JP2014534222A5 - - Google Patents
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- Publication number
- JP2014534222A5 JP2014534222A5 JP2014539297A JP2014539297A JP2014534222A5 JP 2014534222 A5 JP2014534222 A5 JP 2014534222A5 JP 2014539297 A JP2014539297 A JP 2014539297A JP 2014539297 A JP2014539297 A JP 2014539297A JP 2014534222 A5 JP2014534222 A5 JP 2014534222A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- group
- represents hydrogen
- substitution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 BC(*F)(C*N(*1)IN2*CC(BNC(N)=NC(c(nc3*)c(N)nc3N)=O)(*F)C*2)C1NC(N)=NC(c1nc(*)c(N)nc1N)=O Chemical compound BC(*F)(C*N(*1)IN2*CC(BNC(N)=NC(c(nc3*)c(N)nc3N)=O)(*F)C*2)C1NC(N)=NC(c1nc(*)c(N)nc1N)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11187553 | 2011-11-02 | ||
| EP11187553.0 | 2011-11-02 | ||
| PCT/EP2012/071352 WO2013064450A1 (en) | 2011-11-02 | 2012-10-29 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534222A JP2014534222A (ja) | 2014-12-18 |
| JP2014534222A5 true JP2014534222A5 (enExample) | 2015-12-17 |
| JP6091513B2 JP6091513B2 (ja) | 2017-03-08 |
Family
ID=47073464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539297A Active JP6091513B2 (ja) | 2011-11-02 | 2012-10-29 | 複素環化合物、前記化合物を含む薬物、これらの使用及びこれらの調製方法 |
Country Status (34)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| SI2773633T1 (sl) | 2011-11-02 | 2017-11-30 | Boehringer Ingelheim International Gmbh | Heterociklične spojine, zdravila, ki vsebujejo te spojine, njihova uporaba in postopki za njihovo pripravo |
| CN105518000B (zh) * | 2013-07-02 | 2018-09-14 | 加州生物医学研究所 | 用于治疗囊性纤维化的化合物 |
| JP6449870B2 (ja) | 2013-07-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物 |
| EP3204358B1 (en) | 2014-10-07 | 2018-09-19 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| RU2712163C2 (ru) | 2014-10-24 | 2020-01-24 | Оно Фармасьютикал Ко., Лтд. | Активатор kcnq2-5 каналов |
| HK1246718A1 (zh) * | 2015-01-07 | 2018-09-14 | 斯克利普斯研究所 | 用於治疗囊性纤维化的化合物 |
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| CN116438200A (zh) | 2020-09-10 | 2023-07-14 | 普雷西里克斯公司 | 针对fap的抗体片段 |
| CN112107580A (zh) * | 2020-09-29 | 2020-12-22 | 北京鑫开元医药科技有限公司 | 一种脾酪氨酸激酶抑制剂的制剂组合物及其制备方法 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| JP2025517625A (ja) | 2022-05-02 | 2025-06-10 | プレシリックス・ナームローゼ・ベンノートシヤープ | プレターゲティング |
| WO2024243025A1 (en) * | 2023-05-19 | 2024-11-28 | Ikena Oncology, Inc. | Naphthyl-substituted pyrido[4,3-d]pyrimidines and related compounds and their use in treating medical conditions |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6812003A (enExample) | 1967-09-07 | 1969-03-11 | ||
| US3953476A (en) | 1971-12-27 | 1976-04-27 | Merck & Co., Inc. | 3-Amino-5-sulfonylbenzoic acids |
| DE60038449T2 (de) | 1999-07-19 | 2009-04-09 | University Of North Carolina At Chapel Hill | Arzneimittelwirkstoffe mit zwei kovalent verknüpften wirkstoffgruppen (natriumkanalblocker/p2y2 rezeptor agonist) zur behandlung von schleimhäuten |
| WO2001052902A1 (en) | 2000-01-24 | 2001-07-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of inducible nitric oxide synthase expression |
| WO2006023573A2 (en) | 2004-08-18 | 2006-03-02 | Johnson Michael R | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
| GB0526244D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| EP2484308A1 (en) * | 2006-07-24 | 2012-08-08 | International Stem Cell Corporation | Synthetic cornea from retinal stem cells |
| US8318935B2 (en) * | 2007-05-07 | 2012-11-27 | Novartis Ag | Organic compounds 75074 |
| EP2231280B1 (en) | 2007-12-10 | 2016-08-10 | Novartis AG | Amiloride-like Pyrazine-carboxamides as ENaC blockers |
| CN102015662A (zh) | 2008-05-13 | 2011-04-13 | 诺瓦提斯公司 | 3,5-二氨基-6-氯-吡嗪-2-甲酸衍生物和它们作为上皮钠通道阻断剂用于治疗气道疾病的用途 |
| BRPI0915018A2 (pt) | 2008-06-10 | 2015-10-27 | Novartis Ag | compostos orgânicos |
| US9050339B2 (en) | 2010-09-17 | 2015-06-09 | Novartis Ag | Pyrazine derivatives as ENaC blockers |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US9072738B2 (en) | 2011-06-27 | 2015-07-07 | Parion Sciences, Inc. | Chemically and metabolically stable dipeptide possessing potent sodium channel blocker activity |
| SI2773633T1 (sl) * | 2011-11-02 | 2017-11-30 | Boehringer Ingelheim International Gmbh | Heterociklične spojine, zdravila, ki vsebujejo te spojine, njihova uporaba in postopki za njihovo pripravo |
| JP2015501324A (ja) | 2011-11-02 | 2015-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アシルグアニジン及びアシルチオ尿素の新規調製方法 |
-
2012
- 2012-10-29 SI SI201231100T patent/SI2773633T1/sl unknown
- 2012-10-29 DK DK12777930.4T patent/DK2773633T3/da active
- 2012-10-29 HU HUE12777930A patent/HUE034929T2/en unknown
- 2012-10-29 EA EA201400521A patent/EA025158B9/ru not_active IP Right Cessation
- 2012-10-29 GE GEAP201813485A patent/GEAP201813485A/en unknown
- 2012-10-29 WO PCT/EP2012/071352 patent/WO2013064450A1/en not_active Ceased
- 2012-10-29 RS RS20171069A patent/RS56498B1/sr unknown
- 2012-10-29 AP AP2014007670A patent/AP2014007670A0/xx unknown
- 2012-10-29 KR KR1020147012186A patent/KR102006612B1/ko not_active Expired - Fee Related
- 2012-10-29 HR HRP20171614TT patent/HRP20171614T1/hr unknown
- 2012-10-29 CA CA2854217A patent/CA2854217C/en not_active Expired - Fee Related
- 2012-10-29 LT LTEP12777930.4T patent/LT2773633T/lt unknown
- 2012-10-29 ME MEP-2017-247A patent/ME02905B/me unknown
- 2012-10-29 JP JP2014539297A patent/JP6091513B2/ja active Active
- 2012-10-29 PH PH1/2014/500970A patent/PH12014500970B1/en unknown
- 2012-10-29 NO NO12777930A patent/NO2773633T3/no unknown
- 2012-10-29 CN CN201610685839.2A patent/CN106279110B/zh active Active
- 2012-10-29 PL PL12777930T patent/PL2773633T3/pl unknown
- 2012-10-29 US US13/662,791 patent/US8759349B2/en active Active
- 2012-10-29 EP EP12777930.4A patent/EP2773633B1/en active Active
- 2012-10-29 CN CN201280065806.8A patent/CN104024244B/zh active Active
- 2012-10-29 UA UAA201405764A patent/UA115868C2/uk unknown
- 2012-10-29 GE GEAP201213485A patent/GEP20186880B/en unknown
- 2012-10-29 BR BR112014010583A patent/BR112014010583A2/pt active Search and Examination
- 2012-10-29 PT PT127779304T patent/PT2773633T/pt unknown
- 2012-10-29 MX MX2014005166A patent/MX348522B/es active IP Right Grant
- 2012-10-29 SG SG11201401907TA patent/SG11201401907TA/en unknown
- 2012-10-29 AU AU2012331274A patent/AU2012331274B2/en not_active Ceased
- 2012-10-29 ES ES12777930.4T patent/ES2645744T3/es active Active
- 2012-10-29 PE PE2014000641A patent/PE20141607A1/es active IP Right Grant
-
2014
- 2014-04-09 IL IL232035A patent/IL232035A/en not_active IP Right Cessation
- 2014-04-24 CL CL2014001047A patent/CL2014001047A1/es unknown
- 2014-04-28 TN TNP2014000180A patent/TN2014000180A1/en unknown
- 2014-04-28 US US14/263,344 patent/US20140228374A1/en not_active Abandoned
- 2014-04-30 CO CO14092699A patent/CO6940429A2/es unknown
- 2014-05-26 EC ECIEPI20141929A patent/ECSP14001929A/es unknown
-
2015
- 2015-08-05 US US14/818,478 patent/US9920035B2/en active Active
-
2017
- 2017-10-30 CY CY171101128T patent/CY1120974T1/el unknown
- 2017-12-13 US US15/840,309 patent/US20180194747A1/en not_active Abandoned
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