JP2014533823A - カバー部材、基板上の生体サンプルの処理方法および処理モジュール - Google Patents

カバー部材、基板上の生体サンプルの処理方法および処理モジュール Download PDF

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Publication number
JP2014533823A
JP2014533823A JP2014541480A JP2014541480A JP2014533823A JP 2014533823 A JP2014533823 A JP 2014533823A JP 2014541480 A JP2014541480 A JP 2014541480A JP 2014541480 A JP2014541480 A JP 2014541480A JP 2014533823 A JP2014533823 A JP 2014533823A
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cover member
substrate
fluid
sample
processing module
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JP2014533823A5 (enExample
Inventor
マーク・ブライアン・ドックリル
アンソニー・ファバローロ
ケネス・ヘン−チョン・エヌジー
マーティン・リモン
ピーター・トゥーグッド
スティーブン・ジョン・バグナト
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Leica Biosystems Melbourne Pty Ltd
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Leica Biosystems Melbourne Pty Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B01L2300/1866—Microwaves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2014541480A 2011-11-16 2012-11-15 カバー部材、基板上の生体サンプルの処理方法および処理モジュール Pending JP2014533823A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161560543P 2011-11-16 2011-11-16
US61/560,543 2011-11-16
PCT/AU2012/001407 WO2013071352A1 (en) 2011-11-16 2012-11-15 Cover member, method and treatment module for treating a biological sample on a substrate

Related Child Applications (1)

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JP2017194980A Division JP6633586B2 (ja) 2011-11-16 2017-10-05 カバー部材、基板上の生体サンプルの処理方法および処理モジュール

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JP2014533823A true JP2014533823A (ja) 2014-12-15
JP2014533823A5 JP2014533823A5 (enExample) 2016-01-14

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JP2014541480A Pending JP2014533823A (ja) 2011-11-16 2012-11-15 カバー部材、基板上の生体サンプルの処理方法および処理モジュール
JP2017194980A Active JP6633586B2 (ja) 2011-11-16 2017-10-05 カバー部材、基板上の生体サンプルの処理方法および処理モジュール

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US (3) US10549271B2 (enExample)
EP (1) EP2780721B1 (enExample)
JP (2) JP2014533823A (enExample)
CN (1) CN104094122B (enExample)
AU (1) AU2012339616B2 (enExample)
BR (1) BR112014011935B1 (enExample)
CA (1) CA2855511C (enExample)
IN (1) IN2014CN04294A (enExample)
WO (1) WO2013071352A1 (enExample)

Cited By (4)

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JP2015537202A (ja) * 2012-11-01 2015-12-24 ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッドＬｅｉｃａ Ｂｉｏｓｙｓｔｅｍｓ Ｍｅｌｂｏｕｒｎｅ Ｐｔｙ Ｌｔｄ スライド染色組立体及び蓋部材
WO2016190111A1 (ja) * 2015-05-26 2016-12-01 オリンパス株式会社 検体染色装置および検体染色方法
WO2021215755A1 (ko) * 2020-04-24 2021-10-28 (주)바이오니아 추적이 가능한 멀티웰플레이트용 정밀시료주입장치
JP2021530690A (ja) * 2018-07-10 2021-11-11 ナノサイトミクス，エルエルシー 自動化試料堆積および染色システムならびに関連方法

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US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
US10228382B2 (en) * 2012-11-01 2019-03-12 Leica Biosystems Melbourne Pty Ltd Fluid transport system and method for treating one or more tissue samples on a slide
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
US9518920B2 (en) 2013-06-26 2016-12-13 Alentic Microscience Inc. Sample processing improvements for microscopy
US10876937B2 (en) * 2013-10-04 2020-12-29 Biogenex Laboratories, Inc. Assembly for forming microchamber for inverted substrate
US10137450B2 (en) * 2014-07-18 2018-11-27 Tecan Trading Ag Microfluidics cartridge with pipetting guide
US9958362B1 (en) * 2015-10-02 2018-05-01 The Florida State University Research Foundation, Inc. Microscope sample preparation device
EP3427035B1 (en) * 2016-07-26 2023-08-30 Hewlett-Packard Development Company, L.P. Microfluidic apparatuses
GB2562081B (en) * 2017-05-04 2020-07-15 Imrali Ahmet Slide cleaner
EP3441143B1 (en) * 2017-08-08 2022-04-13 Roche Diagnostics GmbH Laboratory instrument base plate
CN108152109B (zh) * 2017-12-14 2021-02-09 深圳达盟生物科技有限公司 载玻片盖体及其用于组织切片清洗的方法
CN108387428A (zh) * 2018-02-26 2018-08-10 深圳安诺康生物医疗有限公司 一种病理切片的染色方法
KR102246609B1 (ko) * 2018-08-01 2021-04-30 주식회사 미코바이오메드 복수의 열 블록을 구비한 핵산 증폭 장치
EP3841387A4 (en) * 2018-12-20 2021-11-17 Leica Biosystems Melbourne Pty Ltd LARGE-VOLUME FLUID WASHING MODULE
US20220034916A1 (en) * 2018-12-20 2022-02-03 Leica Biosystems Melbourne Pty Ltd A slide output module
WO2020154248A1 (en) * 2019-01-21 2020-07-30 Forward Biotech, Inc. Liquid evaluation
CN109900542A (zh) * 2019-03-15 2019-06-18 深圳市金准生物医学工程有限公司 测试卡温育的自动封闭的腔体装置
CN113785184B (zh) * 2019-05-14 2025-02-28 文塔纳医疗系统公司 包括生物学样品处理腔室的系统
EP3825004A1 (en) * 2019-11-22 2021-05-26 Koninklijke Philips N.V. New multi-functional fluidic device for clamping biopsies
CN115773920B (zh) * 2021-09-06 2024-04-19 南京泰立瑞信息科技有限公司 一种低损耗、自动化的切片样本染色方法和系统
WO2023115135A1 (en) * 2021-12-23 2023-06-29 Leica Biosystems Melbourne Pty Ltd Sample processing assembly for treatment of a sample on a substrate
HU231596B1 (hu) * 2022-02-04 2025-03-28 3Dhistech Kft. Tárgylemez takaró eszköz, valamint inkubációs kamra, amely ilyen tárgylemez takaró eszközt tartalmaz
US20240167921A1 (en) * 2022-11-18 2024-05-23 Zomedica Inc. Methods and systems for slide treatment processing
CN116814864B (zh) * 2023-08-30 2023-11-24 深圳赛陆医疗科技有限公司 基因测序中芯片转移控制方法及装置、设备、系统及介质

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JPH11502926A (ja) * 1995-03-28 1999-03-09 メディカル・リサーチ・カウンシル サンプル処理におけるまたはそれに関する改良
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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015537202A (ja) * 2012-11-01 2015-12-24 ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッドＬｅｉｃａ Ｂｉｏｓｙｓｔｅｍｓ Ｍｅｌｂｏｕｒｎｅ Ｐｔｙ Ｌｔｄ スライド染色組立体及び蓋部材
US10145767B2 (en) 2012-11-01 2018-12-04 Leica Biosystems Melbourne Pty Ltd Slide staining assembly and cover member
US10718695B2 (en) 2012-11-01 2020-07-21 Leica Biosystems Melbourne Pty Ltd Slide staining assembly and cover member
US11635356B2 (en) 2012-11-01 2023-04-25 Leica Biosystems Melbourne Pty Ltd Slide staining assembly and cover member
US12140512B2 (en) 2012-11-01 2024-11-12 Leica Biosystems Melbourne Pty Ltd Slide staining assembly and cover member
WO2016190111A1 (ja) * 2015-05-26 2016-12-01 オリンパス株式会社 検体染色装置および検体染色方法
JPWO2016190111A1 (ja) * 2015-05-26 2018-03-15 オリンパス株式会社 検体染色装置および検体染色方法
US10712244B2 (en) 2015-05-26 2020-07-14 Olympus Corporation Specimen staining apparatus and specimen staining method
JP2021530690A (ja) * 2018-07-10 2021-11-11 ナノサイトミクス，エルエルシー 自動化試料堆積および染色システムならびに関連方法
JP7466515B2 (ja) 2018-07-10 2024-04-12 ナノサイトミクス，エルエルシー 自動化試料堆積および染色システムならびに関連方法
US12196770B2 (en) 2018-07-10 2025-01-14 Nanocytomics, LLC Automated sample deposition and staining systems and associated methods
WO2021215755A1 (ko) * 2020-04-24 2021-10-28 (주)바이오니아 추적이 가능한 멀티웰플레이트용 정밀시료주입장치

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EP2780721A1 (en) 2014-09-24
JP2018021932A (ja) 2018-02-08
US11420200B2 (en) 2022-08-23
BR112014011935B1 (pt) 2020-11-03
CA2855511C (en) 2021-03-09
IN2014CN04294A (enExample) 2015-09-04
US20140315256A1 (en) 2014-10-23
US20230077728A1 (en) 2023-03-16
CN104094122B (zh) 2017-03-22
US12157118B2 (en) 2024-12-03
WO2013071352A1 (en) 2013-05-23
EP2780721A4 (en) 2015-07-01
JP6633586B2 (ja) 2020-01-22
EP2780721B1 (en) 2017-08-16
CN104094122A (zh) 2014-10-08
BR112014011935A2 (pt) 2017-05-30
CA2855511A1 (en) 2013-05-23
AU2012339616B2 (en) 2016-04-28
AU2012339616A1 (en) 2014-06-12
US10549271B2 (en) 2020-02-04
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