JP2015500856A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015500856A5 JP2015500856A5 JP2014547934A JP2014547934A JP2015500856A5 JP 2015500856 A5 JP2015500856 A5 JP 2015500856A5 JP 2014547934 A JP2014547934 A JP 2014547934A JP 2014547934 A JP2014547934 A JP 2014547934A JP 2015500856 A5 JP2015500856 A5 JP 2015500856A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- heterocyclyl
- carbocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(N(*)I[Al]*C(C1)CN1[Al])=O Chemical compound *C(N(*)I[Al]*C(C1)CN1[Al])=O 0.000 description 26
- YRKRGYRYEQYTOH-UHFFFAOYSA-N CC(C1)CNC1=O Chemical compound CC(C1)CNC1=O YRKRGYRYEQYTOH-UHFFFAOYSA-N 0.000 description 3
- KYINPWAJIVTFBW-UHFFFAOYSA-N CC1CNCC1 Chemical compound CC1CNCC1 KYINPWAJIVTFBW-UHFFFAOYSA-N 0.000 description 3
- OMSNHBNKSBDDSL-INIZCTEOSA-N CCCOc(cc1OC)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(C)=O)cc1 Chemical compound CCCOc(cc1OC)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(C)=O)cc1 OMSNHBNKSBDDSL-INIZCTEOSA-N 0.000 description 2
- ZLYQZAXQLQPNPE-HNNXBMFYSA-N CCCOc1ccc(N(C2)CC2Oc2ccc([C@H](C)NC(C)=O)cc2)nc1 Chemical compound CCCOc1ccc(N(C2)CC2Oc2ccc([C@H](C)NC(C)=O)cc2)nc1 ZLYQZAXQLQPNPE-HNNXBMFYSA-N 0.000 description 2
- XEHCERKZWHIADP-UHFFFAOYSA-N CCOc(cc1)ccc1N(C1)CC1Oc1ccc(C(C)NC(C2(CC2)C(F)(F)F)=O)cc1 Chemical compound CCOc(cc1)ccc1N(C1)CC1Oc1ccc(C(C)NC(C2(CC2)C(F)(F)F)=O)cc1 XEHCERKZWHIADP-UHFFFAOYSA-N 0.000 description 2
- QWTKWBKJVGEQNA-UHFFFAOYSA-N CCOc(cc1)ccc1N(C1)CC1Oc1ccc(C(C)NC(c2c(C)nc(NC(C)=O)[s]2)=O)cc1 Chemical compound CCOc(cc1)ccc1N(C1)CC1Oc1ccc(C(C)NC(c2c(C)nc(NC(C)=O)[s]2)=O)cc1 QWTKWBKJVGEQNA-UHFFFAOYSA-N 0.000 description 2
- PYMIBEHOGAKRBK-HNNXBMFYSA-N CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(C)=O)cc1 Chemical compound CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(C)=O)cc1 PYMIBEHOGAKRBK-HNNXBMFYSA-N 0.000 description 2
- OHGITAVUYNFLDT-INIZCTEOSA-N CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(C2CC2)=O)cc1 Chemical compound CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(C2CC2)=O)cc1 OHGITAVUYNFLDT-INIZCTEOSA-N 0.000 description 2
- WXTZKTRXTALJCJ-HNNXBMFYSA-N CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(OC)=O)cc1 Chemical compound CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(OC)=O)cc1 WXTZKTRXTALJCJ-HNNXBMFYSA-N 0.000 description 2
- YPLPBSZXYGWBMD-INIZCTEOSA-N CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(c2c[nH]nc2)=O)cc1 Chemical compound CCOc(cc1)ccc1N(C1)CC1Oc1ccc([C@H](C)NC(c2c[nH]nc2)=O)cc1 YPLPBSZXYGWBMD-INIZCTEOSA-N 0.000 description 2
- YCLCQGOATAFIRH-INIZCTEOSA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c(cc1)ccc1OCC1CC1)NC(C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c(cc1)ccc1OCC1CC1)NC(C)=O YCLCQGOATAFIRH-INIZCTEOSA-N 0.000 description 2
- WTGXNJCQAYSVEY-MBIQTGHCSA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c(ccc(OCC(C1)C1(F)F)c1)c1F)NC(C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c(ccc(OCC(C1)C1(F)F)c1)c1F)NC(C)=O WTGXNJCQAYSVEY-MBIQTGHCSA-N 0.000 description 2
- XZRJAPLYDLVTAQ-HNNXBMFYSA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c(ccc(OCC1CC1)c1)c1F)NC(C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c(ccc(OCC1CC1)c1)c1F)NC(C)=O XZRJAPLYDLVTAQ-HNNXBMFYSA-N 0.000 description 2
- CBKNHQRILNEGAA-NSHDSACASA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c(nc1)ncc1Br)NC(C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c(nc1)ncc1Br)NC(C)=O CBKNHQRILNEGAA-NSHDSACASA-N 0.000 description 2
- QDRIDKYKWXKJRI-AWEZNQCLSA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c1ccc2OCCOc2c1)NC(C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c1ccc2OCCOc2c1)NC(C)=O QDRIDKYKWXKJRI-AWEZNQCLSA-N 0.000 description 2
- VZBVWNLNEALYMU-ZDUSSCGKSA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c1nc(C(F)(F)F)ccc1)NC(N(C)C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c1nc(C(F)(F)F)ccc1)NC(N(C)C)=O VZBVWNLNEALYMU-ZDUSSCGKSA-N 0.000 description 2
- VTOFOSHGSKJRLS-NSHDSACASA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c1ncc(C(F)(F)F)cc1F)NC(C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c1ncc(C(F)(F)F)cc1F)NC(C)=O VTOFOSHGSKJRLS-NSHDSACASA-N 0.000 description 2
- FWFDMKCJCYWQBQ-UHFFFAOYSA-N NOCC1(CC1)C(F)F Chemical compound NOCC1(CC1)C(F)F FWFDMKCJCYWQBQ-UHFFFAOYSA-N 0.000 description 2
- GCEPDPUDGADINQ-UHFFFAOYSA-N CC(c(cc1)ccc1OC(C1)CN1c(cc1)ccc1OC1CC1)NC(N(C)C)=O Chemical compound CC(c(cc1)ccc1OC(C1)CN1c(cc1)ccc1OC1CC1)NC(N(C)C)=O GCEPDPUDGADINQ-UHFFFAOYSA-N 0.000 description 1
- GCEPDPUDGADINQ-INIZCTEOSA-N C[C@@H](c(cc1)ccc1OC(C1)CN1c(cc1)ccc1OC1CC1)NC(N(C)C)=O Chemical compound C[C@@H](c(cc1)ccc1OC(C1)CN1c(cc1)ccc1OC1CC1)NC(N(C)C)=O GCEPDPUDGADINQ-INIZCTEOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194277.7 | 2011-12-19 | ||
| EP11194277 | 2011-12-19 | ||
| PCT/EP2012/075996 WO2013092616A1 (en) | 2011-12-19 | 2012-12-18 | New aziridine compounds, pharmaceutical compositions and their use as acetyl-coa carboxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500856A JP2015500856A (ja) | 2015-01-08 |
| JP2015500856A5 true JP2015500856A5 (enExample) | 2016-02-12 |
| JP6051457B2 JP6051457B2 (ja) | 2016-12-27 |
Family
ID=47358497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547934A Expired - Fee Related JP6051457B2 (ja) | 2011-12-19 | 2012-12-18 | 新規アジリジン化合物、医薬組成物、およびアセチルｃｏａ−カルボキシラーゼ阻害剤としてのそれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8530460B2 (enExample) |
| EP (1) | EP2794586B1 (enExample) |
| JP (1) | JP6051457B2 (enExample) |
| WO (1) | WO2013092616A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014061693A1 (ja) * | 2012-10-17 | 2014-04-24 | 塩野義製薬株式会社 | 新規非芳香族炭素環又は非芳香族複素環誘導体 |
| WO2014114578A1 (en) * | 2013-01-25 | 2014-07-31 | Boehringer Ingelheim International Gmbh | Pyrrolidine derivatives, pharmaceutical compositions and uses thereof |
| JPWO2015056782A1 (ja) * | 2013-10-17 | 2017-03-09 | 塩野義製薬株式会社 | 新規アルキレン誘導体 |
| CN106632258B (zh) * | 2016-12-15 | 2019-04-02 | 三峡大学 | 四氢异喹啉-2-基芳氧基苯氧基烷基酮化合物及其应用 |
| TWI832917B (zh) | 2018-11-06 | 2024-02-21 | 美商富曼西公司 | 經取代之甲苯基殺真菌劑 |
| UY39189A (es) | 2020-05-06 | 2021-12-31 | Fmc Corp | Fungicidas de tolilo sustituido y sus mezclas |
| US20250041279A1 (en) | 2021-11-19 | 2025-02-06 | Shionogi & Co., Ltd. | Therapeutic medicine for heart disease or skeletal muscle disease |
