600
aactatgaag ttgaaacaaa gaaagtgatc acctgaagac acctcctctg ctaagaaaca 660
cccccaaatt gtgcagcttc tgccactaga actctcagaa caagagacaa tcttttcaag 720
aaacagaaaa actcaataat gacatctaga ttttcatgag ccaagaactt tcccttcctc 780
atgtgtattc ctctgtttgt acttaaattc atgtgacatt catttttttc ctagtatgga 840
tatgcttatt aatgcacttg tttcaaaatc ccaaattgca caaatgtgtt aatattttaa 900
gaaacaaaat gaatcctaca aggagaatga tttttagcca cacatagggt tggatcttga 960
gagtgaccta cagaataaaa gtacttttaa aataaagtag tcagaggcta ttcaaagggt 1020
aaaataatca tagtaccaca ttggtccact tgacactaac caatcgatca ttttttttta 1080
atcaagaaag ctagattcta tcagataaaa tcactgcttc taaagagttt aaatctagtt 1140
agaaaaagtt atagaaatgt ttgcaaagat aagtaacaga tagagtcagt agaggataag 1200
atcaaaaaca aaaccaagca aaagatgagt tcaggggagt ttgccatcaa gttggcaaaa 1260
ctgacttact tagggaagaa agttataaaa caggaaaata tgagatgaac cttgagtgat 1320
gtggaagatt tagataaatg gaaaggaagg agaaaatgga gttctttagg tggttgtaat 1380
tggaggagga aatgaataca cacatcttgt tgacttaaac ccagacattc agcagctctc 1440
tatacatatc tggaaaagac tgcacagtca cctcctgtct ctcaccccag gtattactta 1500
gaattattat catatttccc ttcctttaaa gtaagtaagg gtgattggtg acaatatgga 1560
gaactatgat ttttccatta acctaataat aattggtatt tattgagttc tgttaagcat 1620
tttacatatt aactcactta agcctttcaa cagccttgca aaataggtat tattatcccc 1680
attttacagg caagaaaact gaggtttaag taacttgccg aagtgccata tacagggctc 1740
acattcagta ttgcagttgc aaagctcatg atctatagtg ccaagttgca atattgtagt 1800
caatgtcaca attattaccc ctttttatat tccttgatat ttttccatgg caaacaatta 1860
gctatttcat ttaataatca cctaaaactt ttcagtcttc tgattaaaat tacgctggag 1920
tgatagaatg tattttcatg atagaaattg ggaaaaaaaa tggggaatga agtttatcag 1980
catttcagac ttgttttttt tttttttttt tgcaagactt tgatgagatt gttcactttt 2040
gtctatgtaa aatcccaaat ccttgagaat aaaaaagggg gaggtttaag tcacttgttg 2100
caatgccctt tttaatagag gcaataaatc taaaggccat aaatttagag tgacttacag 2160
aagatcgaac tttggagtgt ggcagagtaa gggatggaaa ccgggccctc cagttcacta 2220
tcagtagctt ttgcactggt ctgcccttcc taaattaagt atgcacttca atttgatgag 2280
tggaaacagt ctatctgggc agtaaccagg gagctttgtg cctagtagat tgcttctgtt 2340
ctgcacttct ttggtttccc acctcaatgt aaaaaatagc tagcaatgaa gtccagaagt 2400
tgtcaatggt tcatccccag aagaatgcat aatgtccaaa gttgtatgtg tatgatgtct 2460
tcaatggtat taagttattt caaattctta gttcacctac ataaatcatt tctaacaagc 2520
atcttcttaa ccaactttat gcacagtgta tgtttgtaag tgcttctgca cgaatgttta 2580
tacatgactg tttccatagt acttatgttt ttaaaaatat tcagtcattt cctactataa 2640
tcctcatgta tccatgtaac tgactcaaaa atacttcagc cacagaaagc taaaactgag 2700
caaatctcat tcttcttttc catccccttt gcatgtggct ggcatttagt aatgattaat 2760
aatatggcca gctgaataac agaggtttga gacacaattc tttctcaaag gagtcagcta 2820
agctgggtct acttatggac aaacatctaa atgtgtggaa gtatctgata tttgacaatg 2880
gtaaatttcc acttagctag ctagcattgt cagacttcaa tctcctcatg gctctggccg 2940
tcctgtttta agcatgataa ttgttggcca catctcacat agttctcatt gagtgagttc 3000
ataaataaac agggtttttt ttttttttta aagagcagcc aagcacaaag tgtgactttg 3060
ttgacatttt atgtgacttt gtcatatgtt cctaaccccc aataaaagca atgttgcatc 3120
aactgtgaa 3129

Claims (26)

1.由非神经元细胞产生神经元细胞的方法，其包括通过使选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA，或其任意组合的表达或活性增强来使所述非神经元细胞转分化为或重编程为神经元细胞。
2.根据权利要求1所述的方法，其中通过例如过表达、基因激活剂、表观遗传修饰、miRNA模拟物、直接递送RNA、小分子化合物、和/或RNA稳定剂来增强所述miRNA或lncRNA的表达或活性。
3.由非神经元细胞产生神经元细胞的方法，其包括通过使选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA，或其任意组合的表达或活性降低来使所述非神经元细胞转分化为或重编程为神经元细胞。
4.根据权利要求3所述的方法，其中通过例如基因编辑技术介导的DNA编辑和RNA编辑、RNA表达抑制剂、反义寡核苷酸、小RNA干扰、miRNA技术、小分子化合物、基因抑制技术、和/或表观遗传调控来降低所述miRNA或lncRNA的表达或活性。
5.根据权利要求4所述的方法，其中RNA编辑包括CRISPR介导的RNA降解和RNA翻译抑制、RNA单碱基编辑、RNA上碱基的插入或缺失、RNA剪切的改变、RNA表观修饰。
6.根据权利要求1或权利要求3所述的方法，其所述选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA、或选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA,为来自不同物种的同源miRNA或同源lncRNA。
7.根据前述权利要求中任一项所述的方法，其中所述非神经元细胞包括例如胶质细胞、成纤维细胞、干细胞、神经前体细胞、神经干细胞，其中胶质细胞选自星形胶质细胞、小胶质细胞、少突胶质细胞、室管膜细胞、施万细胞、NG2细胞、卫星细胞、视网膜穆勒胶质细胞、耳蜗螺旋神经节胶质细胞或其组合，优选星形胶质细胞、视网膜穆勒胶质细胞和耳蜗螺旋神经节胶质细胞。
8.根据权利要求7所述的方法，其中所述胶质细胞来源于脑、脊髓、眼或耳，其中脑部胶质细胞来源于纹状体、黑质、中脑腹侧被盖区、脊髓、下丘脑、背侧中脑或大脑皮层，优选纹状体和黑质。
9.根据前述权利要求中任一项所述的方法，其中所述神经元细胞优选多巴胺神经元、GABA神经元、5-HT神经元、谷氨酸能神经元、ChAT神经元、NE神经元、运动神经元、脊髓神经元、脊髓运动神经元、脊髓感觉神经元、感光细胞、双极细胞、水平细胞、无长突细胞、视网膜神经节细胞、耳蜗神经细胞、锥体神经元、中间神经元、中型多棘神经元、浦肯野细胞、颗粒细胞、嗅感觉神经元、球周细胞或其组合，更优选多巴胺神经元、视网膜神经节细胞、感光细胞和耳蜗螺旋神经节细胞。
10.根据前述权利要求中任一项所述的方法，其中所述非神经元细胞和/或神经元细胞来自例如人、非人灵长类动物、大鼠和小鼠，优选人。
11.根据前述权利要求中任一项所述的方法，其中所述方法为体内方法或体外方法。
12.使选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA，或其任意组合的表达或活性增强的试剂在制备用于预防和/或治疗与神经元功能缺失或死亡相关疾病的药物的用途，其中所述试剂增强所述miRNA或所述lncRNA的表达或活性。
13.使选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA，或其任意组合的表达或活性降低的试剂在制备用于预防和/或治疗与神经元功能缺失或死亡相关疾病的药物的用途，其中所述试剂降低所述miRNA或所述lncRNA的表达或活性。
14.根据权利要求12或13所述的用途，其中所述药物配制成用于在体内施用于神经系统、视觉系统和听觉系统，例如纹状体、黑质、中脑腹侧被盖区、脊髓、下丘脑、背侧中脑、大脑皮层、海马、小脑、视网膜下、玻璃体腔、内耳耳蜗和前庭，优选纹状体、黑质、视网膜下、玻璃体腔和内耳耳蜗。
