JP2014529612A5 - - Google Patents
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- Publication number
- JP2014529612A5 JP2014529612A5 JP2014527345A JP2014527345A JP2014529612A5 JP 2014529612 A5 JP2014529612 A5 JP 2014529612A5 JP 2014527345 A JP2014527345 A JP 2014527345A JP 2014527345 A JP2014527345 A JP 2014527345A JP 2014529612 A5 JP2014529612 A5 JP 2014529612A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonyl
- phenyl
- sulfonamide
- propane
- quinoxaline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528033P | 2011-08-26 | 2011-08-26 | |
| US61/528,033 | 2011-08-26 | ||
| US201161528151P | 2011-08-27 | 2011-08-27 | |
| US61/528,151 | 2011-08-27 | ||
| PCT/US2012/052390 WO2013032951A1 (en) | 2011-08-26 | 2012-08-24 | Certain chemical entities, compositions, and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016171707A Division JP6250116B2 (ja) | 2011-08-26 | 2016-09-02 | 特定の化学的実体、組成物、および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529612A JP2014529612A (ja) | 2014-11-13 |
| JP2014529612A5 true JP2014529612A5 (enExample) | 2015-10-15 |
| JP6002223B2 JP6002223B2 (ja) | 2016-10-05 |
Family
ID=47744575
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527345A Active JP6002223B2 (ja) | 2011-08-26 | 2012-08-24 | 特定の化学的実体、組成物、および方法 |
| JP2016171707A Active JP6250116B2 (ja) | 2011-08-26 | 2016-09-02 | 特定の化学的実体、組成物、および方法 |
| JP2017223745A Pending JP2018027981A (ja) | 2011-08-26 | 2017-11-21 | 特定の化学的実体、組成物、および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016171707A Active JP6250116B2 (ja) | 2011-08-26 | 2016-09-02 | 特定の化学的実体、組成物、および方法 |
| JP2017223745A Pending JP2018027981A (ja) | 2011-08-26 | 2017-11-21 | 特定の化学的実体、組成物、および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9295671B2 (enExample) |
| EP (1) | EP2747767B8 (enExample) |
| JP (3) | JP6002223B2 (enExample) |
| CN (2) | CN104053442B (enExample) |
| AU (1) | AU2012300317B2 (enExample) |
| CA (1) | CA2846574C (enExample) |
| ES (1) | ES2725790T3 (enExample) |
| IL (1) | IL231168B (enExample) |
| WO (1) | WO2013032951A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| ES2725790T3 (es) | 2011-08-26 | 2019-09-27 | Neupharma Inc | Algunas entidades químicas, composiciones, y métodos |
| WO2013040515A1 (en) | 2011-09-14 | 2013-03-21 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2013043935A1 (en) * | 2011-09-21 | 2013-03-28 | Neupharma, Inc. | Certain chemical entites, compositions, and methods |
| US9249111B2 (en) | 2011-09-30 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-RAF kinase inhibitors |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| WO2013112950A2 (en) | 2012-01-25 | 2013-08-01 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP2841428B1 (en) | 2012-04-24 | 2018-08-22 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| EP2897618B1 (en) | 2012-09-24 | 2021-11-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP2916838B1 (en) | 2012-11-12 | 2019-03-13 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2014159690A1 (en) | 2013-03-12 | 2014-10-02 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| AU2014308616B2 (en) | 2013-08-23 | 2018-12-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| TWI665195B (zh) * | 2013-09-13 | 2019-07-11 | 半導體能源研究所股份有限公司 | 二苯并[f,h]喹啉衍生物、二苯并[f,h]喹啉衍生物的合成方法、發光元件、發光裝置、電子裝置以及照明設備 |
| PL3424920T3 (pl) | 2013-10-17 | 2020-11-16 | Vertex Pharmaceuticals Incorporated | Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK |
| MX370099B (es) | 2014-03-26 | 2019-12-02 | Astex Therapeutics Ltd | Combinación que comprende un inhibidor de fgfr y un inhibidor de cmet para el tratamiento del cáncer. |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| KR102479696B1 (ko) | 2014-03-26 | 2022-12-22 | 아스텍스 테라퓨틱스 리미티드 | Fgfr 억제제 및 igf1r 억제제의 조합물 |
| SG11201700276QA (en) * | 2014-07-16 | 2017-02-27 | Dev Center Biotechnology | Quinoxaline compounds, method for preparing the same and use thereof |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| CA2996857C (en) | 2015-09-23 | 2024-05-21 | Janssen Pharmaceutica Nv | Quinoxaline, quinoline and quinazolinone derivative compounds for the treatment of cancer |
| KR102691777B1 (ko) | 2015-09-23 | 2024-08-02 | 얀센 파마슈티카 엔브이 | 비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도 |
| EP4006035B1 (en) * | 2016-08-15 | 2023-11-22 | Neupharma, Inc. | Quinazoline derivatives as tyrosine kinase inhibitors for the treatment of cancer |
| WO2018064092A1 (en) | 2016-09-27 | 2018-04-05 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors |
| WO2019014668A1 (en) * | 2017-07-14 | 2019-01-17 | Asana Biosciences, Llc | FORMULATIONS, METHODS, KIT AND DOSAGE FORMS FOR ENHANCED STABILITY OF ACTIVE PHARMACEUTICAL INGREDIENT |
| SG11202007143UA (en) | 2018-01-31 | 2020-08-28 | Heparegenix Gmbh | Protein kinase mkk4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US11465975B2 (en) * | 2018-02-08 | 2022-10-11 | Neupharma, Inc | Certain chemical entities, compositions, and methods |
| EP3810139A1 (en) | 2018-06-21 | 2021-04-28 | HepaRegeniX GmbH | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| AU2019303986B2 (en) | 2018-07-16 | 2024-02-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US10986841B2 (en) | 2018-11-06 | 2021-04-27 | The Clorox Company | Bleach compositions |
| JP7639008B2 (ja) | 2020-01-15 | 2025-03-04 | ヘパリジェニックス ゲーエムベーハー | 肝再生促進又は肝細胞死の抑制もしくは防止のためのプロテインキナーゼ阻害剤 |
| US11845916B2 (en) | 2020-06-24 | 2023-12-19 | The Clorox Company | Burstable sporicidal cleaning wipe system containing stabilized hypochlorite |
| TW202231279A (zh) * | 2020-12-02 | 2022-08-16 | 美商潤新生物公司 | 特定化學個體、組合物及方法 |
| US11728962B2 (en) | 2021-12-13 | 2023-08-15 | Xilinx, Inc. | Multi-phase clock signal generation circuitry |
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| US4464533A (en) | 1982-11-08 | 1984-08-07 | Ppg Industries, Inc. | Herbicidally active quinoline or quinoxaline benzoate derivatives |
| CA1250293A (en) | 1983-10-05 | 1989-02-21 | Dieter Jahn | Cyclohexenol derivatives and their use for controlling undesirable plant growth |
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| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| BR0112225A (pt) | 2000-07-07 | 2003-05-06 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| US20050010048A1 (en) | 2000-10-12 | 2005-01-13 | Linghang Zhuang | Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors |
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| ATE400274T1 (de) | 2001-04-10 | 2008-07-15 | Merck & Co Inc | Hemmstoffe der akt aktivität |
| WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
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| DE102004028862A1 (de) * | 2004-06-15 | 2005-12-29 | Merck Patent Gmbh | 3-Aminoindazole |
| JP2008516939A (ja) | 2004-10-15 | 2008-05-22 | アストラゼネカ アクチボラグ | 化学化合物 |
| SI1860098T1 (sl) * | 2005-03-16 | 2013-03-29 | Toyama Chemical Co., Ltd. | Nov derivat antranilne kisline ali sol le-tega |
| GB0509227D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
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| US20100130471A1 (en) * | 2007-04-05 | 2010-05-27 | Baldwin John J | Renin Inhibitors |
| BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
| EP2181987B9 (en) | 2007-08-23 | 2014-09-03 | Takeda Pharmaceutical Company Limited | 2-Carbonylaminobenzothiazoles and their use for the prophylaxis and treatment of cancer |
| EP2065381A1 (de) | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
| BRPI0821227A2 (pt) | 2007-12-19 | 2015-06-16 | Cancer Rec Tech Ltd | Composto, composição farmacêutica, método para preparar a mesma, uso de um composto, método para tratar uma doença ou distúrbio, para inibir função de raf e para inibir proliferação celular, inibir progressão do ciclo celular, promover apoptose, ou uma combinação de um ou mais dos mesmos |
| KR101713501B1 (ko) | 2008-03-17 | 2017-03-07 | 암비트 바이오사이언시즈 코포레이션 | Raf 키나아제 조절제로서의 퀴나졸린 유도체 및 그의 사용방법 |
| US20100197688A1 (en) | 2008-05-29 | 2010-08-05 | Nantermet Philippe G | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
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| CN101693723B (zh) * | 2009-10-22 | 2012-09-05 | 浙江大学 | 间三烷氧基苯基二烷基膦四氟硼酸盐及其合成和应用 |
| TW201124398A (en) | 2009-12-04 | 2011-07-16 | Daiichi Sankyo Co Ltd | Quinazoline derivatives |
| EP2576566B1 (en) | 2010-05-28 | 2015-10-28 | Merck Sharp & Dohme B.V. | Thieno(2,3b)pyrazine compounds as b-raf inhibitors |
| DE102010027215B4 (de) | 2010-07-15 | 2013-09-05 | Continental Automotive Gmbh | Verfahren und Steuergerät zum Steuern einer Brennkraftmaschine |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| EP2670763B1 (en) | 2011-02-02 | 2018-08-01 | Suzhou Neupharma Co., Ltd | Certain chemical entities, compositions, and methods |
| WO2012118492A1 (en) * | 2011-03-01 | 2012-09-07 | Array Biopharma Inc. | Heterocyclic sulfonamides as raf inhibitors |
| ES2725790T3 (es) | 2011-08-26 | 2019-09-27 | Neupharma Inc | Algunas entidades químicas, composiciones, y métodos |
| WO2013040515A1 (en) | 2011-09-14 | 2013-03-21 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| WO2013043935A1 (en) | 2011-09-21 | 2013-03-28 | Neupharma, Inc. | Certain chemical entites, compositions, and methods |
| US9249111B2 (en) | 2011-09-30 | 2016-02-02 | Neupharma, Inc. | Substituted quinoxalines as B-RAF kinase inhibitors |
| WO2013112950A2 (en) | 2012-01-25 | 2013-08-01 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP2897618B1 (en) | 2012-09-24 | 2021-11-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP2916838B1 (en) | 2012-11-12 | 2019-03-13 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
-
2012
- 2012-08-24 ES ES12828679T patent/ES2725790T3/es active Active
- 2012-08-24 WO PCT/US2012/052390 patent/WO2013032951A1/en not_active Ceased
- 2012-08-24 US US13/594,634 patent/US9295671B2/en active Active
- 2012-08-24 CA CA2846574A patent/CA2846574C/en active Active
- 2012-08-24 EP EP12828679.6A patent/EP2747767B8/en active Active
- 2012-08-24 JP JP2014527345A patent/JP6002223B2/ja active Active
- 2012-08-24 AU AU2012300317A patent/AU2012300317B2/en active Active
- 2012-08-24 CN CN201280052615.8A patent/CN104053442B/zh active Active
- 2012-08-24 CN CN201710422196.7A patent/CN107245056A/zh active Pending
-
2014
- 2014-02-26 IL IL231168A patent/IL231168B/en active IP Right Grant
-
2015
- 2015-12-17 US US14/973,492 patent/US9572808B2/en active Active
-
2016
- 2016-09-02 JP JP2016171707A patent/JP6250116B2/ja active Active
-
2017
- 2017-01-06 US US15/400,720 patent/US10137125B2/en active Active
- 2017-11-21 JP JP2017223745A patent/JP2018027981A/ja active Pending
-
2019
- 2019-04-04 US US16/375,466 patent/US10561652B2/en active Active
-
2020
- 2020-08-26 US US17/003,918 patent/US20200390763A1/en not_active Abandoned
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