JP2014533372A5 - - Google Patents
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- JP2014533372A5 JP2014533372A5 JP2014542462A JP2014542462A JP2014533372A5 JP 2014533372 A5 JP2014533372 A5 JP 2014533372A5 JP 2014542462 A JP2014542462 A JP 2014542462A JP 2014542462 A JP2014542462 A JP 2014542462A JP 2014533372 A5 JP2014533372 A5 JP 2014533372A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- kit
- sample
- specifically binds
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 9
- 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102100032912 CD44 antigen Human genes 0.000 claims 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 4
- 241000701806 Human papillomavirus Species 0.000 claims 3
- 239000002131 composite material Substances 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- 108010003272 Hyaluronate lyase Proteins 0.000 claims 2
- 102000001974 Hyaluronidases Human genes 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 229960002773 hyaluronidase Drugs 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- 239000013074 reference sample Substances 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 241000234314 Zingiber Species 0.000 claims 1
- 235000006886 Zingiber officinale Nutrition 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000008995 epigenetic change Effects 0.000 claims 1
- 235000008397 ginger Nutrition 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559974P | 2011-11-15 | 2011-11-15 | |
| US61/559,974 | 2011-11-15 | ||
| US201261654595P | 2012-06-01 | 2012-06-01 | |
| US61/654,595 | 2012-06-01 | ||
| PCT/US2012/065282 WO2013074793A1 (en) | 2011-11-15 | 2012-11-15 | Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533372A JP2014533372A (ja) | 2014-12-11 |
| JP2014533372A5 true JP2014533372A5 (https=) | 2016-01-14 |
| JP6174035B2 JP6174035B2 (ja) | 2017-08-02 |
Family
ID=48430146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542462A Active JP6174035B2 (ja) | 2011-11-15 | 2012-11-15 | ヒトパピローマウイルスを検出し頭頸部扁平上皮癌を予後予測する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20140329230A1 (https=) |
| EP (1) | EP2780714B1 (https=) |
| JP (1) | JP6174035B2 (https=) |
| CN (1) | CN104067126B (https=) |
| AU (3) | AU2012340441A1 (https=) |
| BR (1) | BR112014011563B1 (https=) |
| CA (1) | CA2855971C (https=) |
| CO (1) | CO6980621A2 (https=) |
| ES (1) | ES2640532T3 (https=) |
| IL (1) | IL232556A (https=) |
| MX (1) | MX352642B (https=) |
| PE (1) | PE20141565A1 (https=) |
| WO (1) | WO2013074793A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012340441A1 (en) | 2011-11-15 | 2014-05-29 | University Of Miami | Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma |
| WO2015017692A1 (en) * | 2013-07-31 | 2015-02-05 | University Of Miami | Compositions and methods for identifying a risk of cancer in a subject |
| WO2015026827A2 (en) * | 2013-08-19 | 2015-02-26 | University Of Notre Dame | Method and composition for detection of oncogenic hpv |
| WO2015179712A1 (en) | 2014-05-22 | 2015-11-26 | University Of Notre Dame Du Lac | Integrated membrane sensor for rapid molecular detection |
| WO2016209703A1 (en) * | 2015-06-22 | 2016-12-29 | The Johns Hopkins University | Head and neck squamous cell carcinoma assays |
| JP6655243B2 (ja) * | 2015-09-01 | 2020-02-26 | 国立大学法人 鹿児島大学 | 口腔前癌病変の検出方法 |
| CN107092854B (zh) * | 2016-02-18 | 2020-05-22 | 财团法人金属工业研究发展中心 | 检测细胞受人类乳头瘤病毒(hpv)感染的装置及其检测方法 |
| GB201808839D0 (en) | 2018-05-30 | 2018-07-11 | Cancer Research Tech Ltd | Method of predicting survival rates for cancer patients |
| WO2020018954A1 (en) * | 2018-07-20 | 2020-01-23 | Predentome, Inc. | Methods and systems for oral microbiome analysis |
| US20220137041A1 (en) * | 2019-02-26 | 2022-05-05 | University Of Miami | Device for methods of detecting cancer |
