JP2014527043A - Srcホモロジー2プロテインチロシンホスファターゼ−1を含むアゴニスト及びその治療方法 - Google Patents

Srcホモロジー2プロテインチロシンホスファターゼ−1を含むアゴニスト及びその治療方法 Download PDF

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JP2014527043A
JP2014527043A JP2014523113A JP2014523113A JP2014527043A JP 2014527043 A JP2014527043 A JP 2014527043A JP 2014523113 A JP2014523113 A JP 2014523113A JP 2014523113 A JP2014523113 A JP 2014523113A JP 2014527043 A JP2014527043 A JP 2014527043A
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チョン−ワイ シアオ
クエン−フェン チェン
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    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
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    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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JP2014523113A 2011-08-03 2012-08-03 Srcホモロジー2プロテインチロシンホスファターゼ−1を含むアゴニスト及びその治療方法 Pending JP2014527043A (ja)

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US201161514555P 2011-08-03 2011-08-03
US61/514,555 2011-08-03
PCT/US2012/049446 WO2013020014A1 (en) 2011-08-03 2012-08-03 Agonists of src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same

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JP2019528279A (ja) * 2016-08-17 2019-10-10 アイカーン スクール オブ メディシン アット マウント サイナイ キナーゼ阻害物質化合物、組成物、及びがんの治療方法

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WO2014032755A2 (en) * 2012-08-29 2014-03-06 Merck Patent Gmbh Ddr2 inhibitors for the treatment of osteoarthritis
CN105074467B (zh) * 2013-04-25 2018-06-15 株式会社Cbs生物科学 提高分子靶向治疗肝细胞癌的敏感性的分析方法
WO2015051149A1 (en) * 2013-10-04 2015-04-09 The Trustees Of Columbia University In The City Of New York Sorafenib analogs and uses thereof
HK1248208A1 (zh) * 2015-08-31 2018-10-12 东丽株式会社 尿素衍生物和其用途
CN108026035B (zh) * 2015-09-02 2021-03-30 陈昆锋 具有蛋白酪氨酸磷酸酶shp-1激动剂活性的化合物
WO2018054354A1 (zh) * 2016-09-22 2018-03-29 陈昆锋 含有src同源区2的蛋白酪氨酸磷酸酶-1激动剂用于改善纤维化的用途
SG11201906671SA (en) * 2017-02-03 2019-08-27 Univ California Compositions and methods for inhibiting reticulon 4
WO2020055755A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
CN113402456B (zh) * 2020-03-16 2023-03-03 深圳大学 一种抗肿瘤药物以及一种化合物或其药学上可接受的盐在抗肿瘤药物中的应用
CN112084184B (zh) * 2020-09-15 2022-12-16 青海省地质测绘地理信息院 一种在不同gis平台之间异构数据属性传递的方法
CN120757548A (zh) * 2025-07-01 2025-10-10 遵义医科大学 一种咪唑并[l,2-a]吡啶苯氧基脲类化合物及其制备方法和用途

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WO2003016254A1 (en) * 2001-08-09 2003-02-27 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
JP2003513960A (ja) * 1999-11-11 2003-04-15 バイエル アクチェンゲゼルシャフト 置換フェニルウラシル類及び除草剤としてのそれらの使用
WO2006014134A1 (en) * 2004-08-02 2006-02-09 Astrazeneca Ab Novel piperidine derivative for the treatment of depression
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