| TWI866545B (zh) * | 2022-10-20 | 2024-12-11 | 南韓商東亞Ｓｔ股份有限公司 | 氮雜環丁烷基苯并唑化合物及其等作為mer及axl抑制劑的用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ534582A (en) | 2002-02-27 | 2006-03-31 | Pfizer Prod Inc | ACC inhibitors |
| JP2006131559A (ja) * | 2004-11-05 | 2006-05-25 | Takeda Chem Ind Ltd | 含窒素複素環化合物 |
| DE102005055726A1 (de) | 2005-11-23 | 2007-08-30 | Sanofi-Aventis Deutschland Gmbh | Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| AU2006331882A1 (en) | 2005-12-21 | 2007-07-05 | Schering Corporation | Phenoxypiperidines and analogs thereof useful as histamine H3 antagonists |
| WO2007091046A1 (en) * | 2006-02-09 | 2007-08-16 | Astrazeneca Ab | Chemical compounds |
| CA2654792A1 (en) | 2006-06-12 | 2007-12-21 | Merck Frosst Canada Ltd. | Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| JP2008179621A (ja) * | 2006-12-28 | 2008-08-07 | Taisho Pharmaceutical Co Ltd | 含窒素飽和複素環化合物 |
| JP2010043019A (ja) * | 2008-08-12 | 2010-02-25 | Taisho Pharmaceutical Co Ltd | ピペリジニルピペラジン化合物 |
| WO2010043052A1 (en) | 2008-10-17 | 2010-04-22 | Merck Frosst Canada Ltd. | Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| WO2010127212A1 (en) | 2009-04-30 | 2010-11-04 | Forest Laboratories Holdings Limited | Inhibitors of acetyl-coa carboxylase |
| NZ603777A (en) | 2010-04-27 | 2013-08-30 | Takeda Pharmaceutical | Bicyclic compound derivatives and their use as acc inhibitors. |
| US8835472B2 (en) | 2010-09-02 | 2014-09-16 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
-
2012
- 2012-12-14 US US13/714,511 patent/US8530460B2/en active Active
- 2012-12-18 EP EP12801768.8A patent/EP2794586B1/en not_active Not-in-force
- 2012-12-18 JP JP2014547934A patent/JP6051457B2/ja not_active Expired - Fee Related
- 2012-12-18 WO PCT/EP2012/075996 patent/WO2013092616A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015500856A5 (enExample) | ||
| JP2015506355A5 (enExample) | ||
| JP2014506599A5 (enExample) | ||
| JP2012528166A5 (enExample) | ||
| JP2012523457A5 (enExample) | ||
| JP2017509689A5 (enExample) | ||
| JP2019513778A5 (enExample) | ||
| JP2013541513A5 (enExample) | ||
| RU2014103960A (ru) | Гетероарилзамещенные пиразолопиридины и их применение в качестве стимуляторов растворимой гуанилатциклазы | |
| JP2013545791A5 (enExample) | ||
| SI2961736T1 (en) | Histone demethylase inhibitors | |
| RU2010126105A (ru) | Производные пиридина, замещенные гетероциклическим кольцом и фосфоноксиметильной группой, и содержащие их противогрибковые средства | |
| CN106986822A (zh) | 用于治疗 nk‑1 受体相关疾病的取代的 4‑苯基吡啶 | |
| JP2016517417A5 (enExample) | ||
| RU2010143857A (ru) | Тетрагидрофенантридиноны и тетрагидроциклопентахинолиноны в качестве ингибриторов parp и ингибиторов полимеризации тубулина | |
| JP2006524222A5 (enExample) | ||
| JP2009524670A5 (enExample) | ||
| RU2013149174A (ru) | Новое имидазооксазиновое соединение или его соль | |
| RU2012126083A (ru) | Производные аминооксазина | |
| JP2018524338A5 (enExample) | ||
| JP2014516070A5 (enExample) | ||
| JP2014509600A5 (enExample) | ||
| RU2015101102A (ru) | Гетероароматическое метильное производное циклического амина | |
| JP2020513415A5 (enExample) | ||
| JP2019510794A5 (enExample) |