JP2015214584A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015214584A5 JP2015214584A5 JP2015162006A JP2015162006A JP2015214584A5 JP 2015214584 A5 JP2015214584 A5 JP 2015214584A5 JP 2015162006 A JP2015162006 A JP 2015162006A JP 2015162006 A JP2015162006 A JP 2015162006A JP 2015214584 A5 JP2015214584 A5 JP 2015214584A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- protected
- micelle
- substituted
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000693 micelle Substances 0.000 claims 30
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 27
- 229910052757 nitrogen Inorganic materials 0.000 claims 21
- 229920006395 saturated elastomer Polymers 0.000 claims 20
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 19
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 19
- 229910052760 oxygen Inorganic materials 0.000 claims 19
- 239000001301 oxygen Substances 0.000 claims 19
- 229910052717 sulfur Inorganic materials 0.000 claims 19
- 239000011593 sulfur Substances 0.000 claims 19
- 125000005842 heteroatom Chemical group 0.000 claims 15
- 229920000428 triblock copolymer Polymers 0.000 claims 13
- 150000001412 amines Chemical class 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 12
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 7
- 125000001931 aliphatic group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 230000002209 hydrophobic effect Effects 0.000 claims 6
- 229920001308 poly(aminoacid) Polymers 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 5
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical class OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 150000003573 thiols Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 150000001540 azides Chemical class 0.000 claims 4
- 229920001400 block copolymer Polymers 0.000 claims 4
- ZPWOOKQUDFIEIX-UHFFFAOYSA-N cyclooctyne Chemical group C1CCCC#CCC1 ZPWOOKQUDFIEIX-UHFFFAOYSA-N 0.000 claims 4
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 150000002430 hydrocarbons Chemical group 0.000 claims 3
- 229910021645 metal ion Inorganic materials 0.000 claims 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
- 229920006030 multiblock copolymer Polymers 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 238000006736 Huisgen cycloaddition reaction Methods 0.000 claims 2
- 150000001345 alkine derivatives Chemical class 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- HESCAJZNRMSMJG-HGYUPSKWSA-N epothilone A Natural products O=C1[C@H](C)[C@H](O)[C@H](C)CCC[C@H]2O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C HESCAJZNRMSMJG-HGYUPSKWSA-N 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 1
- TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 claims 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- QXRSDHAAWVKZLJ-OXZHEXMSSA-N Epothilone B Natural products O=C1[C@H](C)[C@H](O)[C@@H](C)CCC[C@@]2(C)O[C@H]2C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C QXRSDHAAWVKZLJ-OXZHEXMSSA-N 0.000 claims 1
- BEFZAMRWPCMWFJ-JRBBLYSQSA-N Epothilone C Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C=C\C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C BEFZAMRWPCMWFJ-JRBBLYSQSA-N 0.000 claims 1
- XOZIUKBZLSUILX-SDMHVBBESA-N Epothilone D Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C(/C)=C/C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C XOZIUKBZLSUILX-SDMHVBBESA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 229940122803 Vinca alkaloid Drugs 0.000 claims 1
