CN104094122B - 用于在基板上处理生物样本的盖元件、方法和处理模块 - Google Patents

用于在基板上处理生物样本的盖元件、方法和处理模块 Download PDF

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Publication number
CN104094122B
CN104094122B CN201280067038.XA CN201280067038A CN104094122B CN 104094122 B CN104094122 B CN 104094122B CN 201280067038 A CN201280067038 A CN 201280067038A CN 104094122 B CN104094122 B CN 104094122B
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substrate
cap member
fluid
sample
chamber
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Chinese (zh)
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CN104094122A (zh
Inventor
马克·布赖恩·多克里尔
安东尼·法瓦洛罗
肯尼思·衡冲·额
马丁·利蒙
彼得·图古德
斯蒂芬·约翰·巴尼亚托
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Leica Biosystems Melbourne Pty Ltd
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Leica Biosystems Melbourne Pty Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B01L2300/1866—Microwaves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280067038.XA 2011-11-16 2012-11-15 用于在基板上处理生物样本的盖元件、方法和处理模块 Active CN104094122B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161560543P 2011-11-16 2011-11-16
US61/560,543 2011-11-16
PCT/AU2012/001407 WO2013071352A1 (en) 2011-11-16 2012-11-15 Cover member, method and treatment module for treating a biological sample on a substrate

Publications (2)

Publication Number Publication Date
CN104094122A CN104094122A (zh) 2014-10-08
CN104094122B true CN104094122B (zh) 2017-03-22

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Country Link
US (3) US10549271B2 (enExample)
EP (1) EP2780721B1 (enExample)
JP (2) JP2014533823A (enExample)
CN (1) CN104094122B (enExample)
AU (1) AU2012339616B2 (enExample)
BR (1) BR112014011935B1 (enExample)
CA (1) CA2855511C (enExample)
IN (1) IN2014CN04294A (enExample)
WO (1) WO2013071352A1 (enExample)

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US10228382B2 (en) * 2012-11-01 2019-03-12 Leica Biosystems Melbourne Pty Ltd Fluid transport system and method for treating one or more tissue samples on a slide
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
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US10876937B2 (en) * 2013-10-04 2020-12-29 Biogenex Laboratories, Inc. Assembly for forming microchamber for inverted substrate
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JPWO2016190111A1 (ja) * 2015-05-26 2018-03-15 オリンパス株式会社 検体染色装置および検体染色方法
US9958362B1 (en) * 2015-10-02 2018-05-01 The Florida State University Research Foundation, Inc. Microscope sample preparation device
EP3427035B1 (en) * 2016-07-26 2023-08-30 Hewlett-Packard Development Company, L.P. Microfluidic apparatuses
EP3441143B1 (en) * 2017-08-08 2022-04-13 Roche Diagnostics GmbH Laboratory instrument base plate
CN108152109B (zh) * 2017-12-14 2021-02-09 深圳达盟生物科技有限公司 载玻片盖体及其用于组织切片清洗的方法
CN108387428A (zh) * 2018-02-26 2018-08-10 深圳安诺康生物医疗有限公司 一种病理切片的染色方法
EP4538716A3 (en) 2018-07-10 2025-06-25 Nanocytomics LLC Automated sample deposition and staining systems and associated methods
KR102246609B1 (ko) * 2018-08-01 2021-04-30 주식회사 미코바이오메드 복수의 열 블록을 구비한 핵산 증폭 장치
EP3841387A4 (en) * 2018-12-20 2021-11-17 Leica Biosystems Melbourne Pty Ltd LARGE-VOLUME FLUID WASHING MODULE
US20220034916A1 (en) * 2018-12-20 2022-02-03 Leica Biosystems Melbourne Pty Ltd A slide output module
WO2020154248A1 (en) * 2019-01-21 2020-07-30 Forward Biotech, Inc. Liquid evaluation
CN109900542A (zh) * 2019-03-15 2019-06-18 深圳市金准生物医学工程有限公司 测试卡温育的自动封闭的腔体装置
CN113785184B (zh) * 2019-05-14 2025-02-28 文塔纳医疗系统公司 包括生物学样品处理腔室的系统
EP3825004A1 (en) * 2019-11-22 2021-05-26 Koninklijke Philips N.V. New multi-functional fluidic device for clamping biopsies
WO2021215755A1 (ko) * 2020-04-24 2021-10-28 (주)바이오니아 추적이 가능한 멀티웰플레이트용 정밀시료주입장치
CN115773920B (zh) * 2021-09-06 2024-04-19 南京泰立瑞信息科技有限公司 一种低损耗、自动化的切片样本染色方法和系统
WO2023115135A1 (en) * 2021-12-23 2023-06-29 Leica Biosystems Melbourne Pty Ltd Sample processing assembly for treatment of a sample on a substrate
HU231596B1 (hu) * 2022-02-04 2025-03-28 3Dhistech Kft. Tárgylemez takaró eszköz, valamint inkubációs kamra, amely ilyen tárgylemez takaró eszközt tartalmaz
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Also Published As

Publication number Publication date
EP2780721A1 (en) 2014-09-24
JP2018021932A (ja) 2018-02-08
US11420200B2 (en) 2022-08-23
BR112014011935B1 (pt) 2020-11-03
CA2855511C (en) 2021-03-09
IN2014CN04294A (enExample) 2015-09-04
US20140315256A1 (en) 2014-10-23
US20230077728A1 (en) 2023-03-16
US12157118B2 (en) 2024-12-03
WO2013071352A1 (en) 2013-05-23
EP2780721A4 (en) 2015-07-01
JP6633586B2 (ja) 2020-01-22
EP2780721B1 (en) 2017-08-16
CN104094122A (zh) 2014-10-08
BR112014011935A2 (pt) 2017-05-30
JP2014533823A (ja) 2014-12-15
CA2855511A1 (en) 2013-05-23
AU2012339616B2 (en) 2016-04-28
AU2012339616A1 (en) 2014-06-12
US10549271B2 (en) 2020-02-04
US20200188904A1 (en) 2020-06-18

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