CN104080459B - 用于治疗骨疾病和断骨的组合物 - Google Patents

用于治疗骨疾病和断骨的组合物 Download PDF

Info

Publication number
CN104080459B
CN104080459B CN201280055680.6A CN201280055680A CN104080459B CN 104080459 B CN104080459 B CN 104080459B CN 201280055680 A CN201280055680 A CN 201280055680A CN 104080459 B CN104080459 B CN 104080459B
Authority
CN
China
Prior art keywords
unsubstituted
alkyl
substituted
group
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280055680.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN104080459A (zh
Inventor
卡尔·吉尼伯格
保罗·B·萨维奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
Original Assignee
Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham Young University filed Critical Brigham Young University
Priority claimed from PCT/US2012/055244 external-priority patent/WO2013040265A1/en
Publication of CN104080459A publication Critical patent/CN104080459A/zh
Application granted granted Critical
Publication of CN104080459B publication Critical patent/CN104080459B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280055680.6A 2011-09-13 2012-09-13 用于治疗骨疾病和断骨的组合物 Active CN104080459B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161534185P 2011-09-13 2011-09-13
US61/534,185 2011-09-13
PCT/US2012/055244 WO2013040265A1 (en) 2011-09-13 2012-09-13 Compositions for treating bone diseases and broken bones

Publications (2)

Publication Number Publication Date
CN104080459A CN104080459A (zh) 2014-10-01
CN104080459B true CN104080459B (zh) 2018-07-03

Family

ID=49157862

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280055680.6A Active CN104080459B (zh) 2011-09-13 2012-09-13 用于治疗骨疾病和断骨的组合物

Country Status (6)

