JP6051457B2 - 新規アジリジン化合物、医薬組成物、およびアセチルｃｏａ−カルボキシラーゼ阻害剤としてのそれらの使用 - Google Patents

新規アジリジン化合物、医薬組成物、およびアセチルｃｏａ−カルボキシラーゼ阻害剤としてのそれらの使用 Download PDF

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JP6051457B2
JP6051457B2 JP2014547934A JP2014547934A JP6051457B2 JP 6051457 B2 JP6051457 B2 JP 6051457B2 JP 2014547934 A JP2014547934 A JP 2014547934A JP 2014547934 A JP2014547934 A JP 2014547934A JP 6051457 B2 JP6051457 B2 JP 6051457B2
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alkyl
group
heterocyclyl
carbocyclyl
heteroaryl
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JP2015500856A5 (enExample
JP2015500856A (ja
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マルティン フレック
マルティン フレック
ゲラルト ユールゲン ロート
ゲラルト ユールゲン ロート
ベルント ノッセ
ベルント ノッセ
ニクラス ハイネ
ニクラス ハイネ
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2014547934A 2011-12-19 2012-12-18 新規アジリジン化合物、医薬組成物、およびアセチルｃｏａ−カルボキシラーゼ阻害剤としてのそれらの使用 Expired - Fee Related JP6051457B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11194277.7 2011-12-19
EP11194277 2011-12-19
PCT/EP2012/075996 WO2013092616A1 (en) 2011-12-19 2012-12-18 New aziridine compounds, pharmaceutical compositions and their use as acetyl-coa carboxylase inhibitors

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JP2015500856A JP2015500856A (ja) 2015-01-08
JP2015500856A5 JP2015500856A5 (enExample) 2016-02-12
JP6051457B2 true JP6051457B2 (ja) 2016-12-27

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JP2014547934A Expired - Fee Related JP6051457B2 (ja) 2011-12-19 2012-12-18 新規アジリジン化合物、医薬組成物、およびアセチルｃｏａ−カルボキシラーゼ阻害剤としてのそれらの使用

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US (1) US8530460B2 (enExample)
EP (1) EP2794586B1 (enExample)
JP (1) JP6051457B2 (enExample)
WO (1) WO2013092616A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014061693A1 (ja) * 2012-10-17 2014-04-24 塩野義製薬株式会社 新規非芳香族炭素環又は非芳香族複素環誘導体
WO2014114578A1 (en) * 2013-01-25 2014-07-31 Boehringer Ingelheim International Gmbh Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
JPWO2015056782A1 (ja) * 2013-10-17 2017-03-09 塩野義製薬株式会社 新規アルキレン誘導体
CN106632258B (zh) * 2016-12-15 2019-04-02 三峡大学 四氢异喹啉-2-基芳氧基苯氧基烷基酮化合物及其应用
TWI832917B (zh) 2018-11-06 2024-02-21 美商富曼西公司 經取代之甲苯基殺真菌劑
UY39189A (es) 2020-05-06 2021-12-31 Fmc Corp Fungicidas de tolilo sustituido y sus mezclas
US20250041279A1 (en) 2021-11-19 2025-02-06 Shionogi & Co., Ltd. Therapeutic medicine for heart disease or skeletal muscle disease
TWI866545B (zh) * 2022-10-20 2024-12-11 南韓商東亞Ｓｔ股份有限公司 氮雜環丁烷基苯并唑化合物及其等作為mer及axl抑制劑的用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ534582A (en) 2002-02-27 2006-03-31 Pfizer Prod Inc ACC inhibitors
JP2006131559A (ja) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd 含窒素複素環化合物
DE102005055726A1 (de) 2005-11-23 2007-08-30 Sanofi-Aventis Deutschland Gmbh Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
AU2006331882A1 (en) 2005-12-21 2007-07-05 Schering Corporation Phenoxypiperidines and analogs thereof useful as histamine H3 antagonists
WO2007091046A1 (en) * 2006-02-09 2007-08-16 Astrazeneca Ab Chemical compounds
CA2654792A1 (en) 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
JP2008179621A (ja) * 2006-12-28 2008-08-07 Taisho Pharmaceutical Co Ltd 含窒素飽和複素環化合物
JP2010043019A (ja) * 2008-08-12 2010-02-25 Taisho Pharmaceutical Co Ltd ピペリジニルピペラジン化合物
WO2010043052A1 (en) 2008-10-17 2010-04-22 Merck Frosst Canada Ltd. Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2010127212A1 (en) 2009-04-30 2010-11-04 Forest Laboratories Holdings Limited Inhibitors of acetyl-coa carboxylase
NZ603777A (en) 2010-04-27 2013-08-30 Takeda Pharmaceutical Bicyclic compound derivatives and their use as acc inhibitors.
US8835472B2 (en) 2010-09-02 2014-09-16 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof

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US8530460B2 (en) 2013-09-10
WO2013092616A1 (en) 2013-06-27
US20130158004A1 (en) 2013-06-20
JP2015500856A (ja) 2015-01-08
EP2794586A1 (en) 2014-10-29
EP2794586B1 (en) 2016-04-20

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