JP2014533114A5 - - Google Patents

Info

Publication number

JP2014533114A5

JP2014533114A5 JP2014541346A JP2014541346A JP2014533114A5 JP 2014533114 A5 JP2014533114 A5 JP 2014533114A5 JP 2014541346 A JP2014541346 A JP 2014541346A JP 2014541346 A JP2014541346 A JP 2014541346A JP 2014533114 A5 JP2014533114 A5 JP 2014533114A5

Authority

JP

Japan

Prior art keywords

group

marker

nras

hematological

tumor

Prior art date

2012-11-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 75
• 239000003550 marker Substances 0.000 claims 53
• 210000004881 tumor cell Anatomy 0.000 claims 48
• 102100039788 GTPase NRas Human genes 0.000 claims 27
• 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 27
• 229940079156 Proteasome inhibitor Drugs 0.000 claims 27
• 239000003207 proteasome inhibitor Substances 0.000 claims 27
• 108090000623 proteins and genes Proteins 0.000 claims 25
• 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 24
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 22
• 239000000523 sample Substances 0.000 claims 19
• 206010028980 Neoplasm Diseases 0.000 claims 18
• 230000035772 mutation Effects 0.000 claims 18
• 206010025323 Lymphomas Diseases 0.000 claims 15
• 201000000050 myeloid neoplasm Diseases 0.000 claims 15
• 201000011510 cancer Diseases 0.000 claims 13
• -1 peptidyl epoxy ketone Chemical compound 0.000 claims 13
• 230000002489 hematologic effect Effects 0.000 claims 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
• 108020004705 Codon Proteins 0.000 claims 10
• 150000007523 nucleic acids Chemical group 0.000 claims 10
• 208000032839 leukemia Diseases 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 7
• 208000034578 Multiple myelomas Diseases 0.000 claims 7
• 239000002253 acid Substances 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 7
• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 6
• 229960001467 bortezomib Drugs 0.000 claims 6
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 6
• 229960002951 ixazomib citrate Drugs 0.000 claims 6
• MBOMYENWWXQSNW-AWEZNQCLSA-N ixazomib citrate Chemical compound N([C@@H](CC(C)C)B1OC(CC(O)=O)(CC(O)=O)C(=O)O1)C(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl MBOMYENWWXQSNW-AWEZNQCLSA-N 0.000 claims 6
• 239000003381 stabilizer Substances 0.000 claims 6
• 108020004414 DNA Proteins 0.000 claims 4
• 239000003153 chemical reaction reagent Substances 0.000 claims 4
• 210000000349 chromosome Anatomy 0.000 claims 4
• 239000002299 complementary DNA Substances 0.000 claims 4
• 108020004999 messenger RNA Proteins 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 108700020796 Oncogene Proteins 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 238000005259 measurement Methods 0.000 claims 3
• 230000005945 translocation Effects 0.000 claims 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 108091005461 Nucleic proteins Proteins 0.000 claims 2
• 241000713810 Rat sarcoma virus Species 0.000 claims 2
• 230000003213 activating effect Effects 0.000 claims 2
• 230000009286 beneficial effect Effects 0.000 claims 2
• 239000008280 blood Substances 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 239000013610 patient sample Substances 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 102000016914 ras Proteins Human genes 0.000 claims 2
• 230000035945 sensitivity Effects 0.000 claims 2
• 238000012163 sequencing technique Methods 0.000 claims 2
• 206010029260 Neuroblastoma Diseases 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 230000003833 cell viability Effects 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 230000002349 favourable effect Effects 0.000 claims 1
• 108010014186 ras Proteins Proteins 0.000 claims 1
• 230000004083 survival effect Effects 0.000 claims 1