JP2011511949A5 - - Google Patents
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- Publication number
- JP2011511949A5 JP2011511949A5 JP2010546779A JP2010546779A JP2011511949A5 JP 2011511949 A5 JP2011511949 A5 JP 2011511949A5 JP 2010546779 A JP2010546779 A JP 2010546779A JP 2010546779 A JP2010546779 A JP 2010546779A JP 2011511949 A5 JP2011511949 A5 JP 2011511949A5
- Authority
- JP
- Japan
- Prior art keywords
- alk
- inversion
- probe
- eml4
- chromosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6542208P | 2008-02-12 | 2008-02-12 | |
| PCT/US2009/000879 WO2009102446A2 (en) | 2008-02-12 | 2009-02-12 | Fish assay for eml4 and alk fusion in lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511949A JP2011511949A (ja) | 2011-04-14 |
| JP2011511949A5 true JP2011511949A5 (enExample) | 2012-03-29 |
Family
ID=40957428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546779A Pending JP2011511949A (ja) | 2008-02-12 | 2009-02-12 | 肺癌におけるｅｍｌ４とａｌｋの融合のためのｆｉｓｈアッセイ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110110923A1 (enExample) |
| EP (1) | EP2255190A4 (enExample) |
| JP (1) | JP2011511949A (enExample) |
| AU (1) | AU2009215168A1 (enExample) |
| CA (1) | CA2715380A1 (enExample) |
| WO (1) | WO2009102446A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| ES2561406T3 (es) | 2006-04-14 | 2016-02-26 | Cell Signaling Technology, Inc. | Defectos de genes y quinasa ALK mutante en tumores sólidos humanos |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| EP3546596B1 (en) | 2009-05-26 | 2022-05-11 | Quest Diagnostics Investments Incorporated | Use of a kit for detecting gene dysregulations |
| US8546552B2 (en) | 2009-12-23 | 2013-10-01 | Quest Diagnostics Investments Incorporated | TMPRSS2 for the diagnosis of prostate disease |
| AR080913A1 (es) * | 2010-04-16 | 2012-05-16 | Response Genetics | Cebadores, sondas, metodos y conjuntos de elementos para la deteccion de variantes de eml4- alk |
| EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| WO2012019132A2 (en) | 2010-08-06 | 2012-02-09 | Cell Signaling Technology, Inc. | Anaplastic lymphoma kinase in kidney cancer |
| EP2670867B1 (en) * | 2011-02-04 | 2017-11-01 | The Trustees Of The University Of Pennsylvania | A method for detecting chromosome structure and gene expression simultaneously in single cells |
| DE102011100242A1 (de) * | 2011-05-02 | 2012-11-08 | Zytovision Gmbh | Verfahren zur Detektion von Chromosomenaberration |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| EP2714038A1 (en) | 2011-05-24 | 2014-04-09 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mtor/pi3k inhibitors |
| CA3113672A1 (en) | 2011-07-01 | 2013-01-10 | Htg Molecular Diagnostics, Inc. | Methods of detecting gene fusions |
| EP2729144A2 (en) * | 2011-07-07 | 2014-05-14 | Synta Pharmaceuticals Corp. | Treating cancer with hsp90 inhibitory compounds |
| CA2853799A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| WO2013074594A1 (en) | 2011-11-14 | 2013-05-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| DK2838998T3 (en) | 2012-04-18 | 2018-01-15 | Cell Signaling Technology Inc | EGFR AND ROS1 IN CANCER |
| AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| WO2013170182A1 (en) | 2012-05-11 | 2013-11-14 | Synta Pharmaceuticals Corp. | Treating cancer with an hsp90 inhibitory compound |
| US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| RU2509153C1 (ru) * | 2012-11-28 | 2014-03-10 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Способ анализа транслокаций eml4-alk, ассоциированных с чувствительностью рака легкого к противоопухолевой таргетной терапии |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| EA033304B1 (ru) | 2014-02-04 | 2019-09-30 | Астеллас Фарма Инк. | Фармацевтическая композиция, включающая диамино-гетероциклическое карбоксамидное соединение в качестве активного ингредиента |
| JP2018504446A (ja) | 2015-02-09 | 2018-02-15 | シンタ ファーマシューティカルズ コーポレーション | がんを処置するためのｈｓｐ９０阻害剤およびｐｄ−１阻害剤の組み合わせ治療 |
| CN105368962A (zh) * | 2015-12-18 | 2016-03-02 | 河南赛诺特生物技术有限公司 | 肺癌alk基因重排快速检测荧光探针及制备方法 |
| CN105543353A (zh) * | 2015-12-30 | 2016-05-04 | 广州安必平医药科技股份有限公司 | Alk基因和eml4基因检测探针及其制备方法和试剂盒 |
| JP6728503B2 (ja) | 2017-02-24 | 2020-07-22 | テグ−キョンプク メディカル イノベーション ファウンデーション | 血液脳関門を通過することができる化合物を有効成分として含有する脳腫瘍の予防または治療用薬学的組成物 |
| CN108998503B (zh) * | 2018-08-17 | 2022-04-05 | 中山康源基因技术科技有限公司 | 一种Oligo探针及其制备方法与应用 |
| CN110066876A (zh) * | 2019-06-06 | 2019-07-30 | 徐州医科大学 | 一种用于癌症诊断的分子标志物 |
| AU2019460208A1 (en) * | 2019-08-05 | 2022-03-17 | Genex Health Co., Ltd | Method for culturing primary cells of lung cancer solid tumor and primary tumor cells of lung cancer pleural effusion, and supporting reagent |
| JP7385191B2 (ja) * | 2019-08-30 | 2023-11-22 | 学校法人同志社 | Ｅｍｌ４－ａｌｋ阻害ペプチドおよびこれを含む肺がん治療薬 |
| KR102449858B1 (ko) * | 2021-07-08 | 2022-09-30 | 가톨릭대학교 산학협력단 | 암 세포 판정을 위한 핵이미지 선별 장치 및 핵이미지 선별 방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756696A (en) * | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
| US5447841A (en) * | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
| US6280929B1 (en) * | 1986-01-16 | 2001-08-28 | The Regents Of The University Of California | Method of detecting genetic translocations identified with chromosomal abnormalities |
| US6344315B1 (en) * | 1986-01-16 | 2002-02-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
| AU647741B2 (en) * | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
| US5491224A (en) * | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
| US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
| US6573043B1 (en) * | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| US7288529B2 (en) * | 2003-04-24 | 2007-10-30 | New York University | ALK protein tyrosine kinase, cells and methods embodying and using same |
| US8062897B2 (en) * | 2003-07-21 | 2011-11-22 | Aureon Laboratories, Inc. | Diagnostic histopathology using multiplex gene expression FISH |
| JP3884462B2 (ja) * | 2005-10-14 | 2007-02-21 | 株式会社ファースト | 高速画像探索方法 |
| ES2561406T3 (es) * | 2006-04-14 | 2016-02-26 | Cell Signaling Technology, Inc. | Defectos de genes y quinasa ALK mutante en tumores sólidos humanos |
| EP1914240B1 (en) * | 2006-10-11 | 2009-12-02 | Astellas Pharma Inc. | EML4-ALK fusion gene |
| CA2598893C (en) * | 2006-10-11 | 2012-04-10 | Astellas Pharma Inc. | Eml4-alk fusion gene |
| JP5562640B2 (ja) * | 2007-04-13 | 2014-07-30 | セル・シグナリング・テクノロジー・インコーポレイテツド | ヒト固形腫瘍における遺伝子欠失及び突然変異ａｌｋキナーゼ |
-
2009
- 2009-02-12 JP JP2010546779A patent/JP2011511949A/ja active Pending
- 2009-02-12 EP EP09711258A patent/EP2255190A4/en not_active Withdrawn
- 2009-02-12 CA CA2715380A patent/CA2715380A1/en not_active Abandoned
- 2009-02-12 US US12/867,336 patent/US20110110923A1/en not_active Abandoned
- 2009-02-12 WO PCT/US2009/000879 patent/WO2009102446A2/en not_active Ceased
- 2009-02-12 AU AU2009215168A patent/AU2009215168A1/en not_active Abandoned
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