JP2014533372A5 - - Google Patents
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- JP2014533372A5 JP2014533372A5 JP2014542462A JP2014542462A JP2014533372A5 JP 2014533372 A5 JP2014533372 A5 JP 2014533372A5 JP 2014542462 A JP2014542462 A JP 2014542462A JP 2014542462 A JP2014542462 A JP 2014542462A JP 2014533372 A5 JP2014533372 A5 JP 2014533372A5
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- Prior art keywords
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- 102000004965 antibodies Human genes 0.000 claims 8
- 108090001123 antibodies Proteins 0.000 claims 8
- 102000033243 CDKN2A Human genes 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 101700078950 CD44 Proteins 0.000 claims 4
- 102100003735 CD44 Human genes 0.000 claims 4
- 241000701806 Human papillomavirus Species 0.000 claims 3
- 239000002131 composite material Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 210000001124 Body Fluids Anatomy 0.000 claims 2
- 102000001974 Hyaluronidase Human genes 0.000 claims 2
- 108010074224 Hyaluronoglucosaminidase Proteins 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 229960002773 hyaluronidase Drugs 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 2
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 108009000344 Head and Neck Squamous Cell Carcinoma Proteins 0.000 claims 1
- 210000003296 Saliva Anatomy 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 206010041823 Squamous cell carcinoma Diseases 0.000 claims 1
- 241000234314 Zingiber Species 0.000 claims 1
- 235000006886 Zingiber officinale Nutrition 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 1
- 230000001973 epigenetic Effects 0.000 claims 1
- 235000008397 ginger Nutrition 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
Claims (14)
- ヒトパピローマウイルスに感染した対象の体液から得た試料を分析する方法であって、
ａ）前記試料のｓｏｌＣＤ４４の濃度を免疫学的に測定する工程と、
ｂ）前記試料の総タンパク質の濃度を測定する工程と、
ｃ）前記測定したｓｏｌＣＤ４４の濃度と総タンパク質の濃度とを組み合わせて、複合的なスコアを得る工程と、
ｄ）前記複合的なスコアを、頭頸部扁平上皮癌のリスクが高くなるしきい値と比較して、前記複合的なスコアが前記しきい値を超えているかを決定する工程であって、前記しきい値は、頭頸部扁平上皮癌のリスクが高い集団から測定したｓｏｌＣＤ４４と総タンパク質を統計的に分析して得たものである工程と
を含む方法。 - 前記体液が唾液である請求項１に記載の方法。
- 前記試料が、含嗽した液である請求項１に記載の方法。
- 前記ｓｏｌＣＤ４４の濃度の測定が、ＥＬＩＳＡ法により行われる請求項１に記載の方法。
- 前記ｓｏｌＣＤ４４の濃度の測定が、側方流動免疫測定法により行われる請求項１に記載の方法。
- 前記試料のヒアルロン酸（ＨＡ）およびヒアルロニダーゼ（ＨＡａｓｅ）のうちの少なくとも１つの濃度を測定する工程を更に含む請求項１に記載の方法。
- ヒトパピローマウイルスがｐ１６ＩＮＫ４ａの検出により検出される請求項１に記載の方法。
- ヒトパピローマウイルスが、ＨＰＶのＤＮＡもしくはＲＮＡ、ＨＰＶタンパク質、又は後成的変化の検出により検出される請求項１に記載の方法。
- ｐ１６ＩＮＫ４ａに特異的に結合する少なくとも１つの抗体と、
ＣＤ４４に特異的に結合する少なくとも１つの抗体と、
試料中の総タンパク質濃度を測定する試薬と
を備えるキット。 - ｐ１６ＩＮＫ４ａに特異的に結合する前記少なくとも１つの抗体が、Ｅ６Ｈ４抗体クローンのイディオタイプを含む請求項９に記載のキット。
- ＣＤ４４基準試料、ｐ１６基準試料、又はこれらの組み合わせを更に備える請求項９に記載のキット。
- ｐ１６ＩＮＫ４ａに特異的に結合する前記抗体、ＣＤ４４に特異的に結合する前記抗体、又はこれらの組み合わせを検出するための１つ又は複数の比色剤を更に備える請求項９に記載のキット。
- 前記キットが側方流動免疫測定法である請求項９に記載のキット。
- 前記キットが、ｐ１６ＩＮＫ４ａに特異的に結合する前記抗体、ＣＤ４４に特異的に結合する前記抗体、又はこれらの組み合わせにより任意選択的に被覆されているマルチウェルプレートを備える請求項９に記載のキット。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559974P | 2011-11-15 | 2011-11-15 | |
| US61/559,974 | 2011-11-15 | ||
| US201261654595P | 2012-06-01 | 2012-06-01 | |
| US61/654,595 | 2012-06-01 | ||
