JP2015500300A5 - - Google Patents
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- Publication number
- JP2015500300A5 JP2015500300A5 JP2014546303A JP2014546303A JP2015500300A5 JP 2015500300 A5 JP2015500300 A5 JP 2015500300A5 JP 2014546303 A JP2014546303 A JP 2014546303A JP 2014546303 A JP2014546303 A JP 2014546303A JP 2015500300 A5 JP2015500300 A5 JP 2015500300A5
- Authority
- JP
- Japan
- Prior art keywords
- polar solvent
- pharmaceutical composition
- composition according
- water
- isoacteoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002798 polar solvent Substances 0.000 claims 19
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- QFRYQWYZSQDFOS-UHFFFAOYSA-N verbascoside Natural products CC1OC(COC2C(O)C(COC3OC(C(O)C(O)C3O)C(=O)O)OC(Oc4cc(O)cc5OC(=CC(=O)c45)c6ccc(O)c(O)c6)C2O)C(O)C(O)C1O QFRYQWYZSQDFOS-UHFFFAOYSA-N 0.000 claims 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- 229930182470 glycoside Natural products 0.000 claims 8
- 150000002338 glycosides Chemical class 0.000 claims 8
- FNMHEHXNBNCPCI-QEOJJFGVSA-N Isoacteoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O[C@H](COC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@H]1O FNMHEHXNBNCPCI-QEOJJFGVSA-N 0.000 claims 7
- 229930185474 acteoside Natural products 0.000 claims 7
- FBSKJMQYURKNSU-ZLSOWSIRSA-N acteoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@@H](CO)O[C@@H](OCCC=2C=C(O)C(O)=CC=2)[C@@H]1O FBSKJMQYURKNSU-ZLSOWSIRSA-N 0.000 claims 7
- FBSKJMQYURKNSU-UKQWSTALSA-N acteoside I Natural products C[C@@H]1O[C@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)C=Cc4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O FBSKJMQYURKNSU-UKQWSTALSA-N 0.000 claims 7
- FNMHEHXNBNCPCI-RYEKTNFUSA-N isoacteoside Natural products C[C@@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](COC(=O)C=Cc3ccc(O)c(O)c3)O[C@@H](OCCc4ccc(O)c(O)c4)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O FNMHEHXNBNCPCI-RYEKTNFUSA-N 0.000 claims 7
- 239000012046 mixed solvent Substances 0.000 claims 6
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 5
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 5
- 238000005406 washing Methods 0.000 claims 5
- 239000011324 bead Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000011347 resin Substances 0.000 claims 4
- 229920005989 resin Polymers 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 201000000166 CST3-related cerebral amyloid angiopathy Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000007487 Familial Cerebral Amyloid Angiopathy Diseases 0.000 claims 1
- 208000032849 Hereditary cerebral hemorrhage with amyloidosis Diseases 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 201000008319 inclusion body myositis Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007087 memory ability Effects 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576367P | 2011-12-16 | 2011-12-16 | |
| US61/576,367 | 2011-12-16 | ||
| PCT/CN2012/086796 WO2013087042A1 (zh) | 2011-12-16 | 2012-12-17 | 预防或治疗淀粉样β肽相关疾病或状况的医药组合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500300A JP2015500300A (ja) | 2015-01-05 |
| JP2015500300A5 true JP2015500300A5 (enExample) | 2016-02-12 |
| JP6134331B2 JP6134331B2 (ja) | 2017-05-24 |
Family
ID=48580733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546303A Active JP6134331B2 (ja) | 2011-12-16 | 2012-12-17 | アミロイドベータペプチド関連の疾患または症状の予防または治療のための医薬組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20150087606A1 (enExample) |
| EP (1) | EP2792361B1 (enExample) |
| JP (1) | JP6134331B2 (enExample) |
| KR (1) | KR102048289B1 (enExample) |
| CN (1) | CN103156867B (enExample) |
| AU (1) | AU2012350437B2 (enExample) |
| CA (1) | CA2859227C (enExample) |
| MY (1) | MY171048A (enExample) |
| SG (1) | SG11201403265VA (enExample) |
| TW (1) | TWI488630B (enExample) |
| WO (1) | WO2013087042A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150291645A1 (en) * | 2014-04-10 | 2015-10-15 | Sinphar Pharmaceutical Co., Ltd. | Isoacteoside derivative and use thereof |
| TWI650131B (zh) * | 2014-07-03 | 2019-02-11 | 杏輝藥品工業股份有限公司 | 管花肉蓯蓉萃取物之用於製備保護眼部細胞之藥品或食品用途 |
| CN104922137B (zh) * | 2015-06-04 | 2018-07-31 | 苏州大学 | 苯乙醇苷类化合物Torenoside B的新用途 |
| KR102018085B1 (ko) * | 2017-12-06 | 2019-09-04 | 김좌진 | 악테오사이드를 함유하는 뇌종양 치료 및 전이 억제용 약학 조성물 |
| KR102135148B1 (ko) * | 2019-08-28 | 2020-07-20 | 김좌진 | 악테오사이드를 함유하는 뇌종양 치료 및 전이 억제용 약학 조성물 |
| CN110812375A (zh) * | 2019-12-12 | 2020-02-21 | 中国海洋大学 | 一种老鼠簕中苯乙醇苷类提取物及其制备方法与作为抗肝损伤药物的应用 |
| CN111632058A (zh) * | 2020-06-24 | 2020-09-08 | 新疆医科大学 | 毛蕊花糖苷在制备预防和治疗神经退行性疾病药物中的应用 |
| CN112225766A (zh) * | 2020-10-27 | 2021-01-15 | 杏辉天力（杭州）药业有限公司 | 一种由肉苁蓉萃取物中富集及分离苯乙醇苷类化合物的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100500584B1 (ko) * | 2002-08-12 | 2005-07-12 | 경희대학교 산학협력단 | 신경성장인자와 유사 작용을 갖는 육종용 추출물 및 이를함유하는 조성물 |
| KR100514076B1 (ko) * | 2003-01-10 | 2005-09-13 | 주식회사 엘컴사이언스 | 페닐에타노이드 유도체를 포함하는 퇴행성 뇌신경계질환의 예방 및 치료용 조성물 |
| TW200416036A (en) * | 2003-02-18 | 2004-09-01 | Sinphar Pharmaceutical Co Ltd | Medicinal preparation containing phenylethanoid glycosides extracted from herbaceous plant, cistanche tubulosa (schenk.) wight, process of making the same, and uses of the same |
| CN1268341C (zh) * | 2003-03-04 | 2006-08-09 | 杏辉天力（杭州）药业有限公司 | 来源于管花肉苁蓉的含有苯乙醇苷的制剂及其制备方法和用途 |
| CN100345857C (zh) * | 2004-07-16 | 2007-10-31 | 北京华医神农医药科技有限公司 | 一种从肉苁蓉药材中提取、分离松果菊苷的方法 |
| EP1736167B1 (en) | 2005-06-20 | 2018-03-21 | I.R.B. Istituto Di Ricerche Biotecnologiche S.r.l. | Extracts obtained from cell line cultures from Syringa vulgaris IRB-SV25/B (DMS:16857), their preparation and use |
| JP5410683B2 (ja) | 2008-02-19 | 2014-02-05 | 学校法人近畿大学 | カンカニクジュヨウから得られる肝保護剤及び抗ＴＮＦ−α作用剤 |
| CN101411753B (zh) * | 2008-12-04 | 2012-02-29 | 闫明 | 列当总苷在制备抗老年痴呆的药物中的应用 |
| CN101797307B (zh) * | 2010-04-09 | 2011-08-10 | 广州中医药大学 | 一种含苯乙醇苷的枇杷叶紫珠提取物及其制备方法 |
| TWI486162B (zh) * | 2010-06-16 | 2015-06-01 | Sinphar Pharmaceutical Co Ltd | 異類葉升麻苷或其醫藥學上可接受之鹽於抑制澱粉樣β肽生成、累積或聚集、以及製備預防或治療澱粉樣β肽相關疾病或狀況的藥物之用途 |
| CN102670631B (zh) * | 2011-12-01 | 2013-07-31 | 河南科技大学 | 一种四楞麻总苯乙醇苷组合物、制备方法及应用 |
-
2012
- 2012-12-17 MY MYPI2014001777A patent/MY171048A/en unknown
- 2012-12-17 AU AU2012350437A patent/AU2012350437B2/en active Active
- 2012-12-17 TW TW101147781A patent/TWI488630B/zh active
- 2012-12-17 CA CA2859227A patent/CA2859227C/en active Active
- 2012-12-17 SG SG11201403265VA patent/SG11201403265VA/en unknown
- 2012-12-17 EP EP12856624.7A patent/EP2792361B1/en active Active
- 2012-12-17 KR KR1020147018051A patent/KR102048289B1/ko active Active
- 2012-12-17 JP JP2014546303A patent/JP6134331B2/ja active Active
- 2012-12-17 CN CN201210548516.0A patent/CN103156867B/zh active Active
- 2012-12-17 WO PCT/CN2012/086796 patent/WO2013087042A1/zh not_active Ceased
- 2012-12-17 US US14/365,404 patent/US20150087606A1/en not_active Abandoned
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