CA2889785C - Reconstituted hdl formulation - Google Patents
Reconstituted hdl formulation Download PDFInfo
- Publication number
- CA2889785C CA2889785C CA2889785A CA2889785A CA2889785C CA 2889785 C CA2889785 C CA 2889785C CA 2889785 A CA2889785 A CA 2889785A CA 2889785 A CA2889785 A CA 2889785A CA 2889785 C CA2889785 C CA 2889785C
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- CA
- Canada
- Prior art keywords
- apolipoprotein
- rhdl
- sucrose
- lipid
- formulation according
- Prior art date
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- 238000004108 freeze drying Methods 0.000 claims abstract description 54
- 239000003381 stabilizer Substances 0.000 claims abstract description 53
- 150000002632 lipids Chemical class 0.000 claims abstract description 40
- 108010010234 HDL Lipoproteins Proteins 0.000 claims abstract description 31
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- 229930006000 Sucrose Natural products 0.000 claims description 83
- 239000005720 sucrose Substances 0.000 claims description 83
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 81
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
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| US201261721771P | 2012-11-02 | 2012-11-02 | |
| US61/721,771 | 2012-11-02 | ||
| EP13153903.3 | 2013-02-04 | ||
| EP13153903 | 2013-02-04 | ||
| US13/803,863 US9125943B2 (en) | 2012-11-02 | 2013-03-14 | Reconstituted HDL formulation |
| US13/803,863 | 2013-03-14 | ||
| AU2013205684 | 2013-04-10 | ||
| AU2013205684A AU2013205684B2 (en) | 2012-11-02 | 2013-04-10 | Reconstituted hdl formulation |
| PCT/AU2013/001260 WO2014066943A1 (en) | 2012-11-02 | 2013-10-31 | Reconstituted hdl formulation |
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| CA2889785A1 CA2889785A1 (en) | 2014-05-08 |
| CA2889785C true CA2889785C (en) | 2022-07-19 |
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| ES2617977T3 (es) | 2010-06-30 | 2017-06-20 | Csl Limited | Una formulación de lipoproteína de alta densidad reconstituida y método de producción de la misma |
| US9125943B2 (en) * | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
| NZ631116A (en) * | 2013-06-05 | 2018-07-27 | Csl Ltd | Process for preparing apolipoprotein a-i (apo a-i) |
| CA2920391C (en) | 2013-08-08 | 2023-03-28 | Csl Limited | Contaminant removal method |
| BR112019001459A2 (pt) | 2016-07-27 | 2019-05-07 | Hartis-Pharma Sa | combinação, composição farmacêutica, e, método de prevenção e/ou de tratamento de uma doença ou de um distúrbio. |
| KR20240044543A (ko) * | 2016-11-10 | 2024-04-04 | 시에스엘 리미티드 | 심근경색의 재구성된 고밀도 지질단백질 치료 |
| CN112546201A (zh) * | 2019-09-26 | 2021-03-26 | 中国科学院生物物理研究所 | 人工脂蛋白颗粒apoA-Ⅳ脂肪体在治疗和/或预防糖尿病中的应用 |
| WO2025185021A1 (zh) * | 2024-03-05 | 2025-09-12 | 维康平生(北京)生物科技有限公司 | 一种脂肪体的冷冻干燥方法 |
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| CA1335077C (en) * | 1988-02-08 | 1995-04-04 | Henri Isliker | Process for the manufacture of apolipoproteins from human blood plasma or serum |
| US5652339A (en) | 1993-12-31 | 1997-07-29 | Rotkreuzstiftung Zentrallaboratorium | Method of producing reconstituted lipoproteins |
| PL372925A1 (en) | 2001-09-28 | 2005-08-08 | Esperion Therapeutics Inc. | Prevention and treatment of restenosis by local administration of drug |
| MXPA04011312A (es) | 2002-05-17 | 2005-02-14 | Esperion Therapeutics Inc | Metodo para el tratamiento de desordenes dislipidemicos. |
| BR0310100A (pt) | 2002-05-17 | 2007-04-27 | Esperion Therapeutics Inc | métodos para tratar, prevenir ou reduzir a lesão de reperfusão isquêmica em um tecido ou órgão, e para prevenir ou tratar de uma condição associada com a privação de oxigênio, seguida por suprimento de oxigênio aumentado a um tecido ou órgão em necessidade disto |
| PE20050438A1 (es) | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
| US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
| KR100992488B1 (ko) | 2006-12-29 | 2010-11-05 | 주식회사 녹십자 | ＡｐｏＡ-Ｉ의 정제방법 및 정제된ＡｐｏＡ-Ｉ을 이용한재구축 ＨＤＬ의 생산 방법 |
| NZ582170A (en) | 2007-08-17 | 2012-02-24 | Csl Behring Gmbh | Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i |
| US8734853B2 (en) | 2008-11-17 | 2014-05-27 | University Of North Texas Health Science Center At Fort Worth | HDL particles for delivery of nucleic acids |
| ES2617977T3 (es) | 2010-06-30 | 2017-06-20 | Csl Limited | Una formulación de lipoproteína de alta densidad reconstituida y método de producción de la misma |
| RS58275B1 (sr) | 2011-02-07 | 2019-03-29 | Cerenis Therapeutics Holding Sa | Lipoproteinski kompleksi i njihova proizvodnja i upotrebe |
| US9125943B2 (en) * | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
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- 2013-10-31 SG SG11201503083UA patent/SG11201503083UA/en unknown
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2015
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2018
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2020
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2022
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2024
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