JP2015134796A5 - - Google Patents
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- JP2015134796A5 JP2015134796A5 JP2015041346A JP2015041346A JP2015134796A5 JP 2015134796 A5 JP2015134796 A5 JP 2015134796A5 JP 2015041346 A JP2015041346 A JP 2015041346A JP 2015041346 A JP2015041346 A JP 2015041346A JP 2015134796 A5 JP2015134796 A5 JP 2015134796A5
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- Prior art keywords
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- polynucleotide sequence
- amino acids
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- 102000003812 Interleukin-15 Human genes 0.000 claims 18
- 239000002157 polynucleotide Substances 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 239000013604 expression vector Substances 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000000833 heterodimer Substances 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 102000004556 Interleukin-15 Receptors Human genes 0.000 claims 1
- 108010017535 Interleukin-15 Receptors Proteins 0.000 claims 1
- 206010025327 Lymphopenia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 231100001023 lymphopenia Toxicity 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23415209P | 2009-08-14 | 2009-08-14 | |
| US23415509P | 2009-08-14 | 2009-08-14 | |
| US61/234,155 | 2009-08-14 | ||
| US61/234,152 | 2009-08-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524911A Division JP2013501817A (ja) | 2009-08-14 | 2010-08-13 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015134796A JP2015134796A (ja) | 2015-07-27 |
| JP2015134796A5 true JP2015134796A5 (https=) | 2015-09-03 |
| JP6162167B2 JP6162167B2 (ja) | 2017-07-12 |
Family
ID=42813425
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524911A Pending JP2013501817A (ja) | 2009-08-14 | 2010-08-13 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
| JP2015041346A Active JP6162167B2 (ja) | 2009-08-14 | 2015-03-03 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524911A Pending JP2013501817A (ja) | 2009-08-14 | 2010-08-13 | 胸腺産出の増大およびリンパ球減少症の治療のためのｉｌ−１５の使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US8871191B2 (https=) |
| EP (2) | EP3135294B1 (https=) |
| JP (2) | JP2013501817A (https=) |
| AU (2) | AU2010282280B2 (https=) |
| CA (1) | CA2768965C (https=) |
| ES (1) | ES2598005T3 (https=) |
| NZ (1) | NZ714757A (https=) |
| WO (1) | WO2011020047A1 (https=) |
Families Citing this family (98)
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| EP2366787B1 (en) | 2006-01-13 | 2019-12-11 | The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services | Codon optimized IL-15 and IL-15R-Alpha genes for expression in mammalian cells |
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2010
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- 2010-08-13 AU AU2010282280A patent/AU2010282280B2/en active Active
- 2010-08-13 ES ES10752466.2T patent/ES2598005T3/es active Active
- 2010-08-13 NZ NZ714757A patent/NZ714757A/en unknown
- 2010-08-13 EP EP16174632.6A patent/EP3135294B1/en active Active
- 2010-08-13 US US13/390,504 patent/US8871191B2/en active Active
- 2010-08-13 CA CA2768965A patent/CA2768965C/en active Active
- 2010-08-13 EP EP10752466.2A patent/EP2464377B1/en active Active
- 2010-08-13 JP JP2012524911A patent/JP2013501817A/ja active Pending
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2014
- 2014-10-13 US US14/512,913 patent/US9975937B2/en active Active
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2015
- 2015-03-03 JP JP2015041346A patent/JP6162167B2/ja active Active
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- 2018-09-06 US US16/123,431 patent/US11041008B2/en active Active
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