JP2014530192A5 - - Google Patents
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- JP2014530192A5 JP2014530192A5 JP2014530805A JP2014530805A JP2014530192A5 JP 2014530192 A5 JP2014530192 A5 JP 2014530192A5 JP 2014530805 A JP2014530805 A JP 2014530805A JP 2014530805 A JP2014530805 A JP 2014530805A JP 2014530192 A5 JP2014530192 A5 JP 2014530192A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- composition
- composition according
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 22
- 206010052428 Wound Diseases 0.000 claims 11
- 208000027418 Wounds and injury Diseases 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 125000002091 cationic group Chemical group 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 2
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000002345 steroid group Chemical group 0.000 claims 2
- 229920000742 Cotton Polymers 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 208000034693 Laceration Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000037581 Persistent Infection Diseases 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000005096 aminoalkylaminocarbonyl group Chemical group 0.000 claims 1
- 125000005123 aminoalkylcarboxy group Chemical group 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 125000005128 aryl amino alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005416 guanidinoalkyloxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 230000002439 hemostatic effect Effects 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161534194P | 2011-09-13 | 2011-09-13 | |
| US61/534,194 | 2011-09-13 | ||
| PCT/US2012/055248 WO2013040269A1 (en) | 2011-09-13 | 2012-09-13 | Products for healing of tissue wounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530192A JP2014530192A (ja) | 2014-11-17 |
| JP2014530192A5 true JP2014530192A5 (enExample) | 2015-10-01 |
| JP6038155B2 JP6038155B2 (ja) | 2016-12-07 |
Family
ID=47071446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530805A Active JP6038155B2 (ja) | 2011-09-13 | 2012-09-13 | 組織創傷を治癒させる製品 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9161942B2 (enExample) |
| EP (1) | EP2760454B1 (enExample) |
| JP (1) | JP6038155B2 (enExample) |
| KR (1) | KR101966293B1 (enExample) |
| CN (1) | CN104080458B (enExample) |
| AU (2) | AU2012308526B2 (enExample) |
| BR (1) | BR112014005914B1 (enExample) |
| CA (1) | CA2848567C (enExample) |
| IL (1) | IL231509B (enExample) |
| MX (1) | MX369385B (enExample) |
| RU (1) | RU2652308C2 (enExample) |
| WO (2) | WO2013040269A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2303026B1 (en) | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| ES2728135T3 (es) | 2011-07-20 | 2019-10-22 | Univ Brigham Young | Materiales de hidrogel que incorporan un compuesto de elución de ceragenina |
| US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
| US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
| US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
| JP6038154B2 (ja) | 2011-09-13 | 2016-12-07 | ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ | 骨疾患および破断骨治療のための組成物 |
| CN104379120A (zh) | 2011-12-21 | 2015-02-25 | 布莱阿姆青年大学 | 口腔护理组合物 |
| US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
| CA2872399C (en) * | 2012-05-02 | 2021-01-12 | Brigham Young University | Ceragenin particulate materials and methods for making same |
| EP2908826A1 (en) | 2012-10-17 | 2015-08-26 | Brigham Young University | Treatment and prevention of mastitis |
| EP2941253B1 (en) | 2013-01-07 | 2021-08-11 | Brigham Young University | Cationic steroid antimicrobial agents for use in treating cancer |
| US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| KR102282183B1 (ko) | 2013-03-15 | 2021-07-26 | 브라이엄 영 유니버시티 | 염증, 자가면역 장애 및 통증의 치료 방법 |
| US9387215B2 (en) * | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
| US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) * | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| CA2844321C (en) | 2014-02-27 | 2021-03-16 | Brigham Young University | Cationic steroidal antimicrobial compounds |
| US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
| US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
| US9931350B2 (en) * | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
| US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
| US10441595B2 (en) * | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
| US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
| US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
| US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
| WO2016172543A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| WO2016172534A1 (en) * | 2015-04-22 | 2016-10-27 | Savage Paul B | Cationic steroidal antimicrobial salts |
| US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
| CN108348484B (zh) * | 2015-04-22 | 2021-12-17 | 布莱阿姆青年大学 | 阳离子甾体抗微生物盐 |
| US9434759B1 (en) * | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US20170080128A1 (en) * | 2015-09-21 | 2017-03-23 | Brigham Young University | Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies |
| US10226550B2 (en) * | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| KR101792535B1 (ko) | 2017-09-27 | 2017-11-02 | 오상자이엘 주식회사 | 화상 치료용 키트 |
| US12186328B2 (en) * | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US428800A (en) * | 1890-05-27 | miller | ||
| US4661341A (en) | 1984-10-30 | 1987-04-28 | The Procter & Gamble Company | Oral compositions |
| US4842593A (en) | 1987-10-09 | 1989-06-27 | The Procter & Gamble Company | Disposable absorbent articles for incontinent individuals |
| US4865855A (en) | 1988-01-11 | 1989-09-12 | Kimberly-Clark Corporation | Antimicrobial absorbent food pad |
| US4990338A (en) | 1988-05-09 | 1991-02-05 | Dow Corning Corporation | Antimicrobial superabsorbent compositions and methods |
| US5356630A (en) | 1989-02-22 | 1994-10-18 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
| US4972848A (en) | 1989-08-23 | 1990-11-27 | Medtronic, Inc. | Medical electrical lead with polymeric monolithic controlled release device and method of manufacture |
| GB9020075D0 (en) | 1990-09-14 | 1990-10-24 | Filler Aaron G | Contrast agents for magnetic resonance imaging of axonal transport |
| US5286479A (en) | 1991-12-10 | 1994-02-15 | The Dow Chemical Company | Oral compositions for suppressing mouth odors |
| NZ263002A (en) | 1993-03-12 | 1996-12-20 | Upjohn Co | Crystalline ceftiofur {namely: 7-[2-(2-amino-1,3-thiazol-4-yl)- 2-methoxyimino)acetamido]-3-[(fur-2-ylcarbonyl)thiomethyl]- 3-cephem-4-carboxylic acid} in free acid form |
| ES2164110T3 (es) | 1994-03-10 | 2002-02-16 | Magainin Pharma | Usos farmaceuticos de derivados de esteroides. |
| US6132765A (en) | 1996-04-12 | 2000-10-17 | Uroteq Inc. | Drug delivery via therapeutic hydrogels |
| WO1998003180A2 (en) * | 1996-07-22 | 1998-01-29 | The Victoria University Of Manchester | Use of sex steroids function modulators to treat wounds and fibrotic disorders |
| US6767904B2 (en) * | 1998-03-06 | 2004-07-27 | Bringham Young University | Steroid derived antibiotics |
| JP2002505292A (ja) | 1998-03-06 | 2002-02-19 | ブリガム ヤング ユニバーシティ | ステロイド由来抗生物質 |
| US6350738B1 (en) | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
| US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
| US6673771B1 (en) | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
| US6551608B2 (en) | 2000-03-06 | 2003-04-22 | Porex Technologies Corporation | Porous plastic media with antiviral or antimicrobial properties and processes for making the same |
| JP5052730B2 (ja) | 2000-08-15 | 2012-10-17 | ブリガム ヤング ユニバーシティ | ステロイド由来抗生物質 |
| US6514556B2 (en) | 2000-12-15 | 2003-02-04 | Ecolab Inc. | Method and composition for washing poultry during processing |
| WO2003015757A1 (en) | 2001-08-16 | 2003-02-27 | The Trustees Of The University Of Pennsylvania | Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies |
| US9056048B2 (en) * | 2001-08-16 | 2015-06-16 | The Trustees Of The University Of Pennsylvania | Synthesis and use of cationic steroids for anti-inflammatory drug therapy |
| US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| DE10218147B4 (de) | 2002-04-23 | 2005-12-22 | Stockhausen Gmbh | Wasserabsorbierende, die Zersetzung von Körperflüssigkeiten verzögernde Polymerteilchen, deren Herstellung und Verwendung |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US7659061B2 (en) | 2002-11-19 | 2010-02-09 | Pharmacia & Upjohn Company | Pharmaceutical compositions having a modified vehicle |
| US7282214B2 (en) | 2002-12-19 | 2007-10-16 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with antimicrobial coatings |
| AU2004248898B2 (en) | 2003-06-23 | 2010-03-18 | Beiersdorf Ag | Antimicrobial wounddressing |
| GB0318901D0 (en) | 2003-08-12 | 2003-09-17 | Univ Bath | Improvements in or relating to bone substitute material |
| US20050267051A1 (en) | 2003-12-19 | 2005-12-01 | Lee Henry J | Antineoplastic and anti-HIV conjugates of steroid acid and nucleosides |
| US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
| US20060062774A1 (en) | 2004-09-21 | 2006-03-23 | The Procter & Gamble Company | Compositions for maintaining and restoring normal urogenital flora |
| US7754705B2 (en) * | 2006-02-01 | 2010-07-13 | Brigham Young University | Cationic steroid antimicrobial compositions and methods of use |
| US20070190067A1 (en) | 2006-02-01 | 2007-08-16 | Savage Paul B | Cationic Steroid Antimicrobial Compositions and Methods of Use |
| WO2007089903A2 (en) | 2006-02-01 | 2007-08-09 | Brigham Young University | Cationic steroid microbial compositions for treating or preventing influenza infections |
| WO2007089906A2 (en) * | 2006-02-01 | 2007-08-09 | Brigham Young University | Cationic steroid antimicrobial compositions for treating or preventing herpes infections |
| WO2007134176A2 (en) | 2006-05-10 | 2007-11-22 | Microban Products Company | Antimicrobial food pad |
| US7858000B2 (en) | 2006-06-08 | 2010-12-28 | Novartis Ag | Method of making silicone hydrogel contact lenses |
| WO2008006083A2 (en) | 2006-07-07 | 2008-01-10 | Surmodics, Inc. | Beaded wound spacer device |
| WO2008038965A1 (en) * | 2006-09-26 | 2008-04-03 | Kyungpook National University Industry-Academic Cooperation Foundation | 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient |
| US7854941B2 (en) | 2007-02-12 | 2010-12-21 | The University Of Southern Mississippi | Method of attaching drug compounds to non-reactive polymer surfaces |
| US20090016973A1 (en) | 2007-07-09 | 2009-01-15 | Micropure, Inc. | Composition and Method for the Prevention of Oral Disease |
| US20090068122A1 (en) | 2007-09-06 | 2009-03-12 | Shira Pilch | Dentifrice Compositions for Treating Xerostomia |
| US9095568B2 (en) | 2007-09-26 | 2015-08-04 | Mark Berninger | Therapeutic and vaccine polyelectrolyte nanoparticle compositions |
| EP2303026B1 (en) | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| US20090324517A1 (en) | 2008-06-30 | 2009-12-31 | Dan Kline | Halitosis treatment |
| EP2451280A4 (en) * | 2009-07-09 | 2012-12-26 | Crescendo Therapeutics Llc | METHOD FOR WOUND HEALING AND SCALING MODULATION |
| US8623416B2 (en) | 2009-11-25 | 2014-01-07 | Michael Zasloff | Formulations comprising aminosterols |
| US8557031B1 (en) * | 2010-01-07 | 2013-10-15 | Sandia Corporation | Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages |
| EP2542245A4 (en) | 2010-03-04 | 2013-08-14 | Univ Pennsylvania | ANTIMICROBIAL CATIONIC STEROIDS AND METHOD FOR THEIR USE |
| US8871716B2 (en) * | 2010-10-08 | 2014-10-28 | Korea Advanced Institute Of Science And Technology | Use of antimicrobial peptides in regeneration of skin cells |
| BR112013010976A2 (pt) | 2010-11-03 | 2016-07-12 | Univ Brigham Young | "artigos que incorporam polímero absorvente e composto ceragenin." |
| CN102172356B (zh) * | 2011-03-03 | 2013-04-03 | 山东农业大学 | 牛磺鹅去氧胆酸在制备防治骨质疏松的药物中的应用 |
| US8810380B2 (en) | 2011-07-01 | 2014-08-19 | Gerald F. Leitz | Golf scoring management system |
| ES2728135T3 (es) | 2011-07-20 | 2019-10-22 | Univ Brigham Young | Materiales de hidrogel que incorporan un compuesto de elución de ceragenina |
| US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
| WO2013029059A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
| WO2013029055A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Incorporation of particulate ceragenins in polymers |
| CN104379120A (zh) | 2011-12-21 | 2015-02-25 | 布莱阿姆青年大学 | 口腔护理组合物 |
| BR112014021505A2 (pt) | 2012-03-01 | 2017-07-18 | Univ Brigham Young | composições de processamento de alimentos antimicrobianas incluindo compostos de ceragenina e métodos de uso |
| US20130280391A1 (en) | 2012-04-24 | 2013-10-24 | Brigham Young University | Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products |
| EP2908826A1 (en) | 2012-10-17 | 2015-08-26 | Brigham Young University | Treatment and prevention of mastitis |
| EP2941253B1 (en) | 2013-01-07 | 2021-08-11 | Brigham Young University | Cationic steroid antimicrobial agents for use in treating cancer |
| KR102282183B1 (ko) | 2013-03-15 | 2021-07-26 | 브라이엄 영 유니버시티 | 염증, 자가면역 장애 및 통증의 치료 방법 |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
-
2012
- 2012-09-13 RU RU2014112784A patent/RU2652308C2/ru active
- 2012-09-13 WO PCT/US2012/055248 patent/WO2013040269A1/en not_active Ceased
- 2012-09-13 EP EP12806192.6A patent/EP2760454B1/en active Active
- 2012-09-13 WO PCT/US2012/055244 patent/WO2013040265A1/en not_active Ceased
- 2012-09-13 JP JP2014530805A patent/JP6038155B2/ja active Active
- 2012-09-13 AU AU2012308526A patent/AU2012308526B2/en active Active
- 2012-09-13 CA CA2848567A patent/CA2848567C/en active Active
- 2012-09-13 MX MX2014003020A patent/MX369385B/es active IP Right Grant
- 2012-09-13 CN CN201280055665.1A patent/CN104080458B/zh active Active
- 2012-09-13 BR BR112014005914-4A patent/BR112014005914B1/pt active IP Right Grant
- 2012-09-13 KR KR1020147009769A patent/KR101966293B1/ko active Active
- 2012-09-13 US US13/615,324 patent/US9161942B2/en active Active
- 2012-09-13 AU AU2012308530A patent/AU2012308530B2/en active Active
-
2014
- 2014-03-13 IL IL231509A patent/IL231509B/en active IP Right Grant
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