JP2015131774A - 筋肉細胞活性化剤 - Google Patents
筋肉細胞活性化剤 Download PDFInfo
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- JP2015131774A JP2015131774A JP2014002961A JP2014002961A JP2015131774A JP 2015131774 A JP2015131774 A JP 2015131774A JP 2014002961 A JP2014002961 A JP 2014002961A JP 2014002961 A JP2014002961 A JP 2014002961A JP 2015131774 A JP2015131774 A JP 2015131774A
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- muscle cell
- muscle
- extract
- cell activator
- cells
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Abstract
Description
アイブライトの乾燥物(地上部)100gに精製水2kgを加え、95〜100℃で2時間抽出した後、濾過し、その濾液を凍結乾燥して熱水抽出物を30g得た。
アイブライトの乾燥物(地上部)100gに精製水1.6kg及びエタノール0.4kgを加え、常温で3日間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥して20%エタノール抽出物を20g得た。
アイブライトの乾燥物(地上部)100gにエタノール2kgを加え、常温で3日間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してエタノール抽出物を9g得た。
アイブライトの乾燥物(地上部)100gに精製水500g及び1,3−ブチレングリコール500gを加え、常温で7日間抽出した後、濾過し、50%1,3−ブチレングリコール抽出物を980g得た。
処方 配合量(%)
1.アイブライトの20%エタノール抽出物(実施例2) 0.01
2.マルチトール 5.0
3.アセスルファムカリウム 0.05
4.スクラロース 0.05
5.クエン酸 5.0
6.香料 0.1
7.精製水 89.79
<製造方法>
成分1〜6を成分7の一部の精製水に撹拌溶解する。成分7の残りの精製水を加えて混合し、90℃に加熱して100mLのアルミ製缶に充填する。
<用法>
1日当り1缶を飲用する。
処方 配合量(%)
1.アイブライトの熱水抽出物(実施例1) 1.0
2.乳糖 70.0
3.還元麦芽糖水飴 20.0
4.結晶セルロース 5.0
5.グリセリン脂肪酸エステル 4.0
<製造方法>
成分1〜5を混合して打錠成型し、0.3gの錠剤を得る。
<用法>
1日当り3粒摂取する。
処方 配合量(%)
1.アイブライトの20%エタノール抽出物(実施例2) 1.0
2.ひまわり油 90.0
3.ミツロウ 6.0
4.ビタミンE 3.0
<製造方法>
成分1〜4を混合し、ゼラチン、グリセリンで構成される被膜に、250mg充填し、乾燥後、軟カプセル剤を得る。
<用法>
1日当り4粒摂取する。
処方 配合量(%)
1.アイブライトのエタノール抽出物(実施例3) 30.0
2.乳糖 65.0
3.結晶セルロース 5.0
<製造方法>
成分1〜3を湿式法により造粒し、乾燥後、顆粒剤を得る。
<用法>
1日当り1g摂取する。
処方 配合量(%)
1.アイブライトの熱水抽出物(実施例1) 10.0
2.ショ糖 90.0
<製造方法>
成分1、2を混合し、散剤を得る。
<用法>
1日当り1g摂取する。
処方 配合量(%)
1.アイブライトの20%エタノール抽出物(実施例2) 0.1
2.エリスリトール 61.8
3.マルチトール 30.0
4.クエン酸 5.0
5.ショ糖脂肪酸エステル 3.0
6.香料 0.1
<製造方法>
成分1〜4を混合し、10%の水を結合剤として加え、流動層造粒する。成形した顆粒に成分5及び6を加えて混合し、打錠する。1粒1gとする。
<用法>1日当たり1粒摂取する。
処方 配合量(%)
1.カラギーナン 1.0
2.ゼラチン 0.5
3.砂糖 20.0
4.アイブライトの熱水抽出物(実施例1) 0.01
5.精製水 78.49
<製造方法>
成分1〜5を混合し、加熱しながら煮詰める。冷却後、ゼリーの型10個に流し込んで冷却し、1個100gのゼリーを得る。
<用法>
1日1個を摂取する。
筋芽細胞であるC2C12を、Cellmatrix I−C(新田ゼラチン)にてコラーゲンコートした12wellプレートに7.5×103個/well播種した。培養した後、DMEM+2%馬血清に置換し、筋管細胞へ分化させた。分化させた筋管細胞に実施例2で調製したアイブライト抽出物を50、100、200μg/mL添加し、遺伝子発現解析を行った。遺伝子発現解析は、筋肉におけるエネルギー代謝に関連する遺伝子であるPGC1、PPARα、ACOX1、UCP2、UCP3の遺伝子発現変動をRT−PCR法で評価した。アイブライト抽出物を添加していないものを1とした遺伝子発現量比を算出した。
筋衛星細胞であるSkMCを、蛍光観察用96wellプレートに2×104個/well播種した。培養した後、DMEM/F12+2%馬血清に置換し、実施例2で調製したアイブライト抽出物を50、100、300μg/mL添加した。その後、筋肉細胞内のミトコンドリアに特異的に結合する蛍光色素Nonyl Acridine Orange(NAO)を5μM添加した培地に置換えた。Hanks溶液(ニッスイ製薬)でプレート上の細胞を2回洗浄し、各ウェルにHanks溶液を100μL添加した。細胞内のミトコンドリアに結合したNAOは蛍光を発するため、励起波長495nm/蛍光波長522nmで蛍光強度を測定し、アイブライト抽出物を添加していないものを1とした相対蛍光強度を算出した。
筋衛星細胞であるSkMCを、蛍光観察用96wellプレートに2×104個/well播種した。培養した後、DMEM/F12+2%馬血清に置換し、実施例2で調製したアイブライト抽出物を50、100、300μg/mL添加した。その後、筋肉細胞内のミトコンドリアの膜電位が高いほどミトコンドリアに多く取り込まれる蛍光色素、5,5’,6,6’−tetrachloro−1,1’,3,3’−tetraethylbenzimidazolylcarbocyanine iodide(JC−1)を1μM添加した培地に置換えた。Hanks溶液(ニッスイ製薬)にてプレート上の細胞を2回洗浄し、各ウェルにHanks溶液を100μL添加した。ミトコンドリアに取り込まれたJC−1は赤色の蛍光を発するため、励起波長550nm蛍光波長/600nmで蛍光強度を測定し、アイブライトの抽出物を添加していないものを1とした相対蛍光強度を算出した。
筋芽細胞であるC2C12を、Cellmatrix I−C(新田ゼラチン)にてコラーゲンコートした24wellプレートに3×103個/well播種した。細胞を増殖させた後、DMEM+2%馬血清に置換し、筋管細胞へ分化させた。分化させた筋管細胞に実施例2で調製したアイブライト抽出物を200μg/mLで添加し、培養した後、細胞上清を回収し、ELISAキットにて、細胞上清中のIGF−1量を測定した。
Claims (8)
- アイブライトの抽出物を含有することを特徴とする筋肉細胞活性化剤。
- 筋肉細胞活性化作用が筋肉細胞のエネルギー代謝改善作用である請求項1記載の筋肉細胞活性化剤。
- 筋肉細胞活性化作用が筋肉細胞のPGC−1、PPARα、ACOX1、UCP−2、UCP−3の遺伝子発現亢進である請求項1又は2記載の筋肉細胞活性化剤。
- 筋肉細胞活性化作用が筋肉細胞の分化促進作用である請求項1記載の筋肉細胞活性化剤。
- 筋肉細胞活性化作用が筋肉細胞のミトコンドリア量増加作用である請求項1又は4記載の筋肉細胞活性化剤。
- 筋肉細胞活性化作用が筋肉細胞のミトコンドリアの膜電位向上作用である請求項1又は4記載の筋肉細胞活性化剤。
- 筋肉細胞活性化作用が筋肉細胞のインスリン様増殖因子1(IGF−1)の産生促進である請求項1又は4記載の筋肉細胞活性化剤。
- 請求項1〜7のいずれか一項記載の内服剤。
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JP2015157785A (ja) * | 2014-02-25 | 2015-09-03 | 日本メナード化粧品株式会社 | 筋機能低下抑制剤 |
JP2017193497A (ja) * | 2016-04-19 | 2017-10-26 | オリザ油化株式会社 | 筋肉増強剤 |
KR20180000127A (ko) * | 2016-06-22 | 2018-01-02 | 동국대학교 경주캠퍼스 산학협력단 | 부자 추출물을 유효성분으로 함유하는 신체 에너지 소비 촉진 또는 근육 대사 촉진용 조성물 |
KR20180000124A (ko) * | 2016-06-22 | 2018-01-02 | 동국대학교 경주캠퍼스 산학협력단 | 육계 추출물을 유효성분으로 함유하는 신체 에너지 소비 촉진 또는 근육 대사 촉진용 조성물 |
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