| PCT/US2012/065282 WO2013074793A1 (en) | 2011-11-15 | 2012-11-15 | Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533372A JP2014533372A (ja) | 2014-12-11 |
| JP2014533372A5 true JP2014533372A5 (ja) | 2016-01-14 |
| JP6174035B2 JP6174035B2 (ja) | 2017-08-02 |
Family
ID=48430146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542462A Active JP6174035B2 (ja) | 2011-11-15 | 2012-11-15 | ヒトパピローマウイルスを検出し頭頸部扁平上皮癌を予後予測する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20140329230A1 (ja) |
| EP (1) | EP2780714B1 (ja) |
| JP (1) | JP6174035B2 (ja) |
| CN (1) | CN104067126B (ja) |
| AU (3) | AU2012340441A1 (ja) |
| BR (1) | BR112014011563B1 (ja) |
| CA (1) | CA2855971C (ja) |
| CO (1) | CO6980621A2 (ja) |
| ES (1) | ES2640532T3 (ja) |
| IL (1) | IL232556A (ja) |
| MX (1) | MX352642B (ja) |
| PE (1) | PE20141565A1 (ja) |
| WO (1) | WO2013074793A1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2640532T3 (es) | 2011-11-15 | 2017-11-03 | University Of Miami | Métodos para la detección de papilomavirus humano y proporcionar un pronóstico para el carcinoma de células escamosas de cabeza y cuello |
| AU2014296090A1 (en) * | 2013-07-31 | 2016-02-11 | University Of Miami | Compositions and methods for identifying a risk of cancer in a subject |
| EP3036345A2 (en) * | 2013-08-19 | 2016-06-29 | Notre Dame Du Lac | Method and composition for detection of oncogenic hpv |
| EP3146321B1 (en) | 2014-05-22 | 2020-12-02 | University of Notre Dame du Lac | Integrated membrane sensor for rapid molecular detection |
| WO2016209703A1 (en) * | 2015-06-22 | 2016-12-29 | The Johns Hopkins University | Head and neck squamous cell carcinoma assays |
| JP6655243B2 (ja) * | 2015-09-01 | 2020-02-26 | 国立大学法人 鹿児島大学 | 口腔前癌病変の検出方法 |
| CN107092854B (zh) * | 2016-02-18 | 2020-05-22 | 财团法人金属工业研究发展中心 | 检测细胞受人类乳头瘤病毒(hpv)感染的装置及其检测方法 |
| GB201808839D0 (en) | 2018-05-30 | 2018-07-11 | Cancer Research Tech Ltd | Method of predicting survival rates for cancer patients |
| WO2020018954A1 (en) * | 2018-07-20 | 2020-01-23 | Predentome, Inc. | Methods and systems for oral microbiome analysis |
| EP3930834A4 (en) * | 2019-02-26 | 2023-01-04 | University of Miami | DEVICE FOR CANCER DETECTION METHODS |
| WO2022226153A1 (en) * | 2021-04-23 | 2022-10-27 | The University Of Chicago | Machine learning based histopathological recurrence prediction models for hpv+ head / neck squamous cell carcinoma |
| WO2024086159A1 (en) * | 2022-10-17 | 2024-04-25 | Vigilant Biosciences, Inc. | Methods and compositions for oral cancer risk |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403551A (en) | 1993-09-16 | 1995-04-04 | Roche Diagnostic Systems, Inc. | Assaying device and container for in field analysis of a specimen and later shipment of the unadulterated specimen |
| US6235470B1 (en) | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| US5990299A (en) * | 1995-08-14 | 1999-11-23 | Icn Pharmaceuticals, Inc. | Control of CD44 gene expression for therapeutic use |
| US5976895A (en) | 1996-03-11 | 1999-11-02 | American Biomedica Corporation | Device for the collection, testing and shipment of body fluid samples |
| DE19829473C2 (de) * | 1998-07-01 | 2000-08-10 | Magnus Von Knebel Doeberitz Ch | Verfahren zur frühen Diagnose von Carcinomen |
| US6379620B1 (en) | 1998-11-16 | 2002-04-30 | Barry M. Tydings | Assaying device and method for in field urinalysis |
| US6294349B1 (en) | 1999-03-01 | 2001-09-25 | University Of Mississippi Medical Ctr. | Method of diagnosing and monitoring malignant breast carcinomas |
| US7189397B2 (en) | 1999-10-08 | 2007-03-13 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US20040029114A1 (en) | 2001-01-24 | 2004-02-12 | Eos Technology, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
| DE60300339T2 (de) * | 2003-08-25 | 2006-04-13 | Mtm Laboratories Ag | Verfahren zum Nachweis von Karzinomen in solubilisierten zervikalen Körperproben |
| JP4563186B2 (ja) | 2004-02-16 | 2010-10-13 | 理研ビタミン株式会社 | 耐熱性が改善されたアントシアニン色素 |
| WO2005095987A2 (en) * | 2004-03-26 | 2005-10-13 | University Of Miami | Salivary soluble cd44: a molecular marker for head and neck cancer |
| WO2007129999A2 (en) | 2004-07-14 | 2007-11-15 | Biospectrum, Inc. | Antiproliferative peptides and antibodies for their detection |
| JP2009516178A (ja) | 2005-11-10 | 2009-04-16 | ユニバーシティー オブ ケンタッキー | 肺癌診断アッセイ |
| EP2032716A4 (en) | 2006-05-12 | 2010-03-17 | Univ Miami | BIOMARKERS FOR THE DETECTION AND DIAGNOSIS OF SPINOCELLULAR MALIPHELL EPIDELIOMA OF THE HEAD AND NECK |
| CN101230390A (zh) * | 2007-12-07 | 2008-07-30 | 湖北大学 | 一种用于妇科恶性肿瘤早期筛选的基因芯片及其检测方法 |
| EP2364371A4 (en) * | 2008-11-24 | 2012-05-02 | Univ Loma Linda | BIOMARKERS FOR DETECTION OF HEAD AND NECK TUMORS |
| ES2640532T3 (es) | 2011-11-15 | 2017-11-03 | University Of Miami | Métodos para la detección de papilomavirus humano y proporcionar un pronóstico para el carcinoma de células escamosas de cabeza y cuello |
-
2012
- 2012-11-15 ES ES12850526.0T patent/ES2640532T3/es active Active
- 2012-11-15 BR BR112014011563-0A patent/BR112014011563B1/pt not_active IP Right Cessation
- 2012-11-15 PE PE2014000699A patent/PE20141565A1/es not_active Application Discontinuation
- 2012-11-15 CN CN201280067010.6A patent/CN104067126B/zh active Active
- 2012-11-15 WO PCT/US2012/065282 patent/WO2013074793A1/en active Application Filing
- 2012-11-15 CA CA2855971A patent/CA2855971C/en active Active
- 2012-11-15 EP EP12850526.0A patent/EP2780714B1/en active Active
- 2012-11-15 MX MX2014005887A patent/MX352642B/es active IP Right Grant
- 2012-11-15 US US14/358,515 patent/US20140329230A1/en not_active Abandoned
- 2012-11-15 AU AU2012340441A patent/AU2012340441A1/en not_active Abandoned
- 2012-11-15 JP JP2014542462A patent/JP6174035B2/ja active Active
-
2014
- 2014-05-12 IL IL232556A patent/IL232556A/en active IP Right Grant
- 2014-06-12 CO CO14127975A patent/CO6980621A2/es unknown
-
2015
- 2015-04-16 US US14/688,221 patent/US10180430B2/en active Active
-
2016
- 2016-06-29 US US15/196,514 patent/US10180431B2/en active Active
-
2018
- 2018-05-14 AU AU2018203361A patent/AU2018203361B2/en not_active Ceased
-
2020
- 2020-11-25 AU AU2020277155A patent/AU2020277155A1/en not_active Abandoned
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