15.根据权利要求12至14中任一项所述的用途，其中所述与神经元功能缺失或死亡相关的疾病选自：帕金森病、阿尔茨海默病、脑卒中、精神分裂症、亨廷顿舞蹈症、抑郁症、运动神经元病、脑缺血、脑损伤、肌萎缩性侧索硬化、脊髓性肌萎缩症、Pick病、睡眠失调、癫痫、共济失调、PloyQ疾病、成瘾、RGC细胞功能缺失或死亡导致的失明或视力损伤、感光细胞功能缺失或死亡导致的失明或视力损伤、青光眼、年龄相关的RGC病变、视神经损伤、视网膜缺血或出血、Leber遗传性视神经病变、损伤或退行性病变导致的感光细胞变性或死亡、黄斑变性、视网膜色素变性、糖尿病有关的失明、夜盲症、色盲、遗传性失明、先天性黑蒙症、耳蜗螺旋神经节细胞死亡导致的耳聋或听觉减退、或其组合，优选帕金森病和RGC或感光细胞功能缺失或死亡导致的视觉系统疾病。
16.根据前述权利要求中任一项所述的方法或用途，其中所述使所述miRNA或lncRNA或其组合的表达或活性增强包括：
(a)外源表达所述miRNA或lncRNA或其组合，例如通过包含启动子的表达载体来实现；
(b)向细胞内递送DNA或RNA形式的所述miRNA或lncRNA或其组合；
(c)激活所述miRNA或lncRNA或其组合的内源表达，如基因表达激活剂和表观调控元件等；或者
(d)向细胞递送所述miRNA或lncRNA或其组合的类似物或激动剂；
其中优选外源表达所述miRNA或lncRNA或其组合，例如通过包含启动子的表达载体来实现。
17.根据前述权利要求中任一项所述的方法或用途，其中通过以下使所述miRNA或lncRNA或其组合的表达或活性降低：抗体、小分子化合物、microRNA、siRNA、shRNA、反义寡核苷酸、结合蛋白或蛋白结构域、多肽、核酸适配体、基因编辑器、表观调控元件、转录抑制元件或其组合。
18.药物组合物或药盒或试剂盒，其包含使选自Let-7a、Let-7b、miR-18a/b、miR-24-3p、miR-34a、miR-92b、miR-96、miR-106、miR-125a/b、miR-128、miR-134、miR-135、miR-137、miR-141、miR-143-3p、miR-184、miR-200、miR-218、miR-219、miR-228、miR-284、miR-429、miR-430的miRNA、或者选自utNgn1、RMST、Tuna、Linc-Brn1b、Dali、Miat/Gomafu、NBAT-1、Malat1、Dlx1as、Six3os、Evf2、LncKdm2b、lncRNA_N1、lncRNA_N2、lncRNA_N3的lncRNA，或其任意组合的表达或活性增强的试剂；或者使选自miR-7a、miR-15、miR-23a/b、miR-25、miR-29a、miR-129、miR-137、miR-138、miR-155、miR-195、miR-214、miR-222、miR-223、miR-132、miR-133的miRNA、或者选自Pnky、Paupar、HOTAIRM1、lncR492、TUG1的lncRNA，或其任意组合的表达或活性降低的试剂。
19.根据权利要求18的药物组合物或药盒或试剂盒，其中使所述miRNA或lncRNA或其组合的表达或活性增强的试剂选自：表达载体，DNA或RNA形式的所述miRNA或lncRNA或其组合，所述miRNA或lncRNA或其组合的内源性激活剂，所述miRNA或lncRNA或其组合的类似物或激动剂。
20.根据权利要求19所述的药物组合物或药盒或试剂盒，其中所述表达载体是基因治疗载体，优选病毒基因治疗载体，更优选选自以下的病毒载体：腺相关病毒载体、重组腺相关病毒载体、自互补AAV、腺病毒载体、慢病毒载体、逆转录病毒载体、疱疹病毒、SV40载体、痘病毒载体、及其组合，其中优选AAV和rAAV。
21.根据权利要求18的药物组合物或药盒或试剂盒，其中使所述miRNA或lncRNA或其组合的表达或活性降低的试剂选自：抗体、小分子化合物、microRNA、siRNA、shRNA、反义寡核苷酸、结合蛋白或蛋白结构域、多肽、核酸适配体、基因编辑器、表观调控元件、转录抑制元件，或其组合。
22.根据权利要求18所述的药物组合物或药盒或试剂盒，其还包含用于递送所述试剂的载体或运载体。
23.根据权利要求22的药物组合物或药盒或试剂盒，其中所述载体或运载体为病毒载体、脂质体、纳米颗粒、外泌体、类病毒颗粒，优选AAV。
24.根据权利要求18至23中任一项的药物组合物或药盒或试剂盒，其中所述组合物局部施用至以下至少一种：1)视网膜中的胶质细胞；ii)纹状体中的胶质细胞；iii)黑质中的胶质细胞；iv)内耳中的胶质细胞；v)脊髓中的胶质细胞；vi)前额皮质中的胶质细胞；vii)运动皮质中的胶质细胞；viii)下丘脑中的胶质细胞；以及ix)腹侧被盖区中的胶质细胞。
25.根据权利要求18至24中任一项的药物组合物或药盒或试剂盒，其配制成用于细胞转染、细胞感染、细胞内吞、注射、颅内给药、眼内给药、内耳注射、吸入、肠胃外施用、静脉内施用、肌内施用、皮内施用、表面施用或经口施用。
26.根据前述权利要求中任一项的方法、用途、或者药物组合物或药盒或试剂盒，其中非神经元细胞的转分化效率为至少1％，或至少10％、20％、30％、40％或50％。
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CN117398404B (zh) * 2023-12-15 2024-03-08 北京大学口腔医学院 一种miRNA-141-5p在制备用于治疗牙周炎症性疾病药物中的应用

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