JP2014532430A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014532430A5 JP2014532430A5 JP2014540177A JP2014540177A JP2014532430A5 JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5 JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014540177 A JP2014540177 A JP 2014540177A JP 2014532430 A5 JP2014532430 A5 JP 2014532430A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- binding
- binding partner
- acid complex
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 claims 57
- 150000007523 nucleic acids Chemical class 0.000 claims 57
- 102000039446 nucleic acids Human genes 0.000 claims 57
- 108091034117 Oligonucleotide Proteins 0.000 claims 42
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 15
- 238000000034 method Methods 0.000 claims 8
- 238000010494 dissociation reaction Methods 0.000 claims 6
- 230000005593 dissociations Effects 0.000 claims 6
- 239000012491 analyte Substances 0.000 claims 5
- 238000004630 atomic force microscopy Methods 0.000 claims 4
- 238000001502 gel electrophoresis Methods 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000000799 fluorescence microscopy Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000000386 microscopy Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 238000012576 optical tweezer Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161556194P | 2011-11-05 | 2011-11-05 | |
| US61/556,194 | 2011-11-05 | ||
| US201261666655P | 2012-06-29 | 2012-06-29 | |
| US61/666,655 | 2012-06-29 | ||
| PCT/US2012/063538 WO2013067489A1 (en) | 2011-11-05 | 2012-11-05 | Nucleic acid-based linkers for detecting and measuring interactions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532430A JP2014532430A (ja) | 2014-12-08 |
| JP2014532430A5 true JP2014532430A5 (cg-RX-API-DMAC7.html) | 2015-12-24 |
| JP6430253B2 JP6430253B2 (ja) | 2018-11-28 |
Family
ID=48192891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540177A Active JP6430253B2 (ja) | 2011-11-05 | 2012-11-05 | 相互作用を検出および測定するための核酸ベースのリンカー |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US9914958B2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6430253B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013067489A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6430253B2 (ja) * | 2011-11-05 | 2018-11-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 相互作用を検出および測定するための核酸ベースのリンカー |
| CA2917435A1 (en) | 2013-07-10 | 2015-01-15 | Children's Medical Center Corporation | Compositions and methods relating to nucleic acid-protein complexes |
| WO2015164602A2 (en) | 2014-04-23 | 2015-10-29 | Children's Medical Center Corporation | High-throughput structure determination using nucleic acid calipers |
| WO2016089588A1 (en) * | 2014-12-06 | 2016-06-09 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| WO2016196824A1 (en) * | 2015-06-02 | 2016-12-08 | Children's Medical Center Corporation | Nucleic acid complexes for screening barcoded compounds |
| WO2017003950A2 (en) * | 2015-06-27 | 2017-01-05 | Children's Medical Center Corporation | Compositions and methods for analyte detection using nanoswitches |
| WO2017055463A1 (en) * | 2015-10-01 | 2017-04-06 | Dynamic Biosensors Gmbh | Method for detecting molecular interactions using an immobilized nucleic acid |
| WO2017139409A1 (en) | 2016-02-09 | 2017-08-17 | Children's Medical Center Corporation | Method for detection of analytes via polymer complexes |
| JP2019512722A (ja) | 2016-02-25 | 2019-05-16 | ザ チルドレンズ メディカル センター コーポレーション | 分子に関連した特徴の測定のためのスピン装置 |
| EP3967651A1 (en) * | 2016-03-11 | 2022-03-16 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| US10919037B2 (en) | 2016-03-23 | 2021-02-16 | Children's Medical Center Corporation | Systems and apparatus for detecting compounds in human biological samples |
| WO2017165647A1 (en) * | 2016-03-23 | 2017-09-28 | Children's Medical Center Corporation | Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods |
| WO2017189794A1 (en) * | 2016-04-27 | 2017-11-02 | President And Fellows Of Harvard College | Method of secure communication via nucleotide polymers |
| US10823699B2 (en) | 2016-07-29 | 2020-11-03 | Vital Biosciences, Inc. | Gel electrophoresis diagnostic kit and methods of using the same |
| CN115948505B (zh) | 2016-08-02 | 2025-07-25 | 哈佛学院院长及董事 | 交叉协同自组装体 |
| US12252507B2 (en) | 2016-12-05 | 2025-03-18 | Children's Medical Center Corporation | Nucleic acid nanoswitch construction methods |
| WO2018119437A2 (en) | 2016-12-23 | 2018-06-28 | Confer Health, Inc. | Electrophoresis diagnostic methods and kits |
| WO2019100080A1 (en) | 2017-11-20 | 2019-05-23 | Children's Medical Center Corporation | Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids |
| FR3075820B1 (fr) | 2017-12-21 | 2022-12-30 | Paris Sciences Lettres Quartier Latin | Molecule d'adn double-brin pour la detection et la caracterisation des interactions moleculaires |
| US11561221B2 (en) * | 2018-05-02 | 2023-01-24 | Trustees Of Boston University | Dynamic tracking of captured targets for enhanced digital biosensing |
| KR102767028B1 (ko) | 2018-06-06 | 2025-02-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 핵산 라이브러리의 생성 방법 및 이를 실행하기 위한 조성물 및 키트 |
| WO2020163397A2 (en) * | 2019-02-04 | 2020-08-13 | Akoya Biosciences, Inc. | Analyte detection by selective labeling of biological samples |
| CN111549098B (zh) * | 2020-06-16 | 2024-10-29 | 南开大学 | 测量人端粒精准长度的单分子力学方法 |
| CN111721504B (zh) * | 2020-06-17 | 2022-02-18 | 中国科学院物理研究所 | 在小力下测算磁镊高度转换系数的方法及应用 |
| EP4504968A1 (en) | 2022-04-01 | 2025-02-12 | Depixus SAS | Methods of screening compounds |
| WO2025041065A1 (en) * | 2023-08-21 | 2025-02-27 | Depixus SAS | Device for determining molecular interactions |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9114525D0 (en) | 1991-07-05 | 1991-08-21 | Delnatte Sabine | Homogeneous nucleic acids probe based tests and substances |
| JPH09500378A (ja) | 1993-07-02 | 1997-01-14 | リンクス セラピューティクス，インコーポレイティド | 枝分れされそして複雑に結合された高分子構造体の集中的合成 |
| US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5888731A (en) * | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
| US5902724A (en) * | 1996-07-12 | 1999-05-11 | Tm Technologies, Inc. | Signal amplification method |
| CA2311501A1 (en) | 1997-11-25 | 1999-06-03 | Mosaic Technologies | Devices and methods for detecting target molecules in biological samples |
| US20020177144A1 (en) | 1997-12-30 | 2002-11-28 | Jose Remacle | Detection and/or quantification method of a target molecule by a binding with a capture molecule fixed on the surface of a disc |
| US6143504A (en) * | 1998-10-27 | 2000-11-07 | Arch Development Corporation | Methods and compositions for the diagnosis of fragile X syndrome |
| GB9827912D0 (en) * | 1998-12-19 | 1999-02-10 | Univ Manchester | Detecting nucleic acids |
| JP3080951B1 (ja) * | 1999-03-04 | 2000-08-28 | 株式会社分子バイオホトニクス研究所 | ウイルスを検出する方法 |
| EP1404878A4 (en) | 2001-07-11 | 2006-12-06 | Applera Corp | INTERNAL CALIBRATION STANDARDS FOR ELECTROPHORETIC ANALYZES |
| US20030143549A1 (en) * | 2002-01-29 | 2003-07-31 | Eastman Kodak Company | Method for DNA sequencing and gene identification |
| US7294513B2 (en) | 2002-07-24 | 2007-11-13 | Wyatt Technology Corporation | Method and apparatus for characterizing solutions of small particles |
| EP1540013B1 (en) * | 2002-08-19 | 2015-07-08 | The President and Fellows of Harvard College | Evolving new molecular function |
| AU2002952797A0 (en) | 2002-11-20 | 2002-12-05 | Bio-Molecular Holdings Pty Limited | Centrifugal device and method using same |
| CN103397082B (zh) * | 2003-02-26 | 2017-05-31 | 考利达基因组股份有限公司 | 通过杂交进行的随机阵列dna分析 |
| JP4318721B2 (ja) | 2004-10-15 | 2009-08-26 | 独立行政法人科学技術振興機構 | ｍＲＮＡ−ピューロマイシン−タンパク質連結体作製用リンカー |
| US20070026423A1 (en) * | 2005-03-16 | 2007-02-01 | Thomas Koehler | Method and test kit for the detection of target nucleic acids |
| CA2610027A1 (en) * | 2005-05-26 | 2006-11-30 | Ensemble Discovery Corporation | Biodetection by nucleic acid-templated chemistry |
| US7842793B2 (en) | 2005-06-14 | 2010-11-30 | The California Institute Of Technology | Methods of making nucleic acid nanostructures |
| WO2007056250A2 (en) | 2005-11-04 | 2007-05-18 | U.S. Genomics, Inc. | Heterogeneous assay of analytes in solution using polymers |
| EP1963531B1 (en) | 2005-12-23 | 2011-09-21 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| WO2008054834A2 (en) * | 2006-02-03 | 2008-05-08 | Columbia University | Binary deoxyribozyme probes for nucleic acid analysis |
| WO2007139849A2 (en) * | 2006-05-25 | 2007-12-06 | The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Modified nucleic acid nanoarrays and uses therefor |
| US20090286694A1 (en) | 2006-08-21 | 2009-11-19 | Gafur Zainiev | Nucleic acid array with releaseable nucleic acid probes |
| JP2008259453A (ja) | 2007-04-12 | 2008-10-30 | Toyobo Co Ltd | 核酸の検出方法 |
| US8043810B2 (en) | 2007-05-02 | 2011-10-25 | Eagle Eye Research, Inc. | Analyte detection using autocatalytic chain reactions |
| US8361299B2 (en) | 2008-10-08 | 2013-01-29 | Sage Science, Inc. | Multichannel preparative electrophoresis system |
| EP3622968A1 (en) | 2008-10-31 | 2020-03-18 | The General Hospital Corporation | Compositions and methods for delivering a substance to a biological target |
| US9354189B2 (en) | 2008-12-02 | 2016-05-31 | President And Fellows Of Harvard College | Apparatus for measurement of spinning forces relating to molecules |
| US8491454B2 (en) | 2008-12-02 | 2013-07-23 | President And Fellows Of Harvard College | Spinning force apparatus |
| SG177395A1 (en) | 2009-07-07 | 2012-02-28 | Agency Science Tech & Res | Methods of identifying a pair of binding partners |
| CA2775613C (en) * | 2009-10-13 | 2018-06-12 | Nanostring Technologies, Inc. | Protein detection via nanoreporters |
| WO2011072133A1 (en) | 2009-12-09 | 2011-06-16 | William Marsh Rice University | Therapeutic compositions and methods for delivery of active agents cleavably linked to nanoparticles |
| US20130196341A1 (en) | 2010-07-06 | 2013-08-01 | T2 Biosystems ,Inc. | Methods and compositions for detection of analytes |
| JP6430253B2 (ja) * | 2011-11-05 | 2018-11-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 相互作用を検出および測定するための核酸ベースのリンカー |
| US9182334B2 (en) | 2012-02-24 | 2015-11-10 | Agilent Technologies, Inc. | Method of determining thermodynamic and kinetic parameters from measured off rates |
| WO2013177046A1 (en) | 2012-05-21 | 2013-11-28 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| WO2014011800A1 (en) | 2012-07-10 | 2014-01-16 | Pivot Bio, Inc. | Methods for multipart, modular and scarless assembly of dna molecules |
| CA2917435A1 (en) | 2013-07-10 | 2015-01-15 | Children's Medical Center Corporation | Compositions and methods relating to nucleic acid-protein complexes |
| US9333463B2 (en) | 2013-07-26 | 2016-05-10 | General Electric Company | Devices and systems for elution of biomolecules |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| US20150361422A1 (en) | 2014-06-16 | 2015-12-17 | Agilent Technologies, Inc. | High throughput gene assembly in droplets |
| WO2016089588A1 (en) | 2014-12-06 | 2016-06-09 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| WO2017003950A2 (en) | 2015-06-27 | 2017-01-05 | Children's Medical Center Corporation | Compositions and methods for analyte detection using nanoswitches |
-
2012
- 2012-11-05 JP JP2014540177A patent/JP6430253B2/ja active Active
- 2012-11-05 WO PCT/US2012/063538 patent/WO2013067489A1/en not_active Ceased
- 2012-11-05 US US14/356,282 patent/US9914958B2/en active Active
-
2018
- 2018-02-05 US US15/888,941 patent/US20180291434A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014532430A5 (cg-RX-API-DMAC7.html) | ||
| Wang et al. | Development of a SPR aptasensor containing oriented aptamer for direct capture and detection of tetracycline in multiple honey samples | |
| JP6525872B2 (ja) | 細胞中の複数のエピトープを同定するためのダイナミックレンジを高めること | |
| JP2013507642A5 (cg-RX-API-DMAC7.html) | ||
| US10415034B2 (en) | Method for the selection of aptamers for unbound targets | |
| Giri et al. | Rapid screening of genetic biomarkers of infectious agents using quantum dot barcodes | |
| Archer et al. | Magnetic bead-based solid phase for selective extraction of genomic DNA | |
| Schaus et al. | A DNA nanoscope via auto-cycling proximity recording | |
| JP2008504842A5 (cg-RX-API-DMAC7.html) | ||
| JP2017525695A5 (cg-RX-API-DMAC7.html) | ||
| He et al. | Highly reproducible and sensitive electrochemiluminescence biosensors for HPV detection based on bovine serum albumin carrier platforms and hyperbranched rolling circle amplification | |
| JP2014513557A5 (cg-RX-API-DMAC7.html) | ||
| JP2012198225A5 (cg-RX-API-DMAC7.html) | ||
| RU2015132798A (ru) | Способ обнаружения модификаций днк и связывания с белком путем манипуляций с одиночными молекулами | |
| JP2018512862A5 (cg-RX-API-DMAC7.html) | ||
| JP2010529474A5 (cg-RX-API-DMAC7.html) | ||
| Wang et al. | Kinetic adsorption profile and conformation evolution at the DNA-gold nanoparticle interface probed by dynamic light scattering | |
| JPWO2017126646A1 (ja) | 核酸アプタマーをスクリーニングするための方法 | |
| Pinto et al. | Real-time apta-PCR for 20 000-fold improvement in detection limit | |
| Miao et al. | Terminal deoxynucleotidyl transferase-induced DNAzyme nanowire sensor for colorimetric detection of lipopolysaccharides | |
| Sato et al. | Bead-based padlock rolling circle amplification for single DNA molecule counting | |
| JP2021092576A (ja) | ２個のリガンドと１個のレセプタとからなる高親和性錯体の特定方法と該方法を実行する装置及び該方法に用いられる自己集合型ケミカルライブラリ | |
| JP6155251B2 (ja) | 核酸の検出方法、そのキット及びその使用 | |
| US20170233723A1 (en) | Method For Affinity Purification | |
| Fakih et al. | Gold nanoparticles-coated polystyrene beads for the multiplex detection of viral DNA |