JP2015502395A - 電位依存性ナトリウムチャネルモジュレーターとしての２−（ピリジン−２イル）−１，７−ジアザ−スピロ［４．４］ノナン−６−オン化合物 - Google Patents
電位依存性ナトリウムチャネルモジュレーターとしての２−（ピリジン−２イル）−１，７−ジアザ−スピロ［４．４］ノナン−６−オン化合物 Download PDFInfo
- Publication number
- JP2015502395A JP2015502395A JP2014548202A JP2014548202A JP2015502395A JP 2015502395 A JP2015502395 A JP 2015502395A JP 2014548202 A JP2014548202 A JP 2014548202A JP 2014548202 A JP2014548202 A JP 2014548202A JP 2015502395 A JP2015502395 A JP 2015502395A
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- methyl
- phenyl
- compound
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LXPYHNFJGNHZJT-CTNGQTDRSA-N C/C=C(\C=C(\[C@@H](CC1)N(C)[C@@]1(CCN1C)C1=O)/[N]#C)/c1ccc(C(F)(F)F)cc1 Chemical compound C/C=C(\C=C(\[C@@H](CC1)N(C)[C@@]1(CCN1C)C1=O)/[N]#C)/c1ccc(C(F)(F)F)cc1 LXPYHNFJGNHZJT-CTNGQTDRSA-N 0.000 description 1
- CQKPADVCSGSSGT-YWNGLHGRSA-N CC1(C(C2)C=CN=C2[C@H](CC2)N[C@@]2(CCN2C)C2=O)C=CC=CC1F Chemical compound CC1(C(C2)C=CN=C2[C@H](CC2)N[C@@]2(CCN2C)C2=O)C=CC=CC1F CQKPADVCSGSSGT-YWNGLHGRSA-N 0.000 description 1
- OKVKXFWBJVSTTH-CTNGQTDRSA-N CN(CC[C@@](CC1)(C#C)N[C@H]1c1cc(-c2cccc(OC(F)(F)F)c2)ccn1)C=O Chemical compound CN(CC[C@@](CC1)(C#C)N[C@H]1c1cc(-c2cccc(OC(F)(F)F)c2)ccn1)C=O OKVKXFWBJVSTTH-CTNGQTDRSA-N 0.000 description 1
- ZLKFVSLORDMXCS-APWZRJJASA-N CN(CC[C@]1(CC2)N[C@H]2c2cc(-c3ccccc3F)ccn2)C1=O Chemical compound CN(CC[C@]1(CC2)N[C@H]2c2cc(-c3ccccc3F)ccn2)C1=O ZLKFVSLORDMXCS-APWZRJJASA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579613P | 2011-12-22 | 2011-12-22 | |
| GB1122113.2 | 2011-12-22 | ||
| GBGB1122113.2A GB201122113D0 (en) | 2011-12-22 | 2011-12-22 | Novel compounds |
| US61/579,613 | 2011-12-22 | ||
| PCT/GB2012/053234 WO2013093497A1 (en) | 2011-12-22 | 2012-12-21 | 2 - (pyridin- 2yl) - 1, 7 -diaza- spiro [4.4] nonane- 6 -one compounds as voltage - gated sodium channels modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2015502395A true JP2015502395A (ja) | 2015-01-22 |
Family
ID=45572877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548202A Pending JP2015502395A (ja) | 2011-12-22 | 2012-12-21 | 電位依存性ナトリウムチャネルモジュレーターとしての２−（ピリジン−２イル）−１，７−ジアザ−スピロ［４．４］ノナン−６−オン化合物 |
| JP2014548201A Pending JP2015502394A (ja) | 2011-12-22 | 2012-12-21 | 電位依存性ナトリウムチャネルモジュレーターとしての２−（ピリジン−２イル）−１，７−ジアザ−スピロ［４．４］ノナン−６−オン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548201A Pending JP2015502394A (ja) | 2011-12-22 | 2012-12-21 | 電位依存性ナトリウムチャネルモジュレーターとしての２−（ピリジン−２イル）−１，７−ジアザ−スピロ［４．４］ノナン−６−オン化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9376436B2 (enExample) |
| EP (2) | EP2797922B1 (enExample) |
| JP (2) | JP2015502395A (enExample) |
| KR (1) | KR20140113692A (enExample) |
| CN (1) | CN104271581B (enExample) |
| AU (1) | AU2012356386A1 (enExample) |
| BR (1) | BR112014014940A2 (enExample) |
| CA (1) | CA2858938C (enExample) |
| EA (1) | EA026500B1 (enExample) |
| ES (1) | ES2581327T3 (enExample) |
| GB (1) | GB201122113D0 (enExample) |
| HK (2) | HK1203501A1 (enExample) |
| IL (1) | IL233215A0 (enExample) |
| IN (1) | IN2014MN01469A (enExample) |
| MX (1) | MX2014007637A (enExample) |
| SG (1) | SG11201403356YA (enExample) |
| WO (2) | WO2013093497A1 (enExample) |
| ZA (1) | ZA201404269B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015502394A (ja) * | 2011-12-22 | 2015-01-22 | クオンベルゲンセ プハルマセウトイカルス リミテッド | 電位依存性ナトリウムチャネルモジュレーターとしての２−（ピリジン−２イル）−１，７−ジアザ−スピロ［４．４］ノナン−６−オン化合物 |
| JP2015517561A (ja) * | 2012-05-22 | 2015-06-22 | クオンベルゲンセ プハルマセウトイカルス リミテッド | 新規化合物 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2650523C1 (ru) | 2017-07-24 | 2018-04-16 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Производное пиридоксина для лечения эпилепсии |
| JP2020536898A (ja) * | 2017-10-10 | 2020-12-17 | バイオジェン インコーポレイテッド | スピロ誘導体を調製するためのプロセス |
| JP7006990B2 (ja) | 2017-11-17 | 2022-02-10 | セリックス バイオ プライヴェート リミテッド | 眼障害の処置のための組成物及び方法 |
| CN113563258A (zh) * | 2021-07-29 | 2021-10-29 | 派普医药(江苏)有限公司 | 一种4-溴-2-(二氟甲基)-5-甲基吡啶的制备方法 |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
| US20230150972A1 (en) * | 2021-09-24 | 2023-05-18 | Xenon Pharmaceuticals Inc. | Pyridinyl derivatives as sodium channel activators |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027691A2 (en) * | 2006-08-31 | 2008-03-06 | Micron Technology, Inc. | Phase-change random access memory employing read before write for resistance stabilization |
| JP2009514801A (ja) * | 2005-10-10 | 2009-04-09 | グラクソ グループ リミテッド | 電位依存性ナトリウムチャネルの調節因子としての第四級α−アミノカルボキサミド誘導体 |
| JP2010516732A (ja) * | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | Ｎｋ１受容体アンタゴニストおよびナトリウムチャンネル遮断剤を含む医薬組成物 |
| WO2011047174A1 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
| JP2015502394A (ja) * | 2011-12-22 | 2015-01-22 | クオンベルゲンセ プハルマセウトイカルス リミテッド | 電位依存性ナトリウムチャネルモジュレーターとしての２−（ピリジン−２イル）−１，７−ジアザ−スピロ［４．４］ノナン−６−オン化合物 |
Family Cites Families (25)
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| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| WO1996025405A1 (en) | 1995-02-13 | 1996-08-22 | G.D. Searle & Co. | Substituted isoxazoles for the treatment of inflammation |
| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| ATE233743T1 (de) | 1996-04-12 | 2003-03-15 | Searle & Co | N-((4-(5-methyl-3-phenylisoxazol-4- yl)phenyl)sulphonylpropylamid und sein natriumsalz als pro-pharmakon von cox-2 inhibitoren |
| SI0912518T1 (en) | 1996-07-18 | 2003-12-31 | Merck Frosst Canada & Co. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| EE04617B1 (et) | 1997-09-05 | 2006-04-17 | Glaxo Group Limited | 2,3-diarüülpürasolo[1,5-b]püridasiini derivaadid,nende valmistamine ja kasutamine tsüklooksügenaas2 (COX-2) inhibiitoritena |
| NZ511349A (en) | 1998-11-03 | 2003-10-31 | Glaxo Group Ltd | Pyrazolopyridine derivatives useful as selective COX-2 inhibitors |
| US6025683A (en) | 1998-12-23 | 2000-02-15 | Stryker Corporation | Motor control circuit for regulating a D.C. motor |
| ES2216631T3 (es) | 1999-02-27 | 2004-10-16 | Glaxo Group Limited | Pirazolpiridinas. |
| GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
| GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
| GB0323204D0 (en) | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
| SE0302811D0 (sv) * | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
| TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| US8143306B2 (en) | 2005-10-10 | 2012-03-27 | Convergence Pharmaceuticals Limited | Methods of treating bipolar disorders |
| GB0520578D0 (en) * | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| EP1943216B1 (en) | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| CN101641099A (zh) | 2007-01-24 | 2010-02-03 | 葛兰素集团有限公司 | 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物 |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| EP2477964B1 (en) | 2009-09-14 | 2015-02-11 | Convergence Pharmaceuticals Limited | Process for preparing alpha-carboxamide derivatives |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
-
2011