| US20240188897A1 (en) * | 2021-04-23 | 2024-06-13 | The University Of Chicago | Machine learning based histopathological recurrence prediction models for hpv+ head / neck squamous cell carcinoma |
| CN120359416A (zh) * | 2022-10-17 | 2025-07-22 | 伟吉朗特生物科学公司 | 用于口腔癌风险的方法和组合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403551A (en) | 1993-09-16 | 1995-04-04 | Roche Diagnostic Systems, Inc. | Assaying device and container for in field analysis of a specimen and later shipment of the unadulterated specimen |
| US6235470B1 (en) | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| US5990299A (en) * | 1995-08-14 | 1999-11-23 | Icn Pharmaceuticals, Inc. | Control of CD44 gene expression for therapeutic use |
| US5976895A (en) | 1996-03-11 | 1999-11-02 | American Biomedica Corporation | Device for the collection, testing and shipment of body fluid samples |
| DE19829473C2 (de) * | 1998-07-01 | 2000-08-10 | Magnus Von Knebel Doeberitz Ch | Verfahren zur frühen Diagnose von Carcinomen |
| US6379620B1 (en) | 1998-11-16 | 2002-04-30 | Barry M. Tydings | Assaying device and method for in field urinalysis |
| US6294349B1 (en) | 1999-03-01 | 2001-09-25 | University Of Mississippi Medical Ctr. | Method of diagnosing and monitoring malignant breast carcinomas |
| US7189397B2 (en) | 1999-10-08 | 2007-03-13 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US20040029114A1 (en) | 2001-01-24 | 2004-02-12 | Eos Technology, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
| ATE289685T1 (de) * | 2003-08-25 | 2005-03-15 | Mtm Lab Ag | Verfahren zum nachweis von karzinomen in solubilisierten zervikalen körperproben |
| JP4563186B2 (ja) | 2004-02-16 | 2010-10-13 | 理研ビタミン株式会社 | 耐熱性が改善されたアントシアニン色素 |
| WO2005095987A2 (en) * | 2004-03-26 | 2005-10-13 | University Of Miami | Salivary soluble cd44: a molecular marker for head and neck cancer |
| WO2007129999A2 (en) | 2004-07-14 | 2007-11-15 | Biospectrum, Inc. | Antiproliferative peptides and antibodies for their detection |
| US20090197285A1 (en) | 2005-11-10 | 2009-08-06 | University Of Kentucky | Lung Cancer Diagnostic Assay |
| WO2007133725A1 (en) | 2006-05-12 | 2007-11-22 | University Of Miami | Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma |
| CN101230390A (zh) * | 2007-12-07 | 2008-07-30 | 湖北大学 | 一种用于妇科恶性肿瘤早期筛选的基因芯片及其检测方法 |
| EP2364371A4 (en) * | 2008-11-24 | 2012-05-02 | Univ Loma Linda | BIOMARKER FOR DETECTING HEADS AND HALSTUMORS |
| AU2012340441A1 (en) | 2011-11-15 | 2014-05-29 | University Of Miami | Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma |
-
2012
- 2012-11-15 AU AU2012340441A patent/AU2012340441A1/en not_active Abandoned
- 2012-11-15 CA CA2855971A patent/CA2855971C/en not_active Expired - Fee Related
- 2012-11-15 EP EP12850526.0A patent/EP2780714B1/en not_active Not-in-force
- 2012-11-15 PE PE2014000699A patent/PE20141565A1/es not_active Application Discontinuation
- 2012-11-15 CN CN201280067010.6A patent/CN104067126B/zh not_active Expired - Fee Related
- 2012-11-15 JP JP2014542462A patent/JP6174035B2/ja active Active
- 2012-11-15 WO PCT/US2012/065282 patent/WO2013074793A1/en not_active Ceased
- 2012-11-15 ES ES12850526.0T patent/ES2640532T3/es active Active
- 2012-11-15 MX MX2014005887A patent/MX352642B/es active IP Right Grant
- 2012-11-15 BR BR112014011563-0A patent/BR112014011563B1/pt not_active IP Right Cessation
- 2012-11-15 US US14/358,515 patent/US20140329230A1/en not_active Abandoned
-
2014
- 2014-05-12 IL IL232556A patent/IL232556A/en active IP Right Grant
- 2014-06-12 CO CO14127975A patent/CO6980621A2/es unknown
-
2015
- 2015-04-16 US US14/688,221 patent/US10180430B2/en active Active
-
2016
- 2016-06-29 US US15/196,514 patent/US10180431B2/en active Active
-
2018
- 2018-05-14 AU AU2018203361A patent/AU2018203361B2/en not_active Ceased
-
2020
- 2020-11-25 AU AU2020277155A patent/AU2020277155A1/en not_active Abandoned
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