RU2669568C2 - Восстанавливаемый состав hdl - Google Patents
Восстанавливаемый состав hdl Download PDFInfo
- Publication number
- RU2669568C2 RU2669568C2 RU2015120808A RU2015120808A RU2669568C2 RU 2669568 C2 RU2669568 C2 RU 2669568C2 RU 2015120808 A RU2015120808 A RU 2015120808A RU 2015120808 A RU2015120808 A RU 2015120808A RU 2669568 C2 RU2669568 C2 RU 2669568C2
- Authority
- RU
- Russia
- Prior art keywords
- composition
- rhdl
- apolipoprotein
- sucrose
- mass
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 173
- 238000009472 formulation Methods 0.000 title abstract description 56
- 238000004108 freeze drying Methods 0.000 claims abstract description 60
- 239000003381 stabilizer Substances 0.000 claims abstract description 57
- 102000007592 Apolipoproteins Human genes 0.000 claims abstract description 54
- 108010071619 Apolipoproteins Proteins 0.000 claims abstract description 54
- 150000002632 lipids Chemical class 0.000 claims abstract description 41
- 102000015779 HDL Lipoproteins Human genes 0.000 claims abstract description 32
- 108010010234 HDL Lipoproteins Proteins 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 9
- 229930006000 Sucrose Natural products 0.000 claims description 75
- 239000005720 sucrose Substances 0.000 claims description 75
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 72
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims description 24
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims description 24
- 150000003904 phospholipids Chemical class 0.000 claims description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 239000003599 detergent Substances 0.000 claims description 15
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 11
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- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 claims description 9
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims description 7
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 3
- 125000000185 sucrose group Chemical group 0.000 claims description 3
- 206010002383 Angina Pectoris Diseases 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 2
- 206010020961 Hypocholesterolaemia Diseases 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
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- 238000007911 parenteral administration Methods 0.000 claims 1
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 11
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- ZFGOPJASRDDARH-UHFFFAOYSA-N 3-[[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene Chemical compound C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C(C2)C1(C)CCC2OC1CC2=CCC3C4CCC(C(C)CCCC(C)C)C4(C)CCC3C2(C)CC1 ZFGOPJASRDDARH-UHFFFAOYSA-N 0.000 description 6
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
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- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- 244000068988 Glycine max Species 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
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- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 description 3
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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| US13/803,863 US9125943B2 (en) | 2012-11-02 | 2013-03-14 | Reconstituted HDL formulation |
| US13/803,863 | 2013-03-14 | ||
| AU2013205684 | 2013-04-10 | ||
| AU2013205684A AU2013205684B2 (en) | 2012-11-02 | 2013-04-10 | Reconstituted hdl formulation |
| PCT/AU2013/001260 WO2014066943A1 (en) | 2012-11-02 | 2013-10-31 | Reconstituted hdl formulation |
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| RU2015120808A RU2015120808A (ru) | 2016-12-20 |
| RU2669568C2 true RU2669568C2 (ru) | 2018-10-12 |
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| RU2823334C1 (ru) * | 2023-07-24 | 2024-07-22 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Способ лечения и профилактики гипергликемии и инсулинорезистентности и связанных с ними заболеваний и функциональных нарушений органов и систем и средство для его осуществления |
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| ES2617977T3 (es) | 2010-06-30 | 2017-06-20 | Csl Limited | Una formulación de lipoproteína de alta densidad reconstituida y método de producción de la misma |
| US9125943B2 (en) * | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
| NZ631116A (en) * | 2013-06-05 | 2018-07-27 | Csl Ltd | Process for preparing apolipoprotein a-i (apo a-i) |
| CA2920391C (en) | 2013-08-08 | 2023-03-28 | Csl Limited | Contaminant removal method |
| BR112019001459A2 (pt) | 2016-07-27 | 2019-05-07 | Hartis-Pharma Sa | combinação, composição farmacêutica, e, método de prevenção e/ou de tratamento de uma doença ou de um distúrbio. |
| KR20240044543A (ko) * | 2016-11-10 | 2024-04-04 | 시에스엘 리미티드 | 심근경색의 재구성된 고밀도 지질단백질 치료 |
| CN112546201A (zh) * | 2019-09-26 | 2021-03-26 | 中国科学院生物物理研究所 | 人工脂蛋白颗粒apoA-Ⅳ脂肪体在治疗和/或预防糖尿病中的应用 |
| WO2025185021A1 (zh) * | 2024-03-05 | 2025-09-12 | 维康平生(北京)生物科技有限公司 | 一种脂肪体的冷冻干燥方法 |
Citations (2)
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| US5652339A (en) * | 1993-12-31 | 1997-07-29 | Rotkreuzstiftung Zentrallaboratorium | Method of producing reconstituted lipoproteins |
| WO2012000048A1 (en) * | 2010-06-30 | 2012-01-05 | Csl Limited | A reconstituted high density lipoprotein formulation and production method thereof |
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| CA1335077C (en) * | 1988-02-08 | 1995-04-04 | Henri Isliker | Process for the manufacture of apolipoproteins from human blood plasma or serum |
| PL372925A1 (en) | 2001-09-28 | 2005-08-08 | Esperion Therapeutics Inc. | Prevention and treatment of restenosis by local administration of drug |
| MXPA04011312A (es) | 2002-05-17 | 2005-02-14 | Esperion Therapeutics Inc | Metodo para el tratamiento de desordenes dislipidemicos. |
| BR0310100A (pt) | 2002-05-17 | 2007-04-27 | Esperion Therapeutics Inc | métodos para tratar, prevenir ou reduzir a lesão de reperfusão isquêmica em um tecido ou órgão, e para prevenir ou tratar de uma condição associada com a privação de oxigênio, seguida por suprimento de oxigênio aumentado a um tecido ou órgão em necessidade disto |
| PE20050438A1 (es) | 2003-10-20 | 2005-06-14 | Esperion Therapeutics Inc | Formulas farmaceuticas, metodos y regimenes de dosificacion para el tratamiento y la prevencion de sindromes coronarios agudos |
| US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
| KR100992488B1 (ko) | 2006-12-29 | 2010-11-05 | 주식회사 녹십자 | ＡｐｏＡ-Ｉ의 정제방법 및 정제된ＡｐｏＡ-Ｉ을 이용한재구축 ＨＤＬ의 생산 방법 |
| NZ582170A (en) | 2007-08-17 | 2012-02-24 | Csl Behring Gmbh | Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i |
| US8734853B2 (en) | 2008-11-17 | 2014-05-27 | University Of North Texas Health Science Center At Fort Worth | HDL particles for delivery of nucleic acids |
| RS58275B1 (sr) | 2011-02-07 | 2019-03-29 | Cerenis Therapeutics Holding Sa | Lipoproteinski kompleksi i njihova proizvodnja i upotrebe |
| US9125943B2 (en) * | 2012-11-02 | 2015-09-08 | Csl Limited | Reconstituted HDL formulation |
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| US5652339A (en) * | 1993-12-31 | 1997-07-29 | Rotkreuzstiftung Zentrallaboratorium | Method of producing reconstituted lipoproteins |
| WO2012000048A1 (en) * | 2010-06-30 | 2012-01-05 | Csl Limited | A reconstituted high density lipoprotein formulation and production method thereof |
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| "Липопротеины сыворотки крови при сахарном диабете типа 2" / Потеряева О.Н., Панин Л.Е., Шевкопляс О.П., Воронова О.С., Костина Н.Е., Поляков Л.М.// Проблемы эндокринологии. Т.49. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2823334C1 (ru) * | 2023-07-24 | 2024-07-22 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр фундаментальной и трансляционной медицины" (ФИЦ ФТМ) | Способ лечения и профилактики гипергликемии и инсулинорезистентности и связанных с ними заболеваний и функциональных нарушений органов и систем и средство для его осуществления |
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