JP2015509107A5 - - Google Patents
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- JP2015509107A5 JP2015509107A5 JP2014555045A JP2014555045A JP2015509107A5 JP 2015509107 A5 JP2015509107 A5 JP 2015509107A5 JP 2014555045 A JP2014555045 A JP 2014555045A JP 2014555045 A JP2014555045 A JP 2014555045A JP 2015509107 A5 JP2015509107 A5 JP 2015509107A5
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- 125000003118 aryl group Chemical group 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 9
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 206010025323 Lymphomas Diseases 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000002837 carbocyclic group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
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- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
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- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
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- QPWWALBJROMWHE-UHFFFAOYSA-N 1-[2-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]prop-2-en-1-one Chemical compound C1=2C(N)=NC=NC=2N(C2CC3(C2)CCN(CC3)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 QPWWALBJROMWHE-UHFFFAOYSA-N 0.000 claims 1
- MDOOZFHNLMQRHG-UHFFFAOYSA-N 1-[6-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound C1=2C(N)=NC=NC=2N(C2CC3(C2)CN(C3)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 MDOOZFHNLMQRHG-UHFFFAOYSA-N 0.000 claims 1
- ISDIBDPXVWNENH-UHFFFAOYSA-N 1-[7-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-2-azaspiro[3.5]nonan-2-yl]prop-2-en-1-one Chemical compound C1=2C(N)=NC=NC=2N(C2CCC3(CN(C3)C(=O)C=C)CC2)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 ISDIBDPXVWNENH-UHFFFAOYSA-N 0.000 claims 1
- -1 2- (4-Amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl) -6-azaspiro [3.5] nonan-6-yl Chemical group 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261632781P | 2012-01-31 | 2012-01-31 | |
| US61/632,781 | 2012-01-31 | ||
| PCT/CA2013/000085 WO2013113097A1 (en) | 2012-01-31 | 2013-01-30 | Cyclic molecules as bruton's tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509107A JP2015509107A (ja) | 2015-03-26 |
| JP2015509107A5 true JP2015509107A5 (enExample) | 2015-07-02 |
| JP5985658B2 JP5985658B2 (ja) | 2016-09-06 |
Family
ID=48904331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555045A Expired - Fee Related JP5985658B2 (ja) | 2012-01-31 | 2013-01-30 | ブルトンチロシンキナーゼ阻害薬としての環状分子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9458162B2 (enExample) |
| EP (1) | EP2809673B1 (enExample) |
| JP (1) | JP5985658B2 (enExample) |
| CN (1) | CN104080789B (enExample) |
| CA (1) | CA2863239C (enExample) |
| WO (1) | WO2013113097A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104603124B (zh) | 2012-08-10 | 2018-04-17 | 勃林格殷格翰国际有限公司 | 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 |
| WO2014151620A1 (en) | 2013-03-14 | 2014-09-25 | Boehringer Ingelheim International Gmbh | 5-thiazolecarboxamide dervatives and their use as btk inhibitors |
| WO2014152114A1 (en) * | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| JP6486954B2 (ja) * | 2014-01-29 | 2019-03-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋ阻害剤としてのピラゾール化合物 |
| SG11201605417QA (en) * | 2014-02-03 | 2016-08-30 | Cadila Healthcare Ltd | Heterocyclic compounds |
| KR102073797B1 (ko) * | 2014-07-07 | 2020-02-05 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 단백질 키나제 저해제로서의 아미노피리다지논 화합물 |
| TWI578574B (zh) * | 2014-07-14 | 2017-04-11 | 新世紀光電股份有限公司 | 發光元件結構 |
| WO2016106629A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
| EP3338310A4 (en) * | 2015-08-17 | 2019-02-27 | Infinite Arthroscopy Inc, Limited | Light source |
| US10358446B2 (en) * | 2015-10-14 | 2019-07-23 | Zibo Biopolar Changsheng Pharmaceutical Co., Ltd. | Bruton's tyrosine kinase inhibitors |
| CN106588914B (zh) * | 2015-10-16 | 2018-11-02 | 陈剑 | 具有取代吡啶并咪唑类衍生物，其制备及其在医药上的应用 |
| HRP20211845T1 (hr) * | 2015-12-16 | 2022-03-04 | Boehringer Ingelheim International Gmbh | Derivati bipirazolila korisni za liječenje autoimunih bolesti |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| AU2017208998B2 (en) * | 2016-01-21 | 2021-07-15 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Bruton's tyrosine kinase inhibitors |
| US10793566B2 (en) | 2016-01-21 | 2020-10-06 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| CN107021963A (zh) | 2016-01-29 | 2017-08-08 | 北京诺诚健华医药科技有限公司 | 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用 |
| EP3426637B1 (en) | 2016-03-11 | 2022-02-09 | Angel Pharmaceutical Co., Ltd. | Compounds and methods for modulating bruton's tyrosine kinase |
| TWI828027B (zh) | 2016-03-28 | 2024-01-01 | 美商英塞特公司 | 作為tam抑制劑之吡咯并三嗪化合物 |
| CN109851620B (zh) * | 2016-08-17 | 2020-08-07 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制酪氨酸激酶活性的稠合双环类化合物 |
| CA2939286A1 (en) * | 2016-08-17 | 2018-02-17 | Pharmascience Inc. | Spirocyclic containing compounds and pharmaceutical uses thereof |
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| CN106831787B (zh) | 2017-01-20 | 2018-10-23 | 成都倍特药业有限公司 | 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用 |
| US11554118B2 (en) | 2017-03-22 | 2023-01-17 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
| CN110944999A (zh) | 2017-08-01 | 2020-03-31 | 勃林格殷格翰国际有限公司 | 中间体化合物和方法 |
| WO2020015735A1 (zh) * | 2018-07-20 | 2020-01-23 | 正大天晴药业集团股份有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| TWI767148B (zh) * | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药（上海）有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| WO2022253250A1 (zh) * | 2021-06-01 | 2022-12-08 | 正大天晴药业集团股份有限公司 | 含有并环或螺环的布鲁顿酪氨酸激酶降解剂 |
| WO2025240240A1 (en) * | 2024-05-14 | 2025-11-20 | Dana-Farber Cancer Institute, Inc. | Novel spirocycle derivatives as inhibitors of hck |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ510588A (en) * | 1998-09-18 | 2003-08-29 | Abbott Gmbh & Co | Pyrrolopyrimidines as protein kinase inhibitors |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| WO2005074603A2 (en) * | 2004-02-03 | 2005-08-18 | Abbott Laboratories | Aminobenzoxazoles as therapeutic agents |
| EP2529621B1 (en) * | 2006-09-22 | 2016-10-05 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| US8129371B2 (en) * | 2007-10-16 | 2012-03-06 | Wyeth Llc | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors |
| JP2011528369A (ja) | 2008-07-16 | 2011-11-17 | シェーリング コーポレイション | 二環式ヘテロ環誘導体およびそれらの使用方法 |
| CN102159214A (zh) * | 2008-07-16 | 2011-08-17 | 药品循环公司 | 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂 |
| CA2773661A1 (en) * | 2009-09-10 | 2011-03-17 | Novartis Ag | Ether derivatives of bicyclic heteroaryls |
| WO2011064211A1 (en) * | 2009-11-25 | 2011-06-03 | Novartis Ag | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls |
| WO2013004551A1 (en) * | 2011-07-01 | 2013-01-10 | Bayer Intellectual Property Gmbh | Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
-
2013
- 2013-01-30 EP EP13743950.1A patent/EP2809673B1/en not_active Not-in-force
- 2013-01-30 JP JP2014555045A patent/JP5985658B2/ja not_active Expired - Fee Related
- 2013-01-30 CA CA2863239A patent/CA2863239C/en not_active Expired - Fee Related
- 2013-01-30 WO PCT/CA2013/000085 patent/WO2013113097A1/en not_active Ceased
- 2013-01-30 CN CN201380007581.5A patent/CN104080789B/zh active Active
- 2013-01-30 US US14/375,539 patent/US9458162B2/en not_active Expired - Fee Related
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