JP2015180278A - 薬剤を生物学的バリアーを横切って送達するための方法及びデバイス - Google Patents
薬剤を生物学的バリアーを横切って送達するための方法及びデバイス Download PDFInfo
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Abstract
Description
この発明は、下記の図を参照しての下記の説明から一層よく理解されうる。
下記の説明中において、値の範囲は、特定の範囲、及び任意の一層小さい範囲、又はその範囲内の単一の値を示すことを意図している。従って、1〜10の範囲は、例えば、1〜10、3〜7、又は5を示す。加えて、同じ参照番号は、同じエレメントを示す。
Claims (33)
- 薬剤を生物学的バリアーを横切って送達するためのデバイスであって、下記を含む当該デバイス:
第一の極微針;
該極微針に一体化された、薬剤を保持するための第一の貯蔵器。 - 生物学的バリアーが、皮膚である、請求項1に記載のデバイス。
- 第一の貯蔵器が、極微針をある幅及び深さで通過する開口部よりなる、請求項1に記載のデバイス。
- 第一の貯蔵器が、極微針中に陥凹を含む、請求項1に記載のデバイス。
- 第一の貯蔵器が、第一の極微針の体積のかなりの部分を占める、請求項1に記載のデバイス。
- 上記の部分が、第一の極微針の体積の約5〜70%である、請求項5に記載のデバイス。
- 上記の部分が、第一の極微針の体積の約20〜50%である、請求項5に記載のデバイス。
- 第一の極微針が、ステンレス鋼及びチタンの一つを含む、請求項1に記載のデバイス。
- 第一の極微針が、約150〜3000μm長である、請求項1に記載のデバイス。
- 第一の極微針が、約300〜1500μm長である、請求項1に記載のデバイス。
- 第一の極微針が、約10〜2000μm幅である、請求項1に記載のデバイス。
- 第一の極微針が、約100〜500μm幅である、請求項1に記載のデバイス。
- 薬剤が、皮内送達に適している、請求項1に記載のデバイス。
- 薬剤が、薬物を含む、請求項1に記載のデバイス。
- 薬剤が、ワクチンを含む、請求項1に記載のデバイス。
- 貯蔵器を、薬剤で充填する、請求項1に記載のデバイス。
- 第二の極微針に一体化された第二の貯蔵器を有する第二の極微針を含む、請求項1に記載のデバイス。
- 第一の貯蔵器が、第一の薬剤を含み、第二の貯蔵器が、同じ薬剤を含む、請求項17に記載のデバイス。
- 第一の貯蔵器が、第一の薬剤を含み、第二の貯蔵器が、異なる薬剤を含む、請求項17に記載のデバイス。
- 第一の極微針が、第一のベースエレメントから伸び、第二の極微針が、第二のベースエレメントから伸び、第一及び第二のベースエレメントが、共通の基材と結合している、請求項17に記載のデバイス。
- 第一の極微針が使用者の皮膚に突き通ることのできる幅を制限するためのデプスガードを含む、請求項1に記載のデバイス。
- デプスガードが、第一の極微針、第一の極微針が伸びている基材、及び第一の極微針が伸びているベースエレメントの一つから伸びている、請求項21に記載のデバイス。
- 近位及び遠位末端を有するベースエレメントを含み、該ベースエレメントが、近位末端で遠位末端より広く、下記を特徴とする、請求項21に記載のデバイス:
第一の極微針が、ベースエレメントの遠位末端から伸びており、そして
デプスガードが、ベースエレメントを超えて、第一の極微針の遠位末端に向かって伸びている。 - 生物分解性ステントの一つを含み、第一の極微針が、薬剤を血管バリアーを横切って送達するための生物分解性ステントに結合している、請求項1に記載のデバイス。
- 外科用ツールを含み、極微針が、薬剤を内部生物学的バリアーを横切って送達するための該外科用ツールに結合されている、請求項1に記載のデバイス。
- 薬剤を生物学的バリアーを横切って送達するためのデバイスを製造する方法であって、下記を含む当該方法:
一体化された薬剤貯蔵器を有する極微針を用意し;そして
該一体化された薬剤貯蔵器に薬剤を充填する。 - 一体化された薬剤貯蔵器の充填が、極微針を、薬剤を含む溶液に浸漬することを含む、請求項26に記載の薬剤を経皮送達するためのデバイスを製造する方法。
