EA025158B9 - Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения - Google Patents

Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения

Info

Publication number
EA025158B9
EA025158B9 EA201400521A EA201400521A EA025158B9 EA 025158 B9 EA025158 B9 EA 025158B9 EA 201400521 A EA201400521 A EA 201400521A EA 201400521 A EA201400521 A EA 201400521A EA 025158 B9 EA025158 B9 EA 025158B9
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
processes
preparation
medicaments containing
diseases
Prior art date
Application number
EA201400521A
Other languages
English (en)
Other versions
EA201400521A1 (ru
EA025158B1 (ru
Inventor
Армин Хеккель
Сара Фраттини
Дитер Хампрехт
Йёрг Клей
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201400521A1 publication Critical patent/EA201400521A1/ru
Publication of EA025158B1 publication Critical patent/EA025158B1/ru
Publication of EA025158B9 publication Critical patent/EA025158B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В патенте описаны соединения общей формулы (I)и их таутомеры и соли, предпочтительно их фармацевтически приемлемые соли с неорганическими или органическими кислотами и основаниями, которые обладают ценными фармакологическими характеристиками, в особенности ингибирующим воздействием на эпителиальные натриевые каналы, их применение для лечения заболеваний, в особенности заболеваний легких и дыхательных путей.
EA201400521A 2011-11-02 2012-10-29 Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения EA025158B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11187553 2011-11-02
PCT/EP2012/071352 WO2013064450A1 (en) 2011-11-02 2012-10-29 Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof

Publications (3)

Publication Number Publication Date
EA201400521A1 EA201400521A1 (ru) 2014-09-30
EA025158B1 EA025158B1 (ru) 2016-11-30
EA025158B9 true EA025158B9 (ru) 2018-03-30

Family

ID=47073464

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400521A EA025158B9 (ru) 2011-11-02 2012-10-29 Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения

Country Status (34)

