JP2014532704A5 - - Google Patents
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- Publication number
- JP2014532704A5 JP2014532704A5 JP2014540046A JP2014540046A JP2014532704A5 JP 2014532704 A5 JP2014532704 A5 JP 2014532704A5 JP 2014540046 A JP2014540046 A JP 2014540046A JP 2014540046 A JP2014540046 A JP 2014540046A JP 2014532704 A5 JP2014532704 A5 JP 2014532704A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- azacytidine
- administering
- pharmaceutical composition
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 claims 33
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 33
- 229960002756 azacitidine Drugs 0.000 claims 33
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 239000003814 drug Substances 0.000 claims 22
- 229940124597 therapeutic agent Drugs 0.000 claims 22
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 1
- 190000008236 carboplatin Chemical group 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554344P | 2011-11-01 | 2011-11-01 | |
| US61/554,344 | 2011-11-01 | ||
| PCT/US2012/062845 WO2013067043A1 (en) | 2011-11-01 | 2012-10-31 | Methods for treating cancers using oral formulations of cytidine analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532704A JP2014532704A (ja) | 2014-12-08 |
| JP2014532704A5 true JP2014532704A5 (OSRAM) | 2015-12-03 |
| JP6162709B2 JP6162709B2 (ja) | 2017-07-12 |
Family
ID=47146759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540046A Active JP6162709B2 (ja) | 2011-11-01 | 2012-10-31 | シチジンアナログの経口製剤を使用して癌を治療する方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9125884B2 (OSRAM) |
| EP (1) | EP2773322A1 (OSRAM) |
| JP (1) | JP6162709B2 (OSRAM) |
| KR (1) | KR20140088603A (OSRAM) |
| CN (1) | CN104168884A (OSRAM) |
| AU (1) | AU2012318239B2 (OSRAM) |
| BR (1) | BR112014010417A2 (OSRAM) |
| CA (1) | CA2853949A1 (OSRAM) |
| EA (1) | EA201490911A1 (OSRAM) |
| HK (1) | HK1200716A1 (OSRAM) |
| IL (1) | IL232268A0 (OSRAM) |
| MX (1) | MX2014005314A (OSRAM) |
| PH (1) | PH12014500965A1 (OSRAM) |
| SG (1) | SG11201401946QA (OSRAM) |
| TW (2) | TW201700103A (OSRAM) |
| WO (1) | WO2013067043A1 (OSRAM) |
| ZA (2) | ZA201403106B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8846628B2 (en) | 2008-05-15 | 2014-09-30 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
| US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| JP6231988B2 (ja) | 2011-11-03 | 2017-11-15 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎｅｄｄ８活性化酵素阻害剤および低メチル化剤の投与 |
| EP3094744A1 (en) * | 2014-01-15 | 2016-11-23 | Apogenix AG | Method of predicting the responsiveness of a cancer disease to treatment on the basis of dna methylation |
| WO2015195634A1 (en) * | 2014-06-17 | 2015-12-23 | Celgne Corporation | Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine |
| WO2015195786A2 (en) * | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| CN104147036B (zh) * | 2014-08-24 | 2017-04-05 | 浙江大学 | 地西他滨和奥沙利铂在制备治疗肾细胞癌组合药物中应用 |
| TWI716415B (zh) | 2015-06-29 | 2021-01-21 | 日商大賽璐股份有限公司 | 易服用性固態製劑之製造方法及易服用性固態製劑 |
| TWI690333B (zh) * | 2015-06-29 | 2020-04-11 | 日商大賽璐股份有限公司 | 易服用性固態製劑（有核錠）之製造方法及易服用性固態製劑 |
| CA2996632C (en) * | 2015-09-01 | 2023-10-17 | Bayer Pharma Aktiengesellschaft | Compounds and methods useful for treating or preventing hematological cancers |
| US11027021B2 (en) | 2016-03-15 | 2021-06-08 | Seagen Inc. | Combinations of PBD-based antibody drug conjugates with Bcl-2 inhibitors |
| US20190117787A1 (en) * | 2016-04-15 | 2019-04-25 | Seattle Genetics, Inc. | Combinations of cd33 antibody drug conjugates with hypomethylating agents |
| EP3463463A4 (en) | 2016-06-03 | 2020-01-15 | Seattle Genetics, Inc. | Combination of cd33 antibody drug conjugates with chemotherapeutic agents |
| IL262565B (en) * | 2016-06-06 | 2022-08-01 | Celgene Corp | Treatment of a hematologic malignancy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| WO2017214433A1 (en) | 2016-06-09 | 2017-12-14 | Seattle Genetics, Inc. | Combinations of pbd-based antibody drug conjugates with flt3 inhibitors |
| EP3481953A4 (en) * | 2016-07-06 | 2020-04-15 | Youhealth Biotech, Limited | SPECIFIC METHYLATION MARKERS OF LIVER CANCER AND USES THEREOF |
| AU2018248423A1 (en) | 2017-04-04 | 2019-10-17 | Loma Linda University | Biologic for the treatment of cancer |
| GB201819453D0 (en) * | 2018-11-29 | 2019-01-16 | Ucl Business Plc | Molecular signature |
| EP4054594A4 (en) * | 2019-11-04 | 2023-12-13 | Geron Corporation | USE OF A JANUS KINASE INHIBITOR AND A TELOMERASE INHIBITOR FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS |
| WO2023140691A1 (ko) * | 2022-01-21 | 2023-07-27 | 주식회사 피노바이오 | 5-아자-4'-티오-2'-데옥시사이티딘을 함유하는 경구용 제형 및 이의 제조방법 |
| WO2024191252A1 (ko) * | 2023-03-14 | 2024-09-19 | 주식회사 피노바이오 | 골수에 작용하는 5-아자-4'-티오-2'-데옥시사이티딘의 최고 혈중농도를 정교하게 제어가능한 경구용 제형 |
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| SG166775A1 (en) | 2005-02-18 | 2010-12-29 | Abraxis Bioscience Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
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| HUE042678T2 (hu) | 2005-08-31 | 2019-07-29 | Abraxis Bioscience Llc | Vízben rosszul oldódó gyógyszerhatóanyagok és antimikrobiális szerek |
| WO2008028193A2 (en) | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
| JP5933893B2 (ja) | 2006-12-14 | 2016-06-15 | アブラクシス バイオサイエンス， エルエルシー | ホルモン受容体状態に基づいてタキサンを含むナノ粒子用いる乳癌治療法 |
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| JP2010540556A (ja) | 2007-09-26 | 2010-12-24 | マウント サイナイ スクール オブ メディシン | アザシチジン類似体およびその使用 |
| US20100311683A1 (en) | 2007-11-01 | 2010-12-09 | Beach C L | Cytidine analogs for treatment of myelodysplastic syndromes |
| WO2009126175A1 (en) | 2008-04-10 | 2009-10-15 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| AU2009234127B2 (en) | 2008-04-10 | 2015-04-30 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| US8846628B2 (en) | 2008-05-15 | 2014-09-30 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
| KR20170015525A (ko) | 2008-11-22 | 2017-02-08 | 제넨테크, 인크. | 유방암의 치료를 위한, 화학요법과 조합된 항-ｖｅｇｆ 항체의 용도 |
| CA2789365A1 (en) | 2009-02-10 | 2010-08-19 | Celgene International Sarl | Methods for treating non-small cell lung cancer using 5-azacytidine |
| NZ707377A (en) | 2010-06-07 | 2015-09-25 | Abraxis Bioscience Llc | Combination therapy methods for treating proliferative diseases |
| WO2013022872A1 (en) | 2011-08-10 | 2013-02-14 | Celgene Corporation | Gene methylation biomarkers and methods of use thereof |
-
2012
- 2012-10-31 BR BRBR112014010417-4A patent/BR112014010417A2/pt not_active Application Discontinuation
- 2012-10-31 SG SG11201401946QA patent/SG11201401946QA/en unknown
- 2012-10-31 KR KR1020147014861A patent/KR20140088603A/ko not_active Withdrawn
- 2012-10-31 EP EP12783817.5A patent/EP2773322A1/en not_active Withdrawn
- 2012-10-31 CA CA2853949A patent/CA2853949A1/en not_active Withdrawn
- 2012-10-31 JP JP2014540046A patent/JP6162709B2/ja active Active
- 2012-10-31 HK HK15101233.8A patent/HK1200716A1/xx unknown
- 2012-10-31 US US13/665,778 patent/US9125884B2/en not_active Expired - Fee Related
- 2012-10-31 EA EA201490911A patent/EA201490911A1/ru unknown
- 2012-10-31 MX MX2014005314A patent/MX2014005314A/es not_active Application Discontinuation
- 2012-10-31 TW TW105130025A patent/TW201700103A/zh unknown
- 2012-10-31 AU AU2012318239A patent/AU2012318239B2/en not_active Ceased
- 2012-10-31 CN CN201280065749.3A patent/CN104168884A/zh active Pending
- 2012-10-31 PH PH1/2014/500965A patent/PH12014500965A1/en unknown
- 2012-10-31 WO PCT/US2012/062845 patent/WO2013067043A1/en not_active Ceased
- 2012-10-31 TW TW101140377A patent/TWI558401B/zh not_active IP Right Cessation
-
2014
- 2014-04-27 IL IL232268A patent/IL232268A0/en unknown
- 2014-04-29 ZA ZA2014/03106A patent/ZA201403106B/en unknown
-
2015
- 2015-04-16 US US14/688,623 patent/US9693987B2/en active Active
- 2015-04-28 ZA ZA2015/02909A patent/ZA201502909B/en unknown
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