JP2015535263A5 - - Google Patents
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- Publication number
- JP2015535263A5 JP2015535263A5 JP2015539998A JP2015539998A JP2015535263A5 JP 2015535263 A5 JP2015535263 A5 JP 2015535263A5 JP 2015539998 A JP2015539998 A JP 2015539998A JP 2015539998 A JP2015539998 A JP 2015539998A JP 2015535263 A5 JP2015535263 A5 JP 2015535263A5
- Authority
- JP
- Japan
- Prior art keywords
- mass
- rhdl
- formulation
- apolipoprotein
- rhdl formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 33
- 238000009472 formulation Methods 0.000 claims 32
- 239000003381 stabilizer Substances 0.000 claims 13
- 102000007592 Apolipoproteins Human genes 0.000 claims 12
- 108010071619 Apolipoproteins Proteins 0.000 claims 12
- 150000002632 lipids Chemical class 0.000 claims 9
- 229930006000 Sucrose Natural products 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 3
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 2
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 1
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010020961 Hypocholesterolaemia Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721771P | 2012-11-02 | 2012-11-02 | |
| US61/721,771 | 2012-11-02 | ||
| EP13153903.3 | 2013-02-04 | ||
| EP13153903 | 2013-02-04 | ||
| US13/803,863 US9125943B2 (en) | 2012-11-02 | 2013-03-14 | Reconstituted HDL formulation |
| US13/803,863 | 2013-03-14 | ||
| AU2013205684 | 2013-04-10 | ||
| AU2013205684A AU2013205684B2 (en) | 2012-11-02 | 2013-04-10 | Reconstituted hdl formulation |
| PCT/AU2013/001260 WO2014066943A1 (en) | 2012-11-02 | 2013-10-31 | Reconstituted hdl formulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535263A JP2015535263A (ja) | 2015-12-10 |
| JP2015535263A5 true JP2015535263A5 (enExample) | 2016-12-08 |
| JP6340372B2 JP6340372B2 (ja) | 2018-06-06 |
Family
ID=47665977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539998A Active JP6340372B2 (ja) | 2012-11-02 | 2013-10-31 | 再構成されたｈｄｌ製剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9125943B2 (enExample) |
| EP (2) | EP3502131A1 (enExample) |
| JP (1) | JP6340372B2 (enExample) |
| KR (1) | KR102263810B1 (enExample) |
| CN (2) | CN108057023B (enExample) |
| AU (1) | AU2013205684B2 (enExample) |
| BR (1) | BR112015009748B1 (enExample) |
| CA (1) | CA2889785C (enExample) |
| IL (1) | IL238504B (enExample) |
| MX (1) | MX364587B (enExample) |
| NZ (1) | NZ631131A (enExample) |
| PL (1) | PL2916857T3 (enExample) |
| RU (1) | RU2669568C2 (enExample) |
| SG (1) | SG11201503083UA (enExample) |
| WO (1) | WO2014066943A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2617977T3 (es) | 2010-06-30 | 2017-06-20 | Csl Limited | Una formulación de lipoproteína de alta densidad reconstituida y método de producción de la misma |
| US9125943B2 (en) * | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
| NZ631116A (en) * | 2013-06-05 | 2018-07-27 | Csl Ltd | Process for preparing apolipoprotein a-i (apo a-i) |
| CA2920391C (en) | 2013-08-08 | 2023-03-28 | Csl Limited | Contaminant removal method |
| BR112019001459A2 (pt) | 2016-07-27 | 2019-05-07 | Hartis-Pharma Sa | combinação, composição farmacêutica, e, método de prevenção e/ou de tratamento de uma doença ou de um distúrbio. |
| KR20240044543A (ko) * | 2016-11-10 | 2024-04-04 | 시에스엘 리미티드 | 심근경색의 재구성된 고밀도 지질단백질 치료 |
| CN112546201A (zh) * | 2019-09-26 | 2021-03-26 | 中国科学院生物物理研究所 | 人工脂蛋白颗粒apoA-Ⅳ脂肪体在治疗和/或预防糖尿病中的应用 |