Country Link
US (1) US9155746B2 (enExample)
EP (1) EP2755661B1 (enExample)
JP (1) JP6038154B2 (enExample)
CN (1) CN104080459B (enExample)
CA (1) CA2852989C (enExample)
IL (1) IL231510B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140063616A (ko) 2011-07-20 2014-05-27 브라이엄 영 유니버시티 소수성 세라게닌 화합물 및 이를 포함하는 기구
US9603859B2 (en) 2011-09-13 2017-03-28 Brigham Young University Methods and products for increasing the rate of healing of tissue wounds
US9694019B2 (en) 2011-09-13 2017-07-04 Brigham Young University Compositions and methods for treating bone diseases and broken bones
US9533063B1 (en) 2012-03-01 2017-01-03 Brigham Young University Aerosols incorporating ceragenin compounds and methods of use thereof
CA2888259C (en) 2012-10-17 2019-05-28 Brigham Young University Treatment and prevention of mastitis
AU2014203882B2 (en) 2013-01-07 2016-06-23 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
BR112015023747B1 (pt) 2013-03-15 2023-04-18 Brigham Young University Uso de um composto antimicrobiano catiônico esteroide (csa) para a preparação de uma composição para tratar, reduzir, ou prevenir inflamação aguda ou crônica e/ou dor aguda ou crônica associada com uma doença ou um sintoma de doença
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
US9931350B2 (en) * 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US9686966B2 (en) 2014-04-30 2017-06-27 Brigham Young University Methods and apparatus for cleaning or disinfecting a water delivery system
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
DE102015100806A1 (de) * 2015-01-20 2016-07-21 Antonis Alexakis Biokompatibles Formteil
US9527883B2 (en) 2015-04-22 2016-12-27 Brigham Young University Methods for the synthesis of ceragenins
US10370403B2 (en) 2015-04-22 2019-08-06 Brigham Young University Methods for the synthesis of ceragenins
US9434759B1 (en) * 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
US20170080128A1 (en) * 2015-09-21 2017-03-23 Brigham Young University Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
US12186328B2 (en) * 2019-05-23 2025-01-07 Brigham Young University Use of CSA compounds to stimulate stem cells and hair growth
EP4003201A4 (en) * 2019-07-24 2023-08-23 Brigham Young University BONE BONDING CONNECTIONS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062562A1 (en) * 2008-10-27 2010-06-03 The Trustees Of The University Of Pennsylvania Synthesis and use of cationic steroids for anti-inflammatory drug therapy
US7754705B2 (en) * 2006-02-01 2010-07-13 Brigham Young University Cationic steroid antimicrobial compositions and methods of use
CN102172356A (zh) * 2011-03-03 2011-09-07 山东农业大学 牛磺鹅去氧胆酸在防治骨质疏松上的应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661341A (en) 1984-10-30 1987-04-28 The Procter & Gamble Company Oral compositions
US4842593A (en) 1987-10-09 1989-06-27 The Procter & Gamble Company Disposable absorbent articles for incontinent individuals
US4865855A (en) 1988-01-11 1989-09-12 Kimberly-Clark Corporation Antimicrobial absorbent food pad
US4990338A (en) 1988-05-09 1991-02-05 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US4972848A (en) 1989-08-23 1990-11-27 Medtronic, Inc. Medical electrical lead with polymeric monolithic controlled release device and method of manufacture
GB9020075D0 (en) 1990-09-14 1990-10-24 Filler Aaron G Contrast agents for magnetic resonance imaging of axonal transport
US5286479A (en) 1991-12-10 1994-02-15 The Dow Chemical Company Oral compositions for suppressing mouth odors
ATE202109T1 (de) 1993-03-12 2001-06-15 Upjohn Co Kristallines ceftiofur (freie säure)
DK0749437T3 (da) 1994-03-10 2002-03-04 Magainin Pharma Farmaceutisk anvendelse af steroidderivater
US6132765A (en) 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US6767904B2 (en) 1998-03-06 2004-07-27 Bringham Young University Steroid derived antibiotics
ATE269086T1 (de) 1998-03-06 2004-07-15 Univ Brigham Young Antibiotische steroidderivate
US6350738B1 (en) 1998-03-06 2002-02-26 Brigham Young University Steroid derived antibiotics
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US6673771B1 (en) * 1999-07-28 2004-01-06 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity
US6551608B2 (en) 2000-03-06 2003-04-22 Porex Technologies Corporation Porous plastic media with antiviral or antimicrobial properties and processes for making the same
CA2419801C (en) 2000-08-15 2010-08-10 Brigham Young University Steroid derived antibiotics
US6514556B2 (en) 2000-12-15 2003-02-04 Ecolab Inc. Method and composition for washing poultry during processing
WO2003015757A1 (en) 2001-08-16 2003-02-27 The Trustees Of The University Of Pennsylvania Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
DE10218147B4 (de) 2002-04-23 2005-12-22 Stockhausen Gmbh Wasserabsorbierende, die Zersetzung von Körperflüssigkeiten verzögernde Polymerteilchen, deren Herstellung und Verwendung
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7659061B2 (en) 2002-11-19 2010-02-09 Pharmacia & Upjohn Company Pharmaceutical compositions having a modified vehicle
US7282214B2 (en) 2002-12-19 2007-10-16 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
WO2004112852A1 (en) 2003-06-23 2004-12-29 Beiersdorf Ag Antimicrobial wounddressing
GB0318901D0 (en) 2003-08-12 2003-09-17 Univ Bath Improvements in or relating to bone substitute material
US20050267051A1 (en) 2003-12-19 2005-12-01 Lee Henry J Antineoplastic and anti-HIV conjugates of steroid acid and nucleosides
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20060062774A1 (en) 2004-09-21 2006-03-23 The Procter & Gamble Company Compositions for maintaining and restoring normal urogenital flora
WO2007089907A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid antimicrobial compositions and methods of use
WO2007089903A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid microbial compositions for treating or preventing influenza infections
WO2007089906A2 (en) 2006-02-01 2007-08-09 Brigham Young University Cationic steroid antimicrobial compositions for treating or preventing herpes infections
WO2007134176A2 (en) 2006-05-10 2007-11-22 Microban Products Company Antimicrobial food pad
US7858000B2 (en) 2006-06-08 2010-12-28 Novartis Ag Method of making silicone hydrogel contact lenses
WO2008006083A2 (en) 2006-07-07 2008-01-10 Surmodics, Inc. Beaded wound spacer device
WO2008038965A1 (en) 2006-09-26 2008-04-03 Kyungpook National University Industry-Academic Cooperation Foundation 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient
US7854941B2 (en) 2007-02-12 2010-12-21 The University Of Southern Mississippi Method of attaching drug compounds to non-reactive polymer surfaces
US20090016973A1 (en) 2007-07-09 2009-01-15 Micropure, Inc. Composition and Method for the Prevention of Oral Disease
US20090068122A1 (en) 2007-09-06 2009-03-12 Shira Pilch Dentifrice Compositions for Treating Xerostomia
US9095568B2 (en) 2007-09-26 2015-08-04 Mark Berninger Therapeutic and vaccine polyelectrolyte nanoparticle compositions
WO2010036427A1 (en) 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
US20090324517A1 (en) 2008-06-30 2009-12-31 Dan Kline Halitosis treatment
WO2011066260A2 (en) 2009-11-25 2011-06-03 Michael Zasloff Formulations comprising aminosterols
US8557031B1 (en) 2010-01-07 2013-10-15 Sandia Corporation Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages
US9180132B2 (en) 2010-03-04 2015-11-10 The Trustees Of The University Of Pennsylvania Antimicrobial cationic steroids and methods of use
KR101303299B1 (ko) 2010-10-08 2013-09-03 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 항균 펩타이드의 피부 세포 재생 촉진제로서의 신규한 용도
US8784857B2 (en) 2010-11-03 2014-07-22 Brigham Young University Articles incorporating absorbent polymer and ceragenin compound
KR20140063616A (ko) 2011-07-20 2014-05-27 브라이엄 영 유니버시티 소수성 세라게닌 화합물 및 이를 포함하는 기구
WO2013029059A1 (en) 2011-08-25 2013-02-28 Brigham Young University Medical devices incorporating ceragenin-containing composites
WO2013029055A1 (en) 2011-08-25 2013-02-28 Brigham Young University Incorporation of particulate ceragenins in polymers
US8932614B2 (en) 2011-08-25 2015-01-13 Paul B. Savage Incorporation of particulate ceragenins in polymers
BR112014005914B1 (pt) 2011-09-13 2021-11-09 Brigham Young University Produtos para cicatrização de feridas tecidulares
EP3449900A1 (en) 2011-12-21 2019-03-06 Brigham Young University Oral care compositions
WO2013131060A1 (en) 2012-03-01 2013-09-06 Brigham Young University Anti-microbial food processing compositions including ceragenin compounds and methods of use
US20130280391A1 (en) 2012-04-24 2013-10-24 Brigham Young University Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products
CA2888259C (en) 2012-10-17 2019-05-28 Brigham Young University Treatment and prevention of mastitis
AU2014203882B2 (en) 2013-01-07 2016-06-23 Brigham Young University Methods for reducing cellular proliferation and treating certain diseases
BR112015023747B1 (pt) 2013-03-15 2023-04-18 Brigham Young University Uso de um composto antimicrobiano catiônico esteroide (csa) para a preparação de uma composição para tratar, reduzir, ou prevenir inflamação aguda ou crônica e/ou dor aguda ou crônica associada com uma doença ou um sintoma de doença
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7754705B2 (en) * 2006-02-01 2010-07-13 Brigham Young University Cationic steroid antimicrobial compositions and methods of use
WO2010062562A1 (en) * 2008-10-27 2010-06-03 The Trustees Of The University Of Pennsylvania Synthesis and use of cationic steroids for anti-inflammatory drug therapy
CN102172356A (zh) * 2011-03-03 2011-09-07 山东农业大学 牛磺鹅去氧胆酸在防治骨质疏松上的应用

