JP5985658B2 - ブルトンチロシンキナーゼ阻害薬としての環状分子 - Google Patents
ブルトンチロシンキナーゼ阻害薬としての環状分子 Download PDFInfo
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- JP5985658B2 JP5985658B2 JP2014555045A JP2014555045A JP5985658B2 JP 5985658 B2 JP5985658 B2 JP 5985658B2 JP 2014555045 A JP2014555045 A JP 2014555045A JP 2014555045 A JP2014555045 A JP 2014555045A JP 5985658 B2 JP5985658 B2 JP 5985658B2
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
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| PCT/CA2013/000085 WO2013113097A1 (en) | 2012-01-31 | 2013-01-30 | Cyclic molecules as bruton's tyrosine kinase inhibitors |
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| CN104603124B (zh) | 2012-08-10 | 2018-04-17 | 勃林格殷格翰国际有限公司 | 用作布鲁顿酪氨酸激酶(btk)抑制剂的杂芳族化合物 |
| WO2014151620A1 (en) | 2013-03-14 | 2014-09-25 | Boehringer Ingelheim International Gmbh | 5-thiazolecarboxamide dervatives and their use as btk inhibitors |
| WO2014152114A1 (en) * | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| JP6486954B2 (ja) * | 2014-01-29 | 2019-03-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋ阻害剤としてのピラゾール化合物 |
| SG11201605417QA (en) * | 2014-02-03 | 2016-08-30 | Cadila Healthcare Ltd | Heterocyclic compounds |
| KR102073797B1 (ko) * | 2014-07-07 | 2020-02-05 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 단백질 키나제 저해제로서의 아미노피리다지논 화합물 |
| TWI578574B (zh) * | 2014-07-14 | 2017-04-11 | 新世紀光電股份有限公司 | 發光元件結構 |
| WO2016106629A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
| EP3338310A4 (en) * | 2015-08-17 | 2019-02-27 | Infinite Arthroscopy Inc, Limited | Light source |
| US10358446B2 (en) * | 2015-10-14 | 2019-07-23 | Zibo Biopolar Changsheng Pharmaceutical Co., Ltd. | Bruton's tyrosine kinase inhibitors |
| CN106588914B (zh) * | 2015-10-16 | 2018-11-02 | 陈剑 | 具有取代吡啶并咪唑类衍生物，其制备及其在医药上的应用 |
| HRP20211845T1 (hr) * | 2015-12-16 | 2022-03-04 | Boehringer Ingelheim International Gmbh | Derivati bipirazolila korisni za liječenje autoimunih bolesti |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| AU2017208998B2 (en) * | 2016-01-21 | 2021-07-15 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Bruton's tyrosine kinase inhibitors |
| US10793566B2 (en) | 2016-01-21 | 2020-10-06 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| CN107021963A (zh) | 2016-01-29 | 2017-08-08 | 北京诺诚健华医药科技有限公司 | 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用 |
| EP3426637B1 (en) | 2016-03-11 | 2022-02-09 | Angel Pharmaceutical Co., Ltd. | Compounds and methods for modulating bruton's tyrosine kinase |
| TWI828027B (zh) | 2016-03-28 | 2024-01-01 | 美商英塞特公司 | 作為tam抑制劑之吡咯并三嗪化合物 |
| CN109851620B (zh) * | 2016-08-17 | 2020-08-07 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制酪氨酸激酶活性的稠合双环类化合物 |
| CA2939286A1 (en) * | 2016-08-17 | 2018-02-17 | Pharmascience Inc. | Spirocyclic containing compounds and pharmaceutical uses thereof |
| US11590167B2 (en) | 2016-12-03 | 2023-02-28 | Juno Therapeutic, Inc. | Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors |
| CN106831787B (zh) | 2017-01-20 | 2018-10-23 | 成都倍特药业有限公司 | 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用 |
| US11554118B2 (en) | 2017-03-22 | 2023-01-17 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
| CN110944999A (zh) | 2017-08-01 | 2020-03-31 | 勃林格殷格翰国际有限公司 | 中间体化合物和方法 |
| WO2020015735A1 (zh) * | 2018-07-20 | 2020-01-23 | 正大天晴药业集团股份有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| TWI767148B (zh) * | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药（上海）有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| WO2022253250A1 (zh) * | 2021-06-01 | 2022-12-08 | 正大天晴药业集团股份有限公司 | 含有并环或螺环的布鲁顿酪氨酸激酶降解剂 |
| WO2025240240A1 (en) * | 2024-05-14 | 2025-11-20 | Dana-Farber Cancer Institute, Inc. | Novel spirocycle derivatives as inhibitors of hck |
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| NZ510588A (en) * | 1998-09-18 | 2003-08-29 | Abbott Gmbh & Co | Pyrrolopyrimidines as protein kinase inhibitors |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| WO2005074603A2 (en) * | 2004-02-03 | 2005-08-18 | Abbott Laboratories | Aminobenzoxazoles as therapeutic agents |
| EP2529621B1 (en) * | 2006-09-22 | 2016-10-05 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| US8129371B2 (en) * | 2007-10-16 | 2012-03-06 | Wyeth Llc | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors |
| JP2011528369A (ja) | 2008-07-16 | 2011-11-17 | シェーリング コーポレイション | 二環式ヘテロ環誘導体およびそれらの使用方法 |
| CN102159214A (zh) * | 2008-07-16 | 2011-08-17 | 药品循环公司 | 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂 |
| CA2773661A1 (en) * | 2009-09-10 | 2011-03-17 | Novartis Ag | Ether derivatives of bicyclic heteroaryls |
| WO2011064211A1 (en) * | 2009-11-25 | 2011-06-03 | Novartis Ag | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls |
| WO2013004551A1 (en) * | 2011-07-01 | 2013-01-10 | Bayer Intellectual Property Gmbh | Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
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| EP2809673A4 (en) | 2015-07-08 |
| WO2013113097A1 (en) | 2013-08-08 |
| CN104080789A (zh) | 2014-10-01 |
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| JP2015509107A (ja) | 2015-03-26 |
| CN104080789B (zh) | 2016-05-11 |
| CA2863239A1 (en) | 2013-08-08 |
| EP2809673B1 (en) | 2016-11-02 |
| EP2809673A1 (en) | 2014-12-10 |
| CA2863239C (en) | 2016-09-13 |
| US20150011530A1 (en) | 2015-01-08 |
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