JP2014533274A5 - - Google Patents
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- Publication number
- JP2014533274A5 JP2014533274A5 JP2014541292A JP2014541292A JP2014533274A5 JP 2014533274 A5 JP2014533274 A5 JP 2014533274A5 JP 2014541292 A JP2014541292 A JP 2014541292A JP 2014541292 A JP2014541292 A JP 2014541292A JP 2014533274 A5 JP2014533274 A5 JP 2014533274A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
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- composition according
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- 241001303601 Rosacea Species 0.000 claims 2
- 206010046851 Uveitis Diseases 0.000 claims 2
- 208000010217 blepharitis Diseases 0.000 claims 2
- 210000005252 bulbus oculi Anatomy 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 210000001508 eye Anatomy 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 201000004700 rosacea Diseases 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 125000006529 (C3-C6) alkyl group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 208000028006 Corneal injury Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 206010065062 Meibomian gland dysfunction Diseases 0.000 claims 1
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 claims 1
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 claims 1
- 206010030865 Ophthalmic herpes zoster Diseases 0.000 claims 1
- 206010037508 Punctate keratitis Diseases 0.000 claims 1
- 206010038848 Retinal detachment Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 210000000795 conjunctiva Anatomy 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- -1 diastereoisomers Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 201000004614 iritis Diseases 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 210000004175 meibomian gland Anatomy 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 230000004264 retinal detachment Effects 0.000 claims 1
- 208000004644 retinal vein occlusion Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000565 sulfonamide group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558775P | 2011-11-11 | 2011-11-11 | |
| US61/558,775 | 2011-11-11 | ||
| PCT/US2012/064293 WO2013071009A1 (en) | 2011-11-11 | 2012-11-09 | 4 - pregenen- 11ss - 17 - 21 -triol-3, 20 -dione derivatives for the treatment of ocular conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533274A JP2014533274A (ja) | 2014-12-11 |
| JP2014533274A5 true JP2014533274A5 (cg-RX-API-DMAC7.html) | 2016-01-07 |
| JP6216719B2 JP6216719B2 (ja) | 2017-10-18 |
Family
ID=47179019
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541292A Expired - Fee Related JP6216719B2 (ja) | 2011-11-11 | 2012-11-09 | 眼病態の治療のための４−プレゲネン−１１ｓｓ−１７−２１−トリオール−３，２０−ジオン誘導体 |
| JP2014541293A Expired - Fee Related JP6158201B2 (ja) | 2011-11-11 | 2012-11-09 | ４−プレゲネン−１１β−１７−２１−トリオール−３，２０−ジオン誘導体の医薬組成物および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541293A Expired - Fee Related JP6158201B2 (ja) | 2011-11-11 | 2012-11-09 | ４−プレゲネン−１１β−１７−２１−トリオール−３，２０−ジオン誘導体の医薬組成物および使用方法 |
Country Status (24)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| UA111867C2 (uk) | 2011-11-11 | 2016-06-24 | Аллерган, Інк. | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ І СПОСІБ ЗАСТОСУВАННЯ ПОХІДНИХ 4-ПРЕГНЕН-11β-17-21-ТРІОЛ-3,20-ДІОНУ |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| BR112015013628A2 (pt) | 2012-12-18 | 2017-07-11 | Almirall Sa | derivados de carbamato de ciclo-hexila e quinuclidinila tendo atividades agonista adrenérgica de beta2 e antagonista muscarínica de m3 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| KR20160098338A (ko) | 2013-12-13 | 2016-08-18 | 알러간, 인코포레이티드 | 코르티솔 17-알파-벤조에이트의 다형성 및 비결정성 형태들, 및 그 조제 방법들 및 용도 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| KR20170120161A (ko) * | 2015-03-05 | 2017-10-30 | 알러간, 인코포레이티드 | 안과용 약물 전달을 위한 자가-유화 약물 전달 시스템(sedds) |
