EP2313398A1 - Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung - Google Patents

Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

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Publication number
EP2313398A1
EP2313398A1 EP09780994A EP09780994A EP2313398A1 EP 2313398 A1 EP2313398 A1 EP 2313398A1 EP 09780994 A EP09780994 A EP 09780994A EP 09780994 A EP09780994 A EP 09780994A EP 2313398 A1 EP2313398 A1 EP 2313398A1
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Prior art keywords
amino
phenyl
quinazoline
methoxy
compounds
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EP09780994A
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German (de)
English (en)
French (fr)
Inventor
Frank Himmelsbach
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Priority to EP09780994A priority Critical patent/EP2313398A1/de
Publication of EP2313398A1 publication Critical patent/EP2313398A1/de
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to cyclohexyloxy-substituted heterocycles of the general formula
  • the object of the present invention is to provide novel compounds which, because of their pharmaceutical activity as tyrosine kinase inhibitors, have therapeutic uses in the art, e.g. to treat pathophysiological processes caused by hyperfunction of tyrosine kinases.
  • R a represents an ethyl, propyl, butyl, cyclopropyl, cyclopropylmethyl, cyclobutyl, cyclobutylmethyl, 3-tetrahydrofuranyl, tetrahydrofuranylmethyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl and tetrahydropyranylmethyl group, and wherein, as far as nothing else is mentioned, the abovementioned alkyl groups may be straight-chain or branched,
  • R a is a radical selected from the group consisting of ethyl, butyl, cyclopropylmethyl and 4-tetrahydropyranyl group,
  • Another object of the invention are compounds of formula (I) for use as medicaments.
  • the compounds of formula (I) which is a disease selected from the group consisting of chronic Bronchitis, acute bronchitis, bronchitis due to bacterial or viral infection or fungi or helminths, allergic bronchitis, toxic bronchitis, chronic obstructive bronchitis (COPD), asthma (intrinsic or allergic), pediatric asthma, bronchiectasis, allergic alveolitis, allergic or non-allergic rhinitis , chronic sinusitis, cystic fibrosis or cystic fibrosis, alpha-1-antitrypsin deficiency, cough, pulmonary emphysema, interstitial lung disease, alveolitis, hyperreactive airways, nasal polyps, pulmonary edema, pneumonitis due to different causes such as radiation-induced or by aspiration or infectious, collagenoses such as lupus eryth, systemic scleroderma, sarcoidosis
  • COPD chronic
  • Another object of the invention is a pharmaceutical formulation containing a compound of formula (I).
  • Another object of the invention is a drug combination containing in addition to one or more compounds of formula (I) as another active ingredient one or more compounds selected from the classes of betamimetics, anticholinergics, corticosteroids, other PDE4 inhibitors, LTD4 antagonists , EGFR inhibitors, dopamine agonists, H1 antihistamines, PAF antagonists and PI3 kinase inhibitors or two or three combinations thereof.
  • Preferred betamimetics for this purpose are compounds selected from the group consisting of arformoterol, carmoterol, formoterol, indacaterol, salmeterol, albuterols, bambuterol, bitolterol, broxaterol, carbuterol, clenbuterol, fenoterol, hexoprenaline, ibuterol, isoetharine, isoprenaline, levosalbutamol , Mabuterol, meluadrin, metaproterenol, milveterol, orciprenaline, pirbuterol, procaterol, reproterol, rimiterol, ritodrine, salmefamol, soterenol, sulfonterol, terbutaline, tiaramide, toluubuterol, zinterol and
  • the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydrooxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.
  • Preferred anticholinergic compounds are compounds which are selected from the group consisting of: tiotropium salts, preferably the bromide salt, oxitropium salts, preferably the bromide salt, flutropium salts, preferably the bromide salt, ipratropium salts, preferably the bromide salt, aclidinium salts, preferably the bromide salt, glycopyrronium salts, preferably the bromide salt, trospium salts, preferably the chloride salt, tolterodine, (3R) -1 -phenethyl-3- (9H-xanthene-9-carbonyloxy) -1 -azoniabicyclo [2.2.2] octane salts.
  • tiotropium salts preferably the bromide salt, oxitropium salts, preferably the bromide salt, flutropium salts, preferably the bromide salt, ipratropium salts, preferably the bromide salt, aclidinium salts,
  • the cations are the pharmacologically active ingredients.
  • the above-mentioned salts may preferably contain chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate , Succinate, benzoate or p-toluenesulfonate, with chloride, bromide, iodide, sulfate, methanesulfonate or p-toluenesulfonate being preferred as counterions.
  • the chlorides, bromides, iodides and methanesulfonates are particularly preferred.
  • Preferred corticosteroids are compounds which are selected from the group consisting of: beclomethasone, betamethasone, budesonide, Butixocort, ciclesonide, deflazacort, dexamethasone, etiprednol, flunisolide, fluticasone, loteprednol, mometasone, prednisolone, prednisone, rofleponide, triamcinolone, tipredane and
  • Steroids includes a reference to their optionally existing salts or derivatives
  • Alkali metal salts such as sodium or potassium salts, sulfobenzoates, phosphates,
  • Isonicotinates acetates, dichloroacetates, propionates, dihydrogen phosphates, palmitates, pivalates or even furoates.
  • Preferred PDE4 inhibitors are compounds selected from the group consisting of enprofylline, theophylline, roflumilast, ariflo (cilomilast), tofimilast pumafentrin, lirimilast, apremilast, arofylline, atizoram, oglemilast, tetomilast, and
  • N- (3,5-dichloro-1-oxido-pyridinyl-carboxamido- ⁇ -methoxy-trifluoromethyl-quinoline (D-4396 (Sch-351591)), N- (3,5-dichloropyrid-4-yl) - [1- (4-fluorobenzyl) -5-hydroxy-indol-3-yl] glyoxylic acid amide (AWD-12-281 (GW-842470)), 9 - [(2-fluorophenyl) methyl] -N-methyl-2 - (trifluoromethyl) -9H-purine-6-amine (NCS-613),
  • Cis [4-cyano-4- (3-cyclopentyloxy-4-methoxyphenyl) cyclohexane-1-carboxylic acid]
  • Cis [4-cyano-4- (3-cyclopropylmethoxy-4-difluoromethoxyphenyl) cyclohexan-1-ol]
  • Acid addition salts selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate are preferred according to the invention.
  • Acid addition salts selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate are preferred according to the invention.
  • Preferred LTD4 receptor antagonists are compounds which are selected from the group consisting of montelukast, pranlukast, zafirlukast, and (E) -8- [2- [4- [4- (4-fluorophenyl) butoxy] phenyl ] ethenyl] -2- (1H-tetrazol-5-yl) -4H-1-benzopyran-4-one (MEN-91507)
  • Acid addition salts selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate are preferred according to the invention.
  • the LTD4 receptor antagonists are optionally able to be understood, for example, alkali metal salts such as sodium or potassium salts, alkaline earth salts, sulfobenzoates, phosphates, isonicotinates, acetates, propionates, dihydrogen phosphates, palmitates, pivalates or furoates.
  • alkali metal salts such as sodium or potassium salts, alkaline earth salts, sulfobenzoates, phosphates, isonicotinates, acetates, propionates, dihydrogen phosphates, palmitates, pivalates or furoates.
  • the histamine H1 receptor antagonists used are preferably compounds selected from the group consisting of epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, ketotifen, emedastine, dimetindene, clemastine, bamipine, cexchlorpheniramine, pheniramine, doxylamine, Chlorphenoxamine, dimenhydrinate, diphenhydramine, promethazine, ebastine, olopatadine, desloratidine and meclocine, optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates.
  • the acid addition salts are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.
  • Preferred PAF antagonists here are compounds which are selected from the group consisting of lexipafant and 4- (2-chlorophenyl) -9-methyl-2- [3 (4-morpholinyl) -3-propanone-1-yl ] -6H-thieno [3,2-f] - [1,2,4] triazolo [4,3-a] [1,4] diazepine
  • Acid addition salts selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate are preferred according to the invention
  • Preferred dopamine receptor agonists are compounds selected from the group consisting of bromocriptine, cabergoline, alpha-dihydroergocryptine, lisuride, pergolide, pramipexole, roxindole, ropinirole, talipexole, terguride and viozan, optionally in the form of their racemates, Enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates.
  • acid addition salts are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, Hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydrooxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate
  • Preferred substances of preferred PI3 kinase antagonists are compounds which are selected from the group consisting of Quinoxalin-6-ylmethylene) thiazolidine-2,4-diones (AS-605240),
  • the term "optionally substituted” is understood to mean the abovementioned group which is optionally substituted by a lower-molecular radical.
  • Low-molecular radicals are understood to be chemically meaningful groups consisting of 1-25 atoms. Preferably, such groups have no negative effect on the pharmacological activity of the compounds.
  • the groups may include:
  • Aromatic or non-aromatic ring systems consisting of carbon atoms and optionally heteroatoms, which in turn may be substituted with functional groups.
  • aromatic or non-aromatic ring systems consisting of carbon atoms and optionally heteroatoms, which can be replaced by one or more
  • Carbon chains optionally interrupted by heteroatoms, optionally substituted with heteroatoms or other common functional groups may be linked.
  • the compounds according to the invention including their salts, in which one or more hydrogen atoms, for example, one, two, three, four or five hydrogen atoms are replaced by deuterium.
  • Compounds of general formula (I) may have acid groups, mainly carboxyl groups, and / or basic groups, e.g. Amino functions.
  • Compounds of general formula (I) can therefore be used as internal salts, as salts with pharmaceutically acceptable inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, sulfonic acid or organic acids (such as maleic acid, fumaric acid, citric acid, tartaric acid or acetic acid) or as salts with pharmaceutically acceptable Bases such as alkali or alkaline earth metal hydroxides or carbonates, zinc or ammonium hydroxides or organic amines such as Diethylamine, triethylamine, triethanolamine, and the like. available.
  • alkali metal and alkaline earth metal salts of the compound of the formula (I) preference is given to the alkali metal hydroxides and alkaline earth hydroxides and hydrides, the hydroxides and hydrides of the alkali metals, especially of sodium and potassium being preferred, sodium and potassium hydroxide being particularly preferred , (see also Pharmaceutical salts, Birge, SM et al., J. Pharm. Sci., (1977), 6 (3, 1-19)
  • the compounds of the general formula (I) can be converted into their salts, in particular for the pharmaceutical application, into their pharmacologically acceptable acid addition salts with an inorganic or organic acid.
  • suitable acids are succinic acid, hydrobromic acid, acetic acid, fumaric acid, maleic acid, methanesulfonic acid, lactic acid, phosphoric acid, hydrochloric acid, sulfuric acid, tartaric acid or citric acid.
  • mixtures of the abovementioned acids can be used.
  • the invention relates to the respective compounds, optionally in the form of the individual diastereomers, mixtures of the individual diastereomers and / or the individual enantiomers, mixtures of the individual enantiomers or racemates, in the form of
  • hydrohalic acids for example, hydrochloric or hydrobromic acid - or organic acids - such as tartaric acid, fumaric acid, citric acid or methanesulfonic acid.
  • Protecting groups in the meaning of the present invention are to be understood as a collective term for such organic radicals with which certain functional groups of a molecule containing several active sites can be temporarily protected against the attack of reagents so that reactions take place only at the desired (unprotected) sites occur.
  • the protecting groups should be selectively introduced under mild conditions. They must be stable for the duration of the protection under all conditions of the reactions and cleaning operations to be performed; Racemizations and epimerizations must be suppressed. Protective groups should again be cleavable under mild conditions selectively and ideally with high yield.
  • an "organic solvent” is understood to mean an organic, low-molecular substance which can bring other organic substances to solution by physical means.
  • Prerequisite for the suitability as a solvent is that during the dissolution process, neither the solvent nor the solute chemically change, so that the components of the solution by physical separation methods such as distillation, crystallization, sublimation, evaporation, adsorption can be recovered in its original form.
  • physical separation methods such as distillation, crystallization, sublimation, evaporation, adsorption
  • Alcohols preferably methanol, ethanol, propanol, butanol, octanol, cyclohexanol;
  • Glycols preferably ethylene glycol, diethylene glycol;
  • Ether / glycol ethers preferably diethyl ether, tert-butyl methyl ether, dibutyl ether, anisole, dioxane, tetrahydrofuran, mono-, di-, tri-, polyethylene glycol ethers;
  • Ketones preferably acetone, butanone, cyclohexanone
  • Esters preferably acetic acid esters, glycol esters;
  • Nitrogen compounds preferably dimethylformamide, pyridine, N-methylpyrrolidone, acetonitrile;
  • Sulfur compounds preferably carbon disulfide, dimethylsulfoxide, sulfolane; Nitro compounds preferably nitrobenzene;
  • Halogenated hydrocarbons preferably dichloromethane, chloroform, carbon tetrachloride, trichlorethylene, tetrachloroethene, 1,2-dichloroethane, chlorofluorocarbons;
  • Aliphatic or alicyclic hydrocarbons preferably benzines, petroleum ethers, cyclohexane, methylcyclohexane, decalin, terpene-L; or
  • Aromatic hydrocarbons preferably benzene, toluene, o-xylene, m-xylene, p-xylene; or corresponding mixtures thereof.
  • diastereomerically pure in the context of the present invention describes compounds of the formula (I) which are present in a diastereomeric purity of at least 85% de, preferably of at least 90% de, particularly preferably> 95% de.
  • de diastereomeric excess
  • de optical purity of diastereomeric compounds.
  • enantiomerically pure in the context of the present invention describes compounds of the formula (I) which are present in an enantiomeric purity of at least 85% ee, preferably of at least 90% ee, particularly preferably of> 95% ee.
  • ee enantiomeric excess
  • d- 6 alkyl (including those which are part of other groups) branched to and understood unbranched alkyl groups having 1 to 6 carbon atoms, and branched by the term "C-M-alkyl” and unbranched alkyl groups having 1 to 4 carbon atoms Understood. Preferred are alkyl groups having 1 to 4 carbon atoms, more preferably alkyl groups having 1 to 2 carbon atoms.
  • Examples include: methyl, ethyl, n-propyl, / so-propyl, n-butyl, / so-butyl, sec-butyl, te / f-butyl, n-pentyl, / so-pentyl, neo-pentyl or hexyl.
  • the abbreviations Me, Et, n-Pr, / -Pr, n-Bu, / -Bu, t-Bu, etc. are also used for the abovementioned groups.
  • the definitions of propyl, butyl, pentyl and hexyl include all conceivable isomeric forms of the respective radicals.
  • propyl includes n-propyl and / so-propyl
  • butyl includes / so-butyl, sec-butyl and te / f-butyl, etc.
  • C 3-7 -cycloalkyl means cyclic alkyl groups having 3 or 7 carbon atoms. Examples include: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl. Unless otherwise stated, the cyclic alkyl groups may be substituted with one or more multiple radicals selected from the group consisting of methyl, ethyl, / so-propyl, tert-butyl, hydroxy and fluorine.
  • aryl (even if they are part of other radicals) are understood as meaning aromatic ring systems having 6, 10 or 14 carbon atoms. Examples include: phenyl, naphthyl, anthracenyl or phenanthrenyl, more preferably aryl is phenyl.
  • Halogen in the context of the present invention is fluorine, chlorine, bromine or iodine. Unless otherwise indicated, fluorine, chlorine and bromine are preferred halogens.
  • Z 1 represents a leaving group such as a halogen atom, for example a chlorine or bromine atom, a sulphonyloxy group such as a Methansulfonyloxy- or p-toluenesulfonyloxy or a hydroxy group.
  • the reaction is conveniently carried out in a solvent such as ethanol, isopropanol, acetonitrile, toluene, tetrahydrofuran, dioxane, dimethylformamide, dimethyl sulfoxide or N-methylpyrrolidinone, preferably in the presence of a base such as potassium carbonate, potassium tert-butoxide, sodium hydride or N-ethyl-diisopropylamine, at temperatures in the range of 20 0 C to 160 0 C, for example at temperatures in the range of 60 ° C to 140 ° C.
  • a solvent such as ethanol, isopropanol, acetonitrile, toluene, tetrahydrofuran, dioxane, dimethylformamide, dimethyl sulfoxide or N-methylpyrrolidinone
  • a base such as potassium carbonate, potassium tert-butoxide, sodium hydride or N-ethyl-diisoprop
  • reaction is carried out in the presence of a dehydrating agent, preferably in the presence of a phosphine and an azodicarboxylic acid derivative such as
  • Triphenylphosphine / Azodicarbonklarediethylester conveniently in a solvent such as methylene chloride, acetonitrile, tetrahydrofuran, dioxane, toluene or Ethylenglycoldiethylether at temperatures between -50 and 150 0 C, but preferably at temperatures between -20 and 80 ° C, carried out.
  • a solvent such as methylene chloride, acetonitrile, tetrahydrofuran, dioxane, toluene or Ethylenglycoldiethylether
  • R a is as defined above
  • a halogenating agent for example an acid halide such as thionyl chloride, thionyl bromide, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, or triphenylphosphine / carbon tetrachloride or triphenylphosphine / N-chlorosuccinimide to give an intermediate compound of general formula (V),
  • an acid halide such as thionyl chloride, thionyl bromide, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, or triphenylphosphine / carbon tetrachloride or triphenylphosphine / N-chlorosuccinimide
  • R a is defined as mentioned above and Z 2 represents a halogen atom, such as a chlorine or bromine atom,
  • the reaction with the halogenating agent is optionally carried out in a solvent such as methylene chloride, chloroform, acetonitrile or toluene and optionally in the presence of a base such as N, N-diethylaniline, triethylamine or N-ethyl-diisopropylamine at temperatures in the range of 20 0 C to 160 0 C. , preferably carried out from 40 ° C to 120 0 C.
  • a solvent such as methylene chloride, chloroform, acetonitrile or toluene
  • a base such as N, N-diethylaniline, triethylamine or N-ethyl-diisopropylamine
  • the reaction is carried out with thionyl chloride and catalytic amounts of dimethylformamide at the boiling temperature of the reaction mixture or with phosphorus oxychloride in acetonitrile in the presence of triethylamine at the boiling temperature of the reaction mixture or with triphenylphosphine / carbon tetrachloride or with triphenylphosphine / N-chlorosuccinimide in acetonitrile.
  • reaction of the compound of the general formula (VI) with the compound of the general formula (VII) or its salts is conveniently carried out in a solvent such as ethanol, isopropanol, acetonitrile, dioxane or dimethylformamide, if appropriate in the presence of a base such as potassium carbonate, triethylamine or N- Ethyl diisopropylamine, at temperatures in the range of 20 ° C and 160 ° C, preferably from 60 0 C to 120 ° C.
  • the reaction is carried out in isopropanol at the boiling temperature of the reaction mixture.
  • the reaction of a compound of the general formula (IV) to give a compound of the general formula (I) can also be carried out as a one-pot reaction, for example in acetonitrile in the presence of triethylamine.
  • R a is as defined above, in the presence of a reducing agent.
  • the reductive amination is, for example, in a solvent such as dichloromethane, 1, 2 dichloroethane, methanol, ethanol, tetrahydrofuran or dioxane in the presence of a reducing agent such as sodium triacetoxyborohydride or sodium cyanborhydrid, optionally in the presence of acetic acid at temperatures between 0 0 C and 80 0 C performed.
  • a reducing agent such as sodium triacetoxyborohydride or sodium cyanborhydrid
  • acetic acid at temperatures between 0 0 C and 80 0 C performed.
  • the reductive amination can also be carried out with hydrogen in the presence of a catalyst such as palladium on activated carbon or platinum oxide.
  • Another possibility is to form the enamine from the ketone of general formula VII and the amine of general formula VIII with elimination of water, for example with titanium (IV) isopropoxide, and then to reduce this, for example with sodium borohydride or hydrogen / palladium activated carbon.
  • optionally present reactive groups such as hydroxyl, amino, alkylamino or imino groups can be protected during the reaction by conventional protecting groups, which are cleaved again after the reaction.
  • Protective radicals for an amino, alkylamino or imino group are, for example, the formyl, acetyl, trifluoroacetyl, ethoxycarbonyl, tert-butoxycarbonyl, benzyloxycarbonyl, benzyl, methoxybenzyl or 2,4-dimethoxybenzyl groups.
  • the optional subsequent cleavage of a protective moiety used is carried out, for example hydrolytically in an aqueous solvent, for example in water, isopropanol / water, acetic acid / water, tetrahydrofuran / water or dioxane / water, in the presence of an acid such as trifluoroacetic acid, hydrochloric acid or sulfuric acid or in the presence an alkali metal base such as sodium hydroxide or potassium hydroxide or aprotic, for example in the presence of iodotrimethylsilane, at temperatures between 0 and 120 0 C, preferably at temperatures between 10 and 100 0 C.
  • an aqueous solvent for example in water, isopropanol / water, acetic acid / water, tetrahydrofuran / water or dioxane / water, in the presence of an acid such as trifluoroacetic acid, hydrochloric acid or sulfuric acid or in the presence an alkali metal base
  • cleavage of a benzyl, methoxybenzyl or Benzyloxycarbonyl restes takes place, for example hydrogenolytically, for example, with hydrogen in the presence of a catalyst such as palladium / carbon in a suitable solvent such as methanol, ethanol, ethyl acetate or glacial acetic acid optionally with the addition of an acid such as hydrochloric acid at temperatures between 0 and 100 ° C, but preferably at room temperatures between 20 and 60 0 C, and at a hydrogen pressure of 1 to 7 bar, but preferably from 3 to 5 bar.
  • a catalyst such as palladium / carbon
  • a suitable solvent such as methanol, ethanol, ethyl acetate or glacial acetic acid
  • an acid such as hydrochloric acid
  • the cleavage of a 2,4-dimethoxybenzyl radical is preferably carried out in trifluoroacetic acid in the presence of anisole, thioanisole, pentamethylbenzene or triethylsilane.
  • tert-butyl or tert. -Butyloxycarbonylrest.es is preferably carried out by treatment with an acid such as trifluoroacetic acid or hydrochloric acid or by treatment with iodotrimethylsilane optionally with the use of a solvent such as methylene chloride, dioxane, methanol or diethyl ether.
  • an acid such as trifluoroacetic acid or hydrochloric acid
  • iodotrimethylsilane optionally with the use of a solvent such as methylene chloride, dioxane, methanol or diethyl ether.
  • the cleavage of a Trifluoracetyl rest is preferably carried out by treatment with an acid such as hydrochloric acid, optionally in the presence of a solvent such as acetic acid
  • the compounds of general formula I obtained can be separated into their enantiomers and / or diastereomers.
  • cis / trans mixtures can be separated into their cis and trans isomers, and compounds having at least one optically active carbon atom can be resolved into their enantiomers.
  • the resulting cis / trans mixtures can be purified by chromatography in their cis and trans isomers, the resulting compounds of general formula I, which in
  • the enantiomer separation is preferably carried out by column separation on chiral phases or by recrystallization from an optically active solvent or by reacting with a, with the racemic compound, salts or derivatives such.
  • Ester or amide-forming optically active substance in particular acids and their activated derivatives or
  • Derivatives e.g. due to different solubilities, wherein from the pure diastereomeric salts or derivatives the free antipodes can be released by the action of suitable agents.
  • Particularly common optically active acids are e.g. the D and L forms of tartaric acid or dibenzoyltartaric acid, di-o-tolyltartaric acid, malic acid,
  • acids examples include hydrochloric, hydrobromic, sulfuric, methanesulfonic, ethanesulfonic, benzenesulfonic, p-toluenesulfonic, phosphoric, fumaric, succinic, benzoic, salicylic, mandelic, lactic, malonic, citric, L-malic, L-tartaric or maleic acid ,
  • bases for this example, sodium hydroxide, potassium hydroxide, calcium hydroxide, diethanolamine or N-methyl-D-glucamine into consideration.
  • the compounds of the general formula (I) according to the invention and their physiologically tolerated salts have valuable pharmacological properties, in particular an inhibitory effect on the signal transduction mediated by the epidermal growth factor receptor (EGF-R) Inhibition of ligand binding, the receptor dimerization or the tyrosine kinase itself can be effected. In addition, it is possible that the signal transmission to further downstream components is blocked.
  • EGF-R epidermal growth factor receptor
  • Reaction mixture refluxed for 2 hours.
  • the mixture is cooled to room temperature, with
  • the reaction mixture is dichloromethane and 1M sodium hydroxide solution, stirred briefly and extracted several times with dichloromethane. The combined organic phases are dried over magnesium sulfate and concentrated. Purification on a silica gel column with ethyl acetate / methanol / aqueous ammonia (95: 5: 0.1 to 80: 20: 0.1) gives the two title compounds as a mixture.
  • the cis / trans mixture is separated by preparative HPLC (xBridge TM C18 from Waters, acetonitrile, water, aqueous ammonia). The assignment of the isomers via 1 H-NMR spectroscopy (400MHz, dimethyl sulfoxide-d6).
  • EGF-R mediated signal transduction may be e.g. with cells expressing human EGF-R and whose survival and proliferation depends on stimulation by EGF or TGF-alpha, respectively.
  • a murine hematopoietic cell line is genetically engineered to express functional human EGF-R. The proliferation of this cell line can therefore be stimulated by EGF.
  • the cells are cultured in RPMI / 1640 medium. Proliferation is stimulated with 20 ng / ml human EGF (Promega). To investigate the inhibitory activity of the compounds according to the invention, these compounds are dissolved in 100% dimethyl sulfoxide (DMSO) and added to the cultures in various dilutions, the maximum DMSO concentration is 1%. The cultures are incubated for 48 hours at 37 ° C.
  • DMSO dimethyl sulfoxide
  • the relative cell count is determined using the Cell Titer 96TM AQueous Non-Radioactive Cell Proliferation Assay
  • the relative cell count is calculated as a percentage of the control and the drug concentration, which inhibits the proliferation of the cells to 50% (IC50) derived.
  • the compounds of formula (I) are characterized by a variety of therapeutic applications. To emphasize are those applications for which the compounds of the formula (I) according to the invention can preferably be used as a tyrosine kinase inhibitor due to their pharmaceutical activity.
  • the compounds of general formula (I) according to the invention thus inhibit the signal transduction by tyrosine kinases, as exemplified by the human EGF receptor and are therefore useful for treating pathophysiological processes caused by hyperfunction of tyrosine kinases.
  • tyrosine kinases as exemplified by the human EGF receptor and are therefore useful for treating pathophysiological processes caused by hyperfunction of tyrosine kinases.
  • These are, for example, benign or malignant tumors, in particular tumors of epithelial and neuro-epithelial origin, metastasis and the abnormal proliferation of vascular endothelial cells (neoangiogenesis).
  • the compounds of the invention are also useful for the prevention and treatment of respiratory and pulmonary diseases associated with increased or altered mucus production caused by stimulation of tyrosine kinases, e.g. in inflammatory diseases of the respiratory tract such as chronic bronchitis, chronic obstructive bronchitis, asthma, bronchiectasis, allergic or non-allergic rhinitis or sinusitis, cystic fibrosis, ⁇ 1-antitrypsin deficiency, or in cough, emphysema, pulmonary fibrosis and hyperreactive airways.
  • inflammatory diseases of the respiratory tract such as chronic bronchitis, chronic obstructive bronchitis, asthma, bronchiectasis, allergic or non-allergic rhinitis or sinusitis, cystic fibrosis, ⁇ 1-antitrypsin deficiency, or in cough, emphysema, pulmonary fibrosis and hyperreactive airways.
  • the compounds are also useful in the treatment of disorders of the gastrointestinal tract and bile ducts and bladder associated with impaired activity of the tyrosine kinases, e.g. in chronic inflammatory disorders, such as cholecystitis, Crohn's disease, ulcerative colitis, and ulcers in the gastrointestinal tract or as they occur in disorders of the gastrointestinal tract associated with increased secretion, such as M. Menetrier, secreting adenomas and protein loss syndromes.
  • chronic inflammatory disorders such as cholecystitis, Crohn's disease, ulcerative colitis, and ulcers in the gastrointestinal tract or as they occur in disorders of the gastrointestinal tract associated with increased secretion, such as M. Menetrier, secreting adenomas and protein loss syndromes.
  • the compounds of general formula (I) and their physiologically acceptable salts may be used for the treatment of other diseases caused by aberrant function of tyrosine kinases, e.g. epidermal hyperproliferation (psoriasis), benign prostatic hyperplasia (BPH), inflammatory processes, diseases of the immune system, hyperproliferation of hematopoietic cells, the treatment of nasal polyps, etc ..
  • tyrosine kinases e.g. epidermal hyperproliferation (psoriasis), benign prostatic hyperplasia (BPH), inflammatory processes, diseases of the immune system, hyperproliferation of hematopoietic cells, the treatment of nasal polyps, etc .
  • the compounds of the invention can be used alone or in combination with other pharmacologically active compounds, for example in tumor therapy in monotherapy or in combination with other anti-tumor therapeutics, for example in combination with topoisomerase inhibitors (eg etoposide), mitotic inhibitors (eg, vinblastine), nucleic acid-interacting compounds (eg, cisplatin, cyclophosphamide, adriamycin), hormone antagonists (eg, tamoxifen), inhibitors of metabolic processes (eg, 5-FU, etc.), cytokines (eg, interferons), antibodies, etc.
  • topoisomerase inhibitors eg etoposide
  • mitotic inhibitors eg, vinblastine
  • nucleic acid-interacting compounds eg, cisplatin, cyclophosphamide, adriamycin
  • hormone antagonists eg, tamoxifen
  • inhibitors of metabolic processes eg, 5-FU, etc.
  • these compounds may be used alone or in combination with other respiratory therapies, such as secretolytic (eg Ambroxol, N- acetylcysteine), broncholytic (eg tiotropium or ipratropium or fenoterol, salmeterol, salbutamol) and / or anti-inflammatory (eg theophylline or glucocorticoids) active substances.
  • secretolytic eg Ambroxol, N- acetylcysteine
  • broncholytic eg tiotropium or ipratropium or fenoterol, salmeterol, salbutamol
  • anti-inflammatory eg theophylline or glucocorticoids
  • the compounds according to the invention can be administered orally, transdermally, by inhalation, parenterally or sublingually.
  • the compounds of the invention are present as active ingredients in conventional dosage forms, for example in compositions consisting essentially of an inert pharmaceutical carrier and an effective dose of the active ingredient, such as tablets, dragees, capsules, wafers, powders, solutions, suspensions, emulsions , Syrups, suppositories, transdermal systems etc.
  • An effective dose of the compounds according to the invention is between 0.1 and 5000, preferably between 1 and 500, more preferably between 5 and 300 mg / dose when administered orally during intravenous, subcutaneous or intramuscular administration 0.001 and 50, preferably between 0.1 and 10 mg / dose.
  • inhalation solutions are suitable according to the invention containing 0.01 to 1, 0, preferably 0.1 to 0.5% active ingredient.
  • the use of powders, ethanolic or aqueous solutions is preferred. It is likewise possible to use the compounds according to the invention as infusion solution, preferably in a physiological saline solution or nutrient salt solution.
  • the compounds according to the invention can be used alone or in combination with other active compounds according to the invention, if appropriate also in combination with other pharmacologically active substances.
  • Suitable application forms are, for example, tablets, capsules, suppositories, solutions, juices, emulsions or dispersible powders.
  • Corresponding tablets can be prepared, for example, by mixing the active substance (s) with known excipients, for example inert diluents such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents to obtain the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
  • excipients for example inert diluents such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents to obtain the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
  • excipients for example iner
  • Coated tablets can accordingly be produced by coating cores produced analogously to the tablets with agents customarily used in tablet coatings, for example collidone or shellac, gum arabic, talc, titanium dioxide or sugar.
  • the core can also consist of several layers.
  • the dragee sheath to achieve a depot effect of several layers may consist of the above mentioned in the tablets excipients can be used.
  • Juices of the active compounds or active compound combinations according to the invention may additionally contain a sweetener, such as saccharin, cyclamate, glycerol or sugar, as well as a taste-improving agent, e.g. Flavorings such as vanillin or orange extract. They may also contain suspending aids or thickening agents, such as sodium carboxymethylcellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.
  • a sweetener such as saccharin, cyclamate, glycerol or sugar
  • a taste-improving agent e.g. Flavorings such as vanillin or orange extract.
  • suspending aids or thickening agents such as sodium carboxymethylcellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.
  • Injection solutions are prepared in a conventional manner, e.g. prepared with the addition of preservatives, such as p-hydroxybenzoates, or stabilizers, such as alkali metal salts of ethylenediaminetetraacetic acid and filled into injection bottles or ampoules.
  • preservatives such as p-hydroxybenzoates, or stabilizers, such as alkali metal salts of ethylenediaminetetraacetic acid
  • the capsules containing one or more active ingredients or combinations of active substances can be prepared, for example, by mixing the active ingredients with inert carriers, such as lactose or sorbitol, and encapsulating them in gelatine capsules.
  • inert carriers such as lactose or sorbitol
  • Suitable suppositories can be prepared, for example, by mixing with suitable carriers, such as neutral fats or polyethylene glycol or its derivatives.
  • the compounds of the invention are generally used in warm-blooded vertebrates, in particular in humans, in dosages of 0.01-
  • these may be, for example, with one or more conventional inert carriers and / or
  • Diluents e.g. with corn starch, lactose, cane sugar, microcrystalline cellulose,
  • Carboxymethylcellulose or fatty substances such as hard fat or their suitable Mixtures are incorporated in conventional pharmaceutical preparations such as tablets, dragees, capsules, powders, suspensions, solutions, sprays or suppositories.
  • 1 drag core contains:
  • the active substance is mixed with calcium phosphate, corn starch, polyvinylpyrrolidone, hydroxypropylmethylcellulose and half of the stated amount of magnesium stearate.
  • a tableting machine compacts are produced with a diameter of about 13 mm, these are ground on a suitable machine through a sieve with 1.5 mm mesh size and mixed with the remaining amount of magnesium stearate. This granulate is pressed on a tabletting machine into tablets of the desired shape.
  • coated dragee cores are coated with a film consisting essentially of hydroxypropylmethylcellulose.
  • the finished film dragees are shined with beeswax.
  • 1 tablet contains:
  • Diameter 10 mm, biplan with facet on both sides and one-sided part notch.
  • 1 tablet contains:
  • the active substance mixed with milk sugar, corn starch and silica is moistened with a 20% strength aqueous solution of polyvinylpyrrolidone and beaten through a sieve with a mesh size of 1.5 mm.
  • the granules dried at 45 ° C are again rubbed through the same sieve and mixed with the stated amount of magnesium stearate. From the mixture tablets are pressed.
  • Composition 1 capsule contains:
  • the active ingredient is mixed with the excipients, passed through a sieve of 0.75 mm mesh size and mixed homogeneously in a suitable device.
  • the final mixture is filled into size 1 hard gelatin capsules.
  • Composition 1 suppository contains:
  • the active ingredient is distributed homogeneously therein and the melt is poured into pre-cooled molds.
  • Carboxymethylcellulose Na salt 0.10 g p-hydroxybenzoic acid methyl ester 0.05 g p-hydroxybenzoic acid propyl ester 0.01 g
  • Distilled water is heated to 70 0 C.
  • p-hydroxybenzoic acid methyl ester and propyl ester and also glycerol and carboxymethylcellulose sodium salt are dissolved with stirring. It is cooled to room temperature and added with stirring, the active ingredient and dispersed homogeneously. After addition and dissolution of the sugar, the sorbitol solution and the aroma, the suspension is evacuated to vent with stirring.
  • 5 ml of suspension contain 50 mg of active ingredient.
  • the active ingredient is dissolved in the required amount of 0.01 N HCl, isotonic with saline, sterile filtered and filled into 2 ml ampoules.
  • Composition Active ingredient 50.0 mg 0.01 n hydrochloric acid s.q.
  • the active ingredient is dissolved in the required amount 0.01 N HCl, made isotonic with sodium chloride, sterile filtered and filled into 10 ml ampoules.
  • 1 capsule contains:
  • the active substance is mixed with lactose for inhalation purposes.
  • the mixture is on one
  • Capsule machine in capsules (weight of the empty capsule about 50 mg) bottled.
  • 1 hub contains:
  • the active substance and benzalkonium chloride are dissolved in ethanol / water (50/50).
  • the pH of the solution is adjusted with 1 N hydrochloric acid.
  • the adjusted solution is filtered and filled into containers suitable for the hand nebulizer (cartridges).

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EP09780994A 2008-08-08 2009-07-23 Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung Withdrawn EP2313398A1 (de)

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PCT/EP2009/059511 WO2010015523A1 (de) 2008-08-08 2009-07-23 Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

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CN103833646A (zh) * 2014-02-28 2014-06-04 广东工业大学 一种脂肪氨基取代喹唑啉酮衍生物及其制备方法和应用
CN105017163A (zh) * 2015-08-25 2015-11-04 佛山市赛维斯医药科技有限公司 双乙氧基苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及其用途
CN105085415A (zh) * 2015-08-25 2015-11-25 佛山市赛维斯医药科技有限公司 一种硝基取代的苯并喹唑啉类酪氨酸激酶抑制剂及用途
CN105085414A (zh) * 2015-08-25 2015-11-25 佛山市赛维斯医药科技有限公司 新型苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及其用途
CN105085416A (zh) * 2015-08-25 2015-11-25 佛山市赛维斯医药科技有限公司 一类硝基取代的双烷氧苯并喹唑啉类酪氨酸激酶抑制剂及用途
CN105130913A (zh) * 2015-08-25 2015-12-09 佛山市赛维斯医药科技有限公司 一类多取代的苯并喹唑啉类酪氨酸激酶抑制剂及用途
CN106349230A (zh) * 2016-08-09 2017-01-25 浙江医药高等专科学校 一种含硝基噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂及用途
CN106317039A (zh) * 2016-08-09 2017-01-11 浙江医药高等专科学校 一种含噻吩磺酰胺结构的乙氧苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途
CN106336404A (zh) * 2016-08-09 2017-01-18 浙江医药高等专科学校 一种含氟苯和噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂、及用途
CN106279135A (zh) * 2016-08-09 2017-01-04 浙江医药高等专科学校 一种噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂
CN106336405A (zh) * 2016-08-09 2017-01-18 浙江医药高等专科学校 一种含噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂、制备方法及用途
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CN106317038A (zh) * 2016-08-09 2017-01-11 浙江医药高等专科学校 一类含噻吩磺酰胺结构的苯并喹唑啉类酪氨酸激酶抑制剂及其用途

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