- 2011-12-22 GB GBGB1122113.2A patent/GB201122113D0/en not_active Ceased
-
2012
- 2012-12-21 WO PCT/GB2012/053234 patent/WO2013093497A1/en not_active Ceased
- 2012-12-21 US US14/365,372 patent/US9376436B2/en not_active Expired - Fee Related
- 2012-12-21 HK HK15104075.3A patent/HK1203501A1/xx unknown
- 2012-12-21 EP EP12810416.3A patent/EP2797922B1/en not_active Not-in-force
- 2012-12-21 ES ES12810416.3T patent/ES2581327T3/es active Active
- 2012-12-21 IN IN1469MUN2014 patent/IN2014MN01469A/en unknown
- 2012-12-21 KR KR1020147019965A patent/KR20140113692A/ko not_active Withdrawn
- 2012-12-21 HK HK15103930.0A patent/HK1203492A1/xx unknown
- 2012-12-21 JP JP2014548202A patent/JP2015502395A/ja active Pending
- 2012-12-21 BR BR112014014940A patent/BR112014014940A2/pt not_active Application Discontinuation
- 2012-12-21 CN CN201280070485.0A patent/CN104271581B/zh not_active Expired - Fee Related
- 2012-12-21 SG SG11201403356YA patent/SG11201403356YA/en unknown
- 2012-12-21 JP JP2014548201A patent/JP2015502394A/ja active Pending
- 2012-12-21 US US14/365,391 patent/US9303032B2/en not_active Expired - Fee Related
- 2012-12-21 EA EA201491251A patent/EA026500B1/ru unknown
- 2012-12-21 AU AU2012356386A patent/AU2012356386A1/en not_active Abandoned
- 2012-12-21 CA CA2858938A patent/CA2858938C/en active Active
- 2012-12-21 WO PCT/GB2012/053233 patent/WO2013093496A1/en not_active Ceased
- 2012-12-21 EP EP12810417.1A patent/EP2794612B1/en not_active Not-in-force
- 2012-12-21 MX MX2014007637A patent/MX2014007637A/es unknown
-
2014
- 2014-06-10 ZA ZA2014/04269A patent/ZA201404269B/en unknown
- 2014-06-18 IL IL233215A patent/IL233215A0/en unknown
-
2016
- 2016-02-25 US US15/053,445 patent/US20160185758A1/en not_active Abandoned
Patent Citations (5)
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| JP2010516732A (ja) * | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | Ｎｋ１受容体アンタゴニストおよびナトリウムチャンネル遮断剤を含む医薬組成物 |
| WO2011047174A1 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
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| JP2015517561A (ja) * | 2012-05-22 | 2015-06-22 | クオンベルゲンセ プハルマセウトイカルス リミテッド | 新規化合物 |
| JP2015517562A (ja) * | 2012-05-22 | 2015-06-22 | クオンベルゲンセ プハルマセウトイカルス リミテッド | 新規化合物 |
| JP2017206534A (ja) * | 2012-05-22 | 2017-11-24 | クオンベルゲンセ プハルマセウトイカルス リミテッド | 新規化合物 |
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| WO2013093497A1 (en) | 2013-06-27 |
| AU2012356386A1 (en) | 2014-07-10 |
| US20140350040A1 (en) | 2014-11-27 |
| IL233215A0 (en) | 2014-08-31 |
| BR112014014940A2 (pt) | 2017-06-13 |
| HK1203492A1 (en) | 2015-10-30 |
| EP2794612B1 (en) | 2016-04-06 |
| CA2858938A1 (en) | 2013-06-27 |
| GB201122113D0 (en) | 2012-02-01 |
| US20150225400A1 (en) | 2015-08-13 |
| EP2797922A1 (en) | 2014-11-05 |
| EA201491251A1 (ru) | 2014-11-28 |
| US9303032B2 (en) | 2016-04-05 |
| HK1203501A1 (en) | 2015-10-30 |
| ES2581327T3 (es) | 2016-09-05 |
| MX2014007637A (es) | 2014-09-26 |
| ZA201404269B (en) | 2016-06-29 |
| SG11201403356YA (en) | 2014-07-30 |
| IN2014MN01469A (enExample) | 2015-04-17 |
| CN104271581A (zh) | 2015-01-07 |
| EP2794612A1 (en) | 2014-10-29 |
| CA2858938C (en) | 2020-03-10 |
| KR20140113692A (ko) | 2014-09-24 |
| US20160185758A1 (en) | 2016-06-30 |
| JP2015502394A (ja) | 2015-01-22 |
| EA026500B1 (ru) | 2017-04-28 |
| CN104271581B (zh) | 2016-08-31 |
| US9376436B2 (en) | 2016-06-28 |
| WO2013093496A1 (en) | 2013-06-27 |
| EP2797922B1 (en) | 2016-04-06 |
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