- 229960003896 aminopterin Drugs 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims 1
- 229940093265 berberine Drugs 0.000 claims 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims 1
- -1 berbervin Chemical compound 0.000 claims 1
- 229960001573 cabazitaxel Drugs 0.000 claims 1
- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 150000003983 crown ethers Chemical class 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- BEFZAMRWPCMWFJ-UHFFFAOYSA-N desoxyepothilone A Natural products O1C(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCCC=CCC1C(C)=CC1=CSC(C)=N1 BEFZAMRWPCMWFJ-UHFFFAOYSA-N 0.000 claims 1
- XOZIUKBZLSUILX-UHFFFAOYSA-N desoxyepothilone B Natural products O1C(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCCC(C)=CCC1C(C)=CC1=CSC(C)=N1 XOZIUKBZLSUILX-UHFFFAOYSA-N 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 229930013356 epothilone Natural products 0.000 claims 1
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical compound C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 claims 1
- QXRSDHAAWVKZLJ-PVYNADRNSA-N epothilone B Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 QXRSDHAAWVKZLJ-PVYNADRNSA-N 0.000 claims 1
- BEFZAMRWPCMWFJ-QJKGZULSSA-N epothilone C Chemical compound O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 BEFZAMRWPCMWFJ-QJKGZULSSA-N 0.000 claims 1
- XOZIUKBZLSUILX-GIQCAXHBSA-N epothilone D Chemical compound O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C(C)=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-GIQCAXHBSA-N 0.000 claims 1
- 150000003883 epothilone derivatives Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- OKPYIWASQZGASP-UHFFFAOYSA-N n-(2-hydroxypropyl)-2-methylprop-2-enamide Chemical compound CC(O)CNC(=O)C(C)=C OKPYIWASQZGASP-UHFFFAOYSA-N 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims 1
- 229950005566 picoplatin Drugs 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
- 229960002066 vinorelbine Drugs 0.000 claims 1
- 0 CC(CC*N)=C Chemical compound CC(CC*N)=C 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622755P | 2012-04-11 | 2012-04-11 | |
| US61/622,755 | 2012-04-11 | ||
| US201261659841P | 2012-06-14 | 2012-06-14 | |
| US61/659,841 | 2012-06-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505769A Division JP5927338B2 (ja) | 2012-04-11 | 2013-03-15 | 安定なミセルのためのブロックコポリマー |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019001801A Division JP6740391B2 (ja) | 2012-04-11 | 2019-01-09 | 安定なミセルのためのブロックコポリマー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015214584A JP2015214584A (ja) | 2015-12-03 |
| JP2015214584A5 true JP2015214584A5 (enExample) | 2016-04-28 |
| JP6466283B2 JP6466283B2 (ja) | 2019-02-06 |
Family
ID=47901746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505769A Active JP5927338B2 (ja) | 2012-04-11 | 2013-03-15 | 安定なミセルのためのブロックコポリマー |
| JP2015162006A Active JP6466283B2 (ja) | 2012-04-11 | 2015-08-19 | 安定なミセルのためのブロックコポリマー |
| JP2019001801A Active JP6740391B2 (ja) | 2012-04-11 | 2019-01-09 | 安定なミセルのためのブロックコポリマー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505769A Active JP5927338B2 (ja) | 2012-04-11 | 2013-03-15 | 安定なミセルのためのブロックコポリマー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019001801A Active JP6740391B2 (ja) | 2012-04-11 | 2019-01-09 | 安定なミセルのためのブロックコポリマー |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US9078930B2 (enExample) |
| EP (2) | EP2660255B1 (enExample) |
| JP (3) | JP5927338B2 (enExample) |
| KR (1) | KR101607422B1 (enExample) |
| CN (2) | CN106511270A (enExample) |
| AU (1) | AU2013201541B2 (enExample) |
| CA (1) | CA2868274C (enExample) |
| ES (1) | ES2560235T3 (enExample) |
| IL (1) | IL235003A (enExample) |
| MX (1) | MX340992B (enExample) |
| NZ (2) | NZ700397A (enExample) |
| WO (1) | WO2013154774A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| WO2013154774A1 (en) * | 2012-04-11 | 2013-10-17 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US9944752B2 (en) * | 2012-04-11 | 2018-04-17 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140127271A1 (en) * | 2012-04-11 | 2014-05-08 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140113879A1 (en) * | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140114051A1 (en) * | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| CN104856973A (zh) * | 2014-02-25 | 2015-08-26 | 苏州雷纳药物研发有限公司 | 一种卡巴他赛胶束载药系统及其制备方法 |
| CN105640882A (zh) * | 2015-10-16 | 2016-06-08 | 姚俊华 | 一种卡巴他赛胶束载药系统及其制备方法和应用 |
| EP3492512A4 (en) | 2016-07-30 | 2020-04-08 | Nippon Kayaku Kabushiki Kaisha | NEW POLYMER DERIVATIVES, AND NEW POLYMER DERIVATIVE IMAGING PROBE USING SAID NEW POLYMER DERIVATIVES |
| EP3495406A4 (en) * | 2016-08-02 | 2020-04-01 | Nippon Kayaku Kabushiki Kaisha | ACTIVE TARGETING TYPE POLYMER DERIVATIVE, COMPOSITION CONTAINING SAID POLYMER DERIVATIVE, AND USES OF SAID POLYMER DERIVATIVE AND COMPOSITION THEREOF |
| JPWO2018088541A1 (ja) * | 2016-11-11 | 2019-10-10 | 国立大学法人北陸先端科学技術大学院大学 | 薬物放出制御用ハイドロゲル及びその製造方法 |
| WO2018148432A1 (en) | 2017-02-08 | 2018-08-16 | Intezyne Technologies, Inc. | Sn-38 loaded iron crosslinked micelle and methods thereof |
| BR112019020853A2 (pt) | 2017-04-04 | 2020-05-12 | Avidea Technologies, Inc. | Vacinas à base de peptídeo, métodos de fabricação e usos das mesmas para induzir uma resposta imune |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| CN111051044B (zh) | 2017-07-14 | 2021-12-17 | 惠普发展公司，有限责任合伙企业 | 3d打印 |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| JP2021504475A (ja) * | 2017-11-22 | 2021-02-15 | ヒルストリーム・バイオファーマ・インコーポレイテッド | ボルテゾミブを含むポリマーナノ粒子 |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US12435048B2 (en) | 2018-09-28 | 2025-10-07 | Lonza Ltd | Method for preparation of n-carboxyanhydrides |
| WO2020072681A1 (en) * | 2018-10-03 | 2020-04-09 | Avidea Technologies, Inc. | Aromatic ring substituted amphiphilic polymers as drug delivery systems |
| CN109762150B (zh) * | 2018-12-14 | 2020-09-22 | 华南理工大学 | 一种具有内在荧光特性可降解生物医用材料及其制备方法 |
| EP3943182A4 (en) | 2019-03-20 | 2022-05-25 | Mitsubishi Chemical Corporation | POLYMER, RELEASING AGENT, METHOD OF MAKING A POLYMER, METHOD OF SEPARATING A JOINT AND METHOD OF MAKING A JOINT |
| CN110105562B (zh) * | 2019-04-23 | 2021-10-12 | 华东师范大学 | 含多巴胺配体的两嵌段聚合物及其合成方法和应用 |
| US11541007B2 (en) * | 2019-05-16 | 2023-01-03 | Megapro Biomedical Co., Ltd. | Pharmaceutical compositions containing mixed polymeric micelles |
| US10836869B1 (en) | 2020-01-10 | 2020-11-17 | Tyndall Formulation Services, LLC | Polymer excipients for drug delivery applications |
| WO2021142202A1 (en) * | 2020-01-10 | 2021-07-15 | R-Pharm Us Operating Llc | Compositions of ixabepilone |
| US10918619B1 (en) | 2020-01-10 | 2021-02-16 | Tyndall Formulation Services, LLC | Formulations of paclitaxel with poly(amino acid) block polymers |
| IL294481B1 (en) * | 2020-01-10 | 2025-10-01 | Tyndall Formulation Services Llc | Polymeric excipients for drug delivery applications |
| WO2021142020A1 (en) | 2020-01-10 | 2021-07-15 | Tyndall Formulation Services, LLC | Formulations of sn-38 with poly(amino acid) block polymers |
