JP2014530821A5 - - Google Patents
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- Publication number
- JP2014530821A5 JP2014530821A5 JP2014535874A JP2014535874A JP2014530821A5 JP 2014530821 A5 JP2014530821 A5 JP 2014530821A5 JP 2014535874 A JP2014535874 A JP 2014535874A JP 2014535874 A JP2014535874 A JP 2014535874A JP 2014530821 A5 JP2014530821 A5 JP 2014530821A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- subject
- fingolimod
- laquinimod
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- SWZTYAVBMYWFGS-UHFFFAOYSA-N fingolimod hydrochloride Chemical compound Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 SWZTYAVBMYWFGS-UHFFFAOYSA-N 0.000 claims 38
- 229960000556 fingolimod Drugs 0.000 claims 37
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 claims 36
- 229960004577 laquinimod Drugs 0.000 claims 36
- 239000008194 pharmaceutical composition Substances 0.000 claims 34
- 208000024891 symptom Diseases 0.000 claims 15
- 201000006417 multiple sclerosis Diseases 0.000 claims 13
- 210000004556 brain Anatomy 0.000 claims 8
- 206010071068 Clinically isolated syndrome Diseases 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 238000002560 therapeutic procedure Methods 0.000 claims 7
- 206010061818 Disease progression Diseases 0.000 claims 5
- 230000005750 disease progression Effects 0.000 claims 5
- 208000028698 Cognitive impairment Diseases 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 4
- 230000036541 health Effects 0.000 claims 4
- 230000005856 abnormality Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 230000000977 initiatory effect Effects 0.000 claims 3
- 208000016285 Movement disease Diseases 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- 238000002648 combination therapy Methods 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 230000000737 periodic effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000024806 Brain atrophy Diseases 0.000 claims 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 claims 1
- 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000006866 deterioration Effects 0.000 claims 1
- 230000009266 disease activity Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 229960004967 fingolimod hydrochloride Drugs 0.000 claims 1
- 230000005021 gait Effects 0.000 claims 1
- 150000002344 gold compounds Chemical class 0.000 claims 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims 1
- 229960004171 hydroxychloroquine Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940124589 immunosuppressive drug Drugs 0.000 claims 1
- 230000003137 locomotive effect Effects 0.000 claims 1
- 210000003141 lower extremity Anatomy 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 230000009251 neurologic dysfunction Effects 0.000 claims 1
- 208000015015 neurological dysfunction Diseases 0.000 claims 1
- 230000009223 neuronal apoptosis Effects 0.000 claims 1
- 230000003961 neuronal insult Effects 0.000 claims 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims 1
- 229960001860 salicylate Drugs 0.000 claims 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 claims 1
- 229960001940 sulfasalazine Drugs 0.000 claims 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000004382 visual function Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161546102P | 2011-10-12 | 2011-10-12 | |
| US61/546,102 | 2011-10-12 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017006394A Division JP2017137298A (ja) | 2011-10-12 | 2017-01-18 | ラキニモドおよびフィンゴリモドを組み合わせた多発性硬化症の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530821A JP2014530821A (ja) | 2014-11-20 |
| JP2014530821A5 true JP2014530821A5 (enExample) | 2015-12-03 |
Family
ID=48082429
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535874A Withdrawn JP2014530821A (ja) | 2011-10-12 | 2012-10-11 | ラキニモドおよびフィンゴリモドを組み合わせた多発性硬化症の治療 |
| JP2017006394A Pending JP2017137298A (ja) | 2011-10-12 | 2017-01-18 | ラキニモドおよびフィンゴリモドを組み合わせた多発性硬化症の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017006394A Pending JP2017137298A (ja) | 2011-10-12 | 2017-01-18 | ラキニモドおよびフィンゴリモドを組み合わせた多発性硬化症の治療 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US8889627B2 (enExample) |
| EP (1) | EP2766020A4 (enExample) |
| JP (2) | JP2014530821A (enExample) |
| KR (1) | KR20140101333A (enExample) |
| CN (2) | CN103974704A (enExample) |
| AR (1) | AR088458A1 (enExample) |
| AU (2) | AU2012322706A1 (enExample) |