Also Published As

Publication number Publication date
EP2755661B1 (en) 2026-08-05
US9155746B2 (en) 2015-10-13
IL231510B (en) 2019-02-28
JP2014530191A (ja) 2014-11-17
CN104080459A (zh) 2014-10-01
EP2755661A1 (en) 2014-07-23
CA2852989A1 (en) 2013-03-21
CA2852989C (en) 2021-06-29
US20130243842A1 (en) 2013-09-19
JP6038154B2 (ja) 2016-12-07
IL231510A0 (en) 2014-04-30

Similar Documents

Publication Publication Date Title
CN104080459A (zh) 用于治疗骨疾病和断骨的组合物
AU2012308526B2 (en) Compositions for treating bone diseases and broken bones
US9694019B2 (en) Compositions and methods for treating bone diseases and broken bones
JP7101413B2 (ja) 真菌感染症の治療方法
JP6518230B2 (ja) 炎症、自己免疫疾患、および疼痛を治療する方法
US11524015B2 (en) Methods for treating inflammation, autoimmune disorders and pain
US9931350B2 (en) Anti-infective and osteogenic compositions and methods of use
US10568893B2 (en) Methods for treating inflammation, autoimmune disorders and pain
JP2015517493A (ja) 新規オキシステロールアナログoxy149は、骨発生及びヘッジホッグシグナル伝達を誘導し、脂肪生成を阻害する
KR20120014251A (ko) 동종이식편의 접합을 개선하기 위한 생체활성 코팅 조성물 및 방법

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant