JP2014528076A5 - - Google Patents
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- Publication number
- JP2014528076A5 JP2014528076A5 JP2014531321A JP2014531321A JP2014528076A5 JP 2014528076 A5 JP2014528076 A5 JP 2014528076A5 JP 2014531321 A JP2014531321 A JP 2014531321A JP 2014531321 A JP2014531321 A JP 2014531321A JP 2014528076 A5 JP2014528076 A5 JP 2014528076A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- aquaporin
- exosomes
- item
- aki
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 55
- 210000001808 exosome Anatomy 0.000 claims description 26
- 210000002700 urine Anatomy 0.000 claims description 24
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 23
- 208000033626 Renal failure acute Diseases 0.000 claims description 23
- 201000011040 acute kidney failure Diseases 0.000 claims description 23
- 239000003550 marker Substances 0.000 claims description 13
- 102000004363 Aquaporin 3 Human genes 0.000 claims description 12
- 108090000991 Aquaporin 3 Proteins 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 9
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 102000012192 Cystatin C Human genes 0.000 claims description 7
- 108010061642 Cystatin C Proteins 0.000 claims description 7
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims description 7
- 101710185991 Hepatitis A virus cellular receptor 1 homolog Proteins 0.000 claims description 7
- 108010051335 Lipocalin-2 Proteins 0.000 claims description 7
- 102000013519 Lipocalin-2 Human genes 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 230000002485 urinary effect Effects 0.000 claims description 7
- 102000003810 Interleukin-18 Human genes 0.000 claims description 6
- 108090000171 Interleukin-18 Proteins 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 239000007850 fluorescent dye Substances 0.000 claims description 4
- 230000003834 intracellular effect Effects 0.000 claims description 4
- 230000002285 radioactive effect Effects 0.000 claims description 4
- 230000008105 immune reaction Effects 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 210000000512 proximal kidney tubule Anatomy 0.000 claims 4
- 210000005239 tubule Anatomy 0.000 claims 2
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 210000000210 loop of henle Anatomy 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 108020001580 protein domains Proteins 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 102000004888 Aquaporin 1 Human genes 0.000 description 8
- 108090001004 Aquaporin 1 Proteins 0.000 description 8
- 108010036221 Aquaporin 2 Proteins 0.000 description 8
- 102100034414 Aquaporin-2 Human genes 0.000 description 8
- 238000012544 monitoring process Methods 0.000 description 5
- -1 IL-1beta Proteins 0.000 description 4
- 102000056430 Member 1 Solute Carrier Family 12 Human genes 0.000 description 4
- 108091006621 SLC12A1 Proteins 0.000 description 4
- 108091006649 SLC9A3 Proteins 0.000 description 4
- 102000046061 Sodium-Hydrogen Exchanger 3 Human genes 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 206010061481 Renal injury Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000001471 micro-filtration Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000037806 kidney injury Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2011/054187 WO2013041913A1 (en) | 2011-09-22 | 2011-09-22 | Method for monitoring, diagnosis and/or prognosis of acute kidney injury in early stage |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528076A JP2014528076A (ja) | 2014-10-23 |
| JP2014528076A5 true JP2014528076A5 (cg-RX-API-DMAC7.html) | 2014-12-04 |
| JP5893742B2 JP5893742B2 (ja) | 2016-03-23 |
Family
ID=47913944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531321A Expired - Fee Related JP5893742B2 (ja) | 2011-09-22 | 2011-09-22 | 早期における急性腎損傷をモニタリング、診断、および／または予後診断するための方法 |
Country Status (15)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| FR3014198B1 (fr) * | 2013-12-03 | 2017-03-03 | Biomerieux Sa | Procede d'isolement d'exosomes |
| WO2016011383A1 (en) * | 2014-07-17 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Methods for using exosomes to monitor transplanted organ status |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| EP3218724A4 (en) * | 2014-11-11 | 2018-08-22 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2016077537A1 (en) * | 2014-11-12 | 2016-05-19 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| WO2016140388A1 (ko) * | 2015-03-05 | 2016-09-09 | 경북대학교 산학협력단 | 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법 |
| US20160320390A1 (en) * | 2015-05-01 | 2016-11-03 | Morehouse School Of Medicine | Compositions and methods for capturing exosomes |
| EP3334498B1 (en) | 2015-08-12 | 2023-06-07 | The Trustees of Columbia University in the City of New York | Methods of treating volume depletion and kidney injury |
| WO2017040520A1 (en) | 2015-08-31 | 2017-03-09 | Hitachi Chemical Co., Ltd. | Molecular methods for assessing urothelial disease |
| JP6531987B2 (ja) * | 2015-10-01 | 2019-06-19 | 国立大学法人名古屋大学 | 腎疾患診断のためのエクソソーム回収法 |
| CN105441578B (zh) * | 2016-01-19 | 2018-08-31 | 中南大学湘雅二医院 | 尿液外泌体microRNA分子标志物的应用及制备的试剂盒 |
| WO2017155894A1 (en) | 2016-03-07 | 2017-09-14 | Cfgenome, Llc | Noninvasive molecular controls |
| CN106053811A (zh) * | 2016-06-05 | 2016-10-26 | 浙江大学 | 一种尿液外泌体elisa的检测方法及其应用 |
| RU2647327C2 (ru) * | 2016-07-05 | 2018-03-15 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО КубГМУ Минздрава России) | Способ ранней диагностики хронической болезни почек у пациентов с хронической обструктивной болезнью легких |
| JP2019168223A (ja) * | 2016-08-12 | 2019-10-03 | 公立大学法人和歌山県立医科大学 | エクソソームの膜に存在するタンパク質の検出方法 |
| CN109425742A (zh) * | 2017-08-23 | 2019-03-05 | 迪亚莱博（张家港）生物科技有限公司 | 一种化学发光法快速检测水通道蛋白1的试剂盒 |
| JPWO2019045049A1 (ja) * | 2017-09-01 | 2020-12-03 | 学校法人帝京大学 | 腎尿細管細胞特異的発現ベクター |
| RU2702023C1 (ru) * | 2018-08-17 | 2019-10-04 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ диагностики острого повреждения почек после органосохраняющего хирургического лечения локализованного рака почки |
| ES2968898T3 (es) * | 2019-06-06 | 2024-05-14 | Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz | Método in vitro para detectar enfermedad renal |
| EP3904883A1 (en) * | 2020-04-07 | 2021-11-03 | Sciomics GmbH | Prediction and early diagnosis of acute kidney injury |
| RU2765678C1 (ru) * | 2020-12-21 | 2022-02-01 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ прогнозирования риска развития острого повреждения почек у больных с острым коронарным синдромом |
| CN113189321B (zh) * | 2021-04-12 | 2024-06-25 | 攸太科技(台州)有限公司 | 一种尿液检测方法 |
| WO2024085722A1 (ko) * | 2022-10-20 | 2024-04-25 | 건국대학교 산학협력단 | 신장 질환의 조기 진단을 위한 바이오마커 조성물 및 이를 이용한 신장 질환의 조기 진단에 필요한 정보를 제공하는 방법 |
| KR20250003155A (ko) * | 2023-06-30 | 2025-01-07 | 연세대학교 산학협력단 | 급성신손상의 회복에 대한 정보 제공 방법 및 이를 이용한 키트 |
| CN116883739A (zh) * | 2023-07-10 | 2023-10-13 | 中国医学科学院生物医学工程研究所 | 一种基于图像识别的尿隐血分类方法和系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9927320D0 (en) * | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US20040241176A1 (en) * | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| WO2004013152A2 (en) * | 2002-08-06 | 2004-02-12 | Duke University | Novel targets for lithium therapy |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| WO2007127848A1 (en) * | 2006-04-26 | 2007-11-08 | University Of Louisville Research Foundation, Inc | Isolation of membrane vesicles from biological fluids and methods of using same |
| KR101970908B1 (ko) * | 2008-02-01 | 2019-04-19 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
| US20110124519A1 (en) * | 2008-03-18 | 2011-05-26 | Frank Walter Falkenberg | Method of assessing kidney function in a human subject |
| US7897356B2 (en) * | 2008-11-12 | 2011-03-01 | Caris Life Sciences | Methods and systems of using exosomes for determining phenotypes |
| US8394606B2 (en) * | 2008-11-05 | 2013-03-12 | Abbott Laboratories | Neutrophil gelatinase-associated lipocalin (NGAL) protein isoforms enriched from urine and recombinant chinese hamster ovary (CHO) cells and related compositions, antibodies, and methods of enrichment, analysis and use |
| CA2744434C (en) * | 2008-11-21 | 2017-10-03 | Phadia Ab | Methods, devices and kits for detecting or monitoring acute kidney injury |
| GB0822836D0 (en) * | 2008-12-15 | 2009-01-21 | Oxford Biomedica Ltd | Method |
| WO2010135334A1 (en) * | 2009-05-18 | 2010-11-25 | Washington University | Methods of renal cancer detection |
-
2011
- 2011-09-22 KR KR1020147009382A patent/KR20140076571A/ko not_active Withdrawn
- 2011-09-22 MX MX2014003422A patent/MX2014003422A/es not_active Application Discontinuation
- 2011-09-22 EP EP20110872834 patent/EP2758774A4/en not_active Withdrawn
- 2011-09-22 RU RU2014115999/15A patent/RU2014115999A/ru unknown
- 2011-09-22 HK HK15100094.8A patent/HK1199754A1/xx unknown
- 2011-09-22 CA CA2849577A patent/CA2849577A1/en not_active Abandoned
- 2011-09-22 JP JP2014531321A patent/JP5893742B2/ja not_active Expired - Fee Related
- 2011-09-22 BR BR112014006741A patent/BR112014006741A2/pt not_active IP Right Cessation
- 2011-09-22 CN CN201180074742.3A patent/CN103917869A/zh active Pending
- 2011-09-22 AU AU2011377379A patent/AU2011377379A1/en not_active Abandoned
- 2011-09-22 PH PH1/2014/500650A patent/PH12014500650A1/en unknown
- 2011-09-22 US US14/346,679 patent/US20140329334A1/en not_active Abandoned
- 2011-09-22 WO PCT/IB2011/054187 patent/WO2013041913A1/en not_active Ceased
-
2014
- 2014-03-20 IL IL231626A patent/IL231626A0/en unknown
- 2014-04-22 IN IN3194DEN2014 patent/IN2014DN03194A/en unknown
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