| BR (1) | BR112014008731A2 (enExample) |
| CA (1) | CA2851525A1 (enExample) |
| EA (1) | EA201490748A1 (enExample) |
| HK (1) | HK1199820A1 (enExample) |
| IL (1) | IL231724A0 (enExample) |
| MX (1) | MX2014004420A (enExample) |
| SG (1) | SG11201401330YA (enExample) |
| TW (1) | TW201321001A (enExample) |
| UY (1) | UY34395A (enExample) |
| WO (1) | WO2013055907A1 (enExample) |
| ZA (1) | ZA201403378B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2234485B1 (en) | 2007-12-20 | 2013-11-13 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
| AU2010282948C1 (en) * | 2009-08-10 | 2017-03-02 | Active Biotech, Ab | Treatment of BDNF-related disorders using laquinimod |
| US8945516B2 (en) | 2009-10-02 | 2015-02-03 | Foamix Pharmaceuticals Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| ES2665461T3 (es) | 2009-11-13 | 2018-04-25 | Celgene International Ii Sàrl | Moduladores del receptor esfingosina 1-fosfato y métodos de síntesis quiral |
| HUE054000T2 (hu) | 2009-11-13 | 2021-08-30 | Receptos Llc | Szelektív szfingozin-1-foszfát-receptor modulátorok és királis szintézis eljárások |
| EP2706999B1 (en) | 2011-05-13 | 2019-08-28 | Celgene International II Sàrl | Selective heterocyclic sphingosine 1 phosphate receptor modulators |
| HK1199820A1 (en) * | 2011-10-12 | 2015-07-24 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| WO2013101314A1 (en) * | 2011-12-28 | 2013-07-04 | Galectin Therapeutics, Inc. | Composition of novel carbohydrate drug for treatment of human diseases |
| AR089862A1 (es) | 2012-02-03 | 2014-09-24 | Teva Pharma | USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA |
| EP2744498A4 (en) | 2012-02-16 | 2014-12-03 | Teva Pharma | N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-CHINOLINE CARBOXAMIDE AND THE PREPARATION AND USE THEREOF |
| TW201347762A (zh) * | 2012-05-02 | 2013-12-01 | Teva Pharma | 高劑量拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）於治療多發性硬化症之用途 |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| UY34896A (es) * | 2012-07-12 | 2014-02-28 | Teva Pharma | Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| CN105263325A (zh) * | 2012-10-12 | 2016-01-20 | 梯瓦制药工业有限公司 | 用于降低多发性硬化症中丘脑损伤的拉喹莫德 |
| HK1215210A1 (zh) | 2012-11-07 | 2016-08-19 | Teva Pharmaceutical Industries Ltd. | 拉喹莫德胺盐 |
| CA2901849A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| HK1223855A1 (zh) * | 2013-07-31 | 2017-08-11 | Teva Pharmaceutical Industries Ltd. | 拉喹莫德和氟吡汀组合物用於治疗多发性硬化症 |
| WO2015066515A1 (en) * | 2013-11-01 | 2015-05-07 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
| HK1225972A1 (zh) * | 2013-12-20 | 2017-09-22 | Teva Pharmaceutical Industries Ltd. | 利用拉喹莫德来延缓亨廷顿氏病的进展 |
| AR098924A1 (es) * | 2013-12-23 | 2016-06-22 | Teva Pharma | Tratamiento de la esclerosis múltiple con una combinación de laquinimod y teriflunomida |
| SG11201608674UA (en) | 2014-04-29 | 2016-11-29 | Teva Pharma | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
| WO2016044103A1 (en) * | 2014-09-16 | 2016-03-24 | Teva Pharmaceutical Industries Ltd. | Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod |
| AU2015332037A1 (en) * | 2014-10-16 | 2017-04-27 | Novartis Ag | Combinations comprising siponimod and laquinimod for the treatment of multiple sclerosis |
| WO2016075543A1 (en) * | 2014-11-13 | 2016-05-19 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and a phosphodiesterase-4 (pde4) inhibitor |
| CA2969715A1 (en) * | 2014-12-10 | 2016-06-16 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and a statin |
| GB2540163A (en) * | 2015-07-07 | 2017-01-11 | Univ London Queen Mary | Combination therapy for treating multiple sclerosis |
| MX377365B (es) | 2016-09-08 | 2025-03-10 | Journey Medical Corp | Composiciones y métodos para tratar rosácea y acné. |
| WO2019245513A2 (en) * | 2018-06-21 | 2019-12-26 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A combination comprising fingolimod and amantadine |
| WO2021158844A1 (en) * | 2020-02-07 | 2021-08-12 | Argentum Pharmaceuticals Llc | Treatment and dosing regimen for s1p receptor modulator |
| WO2021158841A1 (en) * | 2020-02-07 | 2021-08-12 | Argentum Pharmaceuticals Llc | Treatment and dosing regimen for s1p receptor modulator |
| WO2021158847A1 (en) * | 2020-02-07 | 2021-08-12 | Argentum Pharmaceuticals Llc | Treatment and dosing regimen for s1p receptor modulator |
