JP2014528715A - ＣｏｔＨを用いたムコール菌症の免疫療法および診断法 - Google Patents

ＣｏｔＨを用いたムコール菌症の免疫療法および診断法 Download PDF

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JP2014528715A
JP2014528715A JP2014530916A JP2014530916A JP2014528715A JP 2014528715 A JP2014528715 A JP 2014528715A JP 2014530916 A JP2014530916 A JP 2014530916A JP 2014530916 A JP2014530916 A JP 2014530916A JP 2014528715 A JP2014528715 A JP 2014528715A
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coth
nucleic acid
polypeptide
seq
fungal
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JP2014528715A5 (cg-RX-API-DMAC10.html
Inventor
イブラヒム，アシュラフ，エス．
リュー，ミンフー
ゲブレマリアム，テクレギオルギス
フー，ユエ
エドワーズ，ジョン，イー．
フィラー，スコット
Original Assignee
ロサンゼルス バイオメディカル リサーチ インスティテュート アットハーバー− ユーシーエルエー メディカル センター
ロサンゼルス バイオメディカル リサーチ インスティテュート アット ハーバー− ユーシーエルエー メディカル センター
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Publication of JP2014528715A publication Critical patent/JP2014528715A/ja
Publication of JP2014528715A5 publication Critical patent/JP2014528715A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56961—Plant cells or fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Botany (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2014530916A 2011-09-15 2012-09-14 ＣｏｔＨを用いたムコール菌症の免疫療法および診断法 Pending JP2014528715A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535257P 2011-09-15 2011-09-15
US61/535,257 2011-09-15
PCT/US2012/055659 WO2013040517A2 (en) 2011-09-15 2012-09-14 IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING CotH

Publications (2)

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JP2014528715A true JP2014528715A (ja) 2014-10-30
JP2014528715A5 JP2014528715A5 (cg-RX-API-DMAC10.html) 2015-11-05

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JP2014530916A Pending JP2014528715A (ja) 2011-09-15 2012-09-14 ＣｏｔＨを用いたムコール菌症の免疫療法および診断法

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US (3) US9279002B2 (cg-RX-API-DMAC10.html)
EP (1) EP2755681B1 (cg-RX-API-DMAC10.html)
JP (1) JP2014528715A (cg-RX-API-DMAC10.html)
CN (1) CN103998057A (cg-RX-API-DMAC10.html)
AU (1) AU2012308240A1 (cg-RX-API-DMAC10.html)
CA (1) CA2848765A1 (cg-RX-API-DMAC10.html)
WO (1) WO2013040517A2 (cg-RX-API-DMAC10.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10465233B2 (en) * 2016-03-25 2019-11-05 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Time-resolved nucleic acid hybridization beacons
WO2017197386A1 (en) * 2016-05-13 2017-11-16 The Brigham And Women's Hospital, Inc. Volatile metabolite profiles for the diagnosis and treatment of mucorales fungi
US10877037B2 (en) 2016-11-21 2020-12-29 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Fungal toxins and methods related to the same
EP4334344A4 (en) * 2021-05-06 2025-07-02 Lundquist Inst For Biomedical Innovation At Harbor Ucla Medical Center COTH3 BINDING AGENTS AND THEIR USES
CN114324896A (zh) * 2021-12-31 2022-04-12 菲鹏生物股份有限公司 特异性结合mucoricin蛋白的试剂的用途和毛霉菌检测试剂盒
CN114568490B (zh) * 2022-04-01 2023-12-19 眉山职业技术学院(眉山技师学院) 雷帕霉素在抑制柑橘青霉菌生长中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050232947A1 (en) * 2002-03-07 2005-10-20 Cutting Simon M Bacterial spores
US20110059111A1 (en) * 2009-09-01 2011-03-10 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Mammalian receptors as targets for antibody and active vaccination therapy against mold infections
JP2011512817A (ja) * 2008-02-28 2011-04-28 スリーエム イノベイティブ プロパティズ カンパニー クロストリジウム・ディフィシル胞子に対する抗体及びその使用
US20110171267A1 (en) * 2001-08-27 2011-07-14 Bourinbaiar Aldar S Anti-fungal composition

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US4405712A (en) 1981-07-01 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services LTR-Vectors
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4493795A (en) 1983-10-17 1985-01-15 Syntex (U.S.A.) Inc. Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
JP2561478B2 (ja) 1986-07-22 1996-12-11 武田薬品工業株式会社 グリセリン誘導体
ATE110108T1 (de) 1987-12-11 1994-09-15 Whitehead Biomedical Inst Genetische modifizierung von endothelialen zellen.
JPH04507041A (ja) 1988-12-13 1992-12-10 アメリカ合衆国 遺伝工学により修飾された内皮細胞およびその利用方法
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
EP0549723A1 (en) 1990-09-21 1993-07-07 Chiron Corporation Packaging cells
DE69123981T3 (de) 1990-10-31 2006-06-14 Cell Genesys Inc Nützliche retrovirale vektoren für die gentherapie
ATE188740T1 (de) 1991-02-19 2000-01-15 Univ California Viruspartikel mit veraendertem wirtspektrum
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
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WO2008017483A2 (en) * 2006-08-09 2008-02-14 Dsm Ip Assets B.V. Spore surface displays of bioactive molecules
JP2012520878A (ja) * 2009-03-19 2012-09-10 ロサンゼルス ビオメドイカル リサーチ インストイトウテ アト ハルボル‐ユーシーエルエー メドイカル センテル ムコール菌症、及びその他の真菌疾患の治療のためのワクチン組成物、及び方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110171267A1 (en) * 2001-08-27 2011-07-14 Bourinbaiar Aldar S Anti-fungal composition
US20050232947A1 (en) * 2002-03-07 2005-10-20 Cutting Simon M Bacterial spores
JP2011512817A (ja) * 2008-02-28 2011-04-28 スリーエム イノベイティブ プロパティズ カンパニー クロストリジウム・ディフィシル胞子に対する抗体及びその使用
US20110059111A1 (en) * 2009-09-01 2011-03-10 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Mammalian receptors as targets for antibody and active vaccination therapy against mold infections

Also Published As

Publication number Publication date
CN103998057A (zh) 2014-08-20
WO2013040517A3 (en) 2013-07-18
WO2013040517A2 (en) 2013-03-21
EP2755681B1 (en) 2018-06-27
US9279002B2 (en) 2016-03-08
US20190194301A1 (en) 2019-06-27
US20160159887A1 (en) 2016-06-09
CA2848765A1 (en) 2013-03-21
US20130108642A1 (en) 2013-05-02
EP2755681A4 (en) 2015-05-13
AU2012308240A1 (en) 2013-05-02
EP2755681A2 (en) 2014-07-23

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