ES2581327T3 - Compuesto 2-(piridín-2-il)-1,7-diazaspiro[4.4]nonán-6-ona como modulador de los canales ionótropos de sodio dependientes de voltaje - Google Patents
Compuesto 2-(piridín-2-il)-1,7-diazaspiro[4.4]nonán-6-ona como modulador de los canales ionótropos de sodio dependientes de voltaje Download PDFInfo
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- ES2581327T3 ES2581327T3 ES12810416.3T ES12810416T ES2581327T3 ES 2581327 T3 ES2581327 T3 ES 2581327T3 ES 12810416 T ES12810416 T ES 12810416T ES 2581327 T3 ES2581327 T3 ES 2581327T3
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579613P | 2011-12-22 | 2011-12-22 | |
| US201161579613P | 2011-12-22 | ||
| GBGB1122113.2A GB201122113D0 (en) | 2011-12-22 | 2011-12-22 | Novel compounds |
| GB201122113 | 2011-12-22 | ||
| PCT/GB2012/053233 WO2013093496A1 (en) | 2011-12-22 | 2012-12-21 | 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4] nonane- 6 -one compound as voltage-gated sodium channels modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2581327T3 true ES2581327T3 (es) | 2016-09-05 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES12810416.3T Active ES2581327T3 (es) | 2011-12-22 | 2012-12-21 | Compuesto 2-(piridín-2-il)-1,7-diazaspiro[4.4]nonán-6-ona como modulador de los canales ionótropos de sodio dependientes de voltaje |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9376436B2 (enExample) |
| EP (2) | EP2794612B1 (enExample) |
| JP (2) | JP2015502395A (enExample) |
| KR (1) | KR20140113692A (enExample) |
| CN (1) | CN104271581B (enExample) |
| AU (1) | AU2012356386A1 (enExample) |
| BR (1) | BR112014014940A2 (enExample) |
| CA (1) | CA2858938C (enExample) |
| EA (1) | EA026500B1 (enExample) |
| ES (1) | ES2581327T3 (enExample) |
| GB (1) | GB201122113D0 (enExample) |
| HK (2) | HK1203492A1 (enExample) |
| IL (1) | IL233215A0 (enExample) |
| IN (1) | IN2014MN01469A (enExample) |
| MX (1) | MX2014007637A (enExample) |
| SG (1) | SG11201403356YA (enExample) |
| WO (2) | WO2013093496A1 (enExample) |
| ZA (1) | ZA201404269B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| RU2650523C1 (ru) | 2017-07-24 | 2018-04-16 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Производное пиридоксина для лечения эпилепсии |
| MX2020003821A (es) | 2017-10-10 | 2023-01-12 | Biogen Inc | Proceso de elaboración de espiroderivados. |
| BR112020009361A2 (pt) | 2017-11-17 | 2020-10-13 | Cellix Bio Private Limited | composto de fórmula i, composição farmacêutica para tratar um distúrbio ocular ou complicações do mesmo, método de síntese de composto, método de tratamento de um distúrbio ocular ou complicações do mesmo em um indivíduo que precisa do mesmo e uso de um composto |
| CN113563258A (zh) * | 2021-07-29 | 2021-10-29 | 派普医药(江苏)有限公司 | 一种4-溴-2-(二氟甲基)-5-甲基吡啶的制备方法 |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
| AU2022349463A1 (en) * | 2021-09-24 | 2024-03-14 | Xenon Pharmaceuticals Inc. | Pyridinyl derivatives as sodium channel activators |
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| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| JP3267300B2 (ja) | 1995-02-13 | 2002-03-18 | ジー．ディー．サール アンド カンパニー | 炎症の治療のための置換イソオキサゾール |
| US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| GEP20032998B (en) | 1996-04-12 | 2003-06-25 | Searle & Co | Substituted Benzenesulfonamide Derivatives as Prodrugs of Cox-2 Inhibitors |
| SI0912518T1 (en) | 1996-07-18 | 2003-12-31 | Merck Frosst Canada & Co. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| ATE281458T1 (de) | 1997-09-05 | 2004-11-15 | Glaxo Group Ltd | Pharmazeutische zusammensetzung, enthaltend 2,3- diaryl-pyrazolo(1,5-b)pyridazin derivate |
| ATE275148T1 (de) | 1998-11-03 | 2004-09-15 | Glaxo Group Ltd | Pyrazolopyridin derivative als selektive cox-2 inhibitoren |
| US6025683A (en) | 1998-12-23 | 2000-02-15 | Stryker Corporation | Motor control circuit for regulating a D.C. motor |
| WO2000052008A1 (en) | 1999-02-27 | 2000-09-08 | Glaxo Group Limited | Pyrazolopyridines |
| GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
| GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
| GB0323204D0 (en) | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
| SE0302811D0 (sv) * | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
| EP1943216B1 (en) | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| US8143306B2 (en) | 2005-10-10 | 2012-03-27 | Convergence Pharmaceuticals Limited | Methods of treating bipolar disorders |
| GB0520578D0 (en) * | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| TW200728258A (en) | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| US7505330B2 (en) * | 2006-08-31 | 2009-03-17 | Micron Technology, Inc. | Phase-change random access memory employing read before write for resistance stabilization |
| GB0701366D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| US8093268B2 (en) | 2007-01-24 | 2012-01-10 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| DK2477964T5 (en) | 2009-09-14 | 2015-05-26 | Convergence Pharmaceuticals | A process for the preparation of alpha-carboxamide |
| PE20170202A1 (es) * | 2009-10-14 | 2017-03-24 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol |
| GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
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2011
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2012
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| CA2858938C (en) | 2020-03-10 |
| JP2015502395A (ja) | 2015-01-22 |
| US9303032B2 (en) | 2016-04-05 |
| CN104271581B (zh) | 2016-08-31 |
| EP2797922A1 (en) | 2014-11-05 |
| US20160185758A1 (en) | 2016-06-30 |
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| EP2794612A1 (en) | 2014-10-29 |
| MX2014007637A (es) | 2014-09-26 |
| US9376436B2 (en) | 2016-06-28 |
| WO2013093496A1 (en) | 2013-06-27 |
| IL233215A0 (en) | 2014-08-31 |
| AU2012356386A1 (en) | 2014-07-10 |
| IN2014MN01469A (enExample) | 2015-04-17 |
| SG11201403356YA (en) | 2014-07-30 |
| EP2797922B1 (en) | 2016-04-06 |
| CN104271581A (zh) | 2015-01-07 |
| HK1203501A1 (en) | 2015-10-30 |
| US20140350040A1 (en) | 2014-11-27 |
| KR20140113692A (ko) | 2014-09-24 |
| HK1203492A1 (en) | 2015-10-30 |
| WO2013093497A1 (en) | 2013-06-27 |
| ZA201404269B (en) | 2016-06-29 |
| US20150225400A1 (en) | 2015-08-13 |
| BR112014014940A2 (pt) | 2017-06-13 |
| EP2794612B1 (en) | 2016-04-06 |
| EA201491251A1 (ru) | 2014-11-28 |
| CA2858938A1 (en) | 2013-06-27 |
| JP2015502394A (ja) | 2015-01-22 |
| EA026500B1 (ru) | 2017-04-28 |
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