WO2009151628A3 - Monitoring tcr-b to determine hiv therapy and disease progression - Google Patents

Monitoring tcr-b to determine hiv therapy and disease progression Download PDF

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Publication number
WO2009151628A3
WO2009151628A3 PCT/US2009/003532 US2009003532W WO2009151628A3 WO 2009151628 A3 WO2009151628 A3 WO 2009151628A3 US 2009003532 W US2009003532 W US 2009003532W WO 2009151628 A3 WO2009151628 A3 WO 2009151628A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
determining
disease progression
monitoring
hiv
Prior art date
Application number
PCT/US2009/003532
Other languages
French (fr)
Other versions
WO2009151628A2 (en
Inventor
Andrew Redd
Thomas Quinn
Original Assignee
Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US13195408P priority Critical
Priority to US61/131,954 priority
Application filed by Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services filed Critical Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services
Publication of WO2009151628A2 publication Critical patent/WO2009151628A2/en
Publication of WO2009151628A3 publication Critical patent/WO2009151628A3/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development

Abstract

The present invention features methods of monitoring the progression of a disease or disorder in a subject by determining the number of mature T cells in a sample. The invention features methods of monitoring the progression of HIV or AIDS in a subject and determining the prognosis of a subject with HIV or AIDS by determining the number of mature T cells in a sample from the subject. The invention also features methods of determining the effectiveness of ART therapy in a subject infected with HIV or AIDS, and the need for ART therapy in a subject infected with HIV or AIDS, by determining the number of mature T cells in a sample from the subject. Also included in the invention are kits.
PCT/US2009/003532 2008-06-12 2009-06-12 Monitoring tcr-b to determine hiv therapy and disease progression WO2009151628A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13195408P true 2008-06-12 2008-06-12
US61/131,954 2008-06-12

Publications (2)

Publication Number Publication Date
WO2009151628A2 WO2009151628A2 (en) 2009-12-17
WO2009151628A3 true WO2009151628A3 (en) 2010-02-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/003532 WO2009151628A2 (en) 2008-06-12 2009-06-12 Monitoring tcr-b to determine hiv therapy and disease progression

Country Status (1)

Country Link
WO (1) WO2009151628A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8507205B2 (en) 2008-11-07 2013-08-13 Sequenta, Inc. Single cell analysis by polymerase cycling assembly
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9150905B2 (en) 2012-05-08 2015-10-06 Adaptive Biotechnologies Corporation Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
US9181590B2 (en) 2011-10-21 2015-11-10 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9512487B2 (en) 2008-11-07 2016-12-06 Adaptive Biotechnologies Corp. Monitoring health and disease status using clonotype profiles

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
DK3059337T3 (en) 2009-01-15 2019-07-22 Adaptive Biotechnologies Corp Adaptive immunity profiling and methods for producing monoclonal antibodies
KR20120044941A (en) 2009-06-25 2012-05-08 프레드 헛친슨 켄서 리서치 센터 Method of measuring adaptive immunity
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US9824179B2 (en) 2011-12-09 2017-11-21 Adaptive Biotechnologies Corp. Diagnosis of lymphoid malignancies and minimal residual disease detection
EP3372694A1 (en) 2012-03-05 2018-09-12 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
ES2660027T3 (en) 2012-10-01 2018-03-20 Adaptive Biotechnologies Corporation Evaluation of immunocompetence by the diversity of adaptive immunity receptors and clonal characterization
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3132059A4 (en) 2014-04-17 2017-09-06 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
EP2975137A1 (en) * 2014-07-18 2016-01-20 ImmunID Use of immune diversity as a predictive marker for identifying B-cell-lymphomas-patients having an increased risk of febrile or infectious event
AU2015339191A1 (en) 2014-10-29 2017-05-18 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030228586A1 (en) * 1999-06-30 2003-12-11 Rafick-Pierre Sekaly Method for measuring de novo T-cell production in humans
US20070117134A1 (en) * 2005-11-18 2007-05-24 Kou Zhong C Method for detection and quantification of T-cell receptor Vbeta repertoire
US20080112934A1 (en) * 2004-11-24 2008-05-15 Rafick-Pierre Sekaly Methods To Identify, Prepare, And Use Naive T Cell Recent Thymic Emigrants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030228586A1 (en) * 1999-06-30 2003-12-11 Rafick-Pierre Sekaly Method for measuring de novo T-cell production in humans
US20080112934A1 (en) * 2004-11-24 2008-05-15 Rafick-Pierre Sekaly Methods To Identify, Prepare, And Use Naive T Cell Recent Thymic Emigrants
US20070117134A1 (en) * 2005-11-18 2007-05-24 Kou Zhong C Method for detection and quantification of T-cell receptor Vbeta repertoire

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHAIN J L ET AL: "Real-time PCR method for the quantitative analysis of human T-cell receptor gamma and beta gene rearrangements" JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 300, no. 1-2, 1 May 2005 (2005-05-01), pages 12-23, XP004933604 ISSN: 0022-1759 cited in the application *
HODGES E ET AL: "DIAGNOSTIC ROLE OF TESTS FOR T CELL RECEPTOR (TCR) GENES" JOURNAL OF CLINICAL PATHOLOGY, BMJ PUBLISHING GROUP, vol. 56, no. 1, 1 January 2003 (2003-01-01), pages 1-11, XP001196998 ISSN: 0021-9746 *
KUMARASAMY N ET AL: "Monitoring HIV treatment in the developing world" LANCET INFECTIOUS DISEASES, ELSEVIER LTD, US, vol. 2, no. 11, 1 November 2002 (2002-11-01), pages 656-657, XP004811016 ISSN: 1473-3099 *
RICHARDSON MAX W ET AL: "T-cell receptor excision circles (TREC) in SHIV 89.6p and SIVmac251 models of HIV-1 infection." DNA AND CELL BIOLOGY, vol. 23, no. 1, January 2004 (2004-01), pages 1-13, XP002557509 ISSN: 1044-5498 *
TRABATTONI DARIA ET AL: "B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression" BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 101, no. 7, 1 April 2003 (2003-04-01), pages 2514-2520, XP002419628 ISSN: 0006-4971 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8795970B2 (en) 2008-11-07 2014-08-05 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US9512487B2 (en) 2008-11-07 2016-12-06 Adaptive Biotechnologies Corp. Monitoring health and disease status using clonotype profiles
US9416420B2 (en) 2008-11-07 2016-08-16 Adaptive Biotechnologies Corp. Monitoring health and disease status using clonotype profiles
US9217176B2 (en) 2008-11-07 2015-12-22 Sequenta, Llc Methods of monitoring conditions by sequence analysis
US9228232B2 (en) 2008-11-07 2016-01-05 Sequenta, LLC. Methods of monitoring conditions by sequence analysis
US8507205B2 (en) 2008-11-07 2013-08-13 Sequenta, Inc. Single cell analysis by polymerase cycling assembly
US9347099B2 (en) 2008-11-07 2016-05-24 Adaptive Biotechnologies Corp. Single cell analysis by polymerase cycling assembly
US9523129B2 (en) 2008-11-07 2016-12-20 Adaptive Biotechnologies Corp. Sequence analysis of complex amplicons
US9181590B2 (en) 2011-10-21 2015-11-10 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9371558B2 (en) 2012-05-08 2016-06-21 Adaptive Biotechnologies Corp. Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
US9150905B2 (en) 2012-05-08 2015-10-06 Adaptive Biotechnologies Corporation Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions

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