JP2015500840A5 - - Google Patents
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- Publication number
- JP2015500840A5 JP2015500840A5 JP2014547627A JP2014547627A JP2015500840A5 JP 2015500840 A5 JP2015500840 A5 JP 2015500840A5 JP 2014547627 A JP2014547627 A JP 2014547627A JP 2014547627 A JP2014547627 A JP 2014547627A JP 2015500840 A5 JP2015500840 A5 JP 2015500840A5
- Authority
- JP
- Japan
- Prior art keywords
- apolipoprotein
- formulation
- fixed dosage
- dosage
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000007592 Apolipoproteins Human genes 0.000 claims 48
- 108010071619 Apolipoproteins Proteins 0.000 claims 48
- 239000000203 mixture Substances 0.000 claims 37
- 238000009472 formulation Methods 0.000 claims 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 150000002632 lipids Chemical class 0.000 claims 10
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 6
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 4
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 4
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 4
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 206010002388 Angina unstable Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 206010020961 Hypocholesterolaemia Diseases 0.000 claims 2
- 208000007814 Unstable Angina Diseases 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 1
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011905368A AU2011905368A0 (en) | 2011-12-21 | Dosing regime for apolipoprotein formulations | |
| AU2011905368 | 2011-12-21 | ||
| PCT/AU2012/001345 WO2013090978A1 (en) | 2011-12-21 | 2012-11-02 | Dosage regime for apolipoprotein formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017045676A Division JP2017128586A (ja) | 2011-12-21 | 2017-03-10 | アポリポタンパク質製剤のための投与計画 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500840A JP2015500840A (ja) | 2015-01-08 |
| JP2015500840A5 true JP2015500840A5 (enExample) | 2015-12-10 |
| JP6144276B2 JP6144276B2 (ja) | 2017-06-07 |
Family
ID=48667485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547627A Active JP6144276B2 (ja) | 2011-12-21 | 2012-11-02 | アポリポタンパク質製剤のための投与計画 |
| JP2017045676A Pending JP2017128586A (ja) | 2011-12-21 | 2017-03-10 | アポリポタンパク質製剤のための投与計画 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017045676A Pending JP2017128586A (ja) | 2011-12-21 | 2017-03-10 | アポリポタンパク質製剤のための投与計画 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20140378376A1 (enExample) |
| EP (1) | EP2793913B1 (enExample) |
| JP (2) | JP6144276B2 (enExample) |
| KR (3) | KR20140107536A (enExample) |
| CN (2) | CN104010646A (enExample) |
| AU (1) | AU2012310259C1 (enExample) |
| BR (1) | BR112014014403A8 (enExample) |
| CA (1) | CA2857968A1 (enExample) |
| DK (1) | DK2793913T3 (enExample) |
| ES (1) | ES2955110T3 (enExample) |
| IL (1) | IL233236A0 (enExample) |
| MX (1) | MX377093B (enExample) |
| PL (1) | PL2793913T3 (enExample) |
| RU (1) | RU2014129505A (enExample) |
| SG (1) | SG11201402556RA (enExample) |
| WO (1) | WO2013090978A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9645037B2 (en) | 2011-09-28 | 2017-05-09 | Hunter Engineering Company | Method and apparatus for wheel assembly lateral force measurement |
| RU2014129505A (ru) * | 2011-12-21 | 2016-02-10 | СиЭсЭл ЛИМИТЕД | Схема дозирования для составов аполипопротеина |
| KR20240044543A (ko) | 2016-11-10 | 2024-04-04 | 시에스엘 리미티드 | 심근경색의 재구성된 고밀도 지질단백질 치료 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61152632A (ja) * | 1984-12-26 | 1986-07-11 | Dai Ichi Seiyaku Co Ltd | 抗動脈硬化剤 |
| US5652339A (en) | 1993-12-31 | 1997-07-29 | Rotkreuzstiftung Zentrallaboratorium | Method of producing reconstituted lipoproteins |
| BR0115257A (pt) * | 2000-11-10 | 2003-08-12 | Proteopharma Aps | Análogos de apolipoproteìna |
| PL372925A1 (en) * | 2001-09-28 | 2005-08-08 | Esperion Therapeutics Inc. | Prevention and treatment of restenosis by local administration of drug |
| MXPA04011312A (es) * | 2002-05-17 | 2005-02-14 | Esperion Therapeutics Inc | Metodo para el tratamiento de desordenes dislipidemicos. |
| JP2006508045A (ja) * | 2002-07-30 | 2006-03-09 | エスペリオン セラピューティクス，インコーポレイテッド | ヒト以外の動物のアポリポプロテインａ−ｉタンパク質の使用方法 |
| PE20050438A1 (es) * | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
| AP2006003578A0 (en) * | 2003-10-20 | 2006-04-30 | Esperion Therapeutics Inc | Pharmaceutical formulations, methods and dosing regimens for the treatment and prevention of acute coronary syndromes. |
| EP1917278A2 (en) * | 2005-08-26 | 2008-05-07 | Cerenis Therapeutics Holding SA | Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria |
| US20090297577A1 (en) * | 2008-06-02 | 2009-12-03 | Medtronic Vascular, Inc. | Local Delivery of Apolipoproteins and Their Derivatives |
| RU2014129505A (ru) * | 2011-12-21 | 2016-02-10 | СиЭсЭл ЛИМИТЕД | Схема дозирования для составов аполипопротеина |
-
2012
- 2012-11-02 RU RU2014129505A patent/RU2014129505A/ru unknown
- 2012-11-02 DK DK12859136.9T patent/DK2793913T3/da active
- 2012-11-02 KR KR1020147020291A patent/KR20140107536A/ko not_active Ceased
- 2012-11-02 WO PCT/AU2012/001345 patent/WO2013090978A1/en not_active Ceased
- 2012-11-02 US US14/364,764 patent/US20140378376A1/en not_active Abandoned
- 2012-11-02 PL PL12859136.9T patent/PL2793913T3/pl unknown
- 2012-11-02 AU AU2012310259A patent/AU2012310259C1/en active Active
- 2012-11-02 KR KR1020207009276A patent/KR102766038B1/ko active Active
- 2012-11-02 CN CN201280063210.4A patent/CN104010646A/zh active Pending
- 2012-11-02 BR BR112014014403A patent/BR112014014403A8/pt not_active Application Discontinuation
- 2012-11-02 SG SG11201402556RA patent/SG11201402556RA/en unknown
- 2012-11-02 EP EP12859136.9A patent/EP2793913B1/en active Active
- 2012-11-02 CA CA2857968A patent/CA2857968A1/en not_active Abandoned
- 2012-11-02 ES ES12859136T patent/ES2955110T3/es active Active
- 2012-11-02 CN CN202110675512.8A patent/CN113398245A/zh active Pending
- 2012-11-02 KR KR1020197019295A patent/KR20190084334A/ko not_active Ceased
- 2012-11-02 JP JP2014547627A patent/JP6144276B2/ja active Active
- 2012-11-02 MX MX2014006589A patent/MX377093B/es active IP Right Grant
-
2014
- 2014-06-18 IL IL233236A patent/IL233236A0/en active IP Right Grant
-
2016
- 2016-02-26 US US15/054,358 patent/US20160175392A1/en not_active Abandoned
-
2017
- 2017-03-10 JP JP2017045676A patent/JP2017128586A/ja active Pending
-
2023
- 2023-08-14 US US18/449,039 patent/US20240216467A1/en not_active Abandoned
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