| WO2025185021A1 (zh) * | 2024-03-05 | 2025-09-12 | 维康平生(北京)生物科技有限公司 | 一种脂肪体的冷冻干燥方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335077C (en) * | 1988-02-08 | 1995-04-04 | Henri Isliker | Process for the manufacture of apolipoproteins from human blood plasma or serum |
| US5652339A (en) | 1993-12-31 | 1997-07-29 | Rotkreuzstiftung Zentrallaboratorium | Method of producing reconstituted lipoproteins |
| PL372925A1 (en) | 2001-09-28 | 2005-08-08 | Esperion Therapeutics Inc. | Prevention and treatment of restenosis by local administration of drug |
| MXPA04011312A (es) | 2002-05-17 | 2005-02-14 | Esperion Therapeutics Inc | Metodo para el tratamiento de desordenes dislipidemicos. |
| BR0310100A (pt) | 2002-05-17 | 2007-04-27 | Esperion Therapeutics Inc | métodos para tratar, prevenir ou reduzir a lesão de reperfusão isquêmica em um tecido ou órgão, e para prevenir ou tratar de uma condição associada com a privação de oxigênio, seguida por suprimento de oxigênio aumentado a um tecido ou órgão em necessidade disto |
| PE20050438A1 (es) | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
| US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
| KR100992488B1 (ko) | 2006-12-29 | 2010-11-05 | 주식회사 녹십자 | ＡｐｏＡ-Ｉ의 정제방법 및 정제된ＡｐｏＡ-Ｉ을 이용한재구축 ＨＤＬ의 생산 방법 |
| NZ582170A (en) | 2007-08-17 | 2012-02-24 | Csl Behring Gmbh | Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i |
| US8734853B2 (en) | 2008-11-17 | 2014-05-27 | University Of North Texas Health Science Center At Fort Worth | HDL particles for delivery of nucleic acids |
| ES2617977T3 (es) | 2010-06-30 | 2017-06-20 | Csl Limited | Una formulación de lipoproteína de alta densidad reconstituida y método de producción de la misma |
| RS58275B1 (sr) | 2011-02-07 | 2019-03-29 | Cerenis Therapeutics Holding Sa | Lipoproteinski kompleksi i njihova proizvodnja i upotrebe |
| US9125943B2 (en) * | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
-
2013
- 2013-03-14 US US13/803,863 patent/US9125943B2/en active Active
- 2013-04-10 AU AU2013205684A patent/AU2013205684B2/en active Active
- 2013-10-31 RU RU2015120808A patent/RU2669568C2/ru active
- 2013-10-31 CA CA2889785A patent/CA2889785C/en active Active
- 2013-10-31 EP EP19151328.2A patent/EP3502131A1/en active Pending
- 2013-10-31 CN CN201711141045.0A patent/CN108057023B/zh active Active
- 2013-10-31 US US14/439,094 patent/US9925236B2/en active Active
- 2013-10-31 MX MX2015004546A patent/MX364587B/es active IP Right Grant
- 2013-10-31 WO PCT/AU2013/001260 patent/WO2014066943A1/en not_active Ceased
- 2013-10-31 NZ NZ631131A patent/NZ631131A/en unknown
- 2013-10-31 PL PL13851610T patent/PL2916857T3/pl unknown
- 2013-10-31 CN CN201380057007.0A patent/CN104755096B/zh active Active
- 2013-10-31 SG SG11201503083UA patent/SG11201503083UA/en unknown
- 2013-10-31 JP JP2015539998A patent/JP6340372B2/ja active Active
- 2013-10-31 BR BR112015009748-0A patent/BR112015009748B1/pt active IP Right Grant
- 2013-10-31 EP EP13851610.9A patent/EP2916857B1/en active Active
- 2013-10-31 KR KR1020157014530A patent/KR102263810B1/ko active Active
-
2015
- 2015-04-28 IL IL238504A patent/IL238504B/en active IP Right Grant
-
2018
- 2018-02-12 US US15/894,397 patent/US10603355B2/en active Active
-
2020
- 2020-03-23 US US16/826,585 patent/US11464828B2/en active Active
-
2022
- 2022-09-02 US US17/902,580 patent/US11957731B2/en active Active
-
2024
- 2024-04-12 US US18/634,576 patent/US20250099537A1/en active Pending
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