CN103974704A - 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症 - Google Patents

以拉喹莫德和芬戈莫德的组合治疗多发性硬化症 Download PDF

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Publication number
CN103974704A
CN103974704A CN201280057918.9A CN201280057918A CN103974704A CN 103974704 A CN103974704 A CN 103974704A CN 201280057918 A CN201280057918 A CN 201280057918A CN 103974704 A CN103974704 A CN 103974704A
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Prior art keywords
laquinimod
amount
fty720
administration
medical composition
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Pending
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CN201280057918.9A
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Chinese (zh)
Inventor
侯赛因·哈拉克
诺拉·塔克斯克
乔尔·弗拉克斯曼·凯耶
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Teva Pharmaceutical Industries Ltd
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Teva Pharmaceutical Industries Ltd
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Priority to CN201610629442.1A priority Critical patent/CN106344576A/zh
Publication of CN103974704A publication Critical patent/CN103974704A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Emergency Medicine (AREA)
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  • Diabetes (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
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  • Transplantation (AREA)
  • Obesity (AREA)
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  • Endocrinology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280057918.9A 2011-10-12 2012-10-11 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症 Pending CN103974704A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610629442.1A CN106344576A (zh) 2011-10-12 2012-10-11 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161546102P 2011-10-12 2011-10-12
US61/546,102 2011-10-12
PCT/US2012/059733 WO2013055907A1 (en) 2011-10-12 2012-10-11 Treatment of multiple sclerosis with combination of laquinimod and fingolimod

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CN201610629442.1A Pending CN106344576A (zh) 2011-10-12 2012-10-11 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症

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US (4) US8889627B2 (enExample)
EP (1) EP2766020A4 (enExample)
JP (2) JP2014530821A (enExample)
KR (1) KR20140101333A (enExample)
CN (2) CN103974704A (enExample)
AR (1) AR088458A1 (enExample)
AU (2) AU2012322706A1 (enExample)
BR (1) BR112014008731A2 (enExample)
CA (1) CA2851525A1 (enExample)
EA (1) EA201490748A1 (enExample)
HK (1) HK1199820A1 (enExample)
IL (1) IL231724A0 (enExample)
MX (1) MX2014004420A (enExample)
SG (1) SG11201401330YA (enExample)
TW (1) TW201321001A (enExample)
UY (1) UY34395A (enExample)
WO (1) WO2013055907A1 (enExample)
ZA (1) ZA201403378B (enExample)

Cited By (2)

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CN107072988A (zh) * 2014-10-16 2017-08-18 诺华股份有限公司 包含辛波莫德和拉喹莫德的用于治疗多发性硬化症的组合
CN120173888A (zh) * 2025-03-26 2025-06-20 广州通识医学研究有限公司 一种基因修饰的人骨髓间充质干细胞的制备方法及其在治疗神经系统疾病的应用

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TW201347762A (zh) * 2012-05-02 2013-12-01 Teva Pharma 高劑量拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）於治療多發性硬化症之用途
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
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UY34896A (es) * 2012-07-12 2014-02-28 Teva Pharma Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
CN105263325A (zh) * 2012-10-12 2016-01-20 梯瓦制药工业有限公司 用于降低多发性硬化症中丘脑损伤的拉喹莫德
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HK1223855A1 (zh) * 2013-07-31 2017-08-11 Teva Pharmaceutical Industries Ltd. 拉喹莫德和氟吡汀组合物用於治疗多发性硬化症
WO2015066515A1 (en) * 2013-11-01 2015-05-07 Receptos, Inc. Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith
HK1225972A1 (zh) * 2013-12-20 2017-09-22 Teva Pharmaceutical Industries Ltd. 利用拉喹莫德来延缓亨廷顿氏病的进展
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WO2016044103A1 (en) * 2014-09-16 2016-03-24 Teva Pharmaceutical Industries Ltd. Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod
WO2016075543A1 (en) * 2014-11-13 2016-05-19 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and a phosphodiesterase-4 (pde4) inhibitor
CA2969715A1 (en) * 2014-12-10 2016-06-16 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and a statin
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