JP2015500638A5 - - Google Patents

Info

Publication number

JP2015500638A5

JP2015500638A5 JP2014544721A JP2014544721A JP2015500638A5 JP 2015500638 A5 JP2015500638 A5 JP 2015500638A5 JP 2014544721 A JP2014544721 A JP 2014544721A JP 2014544721 A JP2014544721 A JP 2014544721A JP 2015500638 A5 JP2015500638 A5 JP 2015500638A5

Authority

JP

Japan

Prior art keywords

cancer

erbb3

mutation

subject

antagonist

Prior art date

2012-11-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 29
• 230000035772 mutation Effects 0.000 claims 23
• 239000003814 drug Substances 0.000 claims 14
• 150000007523 nucleic acids Chemical group 0.000 claims 14
• 206010028980 Neoplasm Diseases 0.000 claims 11
• 201000011510 cancer Diseases 0.000 claims 11
• 150000001413 amino acids Chemical class 0.000 claims 9
• 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 8
• 230000003321 amplification Effects 0.000 claims 8
• 238000003199 nucleic acid amplification method Methods 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 206010009944 Colon cancer Diseases 0.000 claims 7
• 239000012472 biological sample Substances 0.000 claims 7
• 239000003112 inhibitor Substances 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
• 238000001514 detection method Methods 0.000 claims 6
• 206010041823 squamous cell carcinoma Diseases 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 239000005557 antagonist Substances 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 5
• 229940122558 EGFR antagonist Drugs 0.000 claims 4
• 229940123466 ErbB-3 antagonist Drugs 0.000 claims 4
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
• 208000029742 colonic neoplasm Diseases 0.000 claims 4
• 206010017758 gastric cancer Diseases 0.000 claims 4
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 4
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 4
• 201000005202 lung cancer Diseases 0.000 claims 4
• 208000020816 lung neoplasm Diseases 0.000 claims 4
• 201000011549 stomach cancer Diseases 0.000 claims 4
• 108020004705 Codon Proteins 0.000 claims 3
• 206010041067 Small cell lung cancer Diseases 0.000 claims 3
• 238000007834 ligase chain reaction Methods 0.000 claims 3
• 238000003752 polymerase chain reaction Methods 0.000 claims 3
• 238000012340 reverse transcriptase PCR Methods 0.000 claims 3
• 238000012163 sequencing technique Methods 0.000 claims 3
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 3
• 208000006478 Cecal Neoplasms Diseases 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 229940123852 ERbB-4 antagonist Drugs 0.000 claims 2
• 229940121883 ErbB-2 antagonist Drugs 0.000 claims 2
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
• 206010038389 Renal cancer Diseases 0.000 claims 2
• 208000009956 adenocarcinoma Diseases 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 201000003959 cecum carcinoma Diseases 0.000 claims 2
• 239000003153 chemical reaction reagent Substances 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
• 201000004101 esophageal cancer Diseases 0.000 claims 2
• 201000010982 kidney cancer Diseases 0.000 claims 2
• 210000004072 lung Anatomy 0.000 claims 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
• 201000001441 melanoma Diseases 0.000 claims 2
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
• 201000002528 pancreatic cancer Diseases 0.000 claims 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
• 238000006116 polymerization reaction Methods 0.000 claims 2
• 206010038038 rectal cancer Diseases 0.000 claims 2
• 201000001275 rectum cancer Diseases 0.000 claims 2
• 239000000523 sample Substances 0.000 claims 2
• 150000003384 small molecules Chemical group 0.000 claims 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 206010023774 Large cell lung cancer Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 201000009546 lung large cell carcinoma Diseases 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 238000003753 real-time PCR Methods 0.000 claims 1
• 108091008146 restriction endonucleases Proteins 0.000 claims 1