- 一体化された薬剤貯蔵器の充填が、予め決めた体積の薬剤含む溶液を一体化された薬剤貯蔵器に付着させることを含む、請求項26に記載の薬剤を経皮送達するためのデバイスを製造する方法。
- 一体化された薬剤貯蔵器の充填が、親水性化合物を一体化された薬剤貯蔵器の内側に塗布すること及び疎水性化合物を極微針の残りに塗布することを含む、請求項26に記載の薬剤を経皮送達するためのデバイスを製造する方法。
- 請求項26に記載の薬剤を経皮送達するためのデバイスを製造する方法であって、下記を含む当該方法:
第二の一体化された薬剤貯蔵器を有する第二の極微針を用意し;
第一の極微針及び第二の極微針を基材に結合させ;そして
第二の一体化された薬剤貯蔵器に薬剤を充填する。 - 薬剤を経皮的に送達する方法であって、該方法は、下記:
薬剤を充填した一体化薬剤貯蔵器を有する極微針を用意し;
該極微針を患者の皮膚に適用する
ことを含み、それにより、該極微針が該皮膚を突き通して該一体化貯蔵器を該皮膚の表面下に位置させることを特徴とする当該方法。 - 経皮的薬剤送達のためのデバイスであって、下記を含む当該デバイス:
基材;
該基材に結合された対応するベースエレメントから伸びる複数の極微針であって、その体積の20〜50%を占めて一体化薬剤貯蔵器を規定する開口部を含む当該極微針;
及び
ベースエレメントの少なくとも一つから伸びる、複数の極微針が表面内に挿入されうる深さを制限するためのデプスガード。 - 薬剤を経皮的に送達する方法であって、該方法は、下記:
基材に結合された複数の極微針であって、それらの少なくとも一つが薬剤を保持する一体化貯蔵器を規定する開口部を含む当該複数の極微針を用意し;
該基材を患者の皮膚に適用する
ことを含み、それにより、該皮膚を、極微針の少なくとも一つに結合されたデプスガードが許す深さまで突き通し、それで、一体化貯蔵器が該皮膚の表面下に来ることを特徴とする当該方法。
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WO2003053258A1 (en) * | 2001-12-20 | 2003-07-03 | Alza Corporation | Skin-piercing microprojections having piercing depth control |
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JP2021509344A (ja) * | 2018-01-07 | 2021-03-25 | アミール,アブラハム | 皮膚増強のための高装填マイクロニードル及び組成物 |
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CA2817035A1 (en) | 2007-02-15 |
AU2006278258A1 (en) | 2007-02-15 |
EP1924209A4 (en) | 2010-05-05 |
WO2007019539A2 (en) | 2007-02-15 |
CA2659785A1 (en) | 2007-02-15 |
AU2012203204B2 (en) | 2014-01-30 |
US20090187160A1 (en) | 2009-07-23 |
CA2659785C (en) | 2013-07-30 |
JP6093571B2 (ja) | 2017-03-08 |
US20100152701A1 (en) | 2010-06-17 |
JP2009502447A (ja) | 2009-01-29 |
AU2006278258B2 (en) | 2012-03-15 |
EP2514374A1 (en) | 2012-10-24 |
WO2007019539A3 (en) | 2007-04-12 |
US9011392B2 (en) | 2015-04-21 |
AU2012203204A1 (en) | 2012-06-21 |
US9561042B2 (en) | 2017-02-07 |
EP1924209A2 (en) | 2008-05-28 |
JP2013078646A (ja) | 2013-05-02 |
US20070078414A1 (en) | 2007-04-05 |
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