| WO2021158845A1 (en) * | 2020-02-07 | 2021-08-12 | Argentum Pharmaceuticals Llc | Treatment and dosing regimen for s1p receptor modulator |
| WO2021158838A1 (en) | 2020-02-07 | 2021-08-12 | Argentum Pharmaceuticals Llc | Dosage regimen of an s1p receptor modulator |
| EP4196477A4 (en) * | 2020-08-17 | 2024-10-09 | Vyne Therapeutics Inc. | TOFACITINIB-CONTAINING ANHYDROUS ELASTOMER-BASED GEL FORMULATIONS |
| CN120173888A (zh) * | 2025-03-26 | 2025-06-20 | 广州通识医学研究有限公司 | 一种基因修饰的人骨髓间充质干细胞的制备方法及其在治疗神经系统疾病的应用 |
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| US20130035390A1 (en) | 2010-01-13 | 2013-02-07 | Ramot At Tel-Aviv University Ltd. | Treatment of multiple sclerosis |
| EP2542080B1 (en) | 2010-03-03 | 2016-08-31 | Teva Pharmaceutical Industries Ltd. | Treatment of lupus arthritis using laquinimod |
| CA2791709A1 (en) | 2010-03-03 | 2011-09-09 | Teva Pharmaceutical Industries Ltd. | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
| KR20160129093A (ko) | 2010-03-03 | 2016-11-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
| MX2013000333A (es) | 2010-07-09 | 2013-02-26 | Teva Pharma | N-etil-n-fenil-1,2-dihidro-4-hidroxi-5-cloro-1-metil-2-oxoquinoli na-3-carboxamida deuterada, sales y usos de la misma. |
| JP5934202B2 (ja) | 2010-07-09 | 2016-06-15 | テバ ファーマシューティカル インダストリーズ リミティド | ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用 |
| EP2648732A4 (en) | 2010-12-07 | 2014-04-30 | Teva Pharma | USE OF LAQUINIMOD TO REDUCE TEMPERATURE, IMPROVE FUNCTIONAL STATUS AND IMPROVE LIFE QUALITY IN PATIENTS WITH MULTIPLE SCLEROSIS |
| MX2014001050A (es) | 2011-07-28 | 2014-04-14 | Teva Pharma | Tratamiento de esclerosis multiple con combinacion de laquinimod y acetato de glatiramero. |
| SG10201606204TA (en) | 2011-07-28 | 2016-09-29 | Teva Pharma | Treatment Of Multiple Sclerosis With Combination Of Laquinimod And Interferon-Beta |
| HK1199820A1 (en) * | 2011-10-12 | 2015-07-24 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| AR089862A1 (es) | 2012-02-03 | 2014-09-24 | Teva Pharma | USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA |
| EP2744498A4 (en) | 2012-02-16 | 2014-12-03 | Teva Pharma | N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-CHINOLINE CARBOXAMIDE AND THE PREPARATION AND USE THEREOF |
| US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| TW201347762A (zh) | 2012-05-02 | 2013-12-01 | Teva Pharma | 高劑量拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）於治療多發性硬化症之用途 |
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2012
- 2012-10-11 HK HK15100287.5A patent/HK1199820A1/xx unknown
- 2012-10-11 AU AU2012322706A patent/AU2012322706A1/en not_active Abandoned
- 2012-10-11 CN CN201280057918.9A patent/CN103974704A/zh active Pending
- 2012-10-11 EP EP12840715.2A patent/EP2766020A4/en not_active Withdrawn
- 2012-10-11 JP JP2014535874A patent/JP2014530821A/ja not_active Withdrawn
- 2012-10-11 EA EA201490748A patent/EA201490748A1/ru unknown
- 2012-10-11 KR KR1020147012601A patent/KR20140101333A/ko not_active Withdrawn
- 2012-10-11 MX MX2014004420A patent/MX2014004420A/es unknown
- 2012-10-11 WO PCT/US2012/059733 patent/WO2013055907A1/en not_active Ceased
- 2012-10-11 BR BR112014008731A patent/BR112014008731A2/pt not_active IP Right Cessation
- 2012-10-11 SG SG11201401330YA patent/SG11201401330YA/en unknown
- 2012-10-11 CN CN201610629442.1A patent/CN106344576A/zh active Pending
- 2012-10-11 US US13/650,060 patent/US8889627B2/en not_active Expired - Fee Related
- 2012-10-11 CA CA2851525A patent/CA2851525A1/en not_active Abandoned
- 2012-10-12 UY UY0001034395A patent/UY34395A/es not_active Application Discontinuation
- 2012-10-12 TW TW101137835A patent/TW201321001A/zh unknown
- 2012-10-12 AR ARP120103829A patent/AR088458A1/es unknown
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2014
- 2014-03-26 IL IL231724A patent/IL231724A0/en unknown
- 2014-05-12 ZA ZA2014/03378A patent/ZA201403378B/en unknown
- 2014-10-21 US US14/520,145 patent/US20150037263A1/en not_active Abandoned
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2016
- 2016-06-10 US US15/179,800 patent/US20160279118A1/en not_active Abandoned
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2017
- 2017-01-18 JP JP2017006394A patent/JP2017137298A/ja active Pending
- 2017-07-31 US US15/665,061 patent/US20170333418A1/en not_active Abandoned
- 2017-08-09 AU AU2017213497A patent/AU2017213497A1/en not_active Abandoned
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