| US11286344B2 (en) | 2020-01-10 | 2022-03-29 | Tyndall Formulation Services, LLC | Polymer excipients for drug delivery applications |
| JP7560274B2 (ja) * | 2020-06-08 | 2024-10-02 | 公益財団法人川崎市産業振興財団 | 共重合体、該共重合体の製造方法、およびカルボキシ基またはその塩を有する共重合体の製造方法 |
| CN112190565B (zh) * | 2020-10-27 | 2022-06-14 | 华南理工大学 | 一种能减轻吉非替尼毒性的肾靶向纳米粒子及其制备方法 |
| JP7604878B2 (ja) * | 2020-12-22 | 2024-12-24 | Dic株式会社 | 構造色発現用組成物 |
| CN115368560B (zh) * | 2022-08-26 | 2023-11-14 | 天津大学 | 聚乙二醇-嵌段-聚甲硫氨酸-接枝-海藻糖聚合物及制备方法和应用 |
| KR102640099B1 (ko) * | 2022-11-17 | 2024-02-23 | 주식회사 삼양홀딩스 | 조직 수복용 분말 제형 및 이를 포함하는 조직 수복용 주사제 조성물 |
| IT202300015291A1 (it) * | 2023-07-20 | 2025-01-20 | Fond Riccardo Terzi E Silvio Albini | Sistema di rilascio comprendente nanoparticelle lipidiche o polimeriche comprendenti ormoni tiroidei |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002224526A1 (en) * | 2000-07-24 | 2002-02-05 | Ono Pharmaceutical Co. Ltd. | Freeze-dried preparation of n-(o-(p-pivaloyloxybenzenesulfonylamino)benzoyl)glycine monosodium salt tetrahydrate and process for producing the same |
| WO2006047419A2 (en) | 2004-10-25 | 2006-05-04 | Intezyne Technologies, Incorporated | Heterobifunctional poly(ethylene glycol) and uses thereof |
| WO2006074202A2 (en) | 2005-01-04 | 2006-07-13 | Intezyne Technologies, Incorporated | Synthesis of hybrid block copolymers and uses thereof |
| US7638558B2 (en) | 2005-04-01 | 2009-12-29 | Intezyne Technologies, Inc. | Polymeric micelles for drug delivery |
| US8759465B2 (en) * | 2006-04-25 | 2014-06-24 | Purdue Research Foundation | Cross-linkable polymeric compositions |
| US7799339B2 (en) | 2007-04-30 | 2010-09-21 | Intezyne Technologies, Inc. | Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents |
| WO2008134761A2 (en) | 2007-04-30 | 2008-11-06 | Intezyne Technologies, Inc. | Modification of biological targeting groups for the treatment of cancer |
| WO2010127159A2 (en) * | 2009-04-30 | 2010-11-04 | Intezyne Technologies, Incorporated | Polymeric micelles for polynucleotide encapsulation |
| AU2010246019A1 (en) * | 2009-05-04 | 2011-11-24 | Intezyne Technologies, Incorporated | Polymer micelles containing SN-38 for the treatment of cancer |
| US8609146B2 (en) * | 2011-09-19 | 2013-12-17 | Intezyne Technologies, Inc. | Multi-block copolymers for the preparation of stabilized micelles |
| WO2013154774A1 (en) | 2012-04-11 | 2013-10-17 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US9944752B2 (en) | 2012-04-11 | 2018-04-17 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140113879A1 (en) | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140114051A1 (en) * | 2012-04-11 | 2014-04-24 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
| US20140127271A1 (en) | 2012-04-11 | 2014-05-08 | Intezyne Technologies, Inc. | Block copolymers for stable micelles |
-
2013
- 2013-03-15 WO PCT/US2013/032409 patent/WO2013154774A1/en not_active Ceased
- 2013-03-15 EP EP13001333.7A patent/EP2660255B1/en active Active
- 2013-03-15 EP EP15191496.7A patent/EP3000833B1/en active Active
- 2013-03-15 CA CA2868274A patent/CA2868274C/en active Active
- 2013-03-15 US US13/840,133 patent/US9078930B2/en active Active
- 2013-03-15 ES ES13001333.7T patent/ES2560235T3/es active Active
- 2013-03-15 CN CN201610908380.8A patent/CN106511270A/zh active Pending
- 2013-03-15 NZ NZ700397A patent/NZ700397A/en not_active IP Right Cessation
- 2013-03-15 MX MX2014011980A patent/MX340992B/es active IP Right Grant
- 2013-03-15 KR KR1020147028330A patent/KR101607422B1/ko active Active
- 2013-03-15 NZ NZ709953A patent/NZ709953A/en not_active IP Right Cessation
- 2013-03-15 JP JP2015505769A patent/JP5927338B2/ja active Active
- 2013-03-15 US US13/839,715 patent/US20130296531A1/en not_active Abandoned
- 2013-03-15 CN CN201380023578.2A patent/CN104487481B/zh active Active
- 2013-03-15 AU AU2013201541A patent/AU2013201541B2/en not_active Ceased
- 2013-03-15 US US13/839,994 patent/US20130288991A1/en not_active Abandoned
-
2014
- 2014-10-06 IL IL235003A patent/IL235003A/en active IP Right Grant
-
2015
- 2015-04-23 US US14/694,760 patent/US9499665B2/en active Active
- 2015-08-19 JP JP2015162006A patent/JP6466283B2/ja active Active
-
2016
- 2016-09-28 US US15/279,042 patent/US10047197B2/en active Active
- 2016-09-28 US US15/279,017 patent/US9944754B2/en active Active
-
2019
- 2019-01-09 JP JP2019001801A patent/JP6740391B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015214584A5 (enExample) | ||
| Xu et al. | Polymer vectors via controlled/living radical polymerization for gene delivery | |
| Bernard et al. | Synthesis of various glycopolymer architectures via RAFT polymerization: from block copolymers to stars | |
| Guillerm et al. | How to modulate the chemical structure of polyoxazolines by appropriate functionalization | |
| Neu et al. | Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo | |
| Xu et al. | Pentablock copolymers of poly (ethylene glycol), poly ((2-dimethyl amino) ethyl methacrylate) and poly (2-hydroxyethyl methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene delivery | |
| JP2015512938A5 (enExample) | ||
| Cheng et al. | Development of switchable polymers to address the dilemma of stability and cargo release in polycationic nucleic acid carriers | |
| Li et al. | PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers | |
| England et al. | Synthesis and characterization of dendrimer-based polysarcosine star polymers: well-defined, versatile platforms designed for drug-delivery applications | |
| JP7671389B2 (ja) | Ｐｅｇｍｅｍａ及び薬物担持ポリマーセグメントから構成される自己集合化ジブロックコポリマー | |
| Suo et al. | Folate-decorated PEGylated triblock copolymer as a pH/reduction dual-responsive nanovehicle for targeted intracellular co-delivery of doxorubicin and Bcl-2 siRNA | |
| Burts et al. | Using EPR to compare PEG-branch-nitroxide “bivalent-brush polymers” and traditional PEG bottle–brush polymers: branching makes a difference | |
| Smith et al. | RAFT-synthesized copolymers and conjugates designed for therapeutic delivery of siRNA | |
| WO2010005740A3 (en) | Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles | |
| Zhao et al. | Antifouling and biodegradable poly (N-hydroxyethyl acrylamide)(polyHEAA)-based nanogels | |
| ES2966774T3 (es) | Conjugados polímero-fármaco escindibles | |
| Hashemi et al. | Gene delivery efficiency and cytotoxicity of heterocyclic amine-modified PAMAM and PPI dendrimers | |
| TW200838553A (en) | Polymer encapsulation and/or binding | |
| CN105793307A (zh) | 杂臂支化聚合物 | |
| Hu et al. | Synthesis of star polymers by RAFT polymerization as versatile nanoparticles for biomedical applications | |
| JP2019527209A5 (enExample) | ||
| Kanto et al. | Mixed polyplex micelles with thermoresponsive and lysine-based zwitterionic shells derived from two poly (vinyl amine)-based block copolymers | |
| JP2019535710A5 (enExample) | ||
| Khezrian et al. | Synthesis of combinatorial Janus nanoparticles based on EpCAM‐PEG/PCL for targeted therapy of human colorectal adenocarcinoma |