CN104080458B - 用于组织创伤的愈合的产品 - Google Patents
用于组织创伤的愈合的产品 Download PDFInfo
- Publication number
- CN104080458B CN104080458B CN201280055665.1A CN201280055665A CN104080458B CN 104080458 B CN104080458 B CN 104080458B CN 201280055665 A CN201280055665 A CN 201280055665A CN 104080458 B CN104080458 B CN 104080458B
- Authority
- CN
- China
- Prior art keywords
- unsubstituted
- substituted
- alkyl
- group
- aminoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161534194P | 2011-09-13 | 2011-09-13 | |
| US61/534,194 | 2011-09-13 | ||
| PCT/US2012/055248 WO2013040269A1 (en) | 2011-09-13 | 2012-09-13 | Products for healing of tissue wounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104080458A CN104080458A (zh) | 2014-10-01 |
| CN104080458B true CN104080458B (zh) | 2020-06-02 |
Family
ID=47071446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280055665.1A Active CN104080458B (zh) | 2011-09-13 | 2012-09-13 | 用于组织创伤的愈合的产品 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9161942B2 (enExample) |
| EP (1) | EP2760454B1 (enExample) |
| JP (1) | JP6038155B2 (enExample) |
| KR (1) | KR101966293B1 (enExample) |
| CN (1) | CN104080458B (enExample) |
| AU (2) | AU2012308526B2 (enExample) |
| BR (1) | BR112014005914B1 (enExample) |
| CA (1) | CA2848567C (enExample) |
| IL (1) | IL231509B (enExample) |
| MX (1) | MX369385B (enExample) |
| RU (1) | RU2652308C2 (enExample) |
| WO (2) | WO2013040269A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010036427A1 (en) | 2008-06-17 | 2010-04-01 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| US10676501B2 (en) | 2011-07-20 | 2020-06-09 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
| US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
| US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
| CN104080459B (zh) | 2011-09-13 | 2018-07-03 | 布莱阿姆青年大学 | 用于治疗骨疾病和断骨的组合物 |
| US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
| NZ626144A (en) | 2011-12-21 | 2016-05-27 | Univ Brigham Young | Oral care compositions |
| US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
| CA2872399C (en) * | 2012-05-02 | 2021-01-12 | Brigham Young University | Ceragenin particulate materials and methods for making same |
| CA2888259C (en) | 2012-10-17 | 2019-05-28 | Brigham Young University | Treatment and prevention of mastitis |
| JP6294352B2 (ja) | 2013-01-07 | 2018-03-14 | ブリガム・ヤング・ユニバーシティBrigham Young University | 細胞増殖を減少させ、ある特定の疾患を治療する方法 |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| CN110420211A (zh) | 2013-03-15 | 2019-11-08 | 布莱阿姆青年大学 | 治疗炎症、自身免疫性疾病和疼痛的方法 |
| US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
| US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) * | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| CA2844321C (en) | 2014-02-27 | 2021-03-16 | Brigham Young University | Cationic steroidal antimicrobial compounds |
| US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
| US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
| US9931350B2 (en) * | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
| US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
| US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
| US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
| US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
| US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
| CA2991726C (en) * | 2015-04-22 | 2022-07-19 | Brigham Young University | Cationic steroidal antimicrobial salts |
| CN108348484B (zh) * | 2015-04-22 | 2021-12-17 | 布莱阿姆青年大学 | 阳离子甾体抗微生物盐 |
| WO2016172553A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| WO2016172543A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| US9434759B1 (en) * | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US20170080128A1 (en) * | 2015-09-21 | 2017-03-23 | Brigham Young University | Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies |
| US10226550B2 (en) * | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| KR101792535B1 (ko) | 2017-09-27 | 2017-11-02 | 오상자이엘 주식회사 | 화상 치료용 키트 |
| US12186328B2 (en) * | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070190066A1 (en) * | 2006-02-01 | 2007-08-16 | Savage Paul B | Cationic Steroid Antimicrobial Compositions and Methods of Use |
Family Cites Families (65)
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| US428800A (en) * | 1890-05-27 | miller | ||
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| US4842593A (en) | 1987-10-09 | 1989-06-27 | The Procter & Gamble Company | Disposable absorbent articles for incontinent individuals |
| US4865855A (en) | 1988-01-11 | 1989-09-12 | Kimberly-Clark Corporation | Antimicrobial absorbent food pad |
| US4990338A (en) | 1988-05-09 | 1991-02-05 | Dow Corning Corporation | Antimicrobial superabsorbent compositions and methods |
| US5356630A (en) | 1989-02-22 | 1994-10-18 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
| US4972848A (en) | 1989-08-23 | 1990-11-27 | Medtronic, Inc. | Medical electrical lead with polymeric monolithic controlled release device and method of manufacture |
| GB9020075D0 (en) | 1990-09-14 | 1990-10-24 | Filler Aaron G | Contrast agents for magnetic resonance imaging of axonal transport |
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| US6673771B1 (en) | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
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| JP5052730B2 (ja) | 2000-08-15 | 2012-10-17 | ブリガム ヤング ユニバーシティ | ステロイド由来抗生物質 |
| US6514556B2 (en) | 2000-12-15 | 2003-02-04 | Ecolab Inc. | Method and composition for washing poultry during processing |
| DE60236520D1 (de) * | 2001-08-16 | 2010-07-08 | Univ Pennsylvania | Synthese und verwendung von reagenzien für die verbesserte dna-lipofektion und/oder prodrug- und arzneimitteltherapien mit langsamer freisetzung |
| US9056048B2 (en) * | 2001-08-16 | 2015-06-16 | The Trustees Of The University Of Pennsylvania | Synthesis and use of cationic steroids for anti-inflammatory drug therapy |
| US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| DE10218147B4 (de) | 2002-04-23 | 2005-12-22 | Stockhausen Gmbh | Wasserabsorbierende, die Zersetzung von Körperflüssigkeiten verzögernde Polymerteilchen, deren Herstellung und Verwendung |
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| US7854941B2 (en) | 2007-02-12 | 2010-12-21 | The University Of Southern Mississippi | Method of attaching drug compounds to non-reactive polymer surfaces |
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| US20090068122A1 (en) | 2007-09-06 | 2009-03-12 | Shira Pilch | Dentifrice Compositions for Treating Xerostomia |
| WO2009079066A2 (en) | 2007-09-26 | 2009-06-25 | Aparna Biosciences | Therapeutic and vaccine polyelectrolyte nanoparticle compositions |
| WO2010036427A1 (en) | 2008-06-17 | 2010-04-01 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| US20090324517A1 (en) | 2008-06-30 | 2009-12-31 | Dan Kline | Halitosis treatment |
| CN102480969A (zh) * | 2009-07-09 | 2012-05-30 | 科锐医疗有限公司 | 伤口愈合和瘢痕调制方法 |
| US8623416B2 (en) | 2009-11-25 | 2014-01-07 | Michael Zasloff | Formulations comprising aminosterols |
| US8530002B1 (en) * | 2010-01-07 | 2013-09-10 | Sandia Corporation | Methods for attaching polymerizable ceragenins to water treatment membranes using silane linkages |
| EP2542245A4 (en) | 2010-03-04 | 2013-08-14 | Univ Pennsylvania | ANTIMICROBIAL CATIONIC STEROIDS AND METHOD FOR THEIR USE |
| US8871716B2 (en) * | 2010-10-08 | 2014-10-28 | Korea Advanced Institute Of Science And Technology | Use of antimicrobial peptides in regeneration of skin cells |
| RU2576459C2 (ru) | 2010-11-03 | 2016-03-10 | Брайем Янг Юниверсити | Устойчивые при хранении антимикробные композиции, включающие церагениновые соединения, и способы их применения |
| CN102172356B (zh) * | 2011-03-03 | 2013-04-03 | 山东农业大学 | 牛磺鹅去氧胆酸在制备防治骨质疏松的药物中的应用 |
| US8810380B2 (en) | 2011-07-01 | 2014-08-19 | Gerald F. Leitz | Golf scoring management system |
| US10676501B2 (en) | 2011-07-20 | 2020-06-09 | Brigham Young University | Hydrogel materials incorporating eluting ceragenin compound |
| WO2013029059A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
| US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
| WO2013029055A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Incorporation of particulate ceragenins in polymers |
| NZ626144A (en) | 2011-12-21 | 2016-05-27 | Univ Brigham Young | Oral care compositions |
| EP2819531B1 (en) | 2012-03-01 | 2016-01-20 | Brigham Young University | Anti-microbial food processing compositions including ceragenin compounds and methods of use |
| US20130280391A1 (en) | 2012-04-24 | 2013-10-24 | Brigham Young University | Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products |
| CA2888259C (en) | 2012-10-17 | 2019-05-28 | Brigham Young University | Treatment and prevention of mastitis |
| JP6294352B2 (ja) | 2013-01-07 | 2018-03-14 | ブリガム・ヤング・ユニバーシティBrigham Young University | 細胞増殖を減少させ、ある特定の疾患を治療する方法 |
| CN110420211A (zh) | 2013-03-15 | 2019-11-08 | 布莱阿姆青年大学 | 治疗炎症、自身免疫性疾病和疼痛的方法 |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
-
2012
- 2012-09-13 WO PCT/US2012/055248 patent/WO2013040269A1/en not_active Ceased
- 2012-09-13 AU AU2012308526A patent/AU2012308526B2/en active Active
- 2012-09-13 WO PCT/US2012/055244 patent/WO2013040265A1/en not_active Ceased
- 2012-09-13 MX MX2014003020A patent/MX369385B/es active IP Right Grant
- 2012-09-13 KR KR1020147009769A patent/KR101966293B1/ko active Active
- 2012-09-13 BR BR112014005914-4A patent/BR112014005914B1/pt active IP Right Grant
- 2012-09-13 RU RU2014112784A patent/RU2652308C2/ru active
- 2012-09-13 JP JP2014530805A patent/JP6038155B2/ja active Active
- 2012-09-13 US US13/615,324 patent/US9161942B2/en active Active
- 2012-09-13 CN CN201280055665.1A patent/CN104080458B/zh active Active
- 2012-09-13 AU AU2012308530A patent/AU2012308530B2/en active Active
- 2012-09-13 EP EP12806192.6A patent/EP2760454B1/en active Active
- 2012-09-13 CA CA2848567A patent/CA2848567C/en active Active
-
2014
- 2014-03-13 IL IL231509A patent/IL231509B/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070190066A1 (en) * | 2006-02-01 | 2007-08-16 | Savage Paul B | Cationic Steroid Antimicrobial Compositions and Methods of Use |
Also Published As
| Publication number | Publication date |
|---|---|
| US9161942B2 (en) | 2015-10-20 |
| AU2012308530A1 (en) | 2014-04-03 |
| IL231509A0 (en) | 2014-04-30 |
| RU2652308C2 (ru) | 2018-04-25 |
| AU2012308526B2 (en) | 2016-04-21 |
| BR112014005914A2 (pt) | 2017-06-13 |
| JP6038155B2 (ja) | 2016-12-07 |
| CN104080458A (zh) | 2014-10-01 |
| KR20140075729A (ko) | 2014-06-19 |
| AU2012308530B2 (en) | 2016-04-21 |
| CA2848567A1 (en) | 2013-03-21 |
| EP2760454B1 (en) | 2018-08-29 |
| WO2013040269A1 (en) | 2013-03-21 |
| MX2014003020A (es) | 2014-10-14 |
| RU2014112784A (ru) | 2015-10-20 |
| US20130243823A1 (en) | 2013-09-19 |
| MX369385B (es) | 2019-11-07 |
| CA2848567C (en) | 2020-03-24 |
| WO2013040265A1 (en) | 2013-03-21 |
| EP2760454A1 (en) | 2014-08-06 |
| AU2012308526A1 (en) | 2014-04-03 |
| IL231509B (en) | 2019-02-28 |
| KR101966293B1 (ko) | 2019-04-08 |
| BR112014005914B1 (pt) | 2021-11-09 |
| JP2014530192A (ja) | 2014-11-17 |
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Legal Events
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |