JP2014530009A - 異常細胞を標的とする多重特異性結合分子 - Google Patents

異常細胞を標的とする多重特異性結合分子 Download PDF

Info

Publication number
JP2014530009A
JP2014530009A JP2014533232A JP2014533232A JP2014530009A JP 2014530009 A JP2014530009 A JP 2014530009A JP 2014533232 A JP2014533232 A JP 2014533232A JP 2014533232 A JP2014533232 A JP 2014533232A JP 2014530009 A JP2014530009 A JP 2014530009A
Authority
JP
Japan
Prior art keywords
binding
proteinaceous
molecule
proteinaceous molecule
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014533232A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014530009A5 (OSRAM
Inventor
ラルフ アレキサンダー ウィレムセン，
ラルフ アレキサンダー ウィレムセン，
ヨーハン ルネ，
ヨーハン ルネ，
Original Assignee
エーピーオー‐ティー ビー．ヴイ．
エーピーオー‐ティー ビー．ヴイ．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エーピーオー‐ティー ビー．ヴイ．, エーピーオー‐ティー ビー．ヴイ． filed Critical エーピーオー‐ティー ビー．ヴイ．
Publication of JP2014530009A publication Critical patent/JP2014530009A/ja
Publication of JP2014530009A5 publication Critical patent/JP2014530009A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2014533232A 2011-09-29 2012-09-26 異常細胞を標的とする多重特異性結合分子 Pending JP2014530009A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161540920P 2011-09-29 2011-09-29
US61/540,920 2011-09-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017173519A Division JP2018046811A (ja) 2011-09-29 2017-09-08 異常細胞を標的とする多重特異性結合分子

Publications (2)

Publication Number Publication Date
JP2014530009A true JP2014530009A (ja) 2014-11-17
JP2014530009A5 JP2014530009A5 (OSRAM) 2017-01-19

Family

ID=47018432

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014533232A Pending JP2014530009A (ja) 2011-09-29 2012-09-26 異常細胞を標的とする多重特異性結合分子
JP2017173519A Pending JP2018046811A (ja) 2011-09-29 2017-09-08 異常細胞を標的とする多重特異性結合分子
JP2019211793A Pending JP2020058354A (ja) 2011-09-29 2019-11-22 異常細胞を標的とする多重特異性結合分子

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017173519A Pending JP2018046811A (ja) 2011-09-29 2017-09-08 異常細胞を標的とする多重特異性結合分子
JP2019211793A Pending JP2020058354A (ja) 2011-09-29 2019-11-22 異常細胞を標的とする多重特異性結合分子

Country Status (6)

Country Link
US (3) US11098115B2 (OSRAM)
EP (2) EP2760892A1 (OSRAM)
JP (3) JP2014530009A (OSRAM)
AU (3) AU2012316859A1 (OSRAM)
CA (1) CA2850291A1 (OSRAM)
WO (1) WO2013048243A1 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011353197B2 (en) * 2010-12-27 2017-04-20 Apo-T B.V. A cross linking polypeptide comprising an hexameric single chain antibody binding MHC-MAGE complex that induces apoptosis
US11098115B2 (en) 2011-09-29 2021-08-24 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
EP2802356A1 (en) 2012-01-13 2014-11-19 Apo-T B.V. Aberrant cell-restricted immunoglobulins provided with a toxic moiety
CA2877850A1 (en) * 2012-06-26 2014-01-03 Apo-T B.V. Binding molecules targeting pathogens
WO2016077720A1 (en) * 2014-11-14 2016-05-19 Protein One, Llc Binding agents and uses thereof
US9623118B2 (en) * 2015-09-01 2017-04-18 Immunwork Inc. Multi-arm linker constructs for treating pathological blood clots
EP3402519A4 (en) * 2016-01-13 2020-01-08 Compass Therapeutics LLC Multispecific immunomodulatory antigen-binding constructs
US20210238543A1 (en) * 2018-06-04 2021-08-05 Apo-T B.V. Methods and means for attracting immune effector cells to tumor cells
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
MX2022015872A (es) 2020-06-11 2023-05-16 Provention Bio Inc Metodos y composiciones para prevenir diabetes tipo 1.
EP4171620A4 (en) * 2020-06-26 2025-07-02 Allymab Inc LINK MODULATOR
EP4284835A4 (en) * 2021-01-29 2025-05-28 Chugai Seiyaku Kabushiki Kaisha Molecule specifically acting in a tissue where a cell death being observed
MX2023010541A (es) 2021-03-09 2023-11-24 Cdr Life Ag Proteinas de union al antigeno del peptido del mhc mage-a4.
US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
JP2024516699A (ja) 2021-05-05 2024-04-16 イマティクス バイオテクノロジーズ ゲーエムベーハー Ｂｍａ０３１抗原結合ポリペプチド
CA3264474A1 (en) 2022-09-14 2024-03-21 Cdr-Life Ag MAGE-A4 DOUBLE T LYMPHOCYTE ENGAGEMENT
WO2024081930A1 (en) * 2022-10-14 2024-04-18 Flagship Pioneering Innovations Vii, Llc Compositions and methods for targeted delivery of therapeutic agents
CN119529098B (zh) * 2025-01-22 2025-05-30 北京可瑞生物科技有限公司 对mage-a1具有特异性的结合分子和抗cd3的融合蛋白

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003525016A (ja) * 1998-02-19 2003-08-26 エクサイト セラピーズ， インコーポレイテッド リンパ球活性化を調節するための組成物および方法
JP2005501517A (ja) * 2001-04-11 2005-01-20 中国科学院遺▲傳▼学研究所 環状一本鎖三重特異性抗体
JP2005504524A (ja) * 2001-06-28 2005-02-17 ドマンティス リミテッド 二重特異性リガンドとその利用
JP2009515897A (ja) * 2005-11-10 2009-04-16 キュラジェン コーポレイション Ｔ細胞の免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法
JP2009524422A (ja) * 2006-01-25 2009-07-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム 結合分子３
JP2010535032A (ja) * 2007-07-31 2010-11-18 メディミューン，エルエルシー 多重特異性エピトープ結合性タンパク質およびその用途
JP2014505471A (ja) * 2010-12-27 2014-03-06 エーピーオー‐ティー ビー．ヴイ． アポトーシスを誘導する架橋ポリペプチド

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB601513A (en) 1946-02-06 1948-05-06 Koray Ltd Improvements in or relating to coated tissue especially paper and to coating compositions therefor
DE321017C (OSRAM) 1917-05-15 1920-05-11 Aloysius Petrus Van Leuven
US3687370A (en) 1971-01-18 1972-08-29 Instapak Corp Liquid mixing and dispensing apparatus
NL9001639A (nl) 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
PT1019420E (pt) 1995-05-09 2003-12-31 Kreatech Biotech Bv Metodos para a producao de ligandos baseados em platina para ligacao entre marcadores e moleculas bio-orgaicas na marcacao de moleculas bio-organicas com o fim de detectar substancias biologicas de interesse e conjuntos ("kits") de ensaios de diagnosticos
WO1998045304A1 (en) 1997-04-10 1998-10-15 Kreatech Biotechnology B.V. Trans-platinum compound, and diagnostic kit
SK286235B6 (sk) 1997-08-12 2008-06-06 Leadd B. V. Spôsob zisťovania transformačnej schopnosti látky, spôsob zisťovania predispozície buniek stať sa nádorovými bunkami, použitie nukleovej kyseliny a diagnostická súprava
DK1124568T3 (da) 1998-10-21 2008-01-02 Altor Bioscience Corp Polyspecifikke bindingsmolekyler og anvendelser deraf
IL127142A0 (en) 1998-11-19 1999-09-22 Yeda Res & Dev Immune cells having predefined biological specificity
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7527787B2 (en) 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
DE60229924D1 (de) 2001-03-30 2009-01-02 Leadd Bv Fusionsproteine zur spezifisichen behandlung von krebs und autoimmunkrankheiten
JP4049297B2 (ja) 2001-06-11 2008-02-20 株式会社ルネサステクノロジ 半導体記憶装置
GB0115841D0 (en) 2001-06-28 2001-08-22 Medical Res Council Ligand
US20100081792A1 (en) * 2001-06-28 2010-04-01 Smithkline Beecham Corporation Ligand
US7371849B2 (en) * 2001-09-13 2008-05-13 Institute For Antibodies Co., Ltd. Methods of constructing camel antibody libraries
WO2005063299A2 (en) 2003-12-24 2005-07-14 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
WO2003040722A1 (en) 2001-11-09 2003-05-15 Kreatech Biotechnology B.V. Means and methods for the detection of immunoglobulin capable of binding to mycobacterium antigen
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
WO2003070752A2 (en) 2002-02-20 2003-08-28 Dyax Corporation Mhc-peptide complex binding ligands
FR2837837B1 (fr) 2002-03-28 2006-09-29 Roussy Inst Gustave Epitopes peptidiques communs a des antigenes d'une meme famille multigenique
AU2003214721A1 (en) 2002-04-19 2003-11-03 Leadd B.V. Fragments of apoptin
EP2135879A3 (en) 2002-06-28 2010-06-23 Domantis Limited Ligand
US7820166B2 (en) * 2002-10-11 2010-10-26 Micromet Ag Potent T cell modulating molecules
US20060135418A1 (en) 2002-12-03 2006-06-22 Avidex Ltd. Receptors
EP3000886A1 (en) * 2003-03-19 2016-03-30 Amgen Fremont Inc. Antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen and uses thereof
US8784821B1 (en) * 2003-05-31 2014-07-22 Amgen Research (Munich) Gmbh Human-anti-human cd3 binding molecules
WO2004106381A1 (en) * 2003-05-31 2004-12-09 Micromet Ag Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
ES2296423B1 (es) * 2003-07-31 2009-03-16 Consejo Sup. Investig. Cientificas Construccion de adn para la produccion de proteinas de fusion dimericas y sus aplicaciones.
US7488793B2 (en) * 2003-09-22 2009-02-10 Ludwig Institute For Cancer Research Isolated peptide which binds to HLA-Cw*07 and uses thereof
ES2472690T3 (es) 2003-11-17 2014-07-02 Genentech, Inc. Anticuerpo contra CD22 para el tratamiento de tumores de origen hematopoy�tico
NZ547157A (en) 2003-12-10 2009-07-31 Medarex Inc Interferon Alpha Antibodies and their uses
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
US20050266425A1 (en) * 2003-12-31 2005-12-01 Vaccinex, Inc. Methods for producing and identifying multispecific antibodies
WO2005113595A2 (en) 2004-05-19 2005-12-01 Avidex Ltd High affinity ny-eso t cell receptor
CA2570458C (en) 2004-06-09 2014-05-20 Technion Research & Development Foundation Ltd. Antibodies for selective apoptosis of cells
EP1809669A2 (en) * 2004-10-01 2007-07-25 Avidex Ltd T-cell receptors containing a non-native disulfide interchain bond linked to therapeutic agents
EP1969005A1 (en) 2005-12-20 2008-09-17 Erasmus University Medical Center Rotterdam Apoptosis-inducing protein complexes and therapeutic use thereof
EP1981532A4 (en) * 2005-12-21 2010-06-30 Medimmune Llc EPHA2 MOLECULES AND USES THEREOF
AT503902B1 (de) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von immunglobulinen
CA2682093A1 (en) 2007-03-29 2008-10-09 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
US20100183615A1 (en) * 2007-04-03 2010-07-22 Micromet Ag Cross-species-specific bispecific binders
EP2281005B1 (en) 2008-04-03 2013-11-20 Vib Vzw Single domain antibodies capable of modulating bace1 activity
WO2009131435A1 (en) 2008-04-23 2009-10-29 Erasmus University Medical Center Rotterdam Linker containing bungarotoxin and a binding peptide
EP2297208A4 (en) 2008-06-03 2012-07-11 Abbott Lab DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES
US10981998B2 (en) * 2008-10-01 2021-04-20 Amgen Research (Munich) Gmbh Cross-species-specific single domain bispecific single chain antibody
US8927694B2 (en) 2008-11-18 2015-01-06 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
AU2009329501B2 (en) 2008-12-19 2015-11-26 Ablynx N.V. Genetic immunization for producing immunoglobulins against cell-associated antigens such as P2X7, CXCR7 or CXCR4
GB0908613D0 (en) * 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
PE20120540A1 (es) 2009-05-27 2012-05-09 Hoffmann La Roche Anticuerpos triespecificos o tetraespecificos
GB0911566D0 (en) * 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
CA2781539C (en) * 2009-11-23 2021-07-20 Amgen Inc. Monomeric antibody fc
EP2504358B1 (en) 2009-11-24 2016-10-19 ChronTech Pharma AB T cell receptors specific for immunodominant ctl epitopes of hcv
US20130131088A1 (en) 2010-01-13 2013-05-23 University Health Network Treating cancer with statins and compounds having dipyridamole activity
US20120123218A1 (en) 2010-11-16 2012-05-17 JPWaVe BV Methods and means for clinical investigations
US9821073B2 (en) 2010-12-27 2017-11-21 Apo-T B.V. Polypeptide that binds aberrant cells and induces apoptosis
US11098115B2 (en) 2011-09-29 2021-08-24 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
EP2802356A1 (en) 2012-01-13 2014-11-19 Apo-T B.V. Aberrant cell-restricted immunoglobulins provided with a toxic moiety
CA2877850A1 (en) 2012-06-26 2014-01-03 Apo-T B.V. Binding molecules targeting pathogens

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003525016A (ja) * 1998-02-19 2003-08-26 エクサイト セラピーズ， インコーポレイテッド リンパ球活性化を調節するための組成物および方法
JP2005501517A (ja) * 2001-04-11 2005-01-20 中国科学院遺▲傳▼学研究所 環状一本鎖三重特異性抗体
JP2005504524A (ja) * 2001-06-28 2005-02-17 ドマンティス リミテッド 二重特異性リガンドとその利用
JP2009515897A (ja) * 2005-11-10 2009-04-16 キュラジェン コーポレイション Ｔ細胞の免疫グロブリンドメインおよびムチンドメイン１（ｔｉｍ−１）抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法
JP2009524422A (ja) * 2006-01-25 2009-07-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム 結合分子３
JP2010535032A (ja) * 2007-07-31 2010-11-18 メディミューン，エルエルシー 多重特異性エピトープ結合性タンパク質およびその用途
JP2014505471A (ja) * 2010-12-27 2014-03-06 エーピーオー‐ティー ビー．ヴイ． アポトーシスを誘導する架橋ポリペプチド

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SEGAL, DM., ET AL.: "Introduction: bispecific antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 248, JPN6016025423, 2001, pages 1 - 6, ISSN: 0003349771 *

Also Published As

Publication number Publication date
AU2020200888A1 (en) 2020-02-27
US20250115662A1 (en) 2025-04-10
US20140227273A1 (en) 2014-08-14
JP2020058354A (ja) 2020-04-16
AU2017248425A1 (en) 2017-11-02
US11098115B2 (en) 2021-08-24
AU2012316859A1 (en) 2014-04-17
EP2760892A1 (en) 2014-08-06
JP2018046811A (ja) 2018-03-29
CA2850291A1 (en) 2013-04-04
EP3388451A1 (en) 2018-10-17
US20210355209A1 (en) 2021-11-18
WO2013048243A1 (en) 2013-04-04
AU2017248425B2 (en) 2019-11-14

Similar Documents

Publication Publication Date Title
US20250115662A1 (en) Multi-specific binding molecules targeting aberrant cells
US11578126B2 (en) Chimeric antigen receptor (CAR) comprising a CD19-binding domain
US12421292B2 (en) Anti-DLL3 chimeric antigen receptors and uses thereof
JP2022553464A (ja) 多重特異性抗体とその製造方法および使用
CN111699201B (zh) 抗pd-1/抗her2天然抗体结构的异源二聚双特异性抗体及其制备方法
WO2020017479A1 (ja) 抗ｇｐｃ３一本鎖抗体を含むｃａｒ
WO2022222910A1 (zh) 靶向gprc5d的抗体及其用途
WO2022247795A1 (zh) 靶向Claudin18.2的纳米抗体及其用途
WO2022111405A1 (zh) 靶向Claudin18.2的抗体及其用途
WO2024001470A1 (zh) 靶向b7-h3的抗体及其用途
JP7365654B2 (ja) 抗ｃｌｄｎ４－抗ｃｄ１３７二重特異性抗体
KR102829757B1 (ko) 인간화된 cd22에 특이적인 항체 및 이를 이용한 키메라 항원 수용체
KR102393776B1 (ko) Cd22에 특이적인 인간화 항체 및 이를 이용한 키메라 항원 수용체
EP4606823A1 (en) Synthetic t cell receptor antigen receptor specifically binding to lilrb4 and use thereof
US20250136695A1 (en) Development of novel pdl1 single-domain antibody
WO2024239143A1 (zh) 工程化细胞及其用途

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150901

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160623

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160705

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161005

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20161202

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170509