Country Link
US (4) US8759349B2 (ru)
EP (1) EP2773633B1 (ru)
JP (1) JP6091513B2 (ru)
KR (1) KR102006612B1 (ru)
CN (2) CN104024244B (ru)
AP (1) AP2014007670A0 (ru)
AU (1) AU2012331274B2 (ru)
BR (1) BR112014010583A2 (ru)
CA (1) CA2854217C (ru)
CL (1) CL2014001047A1 (ru)
CO (1) CO6940429A2 (ru)
CY (1) CY1120974T1 (ru)
DK (1) DK2773633T3 (ru)
EA (1) EA025158B9 (ru)
EC (1) ECSP14001929A (ru)
ES (1) ES2645744T3 (ru)
GE (1) GEP20186880B (ru)
HK (1) HK1196819A1 (ru)
HR (1) HRP20171614T1 (ru)
HU (1) HUE034929T2 (ru)
IL (1) IL232035A (ru)
LT (1) LT2773633T (ru)
ME (1) ME02905B (ru)
MX (1) MX348522B (ru)
NO (1) NO2773633T3 (ru)
PE (1) PE20141607A1 (ru)
PL (1) PL2773633T3 (ru)
PT (1) PT2773633T (ru)
RS (1) RS56498B1 (ru)
SG (1) SG11201401907TA (ru)
SI (1) SI2773633T1 (ru)
TN (1) TN2014000180A1 (ru)
UA (1) UA115868C2 (ru)
WO (1) WO2013064450A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5409010B2 (ja) 2005-12-28 2014-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド Ｎ−［２，４−ビス（１，１−ジメチルエチル）−５−ヒドロキシフェニル］−１，４−ジヒドロ−４−オキソキノリン−３−カルボキサミドの固体形態
CN104024244B (zh) 2011-11-02 2016-09-14 勃林格殷格翰国际有限公司 杂环化合物、含有所述化合物的药物及其用途和其制备方法
EP3016944A4 (en) * 2013-07-02 2016-11-16 California Inst Biomedical Res COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS
EP3019492B1 (en) 2013-07-08 2017-09-06 Boehringer Ingelheim International GmbH Amiloride-type compounds as inhibitors in epithelial sodium channels for the treatment of diseases of the lungs and airways
WO2016057730A1 (en) 2014-10-07 2016-04-14 Strohmeier Mark Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CA2965467A1 (en) * 2014-10-24 2016-04-28 Ono Pharmaceutical Co., Ltd. Kcnq2-5 channel activator
CN107405505A (zh) * 2015-01-07 2017-11-28 加州生物医学研究所 用于治疗囊性纤维化的化合物
GB201610854D0 (en) 2016-06-21 2016-08-03 Entpr Therapeutics Ltd Compounds
GB201619694D0 (en) 2016-11-22 2017-01-04 Entpr Therapeutics Ltd Compounds
GB201717051D0 (en) 2017-10-17 2017-11-29 Enterprise Therapeutics Ltd Compounds
GB201808093D0 (en) 2018-05-18 2018-07-04 Enterprise Therapeutics Ltd Compounds
MX2023002850A (es) 2020-09-10 2023-07-07 Precirix N V Fragmento de anticuerpo contra proteina activadora de fibroblastos (fap).
CN112107580A (zh) * 2020-09-29 2020-12-22 北京鑫开元医药科技有限公司 一种脾酪氨酸激酶抑制剂的制剂组合物及其制备方法
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6812003A (ru) 1967-09-07 1969-03-11
US3953476A (en) 1971-12-27 1976-04-27 Merck & Co., Inc. 3-Amino-5-sulfonylbenzoic acids
US6475509B1 (en) 1999-07-19 2002-11-05 The University Of North Carolina At Chapel Hill Covalent conjugates of sodium channel blockers and active compounds
JP2003520042A (ja) 2000-01-24 2003-07-02 アイシス・ファーマシューティカルス・インコーポレーテッド 誘導性一酸化窒素シンターゼ発現のアンチセンスモジュレーション
JP2008510702A (ja) 2004-08-18 2008-04-10 マイケル・アール・ジョンソン 脂肪族アミド及びエステルピラジノイルグアニジンナトリウムチャネル遮断薬
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
JP2009544313A (ja) * 2006-07-24 2009-12-17 インターナショナル ステム セル コーポレイション 網膜幹細胞由来の合成角膜
BRPI0811562A2 (pt) * 2007-05-07 2014-12-09 Novartis Ag Compostos orgânicos
TWI439462B (zh) 2007-12-10 2014-06-01 Novartis Ag 作為ｅｎａｃ阻抑劑之螺環胍化合物
CA2723938A1 (en) * 2008-05-13 2009-11-19 Novartis Ag 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases
CN102112130A (zh) 2008-06-10 2011-06-29 诺瓦提斯公司 作为上皮钠通道阻滞剂的吡嗪衍生物
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
US9050339B2 (en) 2010-09-17 2015-06-09 Novartis Ag Pyrazine derivatives as ENaC blockers
PL2723176T3 (pl) 2011-06-27 2018-01-31 Parion Sciences Inc Chemicznie i metabolicznie stabilny dipeptyd o silnej aktywności blokera kanału sodowego
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
BR112014010462A2 (pt) 2011-11-02 2017-04-18 Boehringer Ingelheim Int processo para a preparação de acilguanidinas e acetioureias
CN104024244B (zh) * 2011-11-02 2016-09-14 勃林格殷格翰国际有限公司 杂环化合物、含有所述化合物的药物及其用途和其制备方法

Also Published As

Publication number Publication date
CL2014001047A1 (es) 2014-11-07
AU2012331274B2 (en) 2017-06-08
DK2773633T3 (da) 2017-11-13
US20180194747A1 (en) 2018-07-12
ECSP14001929A (es) 2015-11-30
KR20140085498A (ko) 2014-07-07
SG11201401907TA (en) 2014-05-29
CN104024244B (zh) 2016-09-14
CN106279110B (zh) 2019-12-10
HK1196819A1 (zh) 2014-12-24
NZ622469A (en) 2016-08-26
PL2773633T3 (pl) 2018-01-31
MX2014005166A (es) 2014-05-28
CO6940429A2 (es) 2014-05-09
CN106279110A (zh) 2017-01-04
US9920035B2 (en) 2018-03-20
US20150336933A1 (en) 2015-11-26
RS56498B1 (sr) 2018-01-31
IL232035A0 (en) 2014-05-28
EP2773633A1 (en) 2014-09-10
JP2014534222A (ja) 2014-12-18
IL232035A (en) 2017-05-29
CN104024244A (zh) 2014-09-03
US20130109697A1 (en) 2013-05-02
HUE034929T2 (en) 2018-03-28
SI2773633T1 (sl) 2017-11-30
CA2854217C (en) 2019-12-31
GEP20186880B (en) 2018-07-25
HRP20171614T1 (hr) 2017-12-01
AU2012331274A1 (en) 2014-04-03
PE20141607A1 (es) 2014-11-23
PT2773633T (pt) 2017-11-14
ES2645744T3 (es) 2017-12-07
KR102006612B1 (ko) 2019-08-02
EA201400521A1 (ru) 2014-09-30
UA115868C2 (uk) 2018-01-10
CA2854217A1 (en) 2013-05-10
TN2014000180A1 (en) 2015-09-30
EP2773633B1 (en) 2017-08-02
EA025158B1 (ru) 2016-11-30
CY1120974T1 (el) 2019-12-11
US8759349B2 (en) 2014-06-24
WO2013064450A1 (en) 2013-05-10
LT2773633T (lt) 2017-11-10
BR112014010583A2 (pt) 2020-04-22
MX348522B (es) 2017-06-16
AP2014007670A0 (en) 2014-05-31
JP6091513B2 (ja) 2017-03-08
NO2773633T3 (ru) 2017-12-30
US20140228374A1 (en) 2014-08-14
ME02905B (me) 2018-10-20

Similar Documents

Publication Publication Date Title
EA025158B9 (ru) Гетероциклические соединения, лекарственные средства, содержащие указанные соединения, их применение и способы их получения
BR112016015717A8 (pt) macrociclos com grupos p2' heterocíclicos como inibidores do fator xia
PH12016502081A1 (en) Compounds for treating spinal muscular atrophy
UA115320C2 (uk) Інгібітори кінази
PH12015502628A1 (en) Pyrazolopyrrolidine derivatives and their use in the treatment of disease
MX2018005890A (es) Composiciones para tratar atrofia muscular espinal.
CA2983481A1 (en) Janus kinase inhibitor
MX2015016344A (es) Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades.
MX363456B (es) Compuestos para tratar atrofia muscular espinal.
BR112015032693A2 (pt) inibidores de bromodomínio
AU2011274192A8 (en) Heterocyclic alkynyl benzene compounds and medical compositions and uses thereof
UA104489C2 (ru) Соединения для лечения дислипидемии и родственных болезней
PH12014501278A1 (en) Kinase inhibitors
PH12016500885A1 (en) Novel heterocyclic compounds
MX367554B (es) Derivados heterocíclicos y sus usos.
CU20110088A7 (es) Derivados de anilina-pirimidina sustituidos con sulfoximina como inhibidores de quinasas dependientes de ciclina (cdk), producción y uso de los mismos como productos medicinales
MX2012007582A (es) Compuestos de 4-fenoxi-nicotinamida o 4-fenoxi-pirimidina-5-carbox amida.
NZ596527A (en) Nitrile derivatives and their pharmaceutical use and compositions
MX2016006667A (es) Derivados de pirrolo-pirrolona y su uso como inhibidores.
MX2014005165A (es) Proceso novedoso para la preparacion de acilguanidinas y aciltioureas.
MX2014005538A (es) 1-piridazinil-hidroxiimino-3-fenil-propanos como agonistas de proteina g-receptor acoplado a acido biliar 1 (gpbar1).
TN2014000218A1 (en) Kinase inhibitors
TH134961B (th) อนุพันธ์ควินาโซลีนสำหรับการรักษาการติดเชื้อไวรัสและโรคเพิ่มเติม

Legal Events

Date Code Title Description
TH4A Publication of the corrected specification to eurasian patent
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU