JP2011530493A5 - - Google Patents

Info

Publication number

JP2011530493A5

JP2011530493A5 JP2011521518A JP2011521518A JP2011530493A5 JP 2011530493 A5 JP2011530493 A5 JP 2011530493A5 JP 2011521518 A JP2011521518 A JP 2011521518A JP 2011521518 A JP2011521518 A JP 2011521518A JP 2011530493 A5 JP2011530493 A5 JP 2011530493A5

Authority

JP

Japan

Prior art keywords

allergic

bronchitis

disease

compound

treating

Prior art date

2009-07-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 6
• 206010006451 bronchitis Diseases 0.000 claims 5
• -1 3-tetrahydrofuranyl Chemical group 0.000 claims 3
• 230000000172 allergic effect Effects 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 239000000825 pharmaceutical preparation Substances 0.000 claims 3
• 125000004487 4-tetrahydropyranyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 206010001889 Alveolitis Diseases 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 208000010668 atopic eczema Diseases 0.000 claims 2
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims 2
• 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 230000002757 inflammatory effect Effects 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 206010052613 Allergic bronchitis Diseases 0.000 claims 1
• 208000035143 Bacterial infection Diseases 0.000 claims 1
• 206010006458 Bronchitis chronic Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010009137 Chronic sinusitis Diseases 0.000 claims 1
• 208000027932 Collagen disease Diseases 0.000 claims 1
• 206010011224 Cough Diseases 0.000 claims 1
• 201000003883 Cystic fibrosis Diseases 0.000 claims 1
• 206010014561 Emphysema Diseases 0.000 claims 1
• 241000233866 Fungi Species 0.000 claims 1
• 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
• 208000000592 Nasal Polyps Diseases 0.000 claims 1
• 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
• 206010035664 Pneumonia Diseases 0.000 claims 1
• 206010037423 Pulmonary oedema Diseases 0.000 claims 1
• 208000002200 Respiratory Hypersensitivity Diseases 0.000 claims 1
• 206010039085 Rhinitis allergic Diseases 0.000 claims 1
• 206010039710 Scleroderma Diseases 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 230000010085 airway hyperresponsiveness Effects 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 201000010105 allergic rhinitis Diseases 0.000 claims 1
• 208000006682 alpha 1-Antitrypsin Deficiency Diseases 0.000 claims 1
• 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 claims 1
• 229940125715 antihistaminic agent Drugs 0.000 claims 1
• 239000000739 antihistaminic agent Substances 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 208000022362 bacterial infectious disease Diseases 0.000 claims 1
• 201000009267 bronchiectasis Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000029771 childhood onset asthma Diseases 0.000 claims 1
• 239000000812 cholinergic antagonist Substances 0.000 claims 1
• 208000007451 chronic bronchitis Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000027157 chronic rhinosinusitis Diseases 0.000 claims 1
• 229940000425 combination drug Drugs 0.000 claims 1
• 239000003246 corticosteroid Substances 0.000 claims 1
• 229960001334 corticosteroids Drugs 0.000 claims 1
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
• 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
• 244000000013 helminth Species 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• YEESKJGWJFYOOK-IJHYULJSSA-N leukotriene D4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@H](N)C(=O)NCC(O)=O YEESKJGWJFYOOK-IJHYULJSSA-N 0.000 claims 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
• 208000037916 non-allergic rhinitis Diseases 0.000 claims 1
• 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 1
• 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 208000005333 pulmonary edema Diseases 0.000 claims 1
• 210000002345 respiratory system Anatomy 0.000 claims 1
• 201000000306 sarcoidosis Diseases 0.000 claims 1
• 125000006223 tetrahydrofuranylmethyl group Chemical group 0.000 claims 1
• 125000006173 tetrahydropyranylmethyl group Chemical group 0.000 claims 1
• 231100000331 toxic Toxicity 0.000 claims 1
• 230000002588 toxic effect Effects 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1