| CA3037176A1 (en) * | 2016-09-16 | 2018-03-22 | Kala Pharmaceuticals, Inc. | Particles, compositions, and methods for ophthalmic and/or other applications |
| WO2019055028A1 (en) * | 2017-09-15 | 2019-03-21 | Kala Pharmaceuticals, Inc. | PARTICLES, COMPOSITIONS AND METHODS FOR OPHTHALMIC APPLICATIONS AND / OR OTHER APPLICATIONS |
| CN116023425B (zh) * | 2023-03-28 | 2023-06-20 | 南京师范大学 | 曲安西龙衍生物及其医药用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6605514A (cg-RX-API-DMAC7.html) * | 1966-04-25 | 1967-10-26 | ||
| IT1056711B (it) * | 1967-04-01 | 1982-02-20 | Vismara F Spa | Derivati dell idrocortisone |
| US3484436A (en) * | 1967-09-07 | 1969-12-16 | Syntex Corp | Bicyclo(2.2.2)octane - 1 - -carboxylate esters of delta**4 - pregnene corticoid steroids |
| GB1227992A (cg-RX-API-DMAC7.html) | 1968-01-23 | 1971-04-15 | Koninklijke Gist Spiritus | |
| US3693032A (en) | 1971-04-23 | 1972-09-19 | Ibm | Antisaturation technique for ttl circuits |
| US3984544A (en) * | 1975-02-28 | 1976-10-05 | Schering Corporation | Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor |
| JPS52136157A (en) * | 1976-04-14 | 1977-11-14 | Taisho Pharmaceut Co Ltd | Preparation of steroid 17-esters |
| JPS60994B2 (ja) * | 1976-07-26 | 1985-01-11 | 大正製薬株式会社 | プレグナン系化合物の１７α―エステル類の製造法 |
| DE2735110A1 (de) * | 1977-08-04 | 1979-02-15 | Hoechst Ag | Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung |
| US4221787A (en) * | 1978-03-28 | 1980-09-09 | Interx Research Corporation | Esteramide prodrugs of anti-inflammatory corticosteroids |
| US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
| DE4025342A1 (de) | 1990-08-10 | 1992-02-13 | Hoechst Ag | In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US6011023A (en) * | 1997-08-27 | 2000-01-04 | Alcon Laboratories, Inc. | Angiostatic steroids |
| CZ20021265A3 (cs) * | 1999-10-15 | 2003-02-12 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemis | Nové deriváty fusidové kyseliny |
| US6395721B1 (en) | 2000-01-05 | 2002-05-28 | Leonard Bloom | Low potency unpreserved sterile topical corticosteroid compositions for dermatitis |
| KR20050036982A (ko) * | 2002-08-29 | 2005-04-20 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | 염증, 알러지 및 증식성 질환의 치료에 글루코코르티코이드모사체로 사용하기 위한 3-(설폰아미도에틸)-인돌 유도체 |
| JP2005008596A (ja) * | 2003-06-20 | 2005-01-13 | Kobayashi Pharmaceut Co Ltd | 眼科用組成物 |
| SI1755616T1 (sl) * | 2004-04-08 | 2014-04-30 | Eye Co Pty Ltd. | Zdravljenje eksudativne retinopatije z mineralkortikoidi |
| BRPI0513243B8 (pt) | 2004-07-12 | 2021-05-25 | Allergan Inc | composições oftálmicas e respectivos usos |
| US7691811B2 (en) * | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
| US7687484B2 (en) * | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
| PT1864668E (pt) | 2006-06-01 | 2013-02-26 | Novagali Pharma Sa | Utilização de pró-fármacos para administração ocular intravítrea |
| ES2493641T3 (es) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Administración nasal de soluciones acuosas de corticosteroides |
| JP2009053880A (ja) | 2007-08-27 | 2009-03-12 | Sony Broadband Solution Corp | 情報処理装置、ならびにｃｐｕユニット |
| CL2008003803A1 (es) * | 2007-12-21 | 2010-02-19 | Schering Corp | Compuestos derivados de esteroides c20-21 sustituidos, agonistas del receptor de glucocorticoide; composicion farmaceutica que comprende a dicho compuesto; y uso para tratar o prevenir una enfermedad o afeccion inmune, autoinmune o inflamatoria, tales como colitis inflamatoria y artritis reumatoide. |
| CA2726836C (en) * | 2008-06-26 | 2019-06-18 | Anterios, Inc. | Use of nanoemulsions in the manufacture of a medicament for treating skin disorders |
| UA111867C2 (uk) * | 2011-11-11 | 2016-06-24 | Аллерган, Інк. | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ І СПОСІБ ЗАСТОСУВАННЯ ПОХІДНИХ 4-ПРЕГНЕН-11β-17-21-ТРІОЛ-3,20-ДІОНУ |
-
2012
- 2012-09-11 UA UAA201406457A patent/UA111867C2/uk unknown
- 2012-09-11 UA UAA201406244A patent/UA116622C2/uk unknown
- 2012-11-09 TW TW101141986A patent/TWI584809B/zh not_active IP Right Cessation
- 2012-11-09 AU AU2012335589A patent/AU2012335589B2/en not_active Ceased
- 2012-11-09 EP EP12787337.0A patent/EP2776041A1/en not_active Withdrawn
- 2012-11-09 BR BR112014011341A patent/BR112014011341A2/pt not_active Application Discontinuation
- 2012-11-09 EP EP12787336.2A patent/EP2776040B1/en active Active
- 2012-11-09 KR KR1020147015650A patent/KR20140095549A/ko not_active Abandoned
- 2012-11-09 SG SG11201402225RA patent/SG11201402225RA/en unknown
- 2012-11-09 RU RU2014123472A patent/RU2688159C2/ru not_active IP Right Cessation
- 2012-11-09 CA CA2991883A patent/CA2991883C/en not_active Expired - Fee Related
- 2012-11-09 MY MYPI2014001373A patent/MY172227A/en unknown
- 2012-11-09 MX MX2014005679A patent/MX365859B/es active IP Right Grant
- 2012-11-09 AU AU2012335590A patent/AU2012335590B2/en not_active Ceased
- 2012-11-09 IN IN3919CHN2014 patent/IN2014CN03919A/en unknown
- 2012-11-09 CA CA2855929A patent/CA2855929C/en not_active Expired - Fee Related
- 2012-11-09 JP JP2014541292A patent/JP6216719B2/ja not_active Expired - Fee Related
- 2012-11-09 JP JP2014541293A patent/JP6158201B2/ja not_active Expired - Fee Related
- 2012-11-09 MY MYPI2014001372A patent/MY182222A/en unknown
- 2012-11-09 HK HK15101080.2A patent/HK1200366A1/xx unknown
- 2012-11-09 US US13/673,623 patent/US8906892B2/en not_active Expired - Fee Related
- 2012-11-09 MX MX2014005678A patent/MX363669B/es unknown
- 2012-11-09 SG SG10201603766PA patent/SG10201603766PA/en unknown
- 2012-11-09 IN IN3903CHN2014 patent/IN2014CN03903A/en unknown
- 2012-11-09 RU RU2014123471A patent/RU2683775C2/ru not_active IP Right Cessation
- 2012-11-09 BR BR112014011333A patent/BR112014011333B1/pt not_active IP Right Cessation
- 2012-11-09 SG SG11201402247PA patent/SG11201402247PA/en unknown
- 2012-11-09 CA CA2855290A patent/CA2855290C/en not_active Expired - Fee Related
- 2012-11-09 US US13/673,074 patent/US8865691B2/en not_active Expired - Fee Related
- 2012-11-09 KR KR1020147015647A patent/KR102049615B1/ko not_active Expired - Fee Related
- 2012-11-09 CN CN201280066021.2A patent/CN104185472B/zh not_active Expired - Fee Related
- 2012-11-09 WO PCT/US2012/064293 patent/WO2013071009A1/en not_active Ceased
- 2012-11-09 WO PCT/US2012/064296 patent/WO2013071010A1/en not_active Ceased
- 2012-11-09 CN CN201280065948.4A patent/CN104203247B/zh not_active Expired - Fee Related
- 2012-11-09 ES ES12787336T patent/ES2806603T3/es active Active
- 2012-11-12 AR ARP120104261A patent/AR088846A1/es unknown
-
2014
- 2014-05-09 PH PH12014501078A patent/PH12014501078B1/en unknown
- 2014-05-09 PH PH12014501079A patent/PH12014501079B1/en unknown
- 2014-05-09 MX MX2019006877A patent/MX2019006877A/es unknown
- 2014-05-11 IL IL232534A patent/IL232534A0/en active IP Right Grant
- 2014-05-11 IL IL232535A patent/IL232535B/en active IP Right Grant
- 2014-05-12 CL CL2014001243A patent/CL2014001243A1/es unknown
- 2014-05-12 CL CL2014001244A patent/CL2014001244A1/es unknown
- 2014-05-13 ZA ZA2014/03430A patent/ZA201403430B/en unknown
- 2014-05-13 ZA ZA2014/03431A patent/ZA201403431B/en unknown
- 2014-05-29 CO CO14116546A patent/CO6970598A2/es unknown
- 2014-06-09 CO CO14124183A patent/CO6970609A2/es unknown
- 2014-09-12 US US14/485,335 patent/US9717743B2/en not_active Expired - Fee Related
- 2014-11-05 US US14/533,847 patent/US9433631B2/en not_active Expired - Fee Related
-
2016
- 2016-08-04 US US15/228,674 patent/US10493082B2/en not_active Expired - Fee Related
-
2017
- 2017-06-30 US US15/640,093 patent/US10188667B2/en not_active Expired - Fee Related
-
2018
- 2018-01-19 AU AU2018200436A patent/AU2018200436B2/en not_active Ceased
- 2018-12-24 US US16/231,901 patent/US20190365786A1/en not_active Abandoned
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