JP2014530191A5 - - Google Patents
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- JP2014530191A5 JP2014530191A5 JP2014530804A JP2014530804A JP2014530191A5 JP 2014530191 A5 JP2014530191 A5 JP 2014530191A5 JP 2014530804 A JP2014530804 A JP 2014530804A JP 2014530804 A JP2014530804 A JP 2014530804A JP 2014530191 A5 JP2014530191 A5 JP 2014530191A5
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- Japan
- Prior art keywords
- unsubstituted
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- alkyl
- group
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000004103 aminoalkyl group Chemical group 0.000 claims 9
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000005123 aminoalkylcarboxy group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 4
- 125000005416 guanidinoalkyloxy group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000005096 aminoalkylaminocarbonyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 239000007943 implant Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000005128 aryl amino alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- -1 C-carboxyalkyl Chemical group 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 125000005197 alkyl carbonyloxy alkyl group Chemical group 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 230000002439 hemostatic effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 235000012431 wafers Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161534185P | 2011-09-13 | 2011-09-13 | |
| US61/534,185 | 2011-09-13 | ||
| PCT/US2012/055244 WO2013040265A1 (en) | 2011-09-13 | 2012-09-13 | Compositions for treating bone diseases and broken bones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530191A JP2014530191A (ja) | 2014-11-17 |
| JP2014530191A5 true JP2014530191A5 (enExample) | 2015-07-23 |
| JP6038154B2 JP6038154B2 (ja) | 2016-12-07 |
Family
ID=49157862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530804A Active JP6038154B2 (ja) | 2011-09-13 | 2012-09-13 | 骨疾患および破断骨治療のための組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9155746B2 (enExample) |
| EP (1) | EP2755661A1 (enExample) |
| JP (1) | JP6038154B2 (enExample) |
| CN (1) | CN104080459B (enExample) |
| CA (1) | CA2852989C (enExample) |
| IL (1) | IL231510B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2728135T3 (es) | 2011-07-20 | 2019-10-22 | Univ Brigham Young | Materiales de hidrogel que incorporan un compuesto de elución de ceragenina |
| US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
| US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
| US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
| EP2908826A1 (en) | 2012-10-17 | 2015-08-26 | Brigham Young University | Treatment and prevention of mastitis |
| EP2941253B1 (en) | 2013-01-07 | 2021-08-11 | Brigham Young University | Cationic steroid antimicrobial agents for use in treating cancer |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| KR102282183B1 (ko) | 2013-03-15 | 2021-07-26 | 브라이엄 영 유니버시티 | 염증, 자가면역 장애 및 통증의 치료 방법 |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
| US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| US9931350B2 (en) * | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
| US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
| US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
| US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
| US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
| US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
| DE102015100806A1 (de) * | 2015-01-20 | 2016-07-21 | Antonis Alexakis | Biokompatibles Formteil |
| WO2016172543A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| US9527883B2 (en) | 2015-04-22 | 2016-12-27 | Brigham Young University | Methods for the synthesis of ceragenins |
| US9434759B1 (en) * | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| US20170080128A1 (en) * | 2015-09-21 | 2017-03-23 | Brigham Young University | Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies |
| US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| US12186328B2 (en) * | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
| CA3145403A1 (en) * | 2019-07-24 | 2021-01-28 | Paul B. Savage | Bone-binding compounds |
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| US4661341A (en) | 1984-10-30 | 1987-04-28 | The Procter & Gamble Company | Oral compositions |
| US4842593A (en) | 1987-10-09 | 1989-06-27 | The Procter & Gamble Company | Disposable absorbent articles for incontinent individuals |
| US4865855A (en) | 1988-01-11 | 1989-09-12 | Kimberly-Clark Corporation | Antimicrobial absorbent food pad |
| US4990338A (en) | 1988-05-09 | 1991-02-05 | Dow Corning Corporation | Antimicrobial superabsorbent compositions and methods |
| US5356630A (en) | 1989-02-22 | 1994-10-18 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
| US4972848A (en) | 1989-08-23 | 1990-11-27 | Medtronic, Inc. | Medical electrical lead with polymeric monolithic controlled release device and method of manufacture |
| GB9020075D0 (en) | 1990-09-14 | 1990-10-24 | Filler Aaron G | Contrast agents for magnetic resonance imaging of axonal transport |
| US5286479A (en) | 1991-12-10 | 1994-02-15 | The Dow Chemical Company | Oral compositions for suppressing mouth odors |
| NZ263002A (en) | 1993-03-12 | 1996-12-20 | Upjohn Co | Crystalline ceftiofur {namely: 7-[2-(2-amino-1,3-thiazol-4-yl)- 2-methoxyimino)acetamido]-3-[(fur-2-ylcarbonyl)thiomethyl]- 3-cephem-4-carboxylic acid} in free acid form |
| ES2164110T3 (es) | 1994-03-10 | 2002-02-16 | Magainin Pharma | Usos farmaceuticos de derivados de esteroides. |
| US6132765A (en) | 1996-04-12 | 2000-10-17 | Uroteq Inc. | Drug delivery via therapeutic hydrogels |
| JP2002505292A (ja) | 1998-03-06 | 2002-02-19 | ブリガム ヤング ユニバーシティ | ステロイド由来抗生物質 |
| US6350738B1 (en) | 1998-03-06 | 2002-02-26 | Brigham Young University | Steroid derived antibiotics |
| US6767904B2 (en) | 1998-03-06 | 2004-07-27 | Bringham Young University | Steroid derived antibiotics |
| US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
| US6673771B1 (en) * | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
| US6551608B2 (en) | 2000-03-06 | 2003-04-22 | Porex Technologies Corporation | Porous plastic media with antiviral or antimicrobial properties and processes for making the same |
| JP5052730B2 (ja) | 2000-08-15 | 2012-10-17 | ブリガム ヤング ユニバーシティ | ステロイド由来抗生物質 |
| US6514556B2 (en) | 2000-12-15 | 2003-02-04 | Ecolab Inc. | Method and composition for washing poultry during processing |
| WO2003015757A1 (en) | 2001-08-16 | 2003-02-27 | The Trustees Of The University Of Pennsylvania | Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies |
| US9056048B2 (en) * | 2001-08-16 | 2015-06-16 | The Trustees Of The University Of Pennsylvania | Synthesis and use of cationic steroids for anti-inflammatory drug therapy |
| US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| DE10218147B4 (de) | 2002-04-23 | 2005-12-22 | Stockhausen Gmbh | Wasserabsorbierende, die Zersetzung von Körperflüssigkeiten verzögernde Polymerteilchen, deren Herstellung und Verwendung |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
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| US7754705B2 (en) * | 2006-02-01 | 2010-07-13 | Brigham Young University | Cationic steroid antimicrobial compositions and methods of use |
| WO2007089906A2 (en) | 2006-02-01 | 2007-08-09 | Brigham Young University | Cationic steroid antimicrobial compositions for treating or preventing herpes infections |
| WO2007089903A2 (en) | 2006-02-01 | 2007-08-09 | Brigham Young University | Cationic steroid microbial compositions for treating or preventing influenza infections |
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| EP2303026B1 (en) | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| US20090324517A1 (en) | 2008-06-30 | 2009-12-31 | Dan Kline | Halitosis treatment |
| US8623416B2 (en) | 2009-11-25 | 2014-01-07 | Michael Zasloff | Formulations comprising aminosterols |
| US8557031B1 (en) | 2010-01-07 | 2013-10-15 | Sandia Corporation | Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages |
| EP2542245A4 (en) | 2010-03-04 | 2013-08-14 | Univ Pennsylvania | ANTIMICROBIAL CATIONIC STEROIDS AND METHOD FOR THEIR USE |
| US8871716B2 (en) | 2010-10-08 | 2014-10-28 | Korea Advanced Institute Of Science And Technology | Use of antimicrobial peptides in regeneration of skin cells |
| BR112013010976A2 (pt) | 2010-11-03 | 2016-07-12 | Univ Brigham Young | "artigos que incorporam polímero absorvente e composto ceragenin." |
| CN102172356B (zh) | 2011-03-03 | 2013-04-03 | 山东农业大学 | 牛磺鹅去氧胆酸在制备防治骨质疏松的药物中的应用 |
| ES2728135T3 (es) | 2011-07-20 | 2019-10-22 | Univ Brigham Young | Materiales de hidrogel que incorporan un compuesto de elución de ceragenina |
| WO2013029059A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
| US8932614B2 (en) | 2011-08-25 | 2015-01-13 | Paul B. Savage | Incorporation of particulate ceragenins in polymers |
| WO2013029055A1 (en) | 2011-08-25 | 2013-02-28 | Brigham Young University | Incorporation of particulate ceragenins in polymers |
| RU2652308C2 (ru) | 2011-09-13 | 2018-04-25 | Брайем Янг Юниверсити | Способы и продукты для заживления ран тканей |
| CN104379120A (zh) | 2011-12-21 | 2015-02-25 | 布莱阿姆青年大学 | 口腔护理组合物 |
| BR112014021505A2 (pt) | 2012-03-01 | 2017-07-18 | Univ Brigham Young | composições de processamento de alimentos antimicrobianas incluindo compostos de ceragenina e métodos de uso |
| US20130280391A1 (en) | 2012-04-24 | 2013-10-24 | Brigham Young University | Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products |
| EP2908826A1 (en) | 2012-10-17 | 2015-08-26 | Brigham Young University | Treatment and prevention of mastitis |
| EP2941253B1 (en) | 2013-01-07 | 2021-08-11 | Brigham Young University | Cationic steroid antimicrobial agents for use in treating cancer |
| KR102282183B1 (ko) | 2013-03-15 | 2021-07-26 | 브라이엄 영 유니버시티 | 염증, 자가면역 장애 및 통증의 치료 방법 |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
-
2012
- 2012-09-13 JP JP2014530804A patent/JP6038154B2/ja active Active
- 2012-09-13 EP EP12775878.7A patent/EP2755661A1/en active Pending
- 2012-09-13 CA CA2852989A patent/CA2852989C/en active Active
- 2012-09-13 CN CN201280055680.6A patent/CN104080459B/zh active Active
- 2012-09-13 US US13/615,244 patent/US9155746B2/en active Active
-
2014
- 2014-03-13 IL IL231510A patent/IL231510B/en active IP Right Grant
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